A repeatedly refuelable mediated biofuel cell based on a hierarchical porous carbon electrode.

Abstract:

:Biofuel cells that generate electricity from renewable fuels, such as carbohydrates, must be reusable through repeated refuelling, should these devices be used in consumer electronics. We demonstrate the stable generation of electricity from a glucose-powered mediated biofuel cell through multiple refuelling cycles. This refuelability is achieved by immobilizing nicotinamide adenine dinucleotide (NAD), an electron-transfer mediator, and redox enzymes in high concentrations on porous carbon particles constituting an anode while maintaining their electrochemical and enzymatic activities after the immobilization. This bioanode can be refuelled continuously for more than 60 cycles at 1.5 mA cm(-2) without significant potential drop. Cells assembled with these bioanodes and bilirubin-oxidase-based biocathodes can be repeatedly used to power a portable music player at 1 mW cm(-3) through 10 refuelling cycles. This study suggests that the refuelability within consumer electronics should facilitate the development of long and repeated use of the mediated biofuel cells as well as of NAD-based biosensors, bioreactors, and clinical applications.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Fujita S,Yamanoi S,Murata K,Mita H,Samukawa T,Nakagawa T,Sakai H,Tokita Y

doi

10.1038/srep04937

subject

Has Abstract

pub_date

2014-05-13 00:00:00

pages

4937

issn

2045-2322

pii

srep04937

journal_volume

4

pub_type

杂志文章
  • Amide-controlled, one-pot synthesis of tri-substituted purines generates structural diversity and analogues with trypanocidal activity.

    abstract::A novel one-pot synthesis of tri-substituted purines and the discovery of purine analogues with trypanocidal activity are reported. The reaction is initiated by a metal-free oxidative coupling of primary alkoxides and diaminopyrimidines with Schiff base formation and subsequent annulation in the presence of large N,N-...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09139

    authors: Pineda de las Infantas y Villatoro MJ,Unciti-Broceta JD,Contreras-Montoya R,Garcia-Salcedo JA,Gallo Mezo MA,Unciti-Broceta A,Diaz-Mochon JJ

    更新日期:2015-03-16 00:00:00

  • Genetic dissection of seed oil and protein content and identification of networks associated with oil content in Brassica napus.

    abstract::High-density linkage maps can improve the precision of QTL localization. A high-density SNP-based linkage map containing 3207 markers covering 3072.7 cM of the Brassica napus genome was constructed in the KenC-8 × N53-2 (KNDH) population. A total of 67 and 38 QTLs for seed oil and protein content were identified with ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46295

    authors: Chao H,Wang H,Wang X,Guo L,Gu J,Zhao W,Li B,Chen D,Raboanatahiry N,Li M

    更新日期:2017-04-10 00:00:00

  • Xiaoyaosan exerts anxiolytic-like effects by down-regulating the TNF-α/JAK2-STAT3 pathway in the rat hippocampus.

    abstract::Although the anxiolytic-like effects of Xiaoyaosan, a Chinese herbal formula, have been described in many previous studies, its underlying mechanism remains undefined. The cytokine tumour necrosis factor-α (TNF-α) and its closely associated janus kinase 2 (JAK2)-signal transducer and activator of transcription (STAT3)...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00496-y

    authors: Li XJ,Ma QY,Jiang YM,Bai XH,Yan ZY,Liu Q,Pan QX,Liu YY,Chen JX

    更新日期:2017-03-23 00:00:00

  • Adipose-derived Stem Cell Conditioned Media Extends Survival time of a mouse model of Amyotrophic Lateral Sclerosis.

    abstract::Adipose stromal cells (ASC) secrete various trophic factors that assist in the protection of neurons in a variety of neuronal death models. In this study, we tested the effects of human ASC conditional medium (ASC-CM) in human amyotrophic lateral sclerosis (ALS) transgenic mouse model expressing mutant superoxide dism...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16953

    authors: Fontanilla CV,Gu H,Liu Q,Zhu TZ,Zhou C,Johnstone BH,March KL,Pascuzzi RM,Farlow MR,Du Y

    更新日期:2015-11-20 00:00:00

  • Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer.

    abstract::Colorectal cancer is one of the main causes of cancer death worldwide, and novel biomarkers are urgently needed for its early diagnosis and treatment. The utilization of metabolomics to identify and quantify metabolites in body fluids may allow the detection of changes in their concentrations that could serve as diagn...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55952-8

    authors: Martín-Blázquez A,Díaz C,González-Flores E,Franco-Rivas D,Jiménez-Luna C,Melguizo C,Prados J,Genilloud O,Vicente F,Caba O,Pérez Del Palacio J

    更新日期:2019-12-27 00:00:00

  • Single florescent nanodiamond in a three dimensional ABEL trap.

    abstract::Three dimensional single particle trapping and manipulation is an outstanding challenge in various fields ranging from basic physics to life sciences. By monitoring the response of a trapped particle to a designed environment one can extract its characteristics. In addition, quantum dynamics of a spatially scanned wel...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16669

    authors: Kayci M,Radenovic A

    更新日期:2015-11-12 00:00:00

  • Plasmodium spp. mixed infection leading to severe malaria: a systematic review and meta-analysis.

    abstract::Mixed Plasmodium malaria infections can lead to severe malaria. This systematic review and meta-analysis aimed to explore the prevalence of severe mixed Plasmodium malaria infection and to compare it with the prevalence of severe P. falciparum malaria mono-infection across the included studies. Original English-langua...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/s41598-020-68082-3

    authors: Kotepui M,Kotepui KU,De Jesus Milanez G,Masangkay FR

    更新日期:2020-07-06 00:00:00

  • Predictive combinatorial design of mRNA translation initiation regions for systematic optimization of gene expression levels.

    abstract::Balancing the amounts of enzymes is one of the important factors to achieve optimum performance of a designed metabolic pathway. However, the random mutagenesis approach is impractical since it requires searching an unnecessarily large number of variants and often results in searching a narrow range of expression leve...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04515

    authors: Seo SW,Yang JS,Cho HS,Yang J,Kim SC,Park JM,Kim S,Jung GY

    更新日期:2014-03-31 00:00:00

  • Developmental toxicity of diclofenac and elucidation of gene regulation in zebrafish (Danio rerio).

    abstract::Environmental pollution by emerging contaminants, e.g. pharmaceuticals, has become a matter of widespread concern in recent years. We investigated the membrane transport of diclofenac and its toxic effects on gene expression and the development of zebrafish embryos. The association of diclofenac with the embryos confo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04841

    authors: Chen JB,Gao HW,Zhang YL,Zhang Y,Zhou XF,Li CQ,Gao HP

    更新日期:2014-05-02 00:00:00

  • An integrative approach to phylogeny reveals patterns of environmental distribution and novel evolutionary relationships in a major group of ciliates.

    abstract::Peritrichs are a major group of ciliates with worldwide distribution. Yet, its internal phylogeny remains unresolved owing to limited sampling. Additionally, ecological distributions of peritrichs are poorly known. We performed substantially expanded phylogenetic analyses of peritrichs that incorporated SSU rDNA seque...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep21695

    authors: Sun P,Clamp J,Xu D,Huang B,Shin MK

    更新日期:2016-02-16 00:00:00

  • Dynamics of Glass Forming Liquids with Randomly Pinned Particles.

    abstract::It is frequently assumed that in the limit of vanishing cooling rate, the glass transition phenomenon becomes a thermodynamic transition at a temperature TK. However, with any finite cooling rate, the system falls out of equilibrium at temperatures near Tg(>TK), implying that the very existence of the putative thermod...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12577

    authors: Chakrabarty S,Karmakar S,Dasgupta C

    更新日期:2015-07-24 00:00:00

  • Modulation of the Mesenchymal Stem Cell Secretome Using Computer-Controlled Bioreactors: Impact on Neuronal Cell Proliferation, Survival and Differentiation.

    abstract::In recent years it has been shown that the therapeutic benefits of human mesenchymal stem/stromal cells (hMSCs) in the Central Nervous System (CNS) are mainly attributed to their secretome. The implementation of computer-controlled suspension bioreactors has shown to be a viable route for the expansion of these cells ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27791

    authors: Teixeira FG,Panchalingam KM,Assunção-Silva R,Serra SC,Mendes-Pinheiro B,Patrício P,Jung S,Anjo SI,Manadas B,Pinto L,Sousa N,Behie LA,Salgado AJ

    更新日期:2016-06-15 00:00:00

  • Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model.

    abstract::The role of transforming growth factor-β (TGF-β) signaling in cancer progression is still under debate. To determine the function of TGF-β signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carcinogenesis. We foun...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29479

    authors: Liang Y,Zhu F,Zhang H,Chen D,Zhang X,Gao Q,Li Y

    更新日期:2016-07-05 00:00:00

  • Automated data cleaning of paediatric anthropometric data from longitudinal electronic health records: protocol and application to a large patient cohort.

    abstract::'Big data' in healthcare encompass measurements collated from multiple sources with various degrees of data quality. These data require quality control assessment to optimise quality for clinical management and for robust large-scale data analysis in healthcare research. Height and weight data represent one of the mos...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66925-7

    authors: Phan HTT,Borca F,Cable D,Batchelor J,Davies JH,Ennis S

    更新日期:2020-06-23 00:00:00

  • Mechanism of the antigen-independent cytokinergic SPE-7 IgE activation of human mast cells in vitro.

    abstract::Release of pro-inflammatory mediators by mast cells is a key feature of allergic disease. The 'dogma' is that IgE molecules merely sensitise mast cells by binding FcεRI prior to cross-linking by multivalent allergen, receptor aggregation and mast cell activation. However, certain monoclonal IgE antibodies have been sh...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09538

    authors: Bax HJ,Bowen H,Dodev TS,Sutton BJ,Gould HJ

    更新日期:2015-04-20 00:00:00

  • Expression and distribution of CD151 as a partner of alpha6 integrin in male germ cells.

    abstract::The physiological importance of CD151 tetraspanin is known from somatic cells and its outside-in signalling through integrins was described. In male germ cells, two tetraspanins, CD9 and CD81, are involved in sperm-egg membrane fusion, and similarly to integrins, they occupy characteristic regions. We report here on a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-61334-2

    authors: Jankovicova J,Frolikova M,Palenikova V,Valaskova E,Cerny J,Secova P,Bartokova M,Horovska L,Manaskova-Postlerova P,Antalikova J,Komrskova K

    更新日期:2020-03-09 00:00:00

  • The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression.

    abstract::The Farnesoid X receptor (FXR) regulates bile salt, glucose and cholesterol homeostasis by binding to DNA response elements, thereby activating gene expression (direct transactivation). FXR also inhibits the immune response via tethering to NF-κB (tethering transrepression). FXR activation therefore has therapeutic po...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14086

    authors: Bijsmans IT,Guercini C,Ramos Pittol JM,Omta W,Milona A,Lelieveld D,Egan DA,Pellicciari R,Gioiello A,van Mil SW

    更新日期:2015-09-15 00:00:00

  • Mean Bias in Seasonal Forecast Model and ENSO Prediction Error.

    abstract::This study uses retrospective forecasts made using an APEC Climate Center seasonal forecast model to investigate the cause of errors in predicting the amplitude of El Niño Southern Oscillation (ENSO)-driven sea surface temperature variability. When utilizing Bjerknes coupled stability (BJ) index analysis, enhanced err...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-05221-3

    authors: Kim ST,Jeong HI,Jin FF

    更新日期:2017-07-20 00:00:00

  • Rbfox2 function in RNA metabolism is impaired in hypoplastic left heart syndrome patient hearts.

    abstract::Hypoplastic left heart syndrome (HLHS) is a fatal congenital heart disease in which the left side of the heart is underdeveloped, impairing the systemic circulation. Underdeveloped left ventricle exerts biomechanical stress on the right ventricle that can progress into heart failure. Genome-wide transcriptome changes ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30896

    authors: Verma SK,Deshmukh V,Nutter CA,Jaworski E,Jin W,Wadhwa L,Abata J,Ricci M,Lincoln J,Martin JF,Yeo GW,Kuyumcu-Martinez MN

    更新日期:2016-08-03 00:00:00

  • Dna is a New Target of Parp3.

    abstract::Most members of the poly(ADP-ribose)polymerase family, PARP family, have a catalytic activity that involves the transfer of ADP-ribose from a beta-NAD+-molecule to protein acceptors. It was recently discovered by Talhaoui et al. that DNA-dependent PARP1 and PARP2 can also modify DNA. Here, we demonstrate that DNA-depe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-22673-3

    authors: Belousova EA,Ishchenko АA,Lavrik OI

    更新日期:2018-03-08 00:00:00

  • All-carbon multi-electrode array for real-time in vitro measurements of oxidizable neurotransmitters.

    abstract::We report on the ion beam fabrication of all-carbon multi electrode arrays (MEAs) based on 16 graphitic micro-channels embedded in single-crystal diamond (SCD) substrates. The fabricated SCD-MEAs are systematically employed for the in vitro simultaneous amperometric detection of the secretory activity from populations...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20682

    authors: Picollo F,Battiato A,Bernardi E,Plaitano M,Franchino C,Gosso S,Pasquarelli A,Carbone E,Olivero P,Carabelli V

    更新日期:2016-02-09 00:00:00

  • Siliceous spicules in a vauxiid sponge (Demospongia) from the Kaili Biota(Cambrian Stage 5), Guizhou, South China.

    abstract::Fossils of the sponge Angulosuspongia sinensis from calcareous mudstones of the middle and upper part of the Kaili Formation (Cambrian Stage 5) in the Jianhe area of Guizhou province, South China, exhibit an apparently reticulate pattern, characteristic of the Vauxiidae. Energy Dispersive X-Ray Spectrometry (EDS) and ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep42945

    authors: Yang XL,Zhao YL,Babcock LE,Peng J

    更新日期:2017-02-21 00:00:00

  • Pu isotopes in soils collected downwind from Lop Nor: regional fallout vs. global fallout.

    abstract::For the first time, soil core samples from the Jiuquan region have been analyzed for Pu isotopes for radioactive source identification and radiological assessment. The Jiuquan region is in downwind from the Lop Nor Chinese nuclear test (CNT) site. The high Pu inventories (13 to 546 Bq/m(2)) in most of the sampling loc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12262

    authors: Bu W,Ni Y,Guo Q,Zheng J,Uchida S

    更新日期:2015-07-17 00:00:00

  • Gabapentin-induced drug-seeking-like behavior: a potential role for the dopaminergic system.

    abstract::Drugs of abuse represent a growing public health crisis. Accumulating evidence indicates that gabapentin (GBP), a prescription drug, is prone to misuse, abuse, withdrawal, and dependence. Commonly, drugs of abuse modulate the dopaminergic system to induce addiction. In this study, we used the conditioned place prefere...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-67318-6

    authors: Althobaiti YS,Alghorabi A,Alshehri FS,Baothman B,Almalki AH,Alsaab HO,Alsanie W,Gaber A,Almalki H,Alghamdi AS,Basfer A,Althobaiti S,Hardy AMG,Shah ZA

    更新日期:2020-06-26 00:00:00

  • Stillbirth risk prediction using machine learning for a large cohort of births from Western Australia, 1980-2015.

    abstract::Quantification of stillbirth risk has potential to support clinical decision-making. Studies that have attempted to quantify stillbirth risk have been hampered by small event rates, a limited range of predictors that typically exclude obstetric history, lack of validation, and restriction to a single classifier (logis...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62210-9

    authors: Malacova E,Tippaya S,Bailey HD,Chai K,Farrant BM,Gebremedhin AT,Leonard H,Marinovich ML,Nassar N,Phatak A,Raynes-Greenow C,Regan AK,Shand AW,Shepherd CCJ,Srinivasjois R,Tessema GA,Pereira G

    更新日期:2020-03-24 00:00:00

  • Oral administration of N-acetyl cysteine prevents osteoarthritis development and progression in a rat model.

    abstract::The number of osteoarthritis patients is increasing with the rise in the number of elderly people in developed countries. Osteoarthritis, which causes joint pain and deformity leading to loss of activities of daily living, is often treated surgically. Here we show that mechanical stress promotes accumulation of reacti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55297-2

    authors: Kaneko Y,Tanigawa N,Sato Y,Kobayashi T,Nakamura S,Ito E,Soma T,Miyamoto K,Kobayashi S,Harato K,Matsumoto M,Nakamura M,Niki Y,Miyamoto T

    更新日期:2019-12-10 00:00:00

  • Genotype-guided warfarin dosing may benefit patients with mechanical aortic valve replacements: randomized controlled study.

    abstract::This prospective, single-blind, randomized study was designed to evaluate the effect of genotype-based warfarin dosing compared with standard warfarin dosing in Korean patients with mechanical cardiac valves. Patients were assigned to either the genotype-based dosing group or the standard dosing group using stratified...

    journal_title:Scientific reports

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41598-020-63985-7

    authors: Lee KE,Yee J,Lee GY,Chung JE,Seong JM,Chang BC,Gwak HS

    更新日期:2020-04-24 00:00:00

  • Campylobacter gastroenteritis in children in north-eastern Israel comparison with other common pathogens.

    abstract::Gastroenteritis is common among children. Campylobacter jejuni is one of the main causative bacterial pathogens, together with Shigella, Salmonella and invasive Escherichia coli. Campylobacteriosis is a zoonotic, usually self-limited disease that does not always require antibiotic treatment. In cases of protracted dia...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62744-y

    authors: Sakran W,Hexner-Erlichman Z,Spiegel R,Batheesh H,Halevy R,Koren A

    更新日期:2020-04-02 00:00:00

  • Sea ice breakup and marine melt of a retreating tidewater outlet glacier in northeast Greenland (81°N).

    abstract::Rising temperatures in the Arctic cause accelerated mass loss from the Greenland Ice Sheet and reduced sea ice cover. Tidewater outlet glaciers represent direct connections between glaciers and the ocean where melt rates at the ice-ocean interface are influenced by ocean temperature and circulation. However, few measu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-05089-3

    authors: Bendtsen J,Mortensen J,Lennert K,K Ehn J,Boone W,Galindo V,Hu YB,Dmitrenko IA,Kirillov SA,Kjeldsen KK,Kristoffersen Y,G Barber D,Rysgaard S

    更新日期:2017-07-10 00:00:00

  • Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia.

    abstract::Chronic myeloid leukemia (CML) is characterized in the majority of cases by a t(9;22)(q34;q11) translocation, also called the Philadelphia chromosome, giving rise to the BCR-ABL1 fusion protein. Current treatment with tyrosine kinase inhibitors is directed against the constitutively active ABL1 domain of the fusion pr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00755-y

    authors: Löf L,Arngården L,Olsson-Strömberg U,Siart B,Jansson M,Dahlin JS,Thörn I,Christiansson L,Hermansson M,Larsson A,Ahlstrand E,Wålinder G,Söderberg O,Rosenquist R,Landegren U,Kamali-Moghaddam M

    更新日期:2017-04-04 00:00:00