当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > An effective treatment of experimental osteomyelitis using the antimicrobial titanium/silver-containing nHP66 (nano-hydroxyapatite/polyamide-66) nanoscaffold biomaterials.

An effective treatment of experimental osteomyelitis using the antimicrobial titanium/silver-containing nHP66 (nano-hydroxyapatite/polyamide-66) nanoscaffold biomaterials.

Abstract：

:Effective treatment of osteomyelitis remains a formidable clinical challenge. The rapid emergence of multidrug-resistant bacteria has renewed interest in developing antimicrobial biomaterials using antiseptic silver ions to treat osteomyelitis. However, inadequate local retention and severe cytotoxic effects have limited the clinical use of ionic silver for bone grafts. We recently developed novel porous nano-hydroxyapatite/polyamide 66 (nHP66)-based nanoscaffold materials containing varied concentrations of silver ions (Ag+) (TA-nHAPA66) and oxidized titanium (TiO2), which was added as a second binary element to enhance antibacterial activity and biocompatibility. In this study, we establish a large cohort of rabbit model of experimental osteomyelitis and investigate the in vivo antimicrobial and therapeutic effects of TA-nHP66 biomaterials and their in vivo silver release kinetics. We find the TA-nHP66 scaffolds exhibit potent antibacterial activities against E. coli and S. aureus, support cell adhesion and cell proliferation of pre-osteoblasts, and stimulate osteogenic regulator/marker expression. Moreover, the TA2-nHP66 scaffold exerts potent antibacterial/anti-inflammation effects in vivo and promotes bone formation at the lesion site of osteomyelitis. We further demonstrate that TA2-nHP66 exhibits excellent biosafety profile without apparent systemic toxicities. Therefore, the TA-nHP66 scaffold biomaterials may be further explored as an effective adjuvant therapy for infected bone defects and/or osteomyelitis debridement.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Lu M,Liao J,Dong J,Wu J,Qiu H,Zhou X,Li J,Jiang D,He TC,Quan Z

doi

10.1038/srep39174

subject

Has Abstract

pub_date

2016-12-16 00:00:00

pages

39174

issn

2045-2322

pii

srep39174

journal_volume

6

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Density-gradient centrifugation enables the purification of cultured corneal endothelial cells for cell therapy by eliminating senescent cells.

    abstract：:The corneal endothelium is essential for maintaining corneal transparency; therefore, corneal endothelial dysfunction causes serious vision loss. Tissue engineering-based therapy is potentially a less invasive and more effective therapeutic modality. We recently started a first-in-man clinical trial of cell-based ther...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep15005

    authors： Okumura N,Kusakabe A,Hirano H,Inoue R,Okazaki Y,Nakano S,Kinoshita S,Koizumi N

    更新日期：2015-10-07 00:00:00

  • Optimal SSSC-based power damping inter-area oscillations using firefly and harmony search algorithms.

    abstract：:The static synchronous series compensator (SSSC) can add a series reactance to the transmission line, and when it is fed using auxiliary signals, it can participate in damping inter-area oscillations by changing the series reactance. In this paper, the effect of the SSSC on small-signal stability is investigated. The ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69123-7

    authors： Naderipour A,Abdul-Malek Z,Ramachandaramurthy VK,Miveh MR,Moghaddam MJH,Guerrero JM

    更新日期：2020-07-22 00:00:00

  • Inflammatory gene expression in adipose tissue according to diagnosis of anxiety and mood disorders in obese and non-obese subjects.

    abstract：:Psychiatric disorders have been widely reported to be associated with systemic inflammation upregulation and adiposity. However, there are no data that link adipose tissue inflammation to these mental disorders. The analysis of adipokines and inflammation-related markers in adipose tissue could help to elucidate the p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35759-9

    authors： Coín-Aragüez L,Pavón FJ,Contreras A,Gentile AM,Lhamyani S,De Diego-Otero Y,Casado Y,Oliva Olivera W,Olveira G,Tinahones FJ,Pérez Costillas L,El Bekay R

    更新日期：2018-11-30 00:00:00

  • Identification and analysis of seven effector protein families with different adaptive and evolutionary histories in plant-associated members of the Xanthomonadaceae.

    abstract：:The Xanthomonadaceae family consists of species of non-pathogenic and pathogenic γ-proteobacteria that infect different hosts, including humans and plants. In this study, we performed a comparative analysis using 69 fully sequenced genomes belonging to this family, with a focus on identifying proteins enriched in phyt...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16325-1

    authors： Assis RAB,Polloni LC,Patané JSL,Thakur S,Felestrino ÉB,Diaz-Caballero J,Digiampietri LA,Goulart LR,Almeida NF,Nascimento R,Dandekar AM,Zaini PA,Setubal JC,Guttman DS,Moreira LM

    更新日期：2017-11-23 00:00:00

  • Metabolomic identification of biochemical changes induced by fluoxetine and imipramine in a chronic mild stress mouse model of depression.

    abstract：:Metabolomics was applied to a C57BL/6N mouse model of chronic unpredictable mild stress (CMS). Such mice were treated with two antidepressants from different categories: fluoxetine and imipramine. Metabolic profiling of the hippocampus was performed using gas chromatography-mass spectrometry analysis on samples prepar...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08890

    authors： Zhao J,Jung YH,Jang CG,Chun KH,Kwon SW,Lee J

    更新日期：2015-03-09 00:00:00

  • Binding modes of environmental endocrine disruptors to human serum albumin: insights from STD-NMR, ITC, spectroscopic and molecular docking studies.

    abstract：:Given that bisphenols have an endocrine-disrupting effect on human bodies, thoroughly exposing their potential effects at the molecular level is important. Saturation transfer difference (STD) NMR-based binding studies were performed to investigate the binding potential of two bisphenol representatives, namely, bisphe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11604-3

    authors： Yang H,Huang Y,Liu J,Tang P,Sun Q,Xiong X,Tang B,He J,Li H

    更新日期：2017-09-11 00:00:00

  • Ocular antigen does not cause disease unless presented in the context of inflammation.

    abstract：:Ocular antigens are sequestered behind the blood-retina barrier and the ocular environment protects ocular tissues from autoimmune attack. The signals required to activate autoreactive T cells and allow them to cause disease in the eye remain in part unclear. In particular, the consequences of peripheral presentation ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-14618-z

    authors： Voigt V,Wikstrom ME,Kezic JM,Schuster IS,Fleming P,Makinen K,Daley SR,Andoniou CE,Degli-Esposti MA,Forrester JV

    更新日期：2017-10-27 00:00:00

  • Two Tau binding sites on tubulin revealed by thiol-disulfide exchanges.

    abstract：:Tau is a Microtubule-associated protein that induces and stabilizes the formation of the Microtubule cytoskeleton and plays an important role in neurodegenerative diseases. The Microtubules binding region of Tau has been determined for a long time but where and how Tau binds to its partner still remain a topic of deba...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-32096-9

    authors： Martinho M,Allegro D,Huvent I,Chabaud C,Etienne E,Kovacic H,Guigliarelli B,Peyrot V,Landrieu I,Belle V,Barbier P

    更新日期：2018-09-14 00:00:00

  • A Feature based Reconstruction Model for Fluorescence Microscopy Image Denoising.

    abstract：:The advent of Fluorescence Microscopy over the last few years have dramatically improved the problem of visualization and tracking of specific cellular objects for biological inference. But like any other imaging system, fluorescence microscopy has its own limitations. The resultant images suffer from the effect of no...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43973-2

    authors： Maji SK,Yahia H

    更新日期：2019-05-22 00:00:00

  • A set of composite, non-redundant EEG measures of NREM sleep based on the power law scaling of the Fourier spectrum.

    abstract：:Features of sleep were shown to reflect aging, typical sex differences and cognitive abilities of humans. However, these measures are characterized by redundancy and arbitrariness. Our present approach relies on the assumptions that the spontaneous human brain activity as reflected by the scalp-derived electroencephal...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81230-7

    authors： Bódizs R,Szalárdy O,Horváth C,Ujma PP,Gombos F,Simor P,Pótári A,Zeising M,Steiger A,Dresler M

    更新日期：2021-01-21 00:00:00

  • The Role of a Crystallographically Unresolved Cytoplasmic Loop in Stabilizing the Bacterial Membrane Insertase YidC2.

    abstract：:YidC, a bacterial member of the YidC/Alb3/Oxa1 insertase family, mediates membrane protein assembly and insertion. Cytoplasmic loops are known to have functional significance in membrane proteins such as YidC. Employing microsecond-level molecular dynamics (MD) simulations, we show that the crystallographically unreso...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-51052-9

    authors： Harkey T,Govind Kumar V,Hettige J,Tabari SH,Immadisetty K,Moradi M

    更新日期：2019-10-08 00:00:00

  • Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage.

    abstract：:In non-growing teeth, such as mouse and human molars, primary odontoblasts are long-lived post-mitotic cells that secrete dentine throughout the life of the tooth. New odontoblast-like cells are only produced in response to a damage or trauma. Little is known about the molecular events that initiate mesenchymal stem c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03145-6

    authors： Babb R,Chandrasekaran D,Carvalho Moreno Neves V,Sharpe PT

    更新日期：2017-06-08 00:00:00

  • Inorganic carbon physiology underpins macroalgal responses to elevated CO2.

    abstract：:Beneficial effects of CO2 on photosynthetic organisms will be a key driver of ecosystem change under ocean acidification. Predicting the responses of macroalgal species to ocean acidification is complex, but we demonstrate that the response of assemblages to elevated CO2 are correlated with inorganic carbon physiology...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep46297

    authors： Cornwall CE,Revill AT,Hall-Spencer JM,Milazzo M,Raven JA,Hurd CL

    更新日期：2017-04-18 00:00:00

  • Enhanced Broadband Electromagnetic Absorption in Silicon Film with Photonic Crystal Surface and Random Gold Grooves Reflector.

    abstract：:We show a hybrid structure consisting of Si film with photonic crystal surface and random triangular gold grooves reflector at the bottom, which is capable of realizing efficient, broad-band, wide-angle optical absorption. It is numerically demonstrated that the enhanced absorption in a broad wavelength range (0.3-9.9...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12794

    authors： Chen ZH,Qiao N,Yang Y,Ye H,Liu S,Wang W,Wang Y

    更新日期：2015-08-04 00:00:00

  • The co-evolution of networks and prisoner's dilemma game by considering sensitivity and visibility.

    abstract：:Strategies adopted by individuals in a social network significantly impact the network, and they strongly affect relationships between individuals in the network. Links between individuals also heavily influence their levels of cooperation. Taking into account the evolution of each individual's connection, we explore ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45237

    authors： Li D,Ma J,Han D,Sun M,Tian L,Stanley HE

    更新日期：2017-03-24 00:00:00

  • Effect of in vitro storage duration on measured mechanical properties of brain tissue.

    abstract：:Accurate characterization of the mechanical properties of brain tissue is essential for understanding the mechanisms of traumatic brain injuries and developing protective gears or facilities. However, how storage conditions might affect the mechanical properties of brain tissue remains unclear. The objective of this s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19687-2

    authors： Zhang W,Liu LF,Xiong YJ,Liu YF,Yu SB,Wu CW,Guo W

    更新日期：2018-01-19 00:00:00

  • Demonstration of Temperature Dependent Energy Migration in Dual-Mode YVO4: Ho3+/Yb3+ Nanocrystals for Low Temperature Thermometry.

    abstract：:A dual mode rare-earth based vanadate material (YVO4: Ho3+/Yb3+), prepared through ethylene glycol assisted hydrothermal method, demonstrating both downconversion and upconversion, along with systematic investigation of the luminescence spectroscopy within 12-300 K is presented herein. The energy transfer processes ha...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep36342

    authors： Kumar Mahata M,Koppe T,Kumar K,Hofsäss H,Vetter U

    更新日期：2016-11-02 00:00:00

  • Cre/lox-Recombinase-Mediated Cassette Exchange for Reversible Site-Specific Genomic Targeting of the Disease Vector, Aedes aegypti.

    abstract：:Site-specific genome modification (SSM) is an important tool for mosquito functional genomics and comparative gene expression studies, which contribute to a better understanding of mosquito biology and are thus a key to finding new strategies to eliminate vector-borne diseases. Moreover, it allows for the creation of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43883

    authors： Häcker I,Harrell Ii RA,Eichner G,Pilitt KL,O'Brochta DA,Handler AM,Schetelig MF

    更新日期：2017-03-07 00:00:00

  • Three-dimensional observation and analysis of remineralization in dentinal caries lesions.

    abstract：:The remineralization mechanism in dental caries lesions is not completely understood. This study reports on ultrastructural and chemical changes observed within arrested caries lesions. Carious human teeth were observed using scanning electron microscopy (SEM) and focused-ion-beam (FIB)-SEM. The crystals detected in t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-61111-1

    authors： Yoshihara K,Nagaoka N,Nakamura A,Hara T,Hayakawa S,Yoshida Y,Van Meerbeek B

    更新日期：2020-03-09 00:00:00

  • Optical pumping and readout of bismuth hyperfine states in silicon for atomic clock applications.

    abstract：:The push for a semiconductor-based quantum information technology has renewed interest in the spin states and optical transitions of shallow donors in silicon, including the donor bound exciton transitions in the near-infrared and the Rydberg, or hydrogenic, transitions in the mid-infrared. The deepest group V donor i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10493

    authors： Saeedi K,Szech M,Dluhy P,Salvail JZ,Morse KJ,Riemann H,Abrosimov NV,Nötzel N,Litvinenko KL,Murdin BN,Thewalt ML

    更新日期：2015-05-20 00:00:00

  • ATF4 overexpression induces early onset of hyperlipidaemia and hepatic steatosis and enhances adipogenesis in zebrafish.

    abstract：:Activating transcription factor 4 (ATF4) is constitutively expressed in a variety of tissues, and regulates several pathological features associated with metabolic diseases such as non-alcoholic fatty liver diseases (NAFLD) and obesity. However, the role of ATF4 in animal model systems is poorly understood. To investi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16587-9

    authors： Yeh KY,Lai CY,Lin CY,Hsu CC,Lo CP,Her GM

    更新日期：2017-11-27 00:00:00

  • Comparative and Phylogenetic Analyses of the Complete Chloroplast Genomes of Six Almond Species (Prunus spp. L.).

    abstract：:As a source of genetic variation, almond germplasm resources are of great significance in breeding. To better reveal the mutation characteristics and evolution patterns of the almond chloroplast (cp) genome, the complete cp genomes from six almond species were analyzed. The lengths of the chloroplast genome of the six...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67264-3

    authors： Wang W,Yang T,Wang HL,Li ZJ,Ni JW,Su S,Xu XQ

    更新日期：2020-06-23 00:00:00

  • Erratum: miR-2478 inhibits TGFβ1 expression by targeting the transcriptional activation region downstream of the TGFβ1 promoter in dairy goats.

    abstract：:This corrects the article DOI: 10.1038/srep42627. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/srep46966

    authors： Li Z,Lan X,Han R,Wang J,Huang Y,Sun J,Guo W,Chen H

    更新日期：2018-04-06 00:00:00

  • Sub-wavelength annular-slit-assisted superoscillatory lens for longitudinally-polarized super-resolution focusing.

    abstract：:A binary metallic superoscillatory lens assisted with annular subwavelength slits is proposed, which generates a longitudinally-polarized super-resolution focal point. The annular slits are designed to selectively transmit radially-polarized light. Simulations using the finite element method show a 0.24 λ focal spot w...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56810-3

    authors： Kim H,Rogers ETF

    更新日期：2020-01-28 00:00:00

  • Glacier ablation and temperature indexed melt models in the Nepalese Himalaya.

    abstract：:Temperature index (TI) models are convenient for modelling glacier ablation since they require only a few input variables and rely on simple empirical relations. The approach is generally assumed to be reliable at lower elevations (below 3500 m above sea level, a.s.l) where air temperature (Ta) relates well to the ene...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41657-5

    authors： Litt M,Shea J,Wagnon P,Steiner J,Koch I,Stigter E,Immerzeel W

    更新日期：2019-03-27 00:00:00

  • Alcohol solvothermal reduction for commercial P25 to harvest weak visible light and fabrication of the resulting floating photocatalytic spheres.

    abstract：:In this study, to fabricate stable floating photocatalytic spheres, facile alcohol solvothermal reduction was first employed to modify commercial TiO2 (P25) photocatalysts to harvest visible light and improve their performances for photodegrading phenol in seawater exciting by visible light. Floating photocatalytic sp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-50457-w

    authors： Wang T,Li Y,Pan JH,Zhang YL,Wu LG,Dong CY,Li CJ

    更新日期：2019-09-25 00:00:00

  • Plasma cell treatment device Plasma-on-Chip: Monitoring plasma-generated reactive species in microwells.

    abstract：:We have developed a plasma cell treatment device called Plasma-on-Chip that enables the real-time monitoring of a single cell culture during plasma treatment. The device consists of three parts: 1) microwells for cell culture, 2) a microplasma device for generating reactive oxygen and nitrogen species (RONS) for use i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41953

    authors： Oh JS,Kojima S,Sasaki M,Hatta A,Kumagai S

    更新日期：2017-02-08 00:00:00

  • The metabolic footprint of compromised insulin sensitivity under fasting and hyperinsulinemic-euglycemic clamp conditions in an Arab population.

    abstract：:Metabolic pathways that are corrupted at early stages of insulin resistance (IR) remain elusive. This study investigates changes in body metabolism in clinically healthy and otherwise asymptomatic subjects that may become apparent already under compromised insulin sensitivity (IS) and prior to IR. 47 clinically health...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73723-8

    authors： Halama A,Suleiman NN,Kulinski M,Bettahi I,Hassoun S,Alkasem M,Abdalhakam I,Iskandarani A,Samra TA,Atkin SL,Suhre K,Abou-Samra AB

    更新日期：2020-10-13 00:00:00

  • Risk assessment and predator learning in a changing world: understanding the impacts of coral reef degradation.

    abstract：:Habitat degradation is among the top drivers of the loss of global biodiversity. This problem is particularly acute in coral reef system. Here we investigated whether coral degradation influences predator risk assessment and learning for damselfish. When in a live coral environment, Ambon damselfish were able to learn...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32542

    authors： Chivers DP,McCormick MI,Allan BJ,Ferrari MC

    更新日期：2016-09-09 00:00:00

  • Phylogenetic analysis of small ruminant lentiviruses in Germany and Iran suggests their expansion with domestic sheep.

    abstract：:Small ruminant lentiviruses (SRLVs) are found in sheep in Germany and Iran. SRLVs have been classified into four genotypes: A-C and E. Genotype A has been subdivided into 20 subtypes. Previous studies suggested that, first, the ancestors of genotype A are those SRLVs found in Turkey, second, the evolution of SRLVs is ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-58990-9

    authors： Molaee V,Bazzucchi M,De Mia GM,Otarod V,Abdollahi D,Rosati S,Lühken G

    更新日期：2020-02-10 00:00:00