Abstract：
:Neuregulin 4 (NRG4), an epidermal growth factor-like signaling molecule, plays an important role in cell-to-cell communication during tissue development. Its function to regulate energy metabolism has recently been reported. This current study was designed to assess the preventive and therapeutic effects of NRG4 overexpression on high fat diet (HFD)-induced obesity. Using the hydrodynamic gene transfer method, we demonstrate that Nrg4 gene transfer in mice suppressed the development of diet-induced obesity, but did not affect pre-existing adiposity and body weight in obese mice. Nrg4 gene transfer curbed HFD-induced hepatic steatosis by inhibiting lipogenesis and PPARγ-mediated lipid storage. Concurrently, overexpression of NRG4 reduced chronic inflammation in both preventive and treatment studies, evidenced by lower mRNA levels of macrophage marker genes including F4/80, Cd68, Cd11b, Cd11c, and macrophage chemokine Mcp1, resulting in improved insulin sensitivity. Collectively, these results demonstrate that overexpression of the Nrg4 gene by hydrodynamic gene delivery prevents HFD-induced weight gain and fatty liver, alleviates obesity-induced chronic inflammation and insulin resistance, and supports the health benefits of NRG4 in managing obesity and obesity-associated metabolic disorders.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ma Y,Gao M,Liu Ddoi
10.1038/srep26242subject
Has Abstractpub_date
2016-05-17 00:00:00pages
26242issn
2045-2322pii
srep26242journal_volume
6pub_type
杂志文章abstract：:Pulse wave transit time (PWTT) has been widely used as an index in assessing arterial stiffness. Percutaneous coronary intervention (PCI) is usually applied to the treatment of coronary artery disease (CAD). Research on the changes in PWTT caused by PCI is helpful for understanding the impact of the PCI procedure. In ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18520-6
更新日期：2018-01-08 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep43923. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/srep46850
更新日期：2017-06-15 00:00:00
abstract：:We present results from first-principles calculations on silane (SiH4) under pressure. We find that a three dimensional P-3 structure becomes the most stable phase above 241 GPa. A prominent structural feature, which separates the P-3 structure from previously observed/predicted SiH4 structures, is that a fraction of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13039
更新日期：2015-08-12 00:00:00
abstract：:During capillary transit, red blood cells (RBCs) must exchange large quantities of CO2 and O2 in typically less than one second, but the degree to which this is rate-limited by diffusion through cytoplasm is not known. Gas diffusivity is intuitively assumed to be fast and this would imply that the intracellular path-l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36018
更新日期：2016-10-25 00:00:00
abstract：:Molecular imaging technique is an attractive tool to detect liver disease at early stage. This study aims to develop a simultaneous dual-isotope single photon emission computed tomography (SPECT)/CT imaging method to assist diagnosis of hepatic tumor and liver fibrosis. Animal models of liver fibrosis and orthotopic h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28812
更新日期：2016-07-05 00:00:00
abstract：:In this work, we report lateral heterojunction formation in as-exfoliated MoS2 flakes by thickness modulation. Kelvin probe force microscopy is used to map the surface potential at the monolayer-multilayer heterojunction, and consequently the conduction band offset is extracted. Scanning photocurrent microscopy is per...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10990
更新日期：2015-06-30 00:00:00
abstract：:Immune responses are critical for defense against pathogens. However, prolonged viral infection can result in defective T cell immunity, leading to chronic viral infection. We studied immune activation in response to arenavirus infection during cholestasis using bile duct ligation (BDL). We monitored T cell responses,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30627-y
更新日期：2018-08-15 00:00:00
abstract：:Zeolites/molecular sieves with uniform, molecular-sized pores are important for many adsorption-based separation processes. Pore size gaps, however, exist in the current zeolite family. This leads to a great challenge of separating molecules with size differences at ~0.01 nm level. Here, we report a novel concept, por...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13981
更新日期：2015-09-11 00:00:00
abstract：:Biomass waste treatment and detrimental dye adsorption are two of the crucial environmental issues nowadays. In this study, we investigate to simultaneously resolve the aforementioned issues by synthesizing chitosan sponges as adsorbents toward rose bengal (RB) dye adsorption. Through a temperature-controlled freeze-c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18302-0
更新日期：2017-12-22 00:00:00
abstract：:Because of the pathogenicity and low incidence of avian influenza virus infections in humans, the immune correlates of protection for avian influenza vaccines cannot be determined from clinical studies. Here, we used the ferret model to address this for an avian influenza H5N1 vaccine. Using oil-in-water adjuvants, we...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44727
更新日期：2017-03-17 00:00:00
abstract：:The application of CLSI and EUCAST guidelines led to many discrepancies. Various doubts have already appeared in preliminary stages of microbiological diagnostics of Haemophilus spp. A total of 87 H. parainfluenzae isolates were obtained from throat or nasopharyngeal swabs from adults 18 to 70 years old, both healthy ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68161-5
更新日期：2020-07-13 00:00:00
abstract：:Parasites exhibiting a high degree of host specificity are expected to be intimately associated with their hosts. Therefore, the evolution of host-specific parasites is at least partially shaped by the evolutionary history and distribution of such hosts. Gill ectoparasites of Dactylogyrus (Monogenea) are specific to c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31382-w
更新日期：2018-08-29 00:00:00
abstract：:Nonalcoholic fibrosing steatohepatitis is a uniform process throughout nonalcoholic fatty liver disease (NAFLD). MicroRNAs (miRNAs) have been suggested to modulate cellular processes in liver diseases. However, the functional role of miRNAs in nonalcoholic fibrosing steatohepatitis is largely unclear. In this study, w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16163
更新日期：2015-11-05 00:00:00
abstract：:Proteins are of interest in nano-bio electronic devices due to their versatile structures, exquisite functionality and specificity. However, quantum transport measurements produce conflicting results due to technical limitations whereby it is difficult to precisely determine molecular orientation, the nature of the mo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39792
更新日期：2017-01-04 00:00:00
abstract：:Magnolia sirindhorniae Noot. & Chalermglin is an endangered species with high ornamental and commercial value that needs to be urgently protected and judiciously commercialized. In this study, a protocol for efficient regeneration of this species is standardized. The lateral buds of the M. sirindhorniae plant were use...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46050-w
更新日期：2019-07-03 00:00:00
abstract：:There are many types of autoregressive patterns in financial time series, and they form a transmission process. Here, we define autoregressive patterns quantitatively through an econometrical regression model. We present a computational algorithm that sets the autoregressive patterns as nodes and transmissions between...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06290
更新日期：2014-09-05 00:00:00
abstract：:The GS Junior sequencer provides simplified procedures for library preparation and data processing. Errors in pyrosequencing generate some biases during library construction and emulsion PCR amplification. False-positive mutations are identified by related characteristics described in the manufacturer's manual, and so...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13116-6
更新日期：2017-10-23 00:00:00
abstract：:Glioblastoma (GBM) is the most aggressive type of brain tumors in adults with survival period <1.5 years of patients. The role of mTOR pathway is documented in invasion and migration, the features associated with aggressive phenotype in human GBM. However, most of the preclinical and clinical studies with mTOR inhibit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22455
更新日期：2016-03-04 00:00:00
abstract：:The development of a miniaturised device that provides efficient beam manipulation with high transmittance is extremely desirable for the broad range of applications including holography, metalens, and imaging. Recently, the potential of dielectric metasurfaces has been unleashed to efficiently manipulate the beam wit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42444-y
更新日期：2019-04-24 00:00:00
abstract：:Our study aimed to investigate the effect of Pap smear screening on stage at diagnosis of cervical cancer in a heterogeneous population of Thai women. Data was merged from the population-based cancer registry and screening registry based on unique identification numbers from 2006 to 2014. Patients being screened had l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52607-6
更新日期：2019-11-15 00:00:00
abstract：:Enterococci are nosocomial pathogens that can form biofilms, which contribute to their virulence and antibiotic resistance. Although many genes involved in biofilm formation have been defined, their distribution among enterococci has not been comprehensively studied on a genome scale, and their diagnostic ability to p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05901-0
更新日期：2017-07-18 00:00:00
abstract：:Human mediated transportation into novel habitats is a prerequisite for the establishment of non-native species that become invasive, so knowledge of common sources may allow prevention. The brown marmorated stink bug (BMSB, Halyomorpha halys) is an East Asian species now established across North America and Europe, t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10315-z
更新日期：2017-08-29 00:00:00
abstract：:Electroceutical wound dressings, especially those involving current flow with silver based electrodes, show promise for treating biofilm infections. However, their mechanism of action is poorly understood. We have developed an in vitro agar based model using a bioluminescent strain of Pseudomonas aeruginosa to measure...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37891-y
更新日期：2019-02-14 00:00:00
abstract：:Pyrochar (PC) is always with high pH value, and improper application might increase rice paddy ammonia volatilization (PAV), which is the main nitrogen loss through air during rice production. Differently, hydrochar (HC) takes the advantages of high productive rate and always with lower pH value compared with PC. Howe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76213-z
更新日期：2020-11-05 00:00:00
abstract：:Unlike MoS2 ultra-thin films, where solution-based single source precursor synthesis for electronic applications has been widely studied, growing uniform and large area few-layer WS2 films using this approach has been more challenging. Here, we report a method for growth of few-layer WS2 that results in continuous and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58694-0
更新日期：2020-02-03 00:00:00
abstract：:An experimental method for fabrication of a nanocomposite metamaterial based on a self-assembly of titanium dioxide microtubes with encapsulated gold nanoparticles (NPs) is proposed. The formation of microtubes is induced by laser irradiation in the presence of an external magnetic field. It is shown that the variatio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43588-7
更新日期：2019-05-07 00:00:00
abstract：:The majority of oligomeric proteins form clusters which have rotational or dihedral symmetry. Despite the many advantages of symmetric packing, protein oligomers are only nearly symmetric, and the origin of this phenomenon is still in need to be fully explored. Here we apply near-symmetry analyses by the Continuous Sy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65097-8
更新日期：2020-05-20 00:00:00
abstract：:Stability and integration are the goals for developing photonic devices. Spirooxazines have the property of photoinduced merocyanine-aggregation in polymer matrix, which can be applied to fluorescence emission and stable information storage. Although visible light coherent radiation with UV-assist has been used to ach...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22202-2
更新日期：2018-02-28 00:00:00
abstract：:Large-scale anthropogenic disturbances can have direct and indirect effects on marine communities, with direct effects often taking the form of widespread injury or mortality and indirect effects manifesting as changes in food web structure. Here, we report a time series that captures both direct and indirect effects ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62574-y
更新日期：2020-04-09 00:00:00
abstract：:Misuse of antibiotics in the clinical and agricultural sectors has caused the emergence of multidrug-resistant (MDR) Klebsiella pneumoniae which contributes a threat to human health. In this study, we assessed the feasibility of lavender essential oil (LVO) as an antimicrobial agent in combinatory therapy with meropen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55601-0
更新日期：2020-01-21 00:00:00
