当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Matching Graft Quality to Recipient's Disease Severity Based on the Survival Benefit in Liver Transplantation.

Matching Graft Quality to Recipient's Disease Severity Based on the Survival Benefit in Liver Transplantation.

Abstract：

:Persistent shortage and heterogeneous quality of liver grafts encourages the optimization of donor-recipient matching in liver transplantation (LT). We explored whether or not there was a survival benefit (SB) of LT according to the quality of grafts assessed by the Donor Quality Index (DQI) and recipients' disease severity, using the Model for End-Stage Liver Disease (MELD) in 8387 French patients wait-listed between 2009 and 2014. SB associated with LT was estimated using the sequential stratification method in different categories of MELD and DQI. For each transplantation, a stratum was created that matched one transplanted patient with all eligible control candidates. Strata were thereafter combined, and a stratified Cox model, adjusted for covariates, was fitted in order to estimate hazard ratios that qualified the SB according to each MELD and DQI sub-group. A significant SB was observed for all MELD and DQI sub-groups, with the exception of high MELD patients transplanted with "high-risk" grafts. More specifically, in decompensated-cirrhosis patients, "high-risk" grafts did not appear to be detrimental in medium MELD patients. Interestingly, in hepatocellular-carcinoma (HCC) patients, a significant SB was found for all MELD-DQI combinations. For MELD exceptions no SB was found. In terms of SB, "low-risk" grafts appeared appropriate for most severe patients (MELD > 30). Conversely, low/medium MELD and HCC patients presented an SB while allocated "high-risk" grafts. Thus, SB based matching rules for LT candidates might improve the survival of the LT population as a whole.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Winter A,Féray C,Antoine C,Azoulay D,Daurès JP,Landais P

doi

10.1038/s41598-020-60973-9

subject

Has Abstract

pub_date

2020-03-05 00:00:00

pages

4111

issue

1

issn

2045-2322

pii

10.1038/s41598-020-60973-9

journal_volume

10

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Hierarchically structured Co₃O₄@Pt@MnO₂ nanowire arrays for high-performance supercapacitors.

    abstract：:Here we proposed a novel architectural design of a ternary MnO2-based electrode - a hierarchical Co3O4@Pt@MnO2 core-shell-shell structure, where the complemental features of the three key components (a well-defined Co3O4 nanowire array on the conductive Ti substrate, an ultrathin layer of small Pt nanoparticles, and a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02978

    authors： Xia H,Zhu D,Luo Z,Yu Y,Shi X,Yuan G,Xie J

    更新日期：2013-10-17 00:00:00

  • Antimicrobial peptide cWFW kills by combining lipid phase separation with autolysis.

    abstract：:The synthetic cyclic hexapeptide cWFW (cyclo(RRRWFW)) has a rapid bactericidal activity against both Gram-positive and Gram-negative bacteria. Its detailed mode of action has, however, remained elusive. In contrast to most antimicrobial peptides, cWFW neither permeabilizes the membrane nor translocates to the cytoplas...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44332

    authors： Scheinpflug K,Wenzel M,Krylova O,Bandow JE,Dathe M,Strahl H

    更新日期：2017-03-09 00:00:00

  • Cross-talk between Human Papillomavirus Oncoproteins and Hedgehog Signaling Synergistically Promotes Stemness in Cervical Cancer Cells.

    abstract：:Viral oncoproteins E6/E7 play key oncogenic role in human papillomavirus (HPV)-mediated cervical carcinogenesis in conjunction with aberrant activation of cellular signaling events. GLI-signaling has been implicated in metastasis and tumor recurrence of cervical cancer. However, the interaction of GLI-signaling with H...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34377

    authors： Vishnoi K,Mahata S,Tyagi A,Pandey A,Verma G,Jadli M,Singh T,Singh SM,Bharti AC

    更新日期：2016-09-28 00:00:00

  • Chocolate for breakfast prevents circadian desynchrony in experimental models of jet-lag and shift-work.

    abstract：:Night-workers, transcontinental travelers and individuals that regularly shift their sleep timing, suffer from circadian desynchrony and are at risk to develop metabolic disease, cancer, and mood disorders, among others. Experimental and clinical studies provide evidence that food intake restricted to the normal activ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-63227-w

    authors： Escobar C,Espitia-Bautista E,Guzmán-Ruiz MA,Guerrero-Vargas NN,Hernández-Navarrete MÁ,Ángeles-Castellanos M,Morales-Pérez B,Buijs RM

    更新日期：2020-04-10 00:00:00

  • Minimally invasive gas embolization using acoustic droplet vaporization in a rodent model of hepatocellular carcinoma.

    abstract：:Hepatocellular carcinoma is the third leading cause of cancer-related deaths worldwide. Many patients are not eligible for curative therapies, such as surgical resection of the tumor or a liver transplant. Transarterial embolization is one therapy clinically used in these cases; however, this requires a long procedure...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-47309-y

    authors： Harmon JS,Kabinejadian F,Seda R,Fabiilli ML,Kuruvilla S,Kuo CC,Greve JM,Fowlkes JB,Bull JL

    更新日期：2019-07-30 00:00:00

  • A Comprehensive Biophysical Analysis of the Effect of DNA Binding Drugs on Protamine-induced DNA Condensation.

    abstract：:DNA condensation is a ubiquitous phenomenon in biology, yet the physical basis for it has remained elusive. Here, we have explored the mechanism of DNA condensation through the protamine-DNA interaction, and by examining on it the influence of DNA binding drugs. We observed that the DNA condensation is accompanied by ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41975-8

    authors： Gupta S,Tiwari N,Munde M

    更新日期：2019-04-10 00:00:00

  • In vitro reconstruction of branched tubular structures from lung epithelial cells in high cell concentration gradient environment.

    abstract：:We have succeeded in developing hollow branching structure in vitro commonly observed in lung airway using primary lung airway epithelial cells. Cell concentration gradient is the key factor that determines production of the branching cellular structures, as optimization of this component removes the need for heteroty...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08054

    authors： Hagiwara M,Peng F,Ho CM

    更新日期：2015-01-27 00:00:00

  • The Soil Geochemistry in the Beardmore Glacier Region, Antarctica: Implications for Terrestrial Ecosystem History.

    abstract：:Although most models suggest continental Antarctica was covered by ice during the Last Glacial Maximum (LGM) it has been speculated that endemic species of soil invertebrates could have survived the Pleistocene at high elevation habitats protruding above the ice sheets. We analyzed a series of soil samples from differ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep26189

    authors： Lyons WB,Deuerling K,Welch KA,Welch SA,Michalski G,Walters WW,Nielsen U,Wall DH,Hogg I,Adams BJ

    更新日期：2016-05-18 00:00:00

  • Fabrication of WS2/GaN p-n Junction by Wafer-Scale WS2 Thin Film Transfer.

    abstract：:High quality wafer-scale free-standing WS2 grown by van der Waals rheotaxy (vdWR) using Ni as a texture promoting layer is reported. The microstructure of vdWR grown WS2 was significantly modified from mixture of crystallites with their c-axes both parallel to (type I) and perpendicular to (type II) the substrate to l...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37833

    authors： Yu Y,Fong PW,Wang S,Surya C

    更新日期：2016-11-29 00:00:00

  • Cysteine-silver-gold Nanocomposite as potential stable green corrosion inhibitor for mild steel under acidic condition.

    abstract：:Cysteine based silver-gold nanocomposite (Cys/Ag-Au NCz) was synthesized, this was followed by its characterization using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Ultraviolet-visible spectroscopy (UV-Vis), Scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDAX), ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-57181-5

    authors： Basik M,Mobin M,Shoeb M

    更新日期：2020-01-14 00:00:00

  • Combination of Simultaneous Artificial Sensory Percepts to Identify Prosthetic Hand Postures: A Case Study.

    abstract：:Multiple sources of sensory information are combined to develop hand posture percepts in the intact system, but the combination of multiple artificial somatosensory percepts by human prosthesis users has not been studied. Here, we report on a case study in which a person with transradial amputation identified prosthet...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62970-4

    authors： Segil JL,Cuberovic I,Graczyk EL,Weir RFF,Tyler D

    更新日期：2020-04-20 00:00:00

  • Cholestasis induced liver pathology results in dysfunctional immune responses after arenavirus infection.

    abstract：:Immune responses are critical for defense against pathogens. However, prolonged viral infection can result in defective T cell immunity, leading to chronic viral infection. We studied immune activation in response to arenavirus infection during cholestasis using bile duct ligation (BDL). We monitored T cell responses,...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30627-y

    authors： Lang E,Pozdeev VI,Shinde PV,Xu HC,Sundaram B,Zhuang Y,Poschmann G,Huang J,Stühler K,Pandyra AA,Keitel V,Häussinger D,Lang KS,Lang PA

    更新日期：2018-08-15 00:00:00

  • Nucleic acid-based polymers effective against hepatitis B Virus infection in patients don't harbor immunostimulatory properties in primary isolated liver cells.

    abstract：:Nucleic acid polymers (NAPs) block the release of subviral particles from hepatocytes, a mechanism consistent with their antiviral activity against hepatitis B virus (HBV) in patients. Analysis of immunostimulatory properties of NAPs were conducted with several NAP species: REP 2006, the prototypic degenerate NAP [dN]...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43838

    authors： Real CI,Werner M,Paul A,Gerken G,Schlaak JF,Vaillant A,Broering R

    更新日期：2017-03-08 00:00:00

  • Elucidating the putative link between prefrontal neurotransmission, functional connectivity, and affective symptoms in irritable bowel syndrome.

    abstract：:Altered neural mechanisms are well-acknowledged in irritable bowel syndrome (IBS), a disorder of brain-gut-communication highly comorbid with anxiety and depression. As a key hub in corticolimbic inhibition, medial prefrontal cortex (mPFC) may be involved in disturbed emotion regulation in IBS. However, aberrant mPFC ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-50024-3

    authors： Icenhour A,Tapper S,Bednarska O,Witt ST,Tisell A,Lundberg P,Elsenbruch S,Walter S

    更新日期：2019-09-19 00:00:00

  • Digital-Analog Quantum Simulation of Spin Models in Trapped Ions.

    abstract：:We propose a method to simulate spin models in trapped ions using a digital-analog approach, consisting in a suitable gate decomposition in terms of analog blocks and digital steps. In this way, we show that the quantum dynamics of an enhanced variety of spin models could be implemented with substantially less number ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep30534

    authors： Arrazola I,Pedernales JS,Lamata L,Solano E

    更新日期：2016-07-29 00:00:00

  • Age, primary symptoms, and genotype characteristics of norovirus outbreaks in Shanghai schools in 2017.

    abstract：:Sixty norovirus outbreaks that occurred in Pudong District, Shanghai in 2017 and affected 959 people were summarised. Of the outbreaks, 29 (48.3%), 27 (45.0%), and 4 (6.7%) occurred in kindergartens, primary schools, and middle schools, respectively. Although the total number of outbreaks peaked in March (13/60, 21.7%...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-33724-0

    authors： Wang Y,Hao L,Pan L,Xue C,Liu Q,Zhao X,Zhu W

    更新日期：2018-10-15 00:00:00

  • Chaotic time series prediction for prenatal exposure to polychlorinated biphenyls in umbilical cord blood using the least squares SEATR model.

    abstract：:Chaotic time series prediction based on nonlinear systems showed a superior performance in prediction field. We studied prenatal exposure to polychlorinated biphenyls (PCBs) by chaotic time series prediction using the least squares self-exciting threshold autoregressive (SEATR) model in umbilical cord blood in an elec...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25005

    authors： Xu X,Tang Q,Xia H,Zhang Y,Li W,Huo X

    更新日期：2016-04-27 00:00:00

  • Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity Disorder.

    abstract：:Working memory (WM) impairments in ADHD have been consistently reported along with deficits in attentional control. Yet, it is not clear which specific WM processes are affected in this condition. A deficient coupling between attention and WM has been reported. Nevertheless, most studies focus on the capacity to retai...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64678-x

    authors： Ortega R,López V,Carrasco X,Escobar MJ,García AM,Parra MA,Aboitiz F

    更新日期：2020-05-08 00:00:00

  • Efficient DNA-Polymer Coupling in Organic Solvents: A Survey of Amide Coupling, Thiol-Ene and Tetrazine-Norbornene Chemistries Applied to Conjugation of Poly(N-Isopropylacrylamide).

    abstract：:A range of chemistries were explored for the efficient covalent conjugation of DNA to poly(N-isopropylacrylamide) (poly(NIPAM)) in organic solvents. Amide coupling and thiol-ene Michael addition were found to be ineffective for the synthesis of the desired products. However, the inverse electron-demand Diels-Alder (DA...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep39192

    authors： Wilks TR,O'Reilly RK

    更新日期：2016-12-16 00:00:00

  • Spin-locking metasurface for surface plasmon routing.

    abstract：:Nanophotonic circuitry requires an ability to externally control and analyze optical signals tightly confined in subwavelength volumes. Various schemes of surface plasmon (SP) routing have been presented using active and passive metasurfaces. One of the most appealing approaches is the use of plasmonic spin-orbit inte...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45513-4

    authors： Revah M,Yaroshevsky A,Gorodetski Y

    更新日期：2019-06-20 00:00:00

  • Dysregulated Neurotransmission induces Trans-synaptic degeneration in reconstructed Neuronal Networks.

    abstract：:Increasing evidence suggests that pathological hallmarks of chronic degenerative syndromes progressively spread among interconnected brain areas in a disease-specific stereotyped pattern. Functional brain imaging from patients affected by various neurological syndromes such as traumatic brain injury and stroke indicat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29918-1

    authors： Deleglise B,Lassus B,Soubeyre V,Doulazmi M,Brugg B,Vanhoutte P,Peyrin JM

    更新日期：2018-08-02 00:00:00

  • Contrasting volcano spacing along SW Japan arc caused by difference in age of subducting lithosphere.

    abstract：:The SW Japan arc built by subduction of the Philippine Sea (PHS) plate exhibits uneven distribution of volcanoes: thirteen Quaternary composite volcanoes form in the western half of this arc, Kyushu Island, while only two in the eastern half, Chugoku district. Reconstruction of the PHS plate back to 14 Ma, together wi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72173-6

    authors： Tatsumi Y,Suenaga N,Yoshioka S,Kaneko K,Matsumoto T

    更新日期：2020-09-14 00:00:00

  • Long-term influence of biochar on native organic carbon mineralisation in a low-carbon clayey soil.

    abstract：:Biochar can influence native soil organic carbon (SOC) mineralisation through "priming effects". However, the long-term direction, persistence and extent of SOC priming by biochar remain uncertain. Using natural (13)C abundance and under controlled laboratory conditions, we show that biochar-stimulated SOC mineralisat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep03687

    authors： Singh BP,Cowie AL

    更新日期：2014-01-21 00:00:00

  • A snake venom group IIA PLA2 with immunomodulatory activity induces formation of lipid droplets containing 15-d-PGJ2 in macrophages.

    abstract：:Crotoxin B (CB) is a catalytically active group IIA sPLA2 from Crotalus durissus terrificus snake venom. In contrast to most GIIA sPLA2s, CB exhibits anti-inflammatory effects, including the ability to inhibit leukocyte functions. Lipid droplets (LDs) are lipid-rich organelles associated with inflammation and recogniz...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04498-8

    authors： Giannotti KC,Leiguez E,Carvalho AEZ,Nascimento NG,Matsubara MH,Fortes-Dias CL,Moreira V,Teixeira C

    更新日期：2017-06-22 00:00:00

  • Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alpha.

    abstract：:Platelet Derived Growth Factor Receptor (PDGFR) signaling is a central mitogenic pathway in development, as well as tissue repair and homeostasis. The rules governing the binding of PDGF ligand to the receptor to produce activation and downstream signaling have been well defined over the last several decades. In cultu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75774-3

    authors： Kadrmas JL,Beckerle MC,Yoshigi M

    更新日期：2020-11-09 00:00:00

  • Microfluidic Electroporation Coupling Pulses of Nanoseconds and Milliseconds to Facilitate Rapid Uptake and Enhanced Expression of DNA in Cell Therapy.

    abstract：:Standard electroporation with pulses in milliseconds has been used as an effective tool to deliver drugs or genetic probes into cells, while irreversible electroporation with nanosecond pulses is explored to alter intracellular activities for pulse-induced apoptosis. A combination treatment, long nanosecond pulses fol...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-63172-8

    authors： Chang AY,Liu X,Tian H,Hua L,Yang Z,Wang S

    更新日期：2020-04-08 00:00:00

  • Human rhinovirus internal ribosome entry site element enhances transgene expression in transfected CHO-S cells.

    abstract：:Chinese hamster ovary (CHO) cells are mainly used for recombinant protein production. However, the unstable transgene expression and lower transgene copy numbers are the major issues need to be resolved. Here, eleven internal ribosome entry site (IRES) elements from viral and cellular IRES were evaluated for foreign g...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-25049-9

    authors： Chai YR,Ge MM,Wei TT,Jia YL,Guo X,Wang TY

    更新日期：2018-04-27 00:00:00

  • Solvable delay model for epidemic spreading: the case of Covid-19 in Italy.

    abstract：:We study a simple realistic model for describing the diffusion of an infectious disease on a population of individuals. The dynamics is governed by a single functional delay differential equation, which, in the case of a large population, can be solved exactly, even in the presence of a time-dependent infection rate. ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72529-y

    authors： Dell'Anna L

    更新日期：2020-09-25 00:00:00

  • Correlation of T2* relaxation times of the retropatellar cartilage with tibial tuberosity-trochlea groove distance in professional soccer players.

    abstract：:The tibial tuberosity-trochlear groove (TT-TG) distance is a radiographic measurement that is used to quantify malalignment of the patellofemoral joint (PFJ) in cross-sectional imaging. There is an ongoing debate about the impact of the TT-TG-distance on lateral patellar instability and the initiating of cartilage deg...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72299-7

    authors： Maas KJ,Warncke M,Behzadi C,Welsch GH,Schoen G,Kaul MG,Adam G,Bannas P,Henes FO

    更新日期：2020-09-18 00:00:00

  • Skeletal muscle cutoff values for sarcopenia diagnosis using T10 to L5 measurements in a healthy US population.

    abstract：:Measurements of skeletal muscle cross-sectional area, index, and radiation attenuation utilizing clinical computed tomography (CT) scans are used in assessments of sarcopenia, the loss of skeletal muscle mass and function associated with aging. To classify individuals as sarcopenic, sex-specific cutoffs for 'low' valu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29825-5

    authors： Derstine BA,Holcombe SA,Ross BE,Wang NC,Su GL,Wang SC

    更新日期：2018-07-27 00:00:00