Abstract:
:We investigated the cognitive and behavioral profile of three distinct groups of epilepsies with a genetic background for intergroup differences: (1) idiopathic/genetic generalized epilepsies (IGE/GGE group); (2) idiopathic focal epilepsies (IFE group); and (3) epilepsies with proven or strongly suggested monogenic or structural/numeric chromosomal etiology (genetic epilepsies, GE group). Cognitive (total IQ and subcategories) and behavioral parameters (CBCL) were assessed at the tertiary epilepsy center of the University of Munich (Germany). We used ANOVA with post-hoc Bonferroni-correction to explore significant mean differences and Fisher's exact test for significant proportional differences of intelligence impairment and behavioral problems. 126 (56 IGE/GGE, 26 IFE, 44 GE) patients were available. Total IQ was 89.0 ± 15.9 (95% CI 84.5-93.4) for IGE/GGE, 94.8 ± 18.1 (95% CI 87.3-102.3) for IFE and 76.4 ± 22.4 (95% CI 67.6-85.3) for GE (p = 0.001). The same trend was significant for all but one IQ subcategory. The rate of patients with an intelligence impairment (total IQ < 70) was higher for GE (40%) than for IGE/GGE (14%) and for IFE (7%) patients (p = 0.033). There were no significant differences between groups for behavior scores and behavioral problems. This study shows that the current ILAE classification of epilepsies with genetic etiology creates a heterogeneous group of patients with respect to cognitive performance but not behavior. These findings may help in further delineating epilepsies as regards cognitive performance, notwithstanding their closely related etiological classification.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Moorhouse FJ,Cornell S,Gerstl L,Tacke M,Roser T,Heinen F,Bonfert M,von Stülpnagel C,Wagner M,Borggraefe Idoi
10.1038/s41598-020-78218-0subject
Has Abstractpub_date
2020-12-09 00:00:00pages
21543issue
1issn
2045-2322pii
10.1038/s41598-020-78218-0journal_volume
10pub_type
杂志文章abstract::On the basis of diet induced obesity and KO mice models, nitric oxide is implied to play an important role in the initiation of dyslipidemia induced insulin resistance. However, outcomes using iNOS KO mice have so far remained inconclusive. The present study aimed to assess IR in iNOS KO mice after 5 weeks of LFD feed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41009
更新日期:2017-01-20 00:00:00
abstract::This study aimed to determine whether formyl peptide receptors (FPRs) regulated the differentiation of neural stem cells (NSCs). FPRs promote the migration of NSCs both in vitro and in vivo. However, the role of FPRs during differentiation of NSCs is unknown. Analysis by Western blot showed significantly increased exp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00314-5
更新日期:2017-03-16 00:00:00
abstract::Gestational diabetes mellitus (GDM) is a hyperglycaemic imbalance first recognized during pregnancy, and affects up to 22% of pregnancies worldwide, bringing negative maternal-fetal consequences in the short- and long-term. In order to better characterize GDM in pregnant women, 100 blood plasma samples (50 GDM and 50 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75539-y
更新日期:2020-11-06 00:00:00
abstract::Quantum walk is a key operation in quantum computing, simulation, communication and information. Here, we report for the first time the demonstration of quantum walks and localized quantum walks in a new type of optical fibers having a ring of cores constructed with both periodic and quasiperiodic Fibonacci sequences,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64065-6
更新日期:2020-04-28 00:00:00
abstract::Mesenchymal stem cells (MSCs) aid the regeneration of tissues damaged by treatment with cisplatin. However, the effects of this cytotoxic drug on the stem cells have been largely unknown. Here we demonstrate that human bone marrow-derived MSCs are relatively resistant to cisplatin treatment and show resistance levels ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20035
更新日期:2016-01-25 00:00:00
abstract::We utilized size-tunable gold nanoparticles (Au NPs) to investigate the toxicogenomic responses of the model organism Caenorhabditis elegans. We demonstrated that the nematode C. elegans can uptake Au NPs coated with or without 11-mercaptoundecanoic acid (MUA), and Au NPs are detectable in worm intestines using X-ray ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33585-7
更新日期:2018-10-15 00:00:00
abstract::The neural bases of the inter-trial validity/invalidity sequential effects in a visuo-auditory modified version of the Central Cue Posner's Paradigm (CCPP) are analyzed by means of Early Directing Attention Negativity (EDAN), Contingent Negative Variation (CNV) and Lateralized Readiness Potential (LRP). ERPs results i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04526
更新日期:2014-03-31 00:00:00
abstract::MicroRNAs (miRNAs) are among the class of noncoding small RNA molecules and play a crucial role in post-transcriptional regulation in plants. Although Lilium is one of the most popular ornamental flowers worldwide, however, there is no report on miRNAs identification. In the present study, therefore, miRNAs and their ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21193-4
更新日期:2018-02-13 00:00:00
abstract::Ovarian tissue cryopreservation is considered as a useful option to preserve fertility for cancer patients. This study purposed to evaluate the change of telomere length and senescence markers during human ovarian tissue cryopreservation. Ovarian tissues were obtained from women who underwent benign ovarian surgery in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81973-3
更新日期:2021-01-26 00:00:00
abstract::Cerebral lateralization is expressed at both the structural and functional levels, and can exist as either a stable characteristic or as a dynamic feature during behavior and development. The anatomically relatively simple olfactory system demonstrates lateralization in both human and non-human animals. Here, we explo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15109-x
更新日期:2017-11-06 00:00:00
abstract::This corrects the article DOI: 10.1038/srep43923. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/srep46850
更新日期:2017-06-15 00:00:00
abstract::Technical guidelines for magnetic resonance imaging (MRI) of the small bowel (SB) in the setting of inflammatory bowel diseases (IBDs) were detailed in a 2017 consensus issued by European Society of Gastrointestinal and Abdominal Radiology (ESGAR) and European Society of Pediatric Radiology (ESPR); however, MRI for no...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50501-9
更新日期:2019-10-01 00:00:00
abstract::The relationship between obstructive sleep apnea (OSA) and chronic rhinosinusitis (CRS) still remains unclear. This retrospective cohort study aimed to investigate the relationship between OSA and subsequent CRS using a population-based dataset. The study used data from the Taiwan Longitudinal Health Insurance Databas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20786
更新日期:2016-02-10 00:00:00
abstract::Carbon-based stationary phases for chromatographic separation have been commercially available since the 1980s. Porous graphitic carbon liquid chromatography columns are known to be highly resistant to aggressive mobile phases and extreme pH values of solvents and eluents, an important advantage compared to convention...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33075-w
更新日期:2018-10-03 00:00:00
abstract::We investigated how skeletal muscle mass (SMM) affects spinal sagittal balance (radiographic parameters) in symptomatic spinal patients. The first purpose of this study was to evaluate the body composition and the spinal sagittal alignment in symptomatic spinal patients. The second purpose of this study was to compare...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33867-0
更新日期:2018-10-19 00:00:00
abstract::For a broad class of input-output maps, arguments based on the coding theorem from algorithmic information theory (AIT) predict that simple (low Kolmogorov complexity) outputs are exponentially more likely to occur upon uniform random sampling of inputs than complex outputs are. Here, we derive probability bounds that...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61135-7
更新日期:2020-03-10 00:00:00
abstract::In a single glass of champagne about a million bubbles nucleate on the wall and rise towards the surface. When these bubbles reach the surface and rupture, they project a multitude of tiny droplets in the form of a particular aerosol holding a concentrate of wine aromas. Based on the model experiment of a single bubbl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25148
更新日期:2016-04-29 00:00:00
abstract::Many practical systems can be described by dynamic networks, for which modern technique can measure their outputs, and accumulate extremely rich data. Nevertheless, the network structures producing these data are often deeply hidden in the data. The problem of inferring network structures by analyzing the available da...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44639
更新日期:2017-03-21 00:00:00
abstract::Group-IVa elements silicon and germanium are known for their semiconducting properties at room temperature, which are technologically critical. Metallicity and superconductivity are found at higher pressures only, Ge β-tin (tI4) being the first high-pressure metallic phase in the phase diagram. However, recent experim...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01466
更新日期:2013-01-01 00:00:00
abstract::Optimized mesoporous photocatalyst endowed with high specific surface area and large pore size was synthesized by sol-gel method. These large pore mesoporous materials (33.39 nm) were conducive to the movement of larger molecules or groups in pore path and for effective use of active sites. The high specific surface a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29902
更新日期:2016-07-19 00:00:00
abstract::A potted experiment with Populus × euramericana 'Neva' was carried out to assess whether there are positive effects of magnetic treatment of saline water (MTSW) on nitrogen metabolism under controlled conditions in a greenhouse. Growth properties, nitrogen contents, enzyme activities and metabolite concentrations were...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45719-6
更新日期:2019-07-11 00:00:00
abstract::Unusual protein-like, partially reversible associative behaviour has recently been observed in solutions of the water soluble carbohydrates known as 6-deoxy-6-(ω-aminoalkyl)aminocelluloses, which produce controllable self-assembling films for enzyme immobilisation and other biotechnological applications. Now, for the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03861
更新日期:2014-01-24 00:00:00
abstract::Anti-PD1 immunotherapy has emerged as a gold-standard treatment for first- or second-line treatment of stage IV NSCLC, with response rates ranging from 10 to 60%. Strategies to improve the disease control rate are needed. Several reports suggested that debulking surgery enhances anti-tumor immunity. We aimed at examin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52913-z
更新日期:2019-11-15 00:00:00
abstract::Zika virus (ZIKV) can cause various diseases in offspring after congenital infection. The purpose of this study was to identify disease phenotypes in pups exposed to ZIKV in utero. Female interferon-α/β, -γ receptor knockout mice (AG129) were infected intraperitoneally with ZIKV 7.5 days' post coitus (dpc). Viral RNA,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27611-x
更新日期:2018-06-20 00:00:00
abstract::Temporomandibular disorders (TMD), when progress to a chronic state, might contribute to psychosocial or psychological distress. This study aimed to evaluate the effect of stabilization splint (SS) therapy on pain, pain-related disability and psychological traits of chronic TMD patients, as well as to assess selected ...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-67383-x
更新日期:2020-07-03 00:00:00
abstract::In the fifty years since the postulation of Moore's Law, the increasing energy consumption in silicon electronics has motivated research into emerging devices. An attractive research direction is processing information via the phase of spin waves within magnonic-logic circuits, which function without charge transport ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08114-7
更新日期:2017-08-11 00:00:00
abstract::An important property of spin-torque nano-oscillators (STNOs) is their ability to produce a frequency modulated (FM) signal, which is very critical for communication applications. We here demonstrate a novel single sideband (SSB) modulation phenomenon using a magnetic tunnel junction (MTJ)-based STNO, which saves tran...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13551-5
更新日期:2017-10-18 00:00:00
abstract::Hippocampal volumes are smaller in psychiatric disorder patients and lower levels of hippocampal neurogenesis are the hypothesized cause. Understanding which molecular processes regulate hippocampal progenitor differentiation might aid in the identification of novel drug targets that can promote larger hippocampal vol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15042-z
更新日期:2017-11-08 00:00:00
abstract::This work describes a simple technique to produce porous ceramics with aligned porosity having very high permeability and specific surface area. SiOC-based compositions were processed from blends of three types of preceramic polymer and a catalyst, followed by curing and pyrolysis. The heating applied from the bottom ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41049
更新日期:2017-01-20 00:00:00
abstract::Bio-functionalized nanoparticles with semiconducting/metallic core encapsulated in a bio- or bio-derived materials are promising for applications in biology and especially in cancer diagnostic and healing. In this report, we report a facile, single-step, first-time synthesis and in-situ functionalization strategy for ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18629
更新日期:2015-12-21 00:00:00