Adalimumab Reduces Photoreceptor Cell Death in A Mouse Model of Retinal Degeneration.

abstract：:Oligomannose-type glycans on HIV-1 gp120 form a patch that is targeted by several broadly neutralizing antibodies (bnAbs) and that therefore is of interest to vaccine design. However, attempts to elicit similar oligomannose-specific bnAbs by immunizing with oligomannosidic glycoconjugates have only been modestly succe...

journal_title：Scientific reports

authors： Bruxelle JF,Kirilenko T,Qureshi Q,Lu N,Trattnig N,Kosma P,Pantophlet R

更新日期：2020-05-05 00:00:00

abstract：:Investigating cytokines in tear fluid and saliva may offer valuable information for understanding the pathogenesis of primary Sjögren's syndrome (pSS). Cytokine profiles in both tear fluid and saliva of pSS patients, non-Sjögren's syndrome (non-SS) subjects with sicca symptoms, and healthy controls without sicca compl...

journal_title：Scientific reports

authors： Chen X,Aqrawi LA,Utheim TP,Tashbayev B,Utheim ØA,Reppe S,Hove LH,Herlofson BB,Singh PB,Palm Ø,Galtung HK,Jensen JCL

更新日期：2019-05-13 00:00:00

abstract：:Divalent metal-ion transporter 1 (DMT1) has been found to play an important role in the iron metabolism and hemogenesis. However, little is known about the potential role of DMT1 in the pathogenesis of anemia from patients with inflammatory bowel disease (IBD). Herein, we investigated expression of DMT1 in the intesti...

journal_title：Scientific reports

authors： Wu W,Song Y,He C,Liu C,Wu R,Fang L,Cong Y,Miao Y,Liu Z

更新日期：2015-11-17 00:00:00

abstract：:Triterpenic acids (TAs), a large group of natural compounds with diverse biological activity, are produced by several plant taxa. Betulinic, oleanolic, and ursolic acids are the most medicinally important TAs and are mainly found in plants of the mint family. Metabolic engineering is strongly dependent on identifying ...

journal_title：Scientific reports

authors： Aminfar Z,Rabiei B,Tohidfar M,Mirjalili MH

更新日期：2019-11-01 00:00:00

abstract：:Insect glutathione S-transferases (GSTs) play important roles in insecticide/drug resistance and stress response. Medically, GSTs of house dust mites (Dermatophagoides pteronyssinus and Blomia tropicalis) and German cockroach (Blattella germanica) are human allergens. In this study, classes, isoforms and B-cell and al...

journal_title：Scientific reports

authors： Sookrung N,Reamtong O,Poolphol R,Indrawattana N,Seesuay W,Saelim N,Tantilipikorn P,Bunnag C,Chaicumpa W,Tungtrongchitr A

更新日期：2018-01-11 00:00:00

abstract：:Ecosystem carbon carrying capacity (CCC) is determined by prevailing climate and natural disturbance regimes, conditions that are projected to change significantly. The interaction of changing climate and its effects on disturbance regimes is expected to affect forest regeneration and growth, which may diminish forest...

journal_title：Scientific reports

authors： Liang S,Hurteau MD,Westerling AL

更新日期：2017-05-25 00:00:00

abstract：:A retrospective immunohistochemical study was designed to investigate the frequency of concomitant traditional infectious disease pathogens in puppies that died suddenly and review the aspects of associated pathogenesis. Fifteen puppies were evaluated; the pathology reports and histopathologic slides of these animals ...

journal_title：Scientific reports

authors： Headley SA,Oliveira TES,Pereira AHT,Moreira JR,Michelazzo MMZ,Pires BG,Marutani VHB,Xavier AAC,Di Santis GW,Garcia JL,Alfieri AA

更新日期：2018-09-07 00:00:00

abstract：:We aimed to analyze the associations of bone mineral density (BMD) of femoral heads, age and gender, and compare the differences in BMD between fracture side and non-fracture side by "3D Spine Exam Analysis" module in QCT Pro software. In this study, we identified patients who had undergone quantitative computed tomog...

journal_title：Scientific reports

authors： Li X,Xu Y,Lin W,Fan Y

更新日期：2020-08-03 00:00:00

abstract：:Animals have evolved limb proportions adapted to different environments, but it is not yet clear to what extent these proportions are directly influenced by the environment during prenatal development. The developing skeleton experiences mechanical loading resulting from embryo movement. We tested the hypothesis that ...

journal_title：Scientific reports

authors： Pollard AS,Charlton BG,Hutchinson JR,Gustafsson T,McGonnell IM,Timmons JA,Pitsillides AA

更新日期：2017-02-06 00:00:00

abstract：:The phylogenetic characteristics of microbial communities associated with periodontitis have been well studied, however, little is known about the functional endowments of this ecosystem. The present study examined 73 microbial assemblages from 25 individuals with generalized chronic periodontitis and 25 periodontally...

journal_title：Scientific reports

authors： Dabdoub SM,Ganesan SM,Kumar PS

更新日期：2016-12-19 00:00:00

abstract：:Diffusion magnetic resonance imaging (dMRI) proved promising in patients with non-myelopathic degenerative cervical cord compression (NMDCCC), i.e., without clinically manifested myelopathy. Aim of the study is to present a fast multi-shell HARDI-ZOOMit dMRI protocol and validate its usability to detect microstructura...

journal_title：Scientific reports

authors： Labounek R,Valošek J,Horák T,Svátková A,Bednařík P,Vojtíšek L,Horáková M,Nestrašil I,Lenglet C,Cohen-Adad J,Bednařík J,Hluštík P

更新日期：2020-10-16 00:00:00

abstract：:In recent years it has been shown that the therapeutic benefits of human mesenchymal stem/stromal cells (hMSCs) in the Central Nervous System (CNS) are mainly attributed to their secretome. The implementation of computer-controlled suspension bioreactors has shown to be a viable route for the expansion of these cells ...

journal_title：Scientific reports

authors： Teixeira FG,Panchalingam KM,Assunção-Silva R,Serra SC,Mendes-Pinheiro B,Patrício P,Jung S,Anjo SI,Manadas B,Pinto L,Sousa N,Behie LA,Salgado AJ

更新日期：2016-06-15 00:00:00

abstract：:Plasmodiophora brassicae causes clubroot disease in cruciferous. In this report, lipid droplets were observed in the resting spores of P. brassicae. 295 lipid droplet-associated proteins were identified and categorized into nine groups. Transcriptome analysis of these proteins during three different zoosporic stages r...

journal_title：Scientific reports

authors： Bi K,He Z,Gao Z,Zhao Y,Fu Y,Cheng J,Xie J,Jiang D,Chen T

更新日期：2016-11-22 00:00:00

abstract：:An impairment of cardiac function is a key feature of the cardiovascular failure associated with sepsis. Although there is some evidence that suppression of sarcoplasmic reticulum Ca2+-ATP-ase (SERCA2) contributes to septic cardiomyopathy, it is not known whether prevention of the down-regulation of SERCA2 improves ou...

journal_title：Scientific reports

authors： Martin L,Horst K,Chiazza F,Oggero S,Collino M,Brandenburg K,Hildebrand F,Marx G,Thiemermann C,Schuerholz T

更新日期：2016-11-17 00:00:00

abstract：:Mechanistic studies of deregulated ERG in prostate cancer and other cancers continue to enhance its role in cancer biology and its utility as a biomarker and therapeutic target. Here, we show that ERG, through its physical interaction with androgen receptor, induces AR aggregation and endoplasmic reticulum stress in t...

journal_title：Scientific reports

authors： Sreenath TL,Macalindong SS,Mikhalkevich N,Sharad S,Mohamed A,Young D,Borbiev T,Xavier C,Gupta R,Jamal M,Babcock K,Tan SH,Nevalainen MT,Dobi A,Petrovics G,Sesterhenn IA,Rosner IL,Bieberich CJ,Nelson P,Vasioukhin V,

更新日期：2017-04-24 00:00:00

abstract：:Gallbladder cancer (GBC) is the most common malignant tumor of the biliary system. However, the mechanisms underlying its tumor initiation, progression, and metastasis are not yet fully understood. The annexin A4 (ANXA4) gene is highly expressed in GBC tissues and may play an important role in the initiation and progr...

journal_title：Scientific reports

authors： Yao HS,Sun C,Li XX,Wang Y,Jin KZ,Zhang XP,Hu ZQ

更新日期：2016-08-05 00:00:00

abstract：:Accumulating evidence implies that both AKT1 and GABAA receptor (GABAAR) subunit genes are involved in schizophrenia pathogenesis. Activated Akt promotes GABAergic neuron differentiation and increases GABAAR expression on the plasma membrane. To elucidate the role of Akt1 in modulating GABAergic functions and schizoph...

journal_title：Scientific reports

authors： Chang CY,Chen YW,Wang TW,Lai WS

更新日期：2016-09-12 00:00:00

abstract：:Quorum-sensing (QS) systems exist universally in bacteria to regulate multiple biological functions. Klebsiella pneumoniae, an industrially important bacterium that produces bio-based chemicals such as 2,3-butanediol and acetoin, can secrete a furanosyl borate diester (AI-2) as the signalling molecule mediating a QS s...

journal_title：Scientific reports

authors： Sun S,Zhang H,Lu S,Lai C,Liu H,Zhu H

更新日期：2016-12-07 00:00:00

abstract：:Settlement-inducing protein complex (SIPC) is a pheromone that triggers conspecific larval settlement in the barnacle Amphibalanus amphitrite. In the present study, immunostaining and scanning electron microscopy of SIPC revealed signals in the frontal horn pores and the secretions from carapace pores, suggesting that...

journal_title：Scientific reports

authors： Zhang G,Yang XX,Leung PM,He LS,Chan TY,Yan GY,Zhang Y,Sun J,Xu Y,Qian PY

更新日期：2016-07-20 00:00:00

abstract：:Tin selenide has attracted much research interest due to its unprecedentedly high thermoelectric figure of merit (ZT). For real applications, it is desirable to increase the ZT value in the lower-temperature range, as the peak ZT value currently exists near the melting point. It is shown in this paper that the structu...

journal_title：Scientific reports

authors： Yu H,Dai S,Chen Y

更新日期：2016-05-19 00:00:00

abstract：:PARP inhibitors have shown remarkable efficacy in the clinical management of several BRCA-mutated tumors. This approach is based on the long-standing hypothesis that PARP inhibition will impair the repair of single stranded breaks, causing synthetic lethality in tumors with loss of high-fidelity double-strand break ho...

journal_title：Scientific reports

authors： Principe DR,Narbutis M,Koch R,Rana A

更新日期：2020-11-19 00:00:00

abstract：:Our motor system can generate representations which carry information about the goals of another agent's actions. However, it is not known whether motor representations play a deeper role in social understanding, and, in particular, whether they enable tracking others' beliefs. Here we show that, for adult observers, ...

journal_title：Scientific reports

authors： Low J,Edwards K,Butterfill SA

更新日期：2020-07-09 00:00:00

abstract：:Most women with ovarian cancer are diagnosed at an advanced stage and there are few therapeutic options. Recently, monoclonal antibody therapies have had limited success, thus more effective antibodies are needed to improve long-term survival. In this report, we prepared polyclonal rabbit anti-ovarian cancer antibody ...

journal_title：Scientific reports

authors： Zhang S,Yu M,Deng H,Shen G,Wei Y

更新日期：2014-05-15 00:00:00

abstract：:The lignite biodegradation procedure to produce water-soluble humic materials (WSHM) with a Penicillium stain was established by previous studies in our laboratory. This study researched the effects of WSHM on the growth of Bradyrhizobium liaoningense CCBAU05525 and its nodulation on soybean. Results showed that WSHM ...

journal_title：Scientific reports

authors： Guo Gao T,Yuan Xu Y,Jiang F,Zhen Li B,Shui Yang J,Tao Wang E,Li Yuan H

更新日期：2015-06-08 00:00:00

abstract：:The green bacterial biosynthesis of lead sulfide nanocrystallites by L-cysteine-desulfurizing bacterium Lysinibacillus sphaericus SH72 was demonstrated in this work. Nanocrystals formed by this bacterial method were characterized using the mineralogical and morphological approaches. The results revealed that the micro...

journal_title：Scientific reports

authors： Wei S,Guo C,Wang L,Xu J,Dong H

更新日期：2021-01-13 00:00:00

abstract：:Chromosomal toxin-antitoxin (TA) systems are widespread genetic elements among bacteria, yet, despite extensive studies in the last decade, their biological importance remains ambivalent. The ability of TA-encoded toxins to affect stress tolerance when overexpressed supports the hypothesis of TA systems being associat...

journal_title：Scientific reports

authors： Rosendahl S,Tamman H,Brauer A,Remm M,Hõrak R

更新日期：2020-06-08 00:00:00

abstract：:Faithful DNA replication is a prerequisite for cell proliferation. Several cytological studies have shown that chromosome structures alter in the S-phase of the cell cycle. However, the molecular mechanisms behind the alteration of chromosome structures associated with DNA replication have not been elucidated. Here, w...

journal_title：Scientific reports

authors： Ruan K,Yamamoto TG,Asakawa H,Chikashige Y,Kimura H,Masukata H,Haraguchi T,Hiraoka Y

更新日期：2015-07-30 00:00:00

abstract：:Burkholderia terrae BS001 has previously been found to be able to disperse along with growing fungal hyphae in soil, with the type-3 secretion system having a supportive role in this movement. In this study, we focus on the role of two motility- and adherence-associated appendages, i.e. type-4 pili (T4P) and flagella....

journal_title：Scientific reports

authors： Yang P,Zhang M,van Elsas JD

更新日期：2017-06-07 00:00:00

abstract：:Dust from grain and feed production may cause adverse health effects in exposed workers. In this study we explored circulating miRNAs as potential biomarkers of occupational grain dust exposure. Twenty-two serum miRNAs were analyzed in 44 grain dust exposed workers and 22 controls. Exposed workers had significantly up...

journal_title：Scientific reports

authors： Straumfors A,Duale N,Foss OAH,Mollerup S

更新日期：2020-07-09 00:00:00

abstract：:Two-dimensional (2D) acoustic vortex allows new physics and applications different from three-dimensional counterparts, yet existing mechanisms usually have to rely on active array composed of transducers which may result in complexity, high cost and, in particular, undesired spatial aliasing effect. We propose to gen...

journal_title：Scientific reports

authors： Liu JJ,Liang B,Yang J,Yang J,Cheng JC

更新日期：2020-03-02 00:00:00