Abstract:
:Salmonids show a high degree of phenotypic plasticity that can differ among genotypes, and this variation is one of the major factors contributing to uncertainty in extrapolating laboratory-based risk assessment data to nature. Many studies have examined the relative growth and survival of transgenic and non-transgenic salmonids, and the results have been highly variable due to genotype × environment interactions. The relative survival of fast- and slow-growing strains can reverse depending on the environment, but it is not clear which specific environmental characteristics are driving these responses. To address this question, two experiments were designed where environmental conditions were varied to investigate the contribution of rearing density, food amount, food type, habitat complexity, and risk of predation on relative growth and survival of fast-growing transgenic and slow-growing wild-type coho salmon. The first experiment altered density (high vs. low) and food amount (high vs. low). Density impacted the relative growth of the genotypes, where transgenic fish grew more than non-transgenic fish in low density streams, regardless of food level. Density also affected survival, with high density causing increased mortality for both genotypes, but the mortality of transgenic relative to non-transgenic fish was lower within the high-density streams, regardless of food level. The second experiment altered habitat complexity (simple vs. complex), food type (artificial vs. natural), amount of food (normal vs. satiation), and risk of predation (present vs. absent). Results from this experiment showed that genotype affected growth and survival, but genotype effects were modulated by one or more environmental factors. The effect of genotype on survival was influenced by all examined environmental factors, such that no predictable trend in relative survival of transgenic versus non-transgenic fry emerged. This was primarily due to variations in survival of non-transgenic fish under different environmental conditions (non-transgenic fry had highest survival in hatchery conditions, and lowest survival in complex conditions with natural food fed at a normal level with or without predators). Transgenic fry survival was only significantly influenced by predator presence. The effects of genotype on mass and length were significantly modulated by food type only. Transgenic fry were able to gain a large size advantage over non-transgenic fish when fed artificial food under all habitat types. These experiments support the observations of dynamic responses in growth and survival depending on the environment, and demonstrate the challenge of applying laboratory-based experiments to risk assessment in nature.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Vandersteen WE,Leggatt R,Sundström LF,Devlin RHdoi
10.1038/s41598-018-35826-1subject
Has Abstractpub_date
2019-01-23 00:00:00pages
406issue
1issn
2045-2322pii
10.1038/s41598-018-35826-1journal_volume
9pub_type
杂志文章abstract::We investigated the cognitive and behavioral profile of three distinct groups of epilepsies with a genetic background for intergroup differences: (1) idiopathic/genetic generalized epilepsies (IGE/GGE group); (2) idiopathic focal epilepsies (IFE group); and (3) epilepsies with proven or strongly suggested monogenic or...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78218-0
更新日期:2020-12-09 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-24031-9
更新日期:2018-04-11 00:00:00
abstract::A silica gel coated microsphere resonator is proposed and experimentally demonstrated for measurements of ammonia (NH3) concentration in air with ultra-high sensitivity. The optical properties of the porous silica gel layer change when it is exposed to low (parts per million (ppm)) and even ultra-low (parts per billio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20025-9
更新日期:2018-01-26 00:00:00
abstract::Endothelial cells respond to changes in subendothelial stiffness by altering their migration and mechanics, but whether those responses are due to transcriptional reprogramming remains largely unknown. We measured traction force generation and also performed gene expression profiling for two endothelial cell types gro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54336-2
更新日期:2019-12-03 00:00:00
abstract::Silicon has emerged as the most promising high-capacity material for lithium-ion batteries. Waste glass can be a potential low cost and environmentally benign silica resource enabling production of nanosized silicon at the industry level. Windshields are generally made of laminated glass comprising two separate glass ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19529-1
更新日期:2018-01-17 00:00:00
abstract::Bast fibres are long extraxylary cells which mechanically support the phloem and they are divided into xylan- and gelatinous-type, depending on the composition of their secondary cell walls. The former, typical of jute/kenaf bast fibres, are characterized by the presence of xylan and a high degree of lignification, wh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05200-8
更新日期:2017-07-10 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-49487-1
更新日期:2019-10-15 00:00:00
abstract::Maize streak virus disease (MSVD), caused by Maize streak virus (MSV; genus Mastrevirus), is one of the most severe and widespread viral diseases that adversely reduces maize yield and threatens food security in Africa. An effective control and management of MSVD requires robust and sensitive diagnostic tests capable ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76612-2
更新日期:2020-11-12 00:00:00
abstract::The marine bacterial strain Desulfovibrio ferrophilus IS5, known for its lithotrophic growth ability to use metallic iron as a sole electron donor and for causing corrosion of steel, was used in the current study. Four commonly used biocides in the oil and gas industry, namely tetrakis(hydroxymethyl) phosphonium sulfa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34789-7
更新日期:2018-11-09 00:00:00
abstract::Regulation of the chromatin state is crucial for biological processes such as the regulation of transcription, DNA replication, and DNA damage repair. Here we show that knockdown of the BRD8 bromodomain protein - a subunit of the p400/Tip60 complex - leads to p21 induction, and concomitant cell cycle arrest in G1/S. W...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32323-3
更新日期:2018-09-20 00:00:00
abstract::Leukocyte-platelet rich fibrin (L-PRF) is extensively used in the dentistry field and other clinical scenarios due to its regeneration properties. The goal of the present study was to depict the L-PRF secretome and how it changes over time. We obtained L-PRF membranes and cultured them in DMEM. The secretome was colle...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71419-7
更新日期:2020-09-03 00:00:00
abstract::The ST2/IL33 signalling pathway has been associated with ulcerative colitis (UC). ST2, encoded by the IL1RL1 gene, is expressed as both a membrane-anchored receptor (ST2L) activated by IL33 and as a soluble receptor (sST2) with anti-inflammatory properties. In UC patients, sST2 is further increased by corticosteroid t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10465-0
更新日期:2017-08-31 00:00:00
abstract::Agglomeration-triggered deactivation of supported platinum electrocatalysts markedly hinders their application in methanol oxidation reaction (MOR). In this study, graphene-supported nickel-iron layered double hydroxide (NiFe-LDH/rGO), in which Fe3+ was introduced to replace Ni2+ partially in the Ni(OH)2 lattice to pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19876-z
更新日期:2018-01-22 00:00:00
abstract::Thrombin-induced and proteinase-activated receptor 1 (PAR1)-mediated signaling increases ROS production, activates ERK, and promotes inflammation and fibroblast proliferation in bleomycin-induced lung injury. Stanniocalcin-1 (STC1) activates anti-oxidant pathways, inhibits inflammation and provides cytoprotection; hen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18117
更新日期:2015-12-07 00:00:00
abstract::Relapse and metastasis of nasopharyngeal carcinoma (NPC) are presumably attributed to cancer stem cells (CSCs). In recent years, chimeric antigen receptor (CAR)-modified immune effector cells have been shown to have impressive antitumour efficacy. In this study, we aimed to identify appropriate tumour-associated antig...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04756-9
更新日期:2017-07-07 00:00:00
abstract::CRISPR/Cas9-derived RNA-guided nucleases (RGNs) are DNA targeting systems, which are rapidly being harnessed for gene regulation and gene editing purposes in model organisms and cell lines. As bona fide gene delivery vehicles, viral vectors may be particularly fit to broaden the applicability of RGNs to other cell typ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05105
更新日期:2014-05-29 00:00:00
abstract::Antimonite [Sb(III)]-oxidizing bacteria can transform the toxic Sb(III) into the less toxic antimonate [Sb(V)]. Recently, the cytoplasmic Sb(III)-oxidase AnoA and the periplasmic arsenite [As(III)] oxidase AioAB were shown to responsible for bacterial Sb(III) oxidation, however, disruption of each gene only partially ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43225
更新日期:2017-03-02 00:00:00
abstract::The unconventional myosin MYO18A that contains a PDZ domain is required for muscle integrity during zebrafish development. However, the mechanism by which it functions in myofibers is not clear. The presence of a PDZ domain suggests that MYO18A may interact with other partners to perform muscle-specific functions. Her...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36768
更新日期:2016-11-08 00:00:00
abstract::The physiologic response to tobacco smoke can be measured by gene-expression profiling of the airway epithelium. Temporal resolution of kinetics of gene-expression alterations upon smoking-cessation might delineate distinct biological processes that are activated during recovery from tobacco smoke exposure. Using whol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43295-3
更新日期:2019-05-06 00:00:00
abstract::Gayal (Bos frontalis) is a semi-wild and endangered bovine species that differs from domestic cattle (Bos taurus and Bos indicus), and its genetic background remains unclear. Here, we performed whole-genome sequencing of one Gayal for the first time, with one Red Angus cattle and one Japanese Black cattle as controls....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19787
更新日期:2016-01-25 00:00:00
abstract::Here we present an experimental as well as theoretical study of third-harmonic generation in tightly focused femtosecond filaments in air at the wavelength of [Formula: see text]. At low intensities, longitudinal phase matching is dominating in the formation of 3rd harmonics, whereas at higher intensities locked X-wav...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74263-x
更新日期:2020-10-15 00:00:00
abstract::Surface plasmonics from metal nanoparticles have been demonstrated as an effective way of improving the performance of low-efficiency light emitters. However, reducing the inherent losses of the metal nanoparticles remains a challenge. Here we study the enhancement properties by Ag nanoparticles for InGaN/GaN quantum-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06392
更新日期:2014-09-22 00:00:00
abstract::Brain imaging genetics intends to uncover associations between genetic markers and neuroimaging quantitative traits. Sparse canonical correlation analysis (SCCA) can discover bi-multivariate associations and select relevant features, and is becoming popular in imaging genetic studies. The L1-norm function is not only ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13930-y
更新日期:2017-10-25 00:00:00
abstract::Music and language are complex hierarchical systems in which individual elements are systematically combined to form larger, syntactic structures. Suggestions that music and language share syntactic processing resources have relied on evidence that syntactic violations in music interfere with syntactic processing in l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36076-x
更新日期:2018-12-17 00:00:00
abstract::Knee osteoarthritis (OA) is the most common musculoskeletal disorder. OA diagnosis is currently conducted by assessing symptoms and evaluating plain radiographs, but this process suffers from subjectivity. In this study, we present a new transparent computer-aided diagnosis method based on the Deep Siamese Convolution...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20132-7
更新日期:2018-01-29 00:00:00
abstract::The prevalence and the distribution characteristics of corneal astigmatism (CA) and anterior segment biometry before surgery in Chinese congenital cataract (CC) patients are not completely understood. This study involved 400 CC patients from the Zhongshan Ophthalmic Center enrolled from February 2011 to August 2015. D...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/srep22092
更新日期:2016-02-25 00:00:00
abstract::microRNAs (miRNAs) are small double stranded RNA molecules consisting of two complementary strands called the 5p and 3p arms. Following imprecise processing and/or addition of nucleotides at the ends, miRNA biogenesis can give rise to variants called isomiRs. Exosomes are small vesicles released by cells. They have at...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56593-7
更新日期:2019-12-27 00:00:00
abstract::Thioflavin T (ThT) is standardly used as a fluorescent marker to detect aggregation of amyloid fibrils by conventional fluorescence microscopy, including polarization resolved imaging that brings information on the orientational order of the fibrils. These techniques are however diffraction limited and cannot provide ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12864-9
更新日期:2017-10-02 00:00:00
abstract::Confocal Raman spectroscopy (CRS) can provide information about oocyte competency through measurement of changes in the macromolecular architecture during oocyte development and maturation. Hitherto most spectroscopic studies have been limited to fixed oocytes due to the inherent difficulties working with live cells. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08973-0
更新日期:2017-08-21 00:00:00
abstract::Bacterial blight and bacterial leaf streak are serious, economically damaging, diseases of rice caused by the bacteria Xanthomonas oryzae pv. oryzae and X. oryzae pv. oryzicola. Bacillus amyloliquefaciens FZB42 was shown to possess biocontrol activity against these Xanthomonas strains by producing the antibiotic compo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12975
更新日期:2015-08-13 00:00:00