Abstract：
:Machine learning algorithms have recently shown their precision and potential in many different use cases and fields of medicine. Most of the algorithms used are supervised and need a large quantity of labeled data to achieve high accuracy. Also, most applications of machine learning in medicine are attempts to mimic or exceed human diagnostic capabilities but little work has been done to show the power of these algorithms to help collect and pre-process a large amount of data. In this study we show how unsupervised learning can extract and sort usable data from large unlabeled datasets with minimal human intervention. Our digital examination tools used in clinical practice store such databases and are largely under-exploited. We applied unsupervised algorithms to corneal topography examinations which remains the gold standard test for diagnosis and follow-up of many corneal diseases and refractive surgery screening. We could extract 7019 usable examinations which were automatically sorted in 3 common diagnoses (Normal, Keratoconus and History of Refractive Surgery) from an unlabeled database with an overall accuracy of 96.5%. Similar methods could be used on any form of digital examination database and greatly speed up the data collection process and yield to the elaboration of stronger supervised models.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zéboulon P,Debellemanière G,Gatinel Ddoi
10.1038/s41598-020-73902-7subject
Has Abstractpub_date
2020-10-12 00:00:00pages
16973issue
1issn
2045-2322pii
10.1038/s41598-020-73902-7journal_volume
10pub_type
杂志文章abstract：:Habitat degradation is among the top drivers of the loss of global biodiversity. This problem is particularly acute in coral reef system. Here we investigated whether coral degradation influences predator risk assessment and learning for damselfish. When in a live coral environment, Ambon damselfish were able to learn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32542
更新日期：2016-09-09 00:00:00
abstract：:Statins are well known to have muscle toxicity problem. Herba Cistanches (HC) is a Chinese herb traditionally used for pain in the loins and knees. Our previous in vitro study suggested that it could protect against statin-induced muscle toxicity. However, its in vivo protective effect has never been investigated. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10008-7
更新日期：2017-08-24 00:00:00
abstract：:The application of nitrogen (N) fertilizer deep in soil at the same time as mechanical transplanting of rice seedlings is an effective alternative to conventional broadcasting of fertilizer, but its effects on yields and profitability have not been analysed in detail. Here, we analysed the effects of a side deep appli...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42039-7
更新日期：2019-04-04 00:00:00
abstract：:Pandanus odorifer (Forssk) Kuntze grows naturally along the coastal regions and withstands salt-sprays as well as strong winds. A combination of omics approaches and enzyme activity studies was employed to comprehend the mechanistic basis of high salinity tolerance in P. odorifer. The young seedlings of P. odorifer we...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37039-y
更新日期：2019-01-30 00:00:00
abstract：:The world is experiencing crisis of antibiotic resistance not only in pathogenic but also in commensal bacteria. We determine the prevalence of antibiotic resistance in commensal Escherichia coli in young children in rural setting of central India and search for its correlations with demographic and behavioral factors...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43227-1
更新日期：2019-04-30 00:00:00
abstract：:Severe sepsis and septic shock are life-threatening conditions, with Gram-negative organisms responsible for most sepsis mortality. Systemic administration of compounds that block the action of lipopolysaccharide (LPS), a constituent of the Gram-negative outer cell membrane, is hampered by their hydrophobicity and cat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29739
更新日期：2016-07-14 00:00:00
abstract：:Herein, by growing mono dispersed gold nanoparticles (MNPAu) on the surface of polystyrene (PS)/nanogold (Au) core-shell composites (PS@Au), we successfully synthesized a micron-sized gold cage (2.6-10.7 μm), referred to as PS@Au@MNPAu for the first time. The new micron-gold cage materials exhibit broadband absorption...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72831-9
更新日期：2020-10-06 00:00:00
abstract：:Haemodynamic disorders are common clinical findings in hypertension and lead to adverse cardiovascular events. However, the haemodynamic conditions in hypertension models are poorly understood. This study aimed to observe the characteristics of haemodynamics in spontaneously hypertensive rats (SHRs) and antihypertensi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01906-x
更新日期：2017-05-17 00:00:00
abstract：:Novel activated boron nitride (BN) as an effective adsorbent for pollutants in water and air has been reported in the present work. The activated BN was synthesized by a simple structure-directed method that enabled us to control the surface area, pore volume, crystal defects and surface groups. The obtained BN exhibi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03208
更新日期：2013-11-13 00:00:00
abstract：:Patient misidentification in imaging examinations has become a serious problem in clinical settings. Such misidentification could be prevented if patient characteristics such as sex, age, and body weight could be predicted based on an image of the patient, with an alert issued when a mismatch between the predicted and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43656-y
更新日期：2019-05-10 00:00:00
abstract：:Coronary computed tomography angiography is an established technique in clinical practice and a valuable tool in the diagnosis of coronary artery disease in humans. Imaging of coronaries in preclinical research, i.e. in small animals, is very difficult due to the high demands on spatial and temporal resolution. Mice e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73735-4
更新日期：2020-10-08 00:00:00
abstract：:Settlement-inducing protein complex (SIPC) is a pheromone that triggers conspecific larval settlement in the barnacle Amphibalanus amphitrite. In the present study, immunostaining and scanning electron microscopy of SIPC revealed signals in the frontal horn pores and the secretions from carapace pores, suggesting that...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29376
更新日期：2016-07-20 00:00:00
abstract：:The surveillance of infectious diseases is of great importance for disease control and prevention, and more attention should be paid to the Class B notifiable diseases in China. Meanwhile, according to the International Monetary Fund (IMF), the annual growth of Chinese gross domestic product (GDP) would decelerate bel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-016-0020-5
更新日期：2016-12-23 00:00:00
abstract：:It is rigorously proved that ideal memcapacitors and meminductors are not passive or cyclo-passive devices. Equivalently, this implies that there exist excitation profiles that allow to extract more energy from the device than it is supplied with; so that their energy conversion efficiency exceeds 100%. This means tha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73833-3
更新日期：2020-10-07 00:00:00
abstract：:Geometric mean concentrations of fecal indicator bacteria E. coli and enterococci are commonly used to evaluate the microbial quality of irrigation, recreation, and other types of waters, as well in watershed-scale microbial water quality modeling. It is not known how the uncertainty of those geometric mean concentrat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58603-5
更新日期：2020-02-03 00:00:00
abstract：:Microbiology of a hypersaline oil reservoir located in Central Africa was investigated with molecular and culture methods applied to preserved core samples. Here we show that the community structure was partially acquired during sedimentation, as many prokaryotic 16S rRNA gene sequences retrieved from the extracted DN...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22960
更新日期：2016-03-11 00:00:00
abstract：:Fermentation is the key process to produce the special color of congou black tea. The machine vision technology is applied to detect the color space changes of black tea's color in RGB, Lab and HSV, and to find out its relevance to black tea's fermentation quality. And then the color feature parameter is used as input...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28767-2
更新日期：2018-07-12 00:00:00
abstract：:Myopic traction maculopathy (MTM) can cause vision disabilities in highly myopic eyes. This retrospective case series investigated the clinical outcomes of posterior scleral contraction (PSC) using genipin-cross-linked sclera as the material to treat MTM in highly myopic eyes. In total, 32 eyes from 29 highly myopic p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43256
更新日期：2017-02-21 00:00:00
abstract：:Tea plant is a typical fluorine (F) accumulator. F concentration in mature tea leaves is several hundred times higher than that in normal field crops. Long-term consumption of teas with high level F will increase the risks of dental and skeletal fluorosis. The mechanism of F accumulation in tea stands unclear. RNA-Seq...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08587-6
更新日期：2017-08-29 00:00:00
abstract：:The physiological function of the pancreas is controlled by the circadian clock. The aim of this study was to determine whether aging-induced changes in glucose homeostasis affect properties of the circadian clock in the pancreas and/or its sensitivity to disturbances in environmental lighting conditions. mPer2Luc mic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30225-y
更新日期：2018-08-03 00:00:00
abstract：:We report measurements of the thermal conductance of a structure made from commercial Acrylonitrile Butadiene Styrene (ABS) modules, known as LEGO® blocks, in the temperature range from 70 mK to 1.8 K. A power law for the sample's thermal conductivity κ = (8.7 ± 0.3) × 10-5 T 1.75±0.02 WK-1 m-1 was determined. We conc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55616-7
更新日期：2019-12-23 00:00:00
abstract：:We investigate the timescales of the horizontal mass flux decay of wind remobilised volcanic particles in Argentina, associated with the tephra-fallout deposit produced by the 2011-2012 Cordón Caulle (Chile) eruption. Particle removal processes are controlled by complex interactions of meteorological conditions, surfa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71022-w
更新日期：2020-09-02 00:00:00
abstract：:Social information use has well-known fitness benefits. However, causes underlying the apparent inter-individual variability in the propensity to use social information are poorly studied. Melanins are pigments responsible for most of intra-specific color variation in vertebrates and their variation is often associate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58826-6
更新日期：2020-02-05 00:00:00
abstract：:Extracellular vesicles (EVs) are membrane-enclosed nanoparticles containing specific repertoires of genetic material. In mammals, EVs can mediate the horizontal transfer of various cargos and signaling molecules, notably miRNA and mRNA species. Whether this form of intercellular communication prevails in other metazoa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27680
更新日期：2016-06-10 00:00:00
abstract：:HCV NS3 protein plays a central role in viral polyprotein processing and RNA replication. We demonstrate that the NS3 protease (NS3(pro)) domain alone can specifically bind to HCV-IRES RNA, predominantly in the SLIV region. The cleavage activity of the NS3 protease domain is reduced upon HCV-RNA binding. More importan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00001
更新日期：2011-01-01 00:00:00
abstract：:All-inorganic visibly-transparent energy-harvesting clear laminated glass windows are the most practical solution to boosting building-integrated photovoltaics (BIPV) energy outputs significantly while reducing cooling- and heating-related energy consumption in buildings. By incorporating luminophore materials into la...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06632
更新日期：2014-10-16 00:00:00
abstract：:In clinical pathology, stent interposition is used to treat vascular disease but can lead to restenosis. Drug-eluting stents (DES) are most commonly used to suppress restenosis but can also have side effects. Therefore, we investigated the anti-proliferative effect and its possible target in vitro and in vivo. We foun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08410-2
更新日期：2017-08-15 00:00:00
abstract：:The present study tested whether the LPS/TLR4 signal pathway in endometrial stromal cells is essential for the pathogenesis of adenomyosis. We tested the expression of TLR4, MD2 in the endometrium without adenomyosis (CE), the eutopic endometrium with adenomyosis (EuE) and the ectopic endometrium with adenomyosis (EE)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21416
更新日期：2016-02-22 00:00:00
abstract：:Application of PCR to multiplexing assays is not trivial; it requires multiple fluorescent labels for amplicon detection and sophisticated software for data interpretation. Alternative PCR-free methods exploiting new concepts in nanotechnology exhibit high sensitivities but require multiple labeling and/or amplificati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02033
更新日期：2013-01-01 00:00:00
abstract：:Photoluminescence and photomodulated reflectivity measurements of ZnOSe alloys are used to demonstrate a splitting of the valence band due to the band anticrossing interaction between localized Se states and the extended valence band states of the host ZnO matrix. A strong multiband emission associated with optical tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44214
更新日期：2017-03-13 00:00:00
