Characterization of germ cell differentiation in the male mouse through single-cell RNA sequencing.

abstract：:Conventional myeloablative conditioning (MAC) regimens often cause severe regimen-related toxicity (RRT). Furthermore, many patients suffer from poor quality of life in accordance with the increase in long-term survivors. We therefore devised a reduced-toxicity myeloablative conditioning (RTMAC) regimen consisting of ...

journal_title：Scientific reports

authors： Hirabayashi K,Nakazawa Y,Sakashita K,Kurata T,Saito S,Yoshikawa K,Tanaka M,Yanagisawa R,Koike K

更新日期：2014-11-06 00:00:00

abstract：:Phytoplasmas are transmitted by insect vectors in a persistent propagative manner; however, detailed movements and multiplication patterns of phytoplasmas within vectors remain elusive. In this study, spatiotemporal dynamics of onion yellows (OY) phytoplasma in its vector Macrosteles striifrons were investigated by im...

journal_title：Scientific reports

authors： Koinuma H,Maejima K,Tokuda R,Kitazawa Y,Nijo T,Wei W,Kumita K,Miyazaki A,Namba S,Yamaji Y

更新日期：2020-03-09 00:00:00

abstract：:Frequency domain measures of heart rate variability (HRV) are associated with adverse events after a myocardial infarction. However, patterns in the traditional frequency domain (measured in Hz, or cycles per second) may capture different cardiac phenomena at different heart rates. An alternative is to consider freque...

journal_title：Scientific reports

authors： Liu Y,Scirica BM,Stultz CM,Guttag JV

更新日期：2016-10-06 00:00:00

abstract：:Among atrial fibrillation (AF) patients, Danish nationwide registries (2011-2015) were used to examine temporal trends of initiation patterns of oral anticoagulation (OAC) treatment according to age. Overall, 43,299 AF patients initiating vitamin K antagonists (VKA) (42%), dabigatran (29%), rivaroxaban (13%), or apixa...

journal_title：Scientific reports

authors： Staerk L,Fosbøl EL,Gadsbøll K,Sindet-Pedersen C,Pallisgaard JL,Lamberts M,Lip GY,Torp-Pedersen C,Gislason GH,Olesen JB

更新日期：2016-08-11 00:00:00

abstract：:In recent years, active targeting strategies by ligand modification have emerged to enhance tumor accumulation of NP, but their clinical application was strictly restricted due to the complex preparation procedures, poor stability and serious toxicity. An effective and clinical translational strategy is required to sa...

journal_title：Scientific reports

authors： Hu G,Cun X,Ruan S,Shi K,Wang Y,Kuang Q,Hu C,Xiao W,He Q,Gao H

更新日期：2016-06-08 00:00:00

abstract：:Ataxia-telangiectasia (AT) and related disorders feature cancer predisposition, neurodegeneration, and immunodeficiency resulting from failure to respond to DNA damage. Hypomorphic mutations in MRE11 cause an AT-like disorder (ATLD) with variable clinical presentation. We have sought to understand how diverse MRE11 mu...

journal_title：Scientific reports

authors： Hartlerode AJ,Regal JA,Ferguson DO

更新日期：2018-07-04 00:00:00

abstract：:Miniaturised optical coherence tomography (OCT) fibre-optic probes have enabled high-resolution cross-sectional imaging deep within the body. However, existing OCT fibre-optic probe fabrication methods cannot generate miniaturised freeform optics, which limits our ability to fabricate probes with both complex optical ...

journal_title：Scientific reports

authors： Li J,Fejes P,Lorenser D,Quirk BC,Noble PB,Kirk RW,Orth A,Wood FM,Gibson BC,Sampson DD,McLaughlin RA

更新日期：2018-10-04 00:00:00

abstract：:Single molecule localization microscopy (SMLM) techniques allow for sub-diffraction imaging with spatial resolutions better than 10 nm reported. Much has been discussed relating to different variations of SMLM and all-inclusive microscopes can now be purchased, removing the need for in-house software or hardware devel...

journal_title：Scientific reports

authors： Whelan DR,Bell TD

更新日期：2015-01-21 00:00:00

abstract：:Endoplasmic reticulum (ER) stress preconditioning protects cells against methylmercury (MeHg) cytotoxicity by inducing integrated stress responses such as eIF2α phosphorylation, ATF4 accumulation, and nonsense-mediated mRNA decay (NMD) suppression. Here we demonstrated that ER stress preconditioning results in the upr...

journal_title：Scientific reports

authors： Usuki F,Fujimura M,Yamashita A

更新日期：2017-09-28 00:00:00

abstract：:Gas-filled hollow-core fiber (HCF) pulse post-compressors generating few- to single-cycle pulses are a key enabling tool for attosecond science and ultrafast spectroscopy. Achieving optimum performance in this regime can be extremely challenging due to the ultra-broad bandwidth of the pulses and the need of an adequat...

journal_title：Scientific reports

authors： Conejero Jarque E,San Roman J,Silva F,Romero R,Holgado W,Gonzalez-Galicia MA,Alonso B,Sola IJ,Crespo H

更新日期：2018-02-02 00:00:00

abstract：:We developed a simple, scalable and high-throughput method for fabrication of large-area three-dimensional rose-like microflowers with controlled size, shape and density on graphene films by femtosecond laser micromachining. The novel biomimetic microflower that composed of numerous turnup graphene nanoflakes can be f...

journal_title：Scientific reports

authors： Shi X,Li X,Jiang L,Qu L,Zhao Y,Ran P,Wang Q,Cao Q,Ma T,Lu Y

更新日期：2015-11-30 00:00:00

abstract：:Iron oxide nanoparticles have attracted a great deal of research interest and have been widely used in bioscience and clinical research including as contrast agents for magnetic resonance imaging, hyperthermia and magnetic field assisted radionuclide therapy. It is therefore important to develop methods, which can pro...

journal_title：Scientific reports

authors： Erofeev A,Gorelkin P,Garanina A,Alova A,Efremova M,Vorobyeva N,Edwards C,Korchev Y,Majouga A

更新日期：2018-05-10 00:00:00

abstract：:Renal fibrosis, the characteristic feature of progressive chronic kidney disease, is associated with unremitting renal inflammation. Although it is reported that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active form of vitamin D, elicits an anti-renal fibrotic effect, its molecular mechanism is still unknown. In thi...

journal_title：Scientific reports

authors： Bi J,Watanabe H,Fujimura R,Nishida K,Nakamura R,Oshiro S,Imafuku T,Komori H,Miyahisa M,Tanaka M,Matsushita K,Maruyama T

更新日期：2018-11-26 00:00:00

abstract：:Friction is a major inhibitor in almost every mechanical system. Enlightened by the Leidenfrost effect - a droplet can be levitated by its own vapor layer on a sufficiently hot surface - we demonstrate for the first time that a small cart can also be levitated by Leidenfrost vapor. The levitated cart can carry certain...

journal_title：Scientific reports

authors： Hashmi A,Xu Y,Coder B,Osborne PA,Spafford J,Michael GE,Yu G,Xu J

更新日期：2012-01-01 00:00:00

abstract：:Arsenic contamination of groundwater is a serious concern worldwide. The research gaps in removing arsenic are selectivity, regeneration and effective removal rate at neutral pH levels. In this study, we discussed the reasons of the high arsenic adsorption from groundwater of our previously developed adsorbent, a cati...

journal_title：Scientific reports

authors： Safi SR,Senmoto K,Gotoh T,Iizawa T,Nakai S

更新日期：2019-08-15 00:00:00

abstract：:Perovskite solar cells based on series of inorganic cesium lead bromide and iodide mixture, CsPbBr3-xI x , where x varies between 0, 0.1, 0.2, and 0.3 molar ratio were synthesized by two step-sequential deposition at ambient condition to design the variations of wide band gap light absorbers. A device with high overal...

journal_title：Scientific reports

authors： Ng CH,Ripolles TS,Hamada K,Teo SH,Lim HN,Bisquert J,Hayase S

更新日期：2018-02-06 00:00:00

abstract：:Thermoelectrics is a challenging issue for modern and future energy conversion and recovery technology. Carbon nanotubes are promising active thermoelectic materials owing to their narrow bandgap energy and high charge carrier mobility, and they can be integrated into flexible thermoelectrics that can recover any wast...

journal_title：Scientific reports

authors： Nonoguchi Y,Ohashi K,Kanazawa R,Ashiba K,Hata K,Nakagawa T,Adachi C,Tanase T,Kawai T

更新日期：2013-11-26 00:00:00

abstract：:Phospholipase A2-like (PLA2-like) proteins contribute to the development of muscle necrosis in Viperidae snake bites and are not efficiently neutralized by current antivenom treatments. The toxic mechanisms of PLA2-like proteins are devoid of catalytic activity and not yet fully understood, although structural and fun...

journal_title：Scientific reports

authors： Borges RJ,Lemke N,Fontes MRM

更新日期：2017-11-14 00:00:00

abstract：:Invasive species are characterized by their ability to colonize new habitats and establish populations away from their native range. In this sense, these plants are expected to have plastic responses to adapt to the environmental pressures during the invasion process. Hence, the role of natural selection is essential ...

journal_title：Scientific reports

authors： Dematteis B,Ferrucci MS,Coulleri JP

更新日期：2020-11-18 00:00:00

abstract：:Securin overexpression correlates with poor prognosis in various tumours. We have previously shown that securin depletion promotes radiation-induced senescence and enhances radiosensitivity in human cancer cells. However, the underlying molecular mechanisms and the paracrine effects remain unknown. In this study, we s...

journal_title：Scientific reports

authors： Yu YC,Yang PM,Chuah QY,Huang YH,Peng CW,Lee YJ,Chiu SJ

更新日期：2013-01-01 00:00:00

abstract：:Desert locusts (Schistocerca gregaria) show a dramatic form of socially induced phenotypic plasticity known as phase polyphenism. In the absence of conspecifics, locusts occur in a shy and cryptic solitarious phase. Crowding with conspecifics drives a behavioural transformation towards gregariousness that occurs withi...

journal_title：Scientific reports

authors： Mallon EB,Amarasinghe HE,Ott SR

更新日期：2016-10-18 00:00:00

abstract：:Dehydroascorbate reductase (DHAR) is a key enzyme involved in the recycling of ascorbate, which catalyses the glutathione (GSH)-dependent reduction of oxidized ascorbate (dehydroascorbate, DHA). As a result, DHAR regenerates a pool of reduced ascorbate and detoxifies reactive oxygen species (ROS). In previous experime...

journal_title：Scientific reports

authors： Do H,Kim IS,Jeon BW,Lee CW,Park AK,Wi AR,Shin SC,Park H,Kim YS,Yoon HS,Kim HW,Lee JH

更新日期：2016-01-18 00:00:00

abstract：:The role of the different lymphocyte populations in liver microenvironment of chronic hepatitis C (CHC) patients is still matter of debate. Since Th17 and Treg have opposite functions, their balance could affect disease progression. The aim was to explore liver microenvironment and its peripheral blood counterpart in ...

journal_title：Scientific reports

authors： Rios DA,Valva P,Casciato PC,Frias S,Soledad Caldirola M,Gaillard MI,Bezrodnik L,Bandi J,Galdame O,Ameigeiras B,Krasniansky D,Brodersen C,Mullen E,Matteo EN,Preciado MV

更新日期：2017-10-16 00:00:00

abstract：:Despite numerous advances in genomics and bioinformatics, technological hurdles remain to examine host-microbe transcriptomics. Sometimes the transcriptome of either or both can be ascertained merely by generating more sequencing reads. However, many cases exist where bacterial mRNA needs to be enriched further to ena...

journal_title：Scientific reports

authors： Kumar N,Lin M,Zhao X,Ott S,Santana-Cruz I,Daugherty S,Rikihisa Y,Sadzewicz L,Tallon LJ,Fraser CM,Dunning Hotopp JC

更新日期：2016-10-07 00:00:00

abstract：:Bile acid (BA) signatures are altered in many disease states. BA metabolism is an important microbial function to assist gut colonization and persistence, as well as microbial survival during gastro intestinal (GI) transit and it is an important criteria for potential probiotic bacteria. Microbes that express bile sal...

journal_title：Scientific reports

authors： Prete R,Long SL,Gallardo AL,Gahan CG,Corsetti A,Joyce SA

更新日期：2020-01-24 00:00:00

abstract：:Metastable ω phase is common in body-centred cubic (bcc) metals and alloys, including high-alloying steels. Recent theoretical calculations also suggest that the ω structure may act as an intermediate phase for face-centred cubic (fcc)-to-bcc transformation. Thus far, the role of the ω phase played in fcc-bcc martensi...

journal_title：Scientific reports

authors： Liu T,Zhang D,Liu Q,Zheng Y,Su Y,Zhao X,Yin J,Song M,Ping D

更新日期：2015-10-27 00:00:00

abstract：:Endothelin-1 (ET-1), a vasoconstrictor, has recently been used to induce focal ischemia in rodents and marmoset monkeys. The rhesus monkey, however, has numerous advantages to the rodent and marmoset that make it a superior and irreplaceable animal model for studying stroke in the brain. In the present study, after ma...

journal_title：Scientific reports

authors： Dai P,Huang H,Zhang L,He J,Zhao X,Yang F,Zhao N,Yang J,Ge L,Lin Y,Yu H,Wang J

更新日期：2017-03-30 00:00:00

abstract：:The brain is possibly the most complex system known to mankind, and its complexity has been called upon to explain the emergence of consciousness. However, complexity has been defined in many ways by multiple different fields: here, we investigate measures of algorithmic and process complexity in both the temporal and...

journal_title：Scientific reports

authors： Varley TF,Luppi AI,Pappas I,Naci L,Adapa R,Owen AM,Menon DK,Stamatakis EA

更新日期：2020-01-23 00:00:00

abstract：:Alzheimer's disease (AD) is mainly characterized by the deposition of extracellular amyloid plaques and intracellular accumulation of neurofibrillary tangles (NFTs). While the recent 5xFAD AD mouse model exhibits many AD-related phenotypes and a relatively early and aggressive amyloid β production, it does not show NF...

journal_title：Scientific reports

authors： Kang S,Kim J,Chang KA

更新日期：2021-01-14 00:00:00

abstract：:A better understanding of the seroprevalence and specificity of influenza HA stem-directed broadly neutralizing antibodies (bNAbs) in the human population could significantly inform influenza vaccine design efforts. Here, we utilized probes comprising headless, HA stabilized stem (SS) to determine the prevalence, bind...

journal_title：Scientific reports

authors： Yassine HM,McTamney PM,Boyington JC,Ruckwardt TJ,Crank MC,Smatti MK,Ledgerwood JE,Graham BS

更新日期：2018-06-05 00:00:00