Abstract：
:We study the global spatio-temporal patterns of influenza dynamics. This is achieved by analysing and modelling weekly laboratory confirmed cases of influenza A and B from 138 countries between January 2006 and January 2015. The data were obtained from FluNet, the surveillance network compiled by the the World Health Organization. We report a pattern of skip-and-resurgence behavior between the years 2011 and 2013 for influenza H1N1pdm, the strain responsible for the 2009 pandemic, in Europe and Eastern Asia. In particular, the expected H1N1pdm epidemic outbreak in 2011/12 failed to occur (or "skipped") in many countries across the globe, although an outbreak occurred in the following year. We also report a pattern of well-synchronized wave of H1N1pdm in early 2011 in the Northern Hemisphere countries, and a pattern of replacement of strain H1N1pre by H1N1pdm between the 2009 and 2012 influenza seasons. Using both a statistical and a mechanistic mathematical model, and through fitting the data of 108 countries, we discuss the mechanisms that are likely to generate these events taking into account the role of multi-strain dynamics. A basic understanding of these patterns has important public health implications and scientific significance.
journal_name
Sci Repjournal_title
Scientific reportsauthors
He D,Lui R,Wang L,Tse CK,Yang L,Stone Ldoi
10.1038/srep11013subject
Has Abstractpub_date
2015-06-05 00:00:00pages
11013issn
2045-2322pii
srep11013journal_volume
5pub_type
杂志文章abstract：:This paper examines how a move from traditional post-harvest operations of smallholder rice farms in the Ayeyarwaddy delta, Myanmar, to improved post-harvest operations affected income, energy efficiency and greenhouse gas emissions (GHGE). Harvest and post-harvest losses were investigated in a field experiment with 5...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76639-5
更新日期：2020-11-13 00:00:00
abstract：:The intercellular spreading of protein assemblies is a major factor in the progression of neurodegenerative disorders. The quantitative study and visualization of cell-to-cell propagation using tagged-proteins is challenging due to the steric effect of relatively large fluorescence tags and the risk of 'false positive...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00657-z
更新日期：2017-03-28 00:00:00
abstract：:1,3,5-trinitroperhydro-1,3,5-triazine (RDX), octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), and pentaerythritol tetranitrate (PETN), the major components in plastic explosives, pose a significant threat to public safety. A quick, sensitive, and low-cost detection method for these non-volatile explosives is ea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25015
更新日期：2016-05-05 00:00:00
abstract：:In this study we used the Illumina Infinium Methylation array to investigate in a cohort of matched archival human tissue samples (n = 32) from 14 individuals with soft tissue sarcomas if genome-wide methylation changes occur during metastatic and recurrent (Met/Rec) disease. A range of sarcoma types were selected for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79648-6
更新日期：2021-01-12 00:00:00
abstract：:We report a novel and facile method to synthesize sulfur-doped titanium oxide sheets and realize TiS2-TiO2 heterostructures by means of a sequential sulfurization and oxidation step in a dual-zone chemical vapor deposition furnace. The inclusion of chlorine and argon gases during the growth of such titanium-based comp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53651-y
更新日期：2019-11-29 00:00:00
abstract：:Anthracnose caused by Colletotrichum is one of the most severe diseases of Hevea brasiliensis. However, research on the diversity and geographical distribution of Colletotrichum remains limited in China. In this study, we investigated the phylogenetic diversity of Colletotrichum isolates associated with symptomatic ti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28166-7
更新日期：2018-07-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00481
更新日期：2012-01-01 00:00:00
abstract：:It is estimated from twin studies that heritable factors account for at-least half of asthma-risk, of which genetic variants identified through population studies explain only a small fraction. Multi-generation large families with high asthma prevalence can serve as a model to identify highly penetrant genetic variant...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54718-6
更新日期：2019-12-13 00:00:00
abstract：:The blood-based diagnosis has a potential to provide an alternative approach for easy diagnosis of Alzheimer's disease (AD) with less invasiveness and low-cost. However, present blood-based AD diagnosis mainly focuses on measuring the plasma Aβ level because no other biomarkers are found to possess evident transport m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15703
更新日期：2015-10-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11764
更新日期：2015-07-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71081-z
更新日期：2020-08-26 00:00:00
abstract：:The definition of a precise illumination region is essential in many applications where the electromagnetic field should be confined in some specific volume. By using conventional structures, it is difficult to achieve an adequate confinement distance (or volume) with negligible levels of radiation leakage beyond it. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37739
更新日期：2016-11-25 00:00:00
abstract：:We use satellite gravity measurements in the Gravity Recovery and Climate Experiment (GRACE) to estimate terrestrial water storage (TWS) change in the continental United States (US) from 2003 to 2012, and establish a GRACE-based Hydrological Drought Index (GHDI) for drought monitoring. GRACE-inferred TWS exhibits oppo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19909
更新日期：2016-01-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32024
更新日期：2016-08-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16436
更新日期：2015-11-10 00:00:00
abstract：:Internet technologies have demonstrated their value for the early detection and prediction of epidemics. In diverse cases, electronic surveillance systems can be created by obtaining and analyzing on-line data, complementing other existing monitoring resources. This paper reports the feasibility of building such a sys...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61686-9
更新日期：2020-03-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59254-2
更新日期：2020-02-11 00:00:00
abstract：:Here, we report direct band gap transition for Gallium Phosphide (GaP) when alloyed with just 1-2 at% antimony (Sb) utilizing both density functional theory based computations and experiments. First principles density functional theory calculations of GaSbxP(1-x) alloys in a 216 atom supercell configuration indicate t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20822
更新日期：2016-02-10 00:00:00
abstract：:Rice bacterial blight caused by Xanthomonas oryzae pv. oryzae (Xoo) is a major rice disease. In Taiwan, the tropical indica type of Oryza sativa originally grown in this area is mix-cultivated with the temperate japonica type of O. sativa, and this might have led to adaptive changes of both rice host and Xoo isolates....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36575-x
更新日期：2019-01-22 00:00:00
abstract：:Sex-dependent effects of mismatched prenatal-postnatal maternal conditions are predicted by combining two evolutionary hypotheses: that foetal conditions provide a forecast of likely postnatal environments (Predictive Adaptive Response), and that the female foetus is better adapted than the male to maternal adversity ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39513-7
更新日期：2019-02-21 00:00:00
abstract：:Apparently mundane, amorphous nanostructures of carbon have optical properties which are as exotic as their crystalline counterparts. In this work we demonstrate a simple and inexpensive mechano-chemical method to prepare bulk quantities of self-passivated, amorphous carbon dots. Like the graphene quantum dots, the wa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28021-9
更新日期：2018-06-27 00:00:00
abstract：:Bacterial global post-transcriptional regulators execute hundreds of interactions with targets that display varying molecular features while retaining specificity. Herein, we develop, validate, and apply a biophysical, statistical thermodynamic model of canonical target mRNA interactions with the CsrA global post-tran...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27474-2
更新日期：2018-07-02 00:00:00
abstract：:Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the elderly. Zinc (Zn) ion interacts with the pathogenic hallmark, amyloid-β (Aβ), and is enriched in senile plaques in brain of AD patients. To understand Zn-chelated Aβ (ZnAβ) species, here we systematically characterized ZnAβ aggregates by ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23122-x
更新日期：2018-03-19 00:00:00
abstract：:Ultracentrifugationon sucrose density gradientappears to be the best purification protocol for extracellular vesicle (EVs) purification. After this step, to reduce disulfide bridges linking exogenous proteins to the vesicles, the collected samples are routinely washed and treated with dithiothreitol (DTT). Such incuba...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47598-3
更新日期：2019-09-10 00:00:00
abstract：:Discrimination of species and geographical origins of traditional Chinese medicine (TCM) is essential to prevent adulteration and inferior problems. We studied Ephedra sinica Stapf, Ephedra intermedia Schrenk et C.A.Mey. and Ephedra przewalskii Bge. to investigate the relationship between inorganic element content and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28558-9
更新日期：2018-07-06 00:00:00
abstract：:Human iPS cells hold great promise for disease modeling and treatment of degenerative disorders including muscular dystrophies. Although a few research groups have used them for skeletal muscle differentiation, most were based on gene over-expression or long-term mesenchymal differentiation and retrospective identific...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18759
更新日期：2016-01-05 00:00:00
abstract：:Antidiabetic medication may modify the incidence of hepatocellular carcinoma (HCC). We aimed to compare the use of different antidiabetic strategies and the incidence of HCC. PubMed, Embase.com and Cochrane Library databases were searched up to 31 October 2015 and randomized controlled trials (RCTs), cohort studies or...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
doi：10.1038/srep33743
更新日期：2016-09-19 00:00:00
abstract：:Homocysteine (Hcy) has been shown to have a neurotoxic effect on ischemic brain cells; however, the underlying mechanisms remain incompletely understood. Here, we examined whether Hcy treatment influences mitochondria injury, oxidative stress, and mitochondrial STAT3 (mitoStat3) expression in rat ischemic brain. Our r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07112-z
更新日期：2017-07-31 00:00:00
abstract：:Metastasis of head and neck tumors is responsible for a high mortality rate. Understanding its biochemistry may allow insights into tumorigenesis. To that end we carried out RNA-Seq analyses of 5 SCC9 derived oral cancer cell lines displaying increased invasive potential. Differentially expressed genes (DEGs) were ann...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-19010-5
更新日期：2018-01-31 00:00:00
abstract：:The multifactorial chronic inflammatory disease periodontitis, which is characterized by destruction of tooth-supporting tissues, has also been implicated as a risk factor for various systemic diseases. Although periodontitis has been studied extensively, neither disease-specific biomarkers nor therapeutic targets hav...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18475
更新日期：2015-12-21 00:00:00
