Abstract:
:The application of CLSI and EUCAST guidelines led to many discrepancies. Various doubts have already appeared in preliminary stages of microbiological diagnostics of Haemophilus spp. A total of 87 H. parainfluenzae isolates were obtained from throat or nasopharyngeal swabs from adults 18 to 70 years old, both healthy volunteers and patients with chronic diseases between 2013 to 2015 in eastern Poland. Haemophilus spp. were identified by colony morphology, Gram-staining, API NH and MALDI-TOF MS technique. Both susceptibility to various antimicrobials and phenotypes of Haemophilus spp. resistance to beta-lactams were determined. Statistically significant association between applied guidelines and drug resistance patterns were observed to as follows: ampicillin, cefuroxime, cefotaxime, amoxicillin-clavulanate, azithromycin, tetracycline and trimethoprim-sulfamethoxazole. Resistance phenotypes according to CLSI vs. EUCAST were as follows: 3.4% vs. 8.0% for BLNAR and 6.9% vs. 19.5% for BLPACR isolates. In conclusion, this is the first study that reports comparative analysis of drug susceptibility interpretation using CLSI and EUCAST of haemophili rods from human respiratory microbiota in Poland. In case of susceptible, increased exposure (formerly intermediate) category of susceptibility within H. parainfluenzae isolates we have observed EUCAST as more restrictive than CLSI. Moreover, BLNAI and BLPAI phenotype isolates have been observed, as well as BLPBR using only CLSI or EUCAST guidelines, respectively.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kosikowska U,Andrzejczuk S,Grywalska E,Chwiejczak E,Winiarczyk S,Pietras-Ożga D,Stępień-Pyśniak Ddoi
10.1038/s41598-020-68161-5subject
Has Abstractpub_date
2020-07-13 00:00:00pages
11512issue
1issn
2045-2322pii
10.1038/s41598-020-68161-5journal_volume
10pub_type
杂志文章abstract::HIV-exposed uninfected (HEU) infants are disproportionately at a higher risk of morbidity and mortality, as compared to HIV-unexposed uninfected (HUU) infants. Here, we used transcriptional profiling of peripheral blood mononuclear cells to determine immunological signatures of in utero HIV exposure. We identified 262...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54083-4
更新日期:2019-12-02 00:00:00
abstract::α-synuclein (α-syn) is the main component of Lewy bodies, which are neuropathological hallmarks of patients with Parkinson's disease. As it has been controversial whether human α-syn from erythrocytes exists as a tetramer under physiological conditions, we tried solving this issue by the small-angle X-ray solution sca...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30473
更新日期:2016-07-29 00:00:00
abstract::During spring of 2009, a new influenza virus AH1N1 spread in the world causing acute respiratory illness and death, resulting in the first influenza pandemic since 1968. Blood levels of potentially-toxic and essential elements of 40 pneumonia and confirmed AH1N1 were evaluated against two different groups of controls,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01284
更新日期:2013-01-01 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is an increasing health problem worldwide, with genetic, epigenetic, and environmental components. Here, we describe the first example of NAFLD caused by genetic disruption of a mammalian potassium channel subunit. Mice with germline deletion of the KCNE2 potassium channel β su...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23118
更新日期:2016-03-17 00:00:00
abstract::Alternative polyadenylation has been recognized as a key contributor of gene expression regulation by generating different transcript isoforms with altered 3' ends. Although polyadenylation is well known for marking the end of a 3' UTR, an increasing number of studies have reported previously less-addressed polyadenyl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28060
更新日期:2016-06-15 00:00:00
abstract::Light pollution and its consequences on ecosystems are increasing worldwide. Knowledge on the threshold levels of light pollution at which significant ecological impacts emerge and the size of dark refuges to maintain natural nocturnal processes is crucial to mitigate its negative consequences. Seabird fledglings are ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10670
更新日期:2015-06-02 00:00:00
abstract::Many remarkable properties of graphene are derived from its large energy window for Dirac-like electronic states and have been explored for applications in electronics and photonics. In addition, strong electron-phonon interaction in graphene has led to efficient photo-thermo energy conversions, which has been harness...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10582
更新日期:2015-06-08 00:00:00
abstract::Here we demonstrate that aerosols of host directed therapies [HDT] administered during a chronic Mycobacterium tuberculosis (Mtb) infection have bactericidal effect. The pulmonary bacterial load of C57BL/6 mice chronically infected with Mtb was reduced by 1.7 and 0.6 log10CFU after two weeks of treatment via aerosol d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35023-0
更新日期:2018-11-09 00:00:00
abstract::The peripheral sensory system is critical to regulating motor plasticity and motor recovery. Peripheral electrical stimulation (ES) can generate constant and adequate sensory input to influence the excitability of the motor cortex. The aim of this proof of concept study was to assess whether ES prior to each hand func...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-018-27553-4
更新日期:2018-06-15 00:00:00
abstract::The photoactive Orange Carotenoid Protein (OCP) plays a key role in cyanobacterial photoprotection. In OCP, a single non-covalently bound keto-carotenoid molecule acts as a light intensity sensor, while the protein is responsible for forming molecular contacts with the light-harvesting antenna, the fluorescence of whi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68463-8
更新日期:2020-07-16 00:00:00
abstract::Currently, light pollution has become a nonnegligible issue in our daily life. Artificial light sources with high color temperature were deem to be the major pollution source, which could induce several adverse effects on human's health. In our previous research, we have firstly developed an artificial indoor light wi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43864-6
更新日期:2019-05-17 00:00:00
abstract::Chaetosiphella stipae stipae is a xerothermophilous aphid, associated with Palaearctic temperate steppe zones or dry mountain valleys, where there are grasses from the genus Stipa. Its geographical distribution shows several populations that are spread from Spain, across Europe and Asia Minor, to Mongolia and China. G...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43988
更新日期:2017-03-08 00:00:00
abstract::The cytoskeletal filament vimentin is inherent to the endothelial phenotype and is critical for the proper function of endothelial cells in adult mice. It is unclear, however, if the presence of vimentin is necessary during differentiation to the endothelial phenotype. Here we evaluated gene and protein expression of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30814
更新日期:2016-08-02 00:00:00
abstract::In this study we analysed the acoustic properties and presence of haddock calls in the Arctic fjord Kongsfjorden (79° N-12° E, Svalbard Islands, Norway) in one year. Data were collected with three autonomous acoustic recorders located in the inner, middle, and outer parts of the fjord. The fjord is characterized by a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75415-9
更新日期:2020-10-26 00:00:00
abstract::Recently, platelet-rich plasma (PRP) has received attention as a treatment for patients with osteoarthritis of the knee (OAK), a chronic degenerative disease, to bridge the gap between conservative and surgical treatments. Here, we investigated the differences in the humoral factors present in two types of PRP purifie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67099-y
更新日期:2020-06-29 00:00:00
abstract::PAP80-2a, purified from Pholiota adiposa mycelia, is a polysaccharide exhibiting prominent antitumor effects. However, the yield of PAP80-2a was low and its structure has not been characterized, impeding the exploration of its structure-function relationship, thus influencing the development of oral drugs for antitumo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38251-6
更新日期:2019-02-11 00:00:00
abstract::The sulfur-selenium doped carbon quantum dots (S,Se-CQDs) were synthesized by one-step through hydrothermal method in this study, which have high fluorescence quantum yield (43%) and advanced ability to scavenge reactive oxygen species (ROS). They were characterized by transmission electron microscope (TEM), nuclear m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55996-w
更新日期:2019-12-23 00:00:00
abstract::Euphausia pacifica is a good candidate for a resource of marine n-3 PUFA. However, few reports exist of the lipid and fatty acid composition of E. pacifica. To examine the potential of E. pacifica as a resource of marine n-3 PUFA, we analyzed E. pacifica oil. We extracted lipids from E. pacifica harvested from the Pac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09637-9
更新日期:2017-08-30 00:00:00
abstract::Cyanobacteria are ubiquitous organisms with a relevant contribution to primary production in all range of habitats. Cyanobacteria are well known for their part in worldwide occurrence of aquatic blooms while producing a myriad of natural compounds, some with toxic potential, but others of high economical impact, as ge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64774-y
更新日期:2020-05-26 00:00:00
abstract::To understand the mechanisms of male sterility in cotton (Gossypium spp.), combined histological, biochemical and transcription analysis using RNA-Seq was carried out in the anther of the single-gene recessive genic male sterility system of male sterile line 1355A and male fertile line 1355B, which are near-isogenic l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09608
更新日期:2015-06-05 00:00:00
abstract::Ebola virus disease (EVD) is a contagious, severe and often lethal form of hemorrhagic fever in humans. The association of EVD outbreaks with forest clearance has been suggested previously but many aspects remained uncharacterized. We used remote sensing techniques to investigate the association between deforestation ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14727-9
更新日期:2017-10-30 00:00:00
abstract::Awe, a complex emotion composed by the appraisal components of vastness and need for accommodation, is a profound and often meaningful experience. Despite its importance, psychologists have only recently begun empirical study of awe. At the experimental level, a main issue concerns how to elicit high intensity awe exp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01242-0
更新日期:2017-04-27 00:00:00
abstract::This study assessed cortical tracking of temporal information in incoming natural speech in seven-month-old infants. Cortical tracking refers to the process by which neural activity follows the dynamic patterns of the speech input. In adults, it has been shown to involve attentional mechanisms and to facilitate effect...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32150-6
更新日期:2018-09-13 00:00:00
abstract::Biological invasions are a major threat to biodiversity and ecosystem functioning. Successful invasions depend on the interplay of multiple abiotic and biotic factors, however, the process of the invasion itself is often overlooked. The temporal variation of environmental factors suggests that a 'window of opportunity...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44737-8
更新日期:2019-06-05 00:00:00
abstract::The ultrathin SmCo5 nanoflakes with average thickness smaller than 50 nm are prepared by a novel method of solid particle (NaCl) and surfactant co-assisted ball milling. The as-prepared nanoflakes exhibit a narrower thickness distribution of 10-50 nm and high coercivity of 23 kOe. The possible formation mechanism of n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25805
更新日期:2016-05-13 00:00:00
abstract::A hybrid optoplasmonic amplifier, injection-seeded by an internally-generated Raman signal and operating in the visible (563-675 nm), is proposed and evidence for amplification is presented. Comprising a gain medium tethered to a whispering gallery mode (WGM) resonator with a protein, and a plasmonic surface, the opti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06168
更新日期:2014-08-26 00:00:00
abstract::Excess alcohol use is known to promote development of aggressive tumors in various tissues in human patients, but the cause of alcohol promotion of tumor aggressiveness is not clearly understood. We used an animals model of fetal alcohol exposure that is known to promote tumor development and determined if alcohol pro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25785-y
更新日期:2018-05-16 00:00:00
abstract::The type II bacterial CRISPR/Cas9 system is rapidly becoming popular for genome-engineering due to its simplicity, flexibility, and high efficiency. Recently, targeted knock-in of a long DNA fragment via homology-independent DNA repair has been achieved in zebrafish using CRISPR/Cas9 system. This raised the possibilit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06545
更新日期:2014-10-08 00:00:00
abstract::Ferroelectric tunneling junctions (FTJs) with tunable tunneling electroresistance (TER) are promising for many emerging applications, including non-volatile memories and neurosynaptic computing. One of the key challenges in FTJs is the balance between the polarization value and the tunneling current. In order to achie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56816-x
更新日期:2019-12-31 00:00:00
abstract::We report, for the first time, the generation of high-order harmonics in a spectral range between 200 eV and 1 keV with an unusual spectral property: only every 4(th) (4i + 1, i∈ℵ) harmonic line appears, whereas the usual high-harmonic spectra consist of every odd (2i + 1) harmonic. We attribute this unique property t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04234
更新日期:2014-02-28 00:00:00