Simultaneous Analysis of Secondary Structure and Light Scattering from Circular Dichroism Titrations: Application to Vectofusin-1.

abstract：:In all organisms, salts produce either appetitive or aversive responses depending on the concentration. While low-salt concentration in food elicits positive responses to ingest, high-salt triggers aversion. Still the mechanisms involved in this dual behavior have just started to be uncovered in some organisms. In Rho...

journal_title：Scientific reports

authors： Cano A,Pontes G,Sfara V,Anfossi D,Barrozo RB

更新日期：2017-11-14 00:00:00

abstract：:Kidney regeneration from pluripotent stem cells is receiving a lot of attention because limited treatments are currently available for chronic kidney disease (CKD). It has been shown that uremic state in CKD is toxic to somatic stem/progenitor cells, such as endothelial progenitor and mesenchymal stem cells, affecting...

journal_title：Scientific reports

authors： Tajiri S,Yamanaka S,Fujimoto T,Matsumoto K,Taguchi A,Nishinakamura R,Okano HJ,Yokoo T

更新日期：2018-10-08 00:00:00

abstract：:Similar to the onset phase of inflammation, its resolution is a process that unfolds in a manner that is coordinated and regulated by a panel of mediators. Lipoxin A4 (LXA4) has been implicated as an anti-inflammatory, pro-resolving mediator. We hypothesized that LXA4 attenuates or prevents an inflammatory response vi...

journal_title：Scientific reports

authors： Gaudin A,Tolar M,Peters OA

更新日期：2018-06-11 00:00:00

abstract：:Nitrous-oxide emission and nitrate addition from agriculture to earth's environment are two main agriculture related anthropogenic causes of environmental degradation that needs greater attention. For addressing the aforesaid issue, new techniques/practices need to be developed and implemented. The present investigati...

journal_title：Scientific reports

authors： Sharma A,Kumar S,Khan SA,Kumar A,Mir JI,Sharma OC,Singh DB,Arora S

更新日期：2021-01-28 00:00:00

abstract：:To identify novel phenotypic associations related to Cytochrome P450 Family 2 Subfamily A Member 6 (CYP2A6), we investigated the human phenome in a total of 11,271 individuals. Initially, we conducted a phenome-wide association study in 3,401 nicotine-exposed elderly subjects considering 358 phenotypic traits. We iden...

journal_title：Scientific reports

authors： Polimanti R,Jensen KP,Gelernter J

更新日期：2017-04-21 00:00:00

abstract：:Botulinum neurotoxins (BoNTs) are highly potent toxins that cleave neuronal SNARE proteins required for neurotransmission, causing flaccid paralysis and death by asphyxiation. Currently, there are no clinical treatments to delay or reverse BoNT-induced blockade of neuromuscular transmission. While aminopyridines have ...

journal_title：Scientific reports

authors： Beske PH,Hoffman KM,Machamer JB,Eisen MR,McNutt PM

更新日期：2017-11-20 00:00:00

abstract：:Despite the effectiveness of combined anti-retroviral therapy, human immunodeficiency virus (HIV) infected-patients frequently report diarrhea and neuropsychological deficits. It is claimed that the viral HIV-1 Trans activating factor (HIV-1 Tat) protein is responsible for both diarrhea and neurotoxic effects, but the...

journal_title：Scientific reports

authors： Esposito G,Capoccia E,Gigli S,Pesce M,Bruzzese E,D'Alessandro A,Cirillo C,di Cerbo A,Cuomo R,Seguella L,Steardo L,Sarnelli G

更新日期：2017-08-10 00:00:00

abstract：:Data on predictors of intraoperative cardiac arrest (ICA) outcomes are scarce in the literature. This study analysed predictors of poor outcome and their prognostic value after an ICA. Clinical and laboratory data before and 24 hours (h) after ICA were analysed as predictors for no return of spontaneous circulation (R...

journal_title：Scientific reports

authors： Vane MF,Carmona MJC,Pereira SM,Kern KB,Timerman S,Perez G,Vane LA,Otsuki DA,Auler JOC Jr

更新日期：2019-10-18 00:00:00

abstract：:Modern flow cytometry instruments have become vital tools for high-throughput analysis of single cells. However, as issues with the cellular labeling techniques often used in flow cytometry have become more of a concern, the development of label-free modalities for cellular analysis is increasingly desired. Non-linear...

journal_title：Scientific reports

authors： Collier BB,Awasthi S,Lieu DK,Chan JW

更新日期：2015-05-29 00:00:00

abstract：:Dust from grain and feed production may cause adverse health effects in exposed workers. In this study we explored circulating miRNAs as potential biomarkers of occupational grain dust exposure. Twenty-two serum miRNAs were analyzed in 44 grain dust exposed workers and 22 controls. Exposed workers had significantly up...

journal_title：Scientific reports

authors： Straumfors A,Duale N,Foss OAH,Mollerup S

更新日期：2020-07-09 00:00:00

abstract：:The place conditioning paradigm is an efficient, widely-used method to study mechanisms that underlie appetitive or aversive learning and memory processes. However, pharmacological agents used to induce conditioned place preference (CPP) or aversion (CPA) can per se interfere with learning and memory processing, hence...

journal_title：Scientific reports

authors： Goltseker K,Barak S

更新日期：2018-05-08 00:00:00

abstract：:Antimonite [Sb(III)]-oxidizing bacteria can transform the toxic Sb(III) into the less toxic antimonate [Sb(V)]. Recently, the cytoplasmic Sb(III)-oxidase AnoA and the periplasmic arsenite [As(III)] oxidase AioAB were shown to responsible for bacterial Sb(III) oxidation, however, disruption of each gene only partially ...

journal_title：Scientific reports

authors： Li J,Yang B,Shi M,Yuan K,Guo W,Wang Q,Wang G

更新日期：2017-03-02 00:00:00

abstract：:α-synuclein (α-syn) is the main component of Lewy bodies, which are neuropathological hallmarks of patients with Parkinson's disease. As it has been controversial whether human α-syn from erythrocytes exists as a tetramer under physiological conditions, we tried solving this issue by the small-angle X-ray solution sca...

journal_title：Scientific reports

authors： Araki K,Yagi N,Nakatani R,Sekiguchi H,So M,Yagi H,Ohta N,Nagai Y,Goto Y,Mochizuki H

更新日期：2016-07-29 00:00:00

abstract：:Accurate placement of a coordinate system on the radius is important to quantitatively report 3D surgical planning parameters or joint kinematics using 4D imaging techniques. In clinical practice, the scanned length of the radial shaft varies among scanning protocols and scientific studies. The error in positioning a ...

journal_title：Scientific reports

authors： de Roo MGA,Dobbe JGG,Peymani A,van der Made AD,Strackee SD,Streekstra GJ

更新日期：2020-05-15 00:00:00

abstract：:Increased proteolytic activity has been widely associated with skeletal muscle atrophy. However, elevated proteolysis is also critical for the maintenance of cellular homeostasis by disposing cytotoxic proteins and non-functioning organelles. We recently demonstrated that exercise activates autophagy and re-establishe...

journal_title：Scientific reports

authors： Campos JC,Baehr LM,Gomes KMS,Bechara LRG,Voltarelli VA,Bozi LHM,Ribeiro MAC,Ferreira ND,Moreira JBN,Brum PC,Bodine SC,Ferreira JCB

更新日期：2018-08-07 00:00:00

abstract：:Previous reports on epigenetic mechanisms involved in alcohol abuse have focus on hepatic and neuronal regions, leaving the immune system and specifically monocyte-derived dendritic cells (MDDCs) understudied. Our lab has previously shown histone deacetylases are modulated in cells derived from alcohol users and after...

journal_title：Scientific reports

authors： Parira T,Figueroa G,Laverde A,Casteleiro G,Gomez Hernandez ME,Fernandez-Lima F,Agudelo M

更新日期：2017-09-11 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are vital for diverse biological functions, including vision, smell, and aging. They are involved in a wide range of diseases, and are among the most important targets of medicinal drugs. Tools that facilitate GPCR studies or GPCR-based technologies or therapies are thus critical to...

journal_title：Scientific reports

authors： Tegler L,Corin K,Pick H,Brookes J,Skuhersky M,Vogel H,Zhang S

更新日期：2020-12-07 00:00:00

abstract：:Here we report the study of two bioengineered variants of human trace amine-associated receptor 5 (hTAAR5) that were expressed in stable tetracycline-inducible HEK293S cell lines. A systematic detergent screen showed that fos-choline-14 was the optimal detergent to solubilize and subsequently purify the receptors. Mil...

journal_title：Scientific reports

authors： Wang X,Corin K,Rich C,Zhang S

更新日期：2011-01-01 00:00:00

abstract：:Recently proposed tumor fitness measures, based on profiling neoepitopes for reactive viral epitope similarity, have been proposed to predict response to immune checkpoint inhibitors in melanoma and small-cell lung cancer. Here we applied these checkpoint based fitness measures to the matched checkpoint treatment naiv...

journal_title：Scientific reports

authors： Bubie A,Gonzalez-Kozlova E,Akers N,Villanueva A,Losic B

更新日期：2020-03-19 00:00:00

abstract：:Advanced colorectal cancer (CRC) remains a critical health care challenge worldwide. Various TGF-β superfamily members are important in colorectal cancer metastasis, but their signaling effects and predictive value have only been assessed in isolation. Here, we examine cross-regulation and combined functions of the tw...

journal_title：Scientific reports

authors： Staudacher JJ,Bauer J,Jana A,Tian J,Carroll T,Mancinelli G,Özden Ö,Krett N,Guzman G,Kerr D,Grippo P,Jung B

更新日期：2017-07-17 00:00:00

abstract：:Tumor tissue mutational burden (TMB) has emerged as a promising predictive biomarker for immune checkpoint therapy. Measuring TMB from circulating tumor DNA (ctDNA) found in plasma is attractive in tissue-constrained indications. We compared the performance of two plasma-based commercial TMB assays including the effec...

journal_title：Scientific reports

authors： Qiu P,Poehlein CH,Marton MJ,Laterza OF,Levitan D

更新日期：2019-01-14 00:00:00

abstract：:To understand the mechanisms of male sterility in cotton (Gossypium spp.), combined histological, biochemical and transcription analysis using RNA-Seq was carried out in the anther of the single-gene recessive genic male sterility system of male sterile line 1355A and male fertile line 1355B, which are near-isogenic l...

journal_title：Scientific reports

authors： Wu Y,Min L,Wu Z,Yang L,Zhu L,Yang X,Yuan D,Guo X,Zhang X

更新日期：2015-06-05 00:00:00

abstract：:Molecular behaviour of liquid water under proton irradiation is of great importance to a number of technological and medical applications. The highly energetic proton generates a time-varying field that is highly localized and heterogeneous at the molecular scale, and massive electronic excitations are produced as a r...

journal_title：Scientific reports

authors： Reeves KG,Kanai Y

更新日期：2017-01-13 00:00:00

abstract：:The occurrence of biochemical alterations that last for a long period of time in diabetic individuals even after adequate handling of glycemia is an intriguing phenomenon named metabolic memory. In this study, we show that a kidney pathway is gradually altered during the course of diabetes and remains persistently cha...

journal_title：Scientific reports

authors： de Oliveira AA,de Oliveira TF,Bobadilla LL,Garcia CC,Berra CM,de Souza-Pinto NC,Medeiros MH,Di Mascio P,Zatz R,de M Loureiro AP

更新日期：2017-01-12 00:00:00

abstract：:G-proteins are implicated in plant productivity, but their genome-wide roles in regulating agronomically important traits remain uncharacterized. Transcriptomic analyses of rice G-protein alpha subunit mutant (rga1) revealed 2270 differentially expressed genes (DEGs) including those involved in C/N and lipid metabolis...

journal_title：Scientific reports

authors： Pathak RR,Mandal VK,Jangam AP,Sharma N,Madan B,Jaiswal DK,Raghuram N

更新日期：2021-01-27 00:00:00

abstract：:Cardiorenal syndrome, de novo renal pathology arising secondary to cardiac insufficiency, is clinically recognised but poorly characterised. This study establishes and characterises a valid model representative of Type 2 cardiorenal syndrome. Extensive permanent left ventricular infarction, induced by ligation of the ...

journal_title：Scientific reports

authors： Harrison JC,Smart SDG,Besley EMH,Kelly JR,Read MI,Yao Y,Sammut IA

更新日期：2020-01-27 00:00:00

abstract：:Transport of mesoscale particles due to driving flow fields or external forces on a periodic surface appears in many areas. Geometrical and physical characteristics of particles affect the velocities of the particles in these periodic landscapes. In this paper, we present a numerical simulation based on solving the La...

journal_title：Scientific reports

authors： Madadi E,Biagooi M,Mohammadjafari F,Nedaaee Oskoee S

更新日期：2020-10-26 00:00:00

abstract：:William Adams (Miura Anjin) was an English navigator who sailed with a Dutch trading fleet to the far East and landed in Japan in 1600. He became a vassal under the Shogun, Tokugawa Ieyasu, was bestowed with a title, lands and swords, and became the first SAMURAI from England. "Miura" comes from the name of the territ...

journal_title：Scientific reports

authors： Mizuno F,Ishiya K,Matsushita M,Matsushita T,Hampson K,Hayashi M,Tokanai F,Kurosaki K,Ueda S

更新日期：2020-12-10 00:00:00

abstract：:The anti-diabetic biguanide drugs metformin (METF) and phenformin (PHEN) may have anti-cancer effects. Biguanides suppress plasma growth factors, but nonetheless, the view that these mitochondrial inhibitors accumulate in tumor tissue to an extent that leads to severe energetic stress or alleviation of hypoxia-induced...

journal_title：Scientific reports

authors： Iversen AB,Horsman MR,Jakobsen S,Jensen JB,Garm C,Jessen N,Breining P,Frøkiær J,Busk M

更新日期：2017-08-25 00:00:00

abstract：:Bovine lactoferrin is a biglobular multifunctional iron binding glycoprotein that plays an important role in innate immunity against infections. We have previously demonstrated that selected peptides from bovine lactoferrin C-lobe are able to prevent both Influenza virus hemagglutination and cell infection. To deeper ...

journal_title：Scientific reports

authors： Scala MC,Sala M,Pietrantoni A,Spensiero A,Di Micco S,Agamennone M,Bertamino A,Novellino E,Bifulco G,Gomez-Monterrey IM,Superti F,Campiglia P

更新日期：2017-09-06 00:00:00