Abstract：
:Among atrial fibrillation (AF) patients, Danish nationwide registries (2011-2015) were used to examine temporal trends of initiation patterns of oral anticoagulation (OAC) treatment according to age. Overall, 43,299 AF patients initiating vitamin K antagonists (VKA) (42%), dabigatran (29%), rivaroxaban (13%), or apixaban (16%) were included with mean age (SD) 72.1 (11.3), 71.5 (11.0), 74.3 (11.1), and 75.3 (11.1) years, respectively. Patients aged ≥85 years comprised 15%. Trend tests showed increase in patients ≥85 years initiating OAC (p < 0.0001). VKA usage decreased from 92% to 24% (p < 0.0001). This decrease was independent of age. Dabigatran was the most common non-VKA OAC (NOAC) (40% users), but usage decreased from 2014 until study end (6%) (p < 0.0001). Apixaban was the most used OAC at study end (41%), in particular among those ≥85 years (44%). Compared with patients aged <65 years, the odds ratios associated with initiating VKA, dabigatran, rivaroxaban, or apixaban for patients aged ≥85 years were 0.81 (95% CI 0.75-0.86), 0.65 (95% CI 0.60-0.70), 1.52 (95% CI 1.38-1.67), and 2.09 (95% CI 1.89-2.30), respectively. In conclusion, substantial increase in NOAC usage has occurred. Increasing age was associated with upstart of rivaroxaban or apixaban with reference to age <65 within the specific agent.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Staerk L,Fosbøl EL,Gadsbøll K,Sindet-Pedersen C,Pallisgaard JL,Lamberts M,Lip GY,Torp-Pedersen C,Gislason GH,Olesen JBdoi
10.1038/srep31477subject
Has Abstractpub_date
2016-08-11 00:00:00pages
31477issn
2045-2322pii
srep31477journal_volume
6pub_type
杂志文章abstract：:Spatially resolved analysis of uranium (U) isotopes in small volumes of actinide-bearing materials is critical for a variety of technical disciplines, including earth and planetary sciences, environmental monitoring, bioremediation, and the nuclear fuel cycle. However, achieving subnanometer-scale spatial resolution f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48479-5
更新日期：2019-08-23 00:00:00
abstract：:Here, we report direct band gap transition for Gallium Phosphide (GaP) when alloyed with just 1-2 at% antimony (Sb) utilizing both density functional theory based computations and experiments. First principles density functional theory calculations of GaSbxP(1-x) alloys in a 216 atom supercell configuration indicate t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20822
更新日期：2016-02-10 00:00:00
abstract：:We present theoretical results on the high-temperature phase stability and phonon spectra of paramagnetic bcc iron which explicitly take into account many-body effects. Several peculiarities, including a pronounced softening of the [110] transverse (T1) mode and a dynamical instability of the bcc lattice in harmonic a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05585
更新日期：2014-07-07 00:00:00
abstract：:In this study, we sequenced the complete mitochondrial genome of Eligma narcissus and compared it with 18 other lepidopteran species. The mitochondrial genome (mitogenome) was a circular molecule of 15,376 bp containing 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, two ribosomal RNA (rRNA) genes and an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26387
更新日期：2016-05-25 00:00:00
abstract：:MicroRNAs can promote translation of specific mRNAs in quiescent (G0) mammalian cells and immature Xenopus laevis oocytes. We report that microRNA-mediated upregulation of target mRNAs in oocytes is dependent on nuclear entry of the microRNA; cytoplasmically-injected microRNA repress target mRNAs. Components of the ac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00842
更新日期：2012-01-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-60111-5
更新日期：2020-02-18 00:00:00
abstract：:In this study, an interval optimization model is developed to maximize the benefits of a water rights transfer system that comprises industry and agriculture sectors in the Ningxia Hui Autonomous Region in China. The model is subjected to a number of constraints including water saving potential from agriculture and ec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02734-9
更新日期：2017-06-14 00:00:00
abstract：:Nanoscale real-time molecular sensing requires large signal enhancement, small background, short detection time and high spectral resolution. We demonstrate a new vibrational spectroscopic technique which satisfies all of these conditions. This time-resolved surface-enhanced coherent anti-Stokes Raman scattering (tr-S...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00891
更新日期：2012-01-01 00:00:00
abstract：:Comparison of kinetic and thermodynamic properties of IRP1 (iron regulatory protein1) binding to FRT (ferritin) and ACO2 (aconitase2) IRE-RNAs, with or without Mn2+, revealed differences specific to each IRE-RNA. Conserved among animal mRNAs, IRE-RNA structures are noncoding and bind Fe2+ to regulate biosynthesis rate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09093-5
更新日期：2017-08-17 00:00:00
abstract：:Telomere length (TL) is linked to various age-related diseases, but little is known about telomeres in gestational diabetes mellitus (GDM). We surveyed 509 subjects (113 GDM patients and 396 frequency matched controls) in Nanjing Drum Tower Hospital, Jiangsu province of eastern China. Relative telomere length (RTL) of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44968-9
更新日期：2019-06-11 00:00:00
abstract：:This study shows that DKK-1, a member of the Dickkopf family and a regulator of the Wnt pathways, represents a novel target of statins which, through the inhibition of HMG-CoA reductase and of non-steroidal isoprenoid intermediates, exert extra-beneficial effect in preventing atherosclerosis beyond their effect on the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35119-7
更新日期：2018-11-12 00:00:00
abstract：:Omniphobic surfaces with reentrant microstructures have been investigated for a range of applications, but the evaporation of high- and low-surface-tension liquid droplets placed on such surfaces has not been rigorously studied. In this work, we develop a technique to fabricate omniphobic surfaces on copper substrates...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17110
更新日期：2015-11-25 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-58755-4
更新日期：2020-01-30 00:00:00
abstract：:Modulation of initial burst and long term release from electrospun fibrous mats can be achieved by sandwiching the drug loaded mats between hydrophobic layers of fibrous polycaprolactone (PCL). Ibuprofen (IBU) loaded PCL fibrous mats (12% PCL-IBU) were sandwiched between fibrous polycaprolactone layers during the proc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74885-1
更新日期：2020-10-23 00:00:00
abstract：:This article shows that nanodiamonds can transmigrate through the insect cuticle easily, and the doses used were not hemocytotoxic and did not cause inhibition of cellular and humoral immune responses in larvae, pupae and adults of Tenebrio molitor. The examination of the nanodiamond biodistribution in insect cells de...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46720-9
更新日期：2019-07-17 00:00:00
abstract：:Dogs (Canis familiaris) are the first animals to be domesticated by humans and the only ones domesticated by mobile hunter-gatherers. Wolves and humans were both persistent, pack hunters of large prey. They were species competing over resources in partially overlapping ecological niches and capable of killing each oth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78214-4
更新日期：2021-01-07 00:00:00
abstract：:We prospectively compared visual and refractive outcomes in patients with high myopia and myopic astigmatism after small-incision lenticule extraction (SMILE) and photorefractive keratetctomy (PRK) with mitomycin C. Sixty-six eyes of 33 patients (mean age, 29.7 ± 5.6 years) were included (SMILE: 34 eyes, PRK 32 eyes)....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32820
更新日期：2016-09-07 00:00:00
abstract：:Cd3As2 has long been known as a high-mobility semiconductor. The recent finding of a topological semimetal state in this compound has demanded growth of epitaxial films with high crystallinity and controlled thickness. Here we report the structural characterisation of Cd3As2 films grown on SrTiO3 substrates by solid-p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20758-7
更新日期：2018-02-02 00:00:00
abstract：:We utilized size-tunable gold nanoparticles (Au NPs) to investigate the toxicogenomic responses of the model organism Caenorhabditis elegans. We demonstrated that the nematode C. elegans can uptake Au NPs coated with or without 11-mercaptoundecanoic acid (MUA), and Au NPs are detectable in worm intestines using X-ray ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33585-7
更新日期：2018-10-15 00:00:00
abstract：:The concept of multiscale architectured materials is established using composition and grain size gradients. Composition-gradient nanostructured materials are produced from coarse grained interstitial free steels via carburization and high-pressure torsion. Quantitative analyses of the dislocation density using X-ray ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26590
更新日期：2016-05-27 00:00:00
abstract：:Photodynamic therapy is attracting increasing attention, but how to increase its tumor-specificity remains a daunting challenge. Herein we report a theranostic probe (azo-PDT) that integrates pyropheophorbide α as a photosensitizer and a NIR fluorophore for tumor imaging. The two functionalities are linked with a hypo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68847-w
更新日期：2020-07-22 00:00:00
abstract：:Small oligomers formed early along human islet amyloid polypeptide (hIAPP) aggregation is responsible for the cell death in Type II diabetes. The epigallocatechin gallate (EGCG), a green tea extract, was found to inhibit hIAPP fibrillation. However, the inhibition mechanism and the conformational distribution of the s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33076
更新日期：2016-09-13 00:00:00
abstract：:The high theoretical capacity and low discharge potential of silicon have attracted much attention on Si-based anodes. Herein, hollow porous SiO2 nanocubes have been prepared via a two-step hard-template process and evaluated as electrode materials for lithium-ion batteries. The hollow porous SiO2 nanocubes exhibited ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01568
更新日期：2013-01-01 00:00:00
abstract：:Familial hypercholesterolemia (FH) is an inherited disease of lipoprotein metabolism caused by a defect in the LDL receptor (LDLR) leading to severe hypercholesterolemia, and associated with an increased risk of coronary heart disease and myocardial infarction. We have developed a gene therapy protocol for FH using AA...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43459-1
更新日期：2019-05-06 00:00:00
abstract：:Polyphenol oxidases (PPOs) comprise tyrosinases (TYRs) and catechol oxidases (COs), which catalyse the initial reactions in the biosynthesis of melanin. TYRs hydroxylate monophenolic (monophenolase activity) and oxidize diphenolic (diphenolase activity) substrates, whereas COs react only with diphenols. In order to el...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57671-x
更新日期：2020-02-03 00:00:00
abstract：:We aimed to evaluate the association of plasma biomarkers linked to inflammation (bacterial translocation, inflammatory response, and endothelial dysfunction), coagulopathy, and angiogenesis with the severity of liver cirrhosis (assessed by the Child-Pugh-Turcotte score, CTP) and Child-Pugh B cirrhosis (CTP 7-9) in pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67159-3
更新日期：2020-06-25 00:00:00
abstract：:The possibility of changing the intracranial vasculature computed tomography (CT) attenuation under the influence of variable factors is a long-held unestablished belief. The purpose of this study is to evaluate factors affecting dural sinus density in non-contrast computed tomography of the brain. Patients presented ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48545-y
更新日期：2019-08-19 00:00:00
abstract：:Phaeocystis globosa, one of the most typical red tide-forming species, is usually mixed in the food composition of rotifers. To explore how rotifers respond by adjusting life history strategy when feeding on different quality foods, we exposed the rotifer Brachionus plicatilis to cultures with 100% Chlorella, a mixtur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15863-y
更新日期：2017-11-13 00:00:00
abstract：:The lateral movement of soil carbon has a profound effect on the carbon budget of terrestrial ecosystems; however, it has never been quantified in China, which is one of the strongest soil erosion areas in the world. In this study, we estimated that the overall soil erosion in China varies from 11.27 to 18.17 Pg yr(-1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07247
更新日期：2014-11-28 00:00:00
abstract：:We study the S = 1/2 Kondo lattice model which is widely used to describe heavy fermion behavior. In conventional treatments of the model the Kondo interaction is decoupled in favour of a hybridization of conduction and localized f electrons. However, such an approximation breaks the local gauge symmetry and implicate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02691
更新日期：2013-01-01 00:00:00
