Abstract:
:Hepatocellular carcinoma is the third leading cause of cancer-related deaths worldwide. Many patients are not eligible for curative therapies, such as surgical resection of the tumor or a liver transplant. Transarterial embolization is one therapy clinically used in these cases; however, this requires a long procedure and careful placement of an intraarterial catheter. Gas embolization has been proposed as a fast, easily administered, more spatially selective, and less invasive alternative. Here, we demonstrate the feasibility and efficacy of using acoustic droplet vaporization to noninvasively generate gas emboli within vasculature. Intravital microscopy experiments were performed using the rat cremaster muscle to visually observe the formation of occlusions. Large gas emboli were produced within the vasculature in the rat cremaster, effectively occluding blood flow. Following these experiments, the therapeutic efficacy of gas embolization was investigated in an ectopic xenograft model of hepatocellular carcinoma in mice. The treatment group exhibited a significantly lower final tumor volume (ANOVA, p = 0.008) and growth rate than control groups - tumor growth was completely halted. Additionally, treated tumors exhibited significant necrosis as determined by histological analysis. To our knowledge, this study is the first to demonstrate the therapeutic efficacy of gas embolotherapy in a tumor model.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Harmon JS,Kabinejadian F,Seda R,Fabiilli ML,Kuruvilla S,Kuo CC,Greve JM,Fowlkes JB,Bull JLdoi
10.1038/s41598-019-47309-ysubject
Has Abstractpub_date
2019-07-30 00:00:00pages
11040issue
1issn
2045-2322pii
10.1038/s41598-019-47309-yjournal_volume
9pub_type
杂志文章abstract::Nuclear factor-kB (NF-kB) is a crucial transcription factor in the signal transduction cascade of the inflammatory signaling. Activation of NF-κB depends on the phosphorylation of IκBα by IκB kinase (IKKβ) followed by subsequent ubiquitination and degradation. This leads to the nuclear translocation of the p50- p65 su...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30763-5
更新日期:2018-08-20 00:00:00
abstract::Prostate cancer is a common malignancy in men worldwide and it is known that oxidative stress is a risk factor for cancer development. A common functional haptoglobin (Hp) polymorphism, originating from a duplication of a gene segment spanning over two exons, results in three distinct phenotypes with different anti-ox...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69333-z
更新日期:2020-08-04 00:00:00
abstract::Competing endogenous RNA (ceRNA) have received wide attention because they are a novel way to regulate genes through sharing microRNAs (miRNAs) that are crucial for complex processes in many diseases. However, no systematic analysis of ceRNA mechanism in cardiovascular disease (CVD) is known. To gain insights into the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10547-z
更新日期:2017-08-31 00:00:00
abstract::Natural killer (NK) cells are essential for immunosurveillance against transformed cells. Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel gated by ADP-ribose (ADPR). However, the role of TRPM2-mediated Ca(2+) signaling in the antitumor response of NK cells has not been explored. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09482
更新日期:2015-03-25 00:00:00
abstract::Quantifying multi-molecular complex assembly in specific cytoplasmic compartments is crucial to understand how cells use assembly/disassembly of these complexes to control function. Currently, biophysical methods like Fluorescence Resonance Energy Transfer and Fluorescence Correlation Spectroscopy provide quantitative...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28822
更新日期:2016-06-30 00:00:00
abstract::Interleukin-36 (IL-36) represents three cytokines, IL-36α, IL-36β and IL-36γ, which bind to the same receptor, IL-1RL2; however, their physiological function(s) remain poorly understood. Here, the role of IL-36 in immunity against HSV-1 was examined using the flank skin infection mouse model. Expression analyses revea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05363-4
更新日期:2017-07-19 00:00:00
abstract::Bisphenol A (BPA) is one of the commonest Endocrine Disruptor Compounds worldwide. It interferes with vertebrate reproduction, possibly by inducing deregulation of epigenetic mechanisms. To determine its effects on female reproductive physiology and investigate whether changes in the expression levels of genes related...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21982
更新日期:2016-02-25 00:00:00
abstract::We have successfully grown centimeter-sized layered [Formula: see text] single crystals under high oxygen pressures of 120-150 bar by the floating zone technique. This enabled us to perform neutron scattering experiments where we observe close to quarter-integer magnetic peaks below [Formula: see text] that are accomp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74884-2
更新日期:2020-10-22 00:00:00
abstract::We analyze the ferroelectric domain-wall induced negative capacitance (NC) effect in Metal-FE-Insulator-Metal (MFIM) and Metal-FE-Insulator-Semiconductor (MFIS) stacks through phase-field simulations by self-consistently solving time-dependent Ginzburg Landau equation, Poisson's equation and semiconductor charge equat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66313-1
更新日期:2020-06-23 00:00:00
abstract::Aquaculture has become imperative to cover the demands for dietary animal protein. Simultaneously, it has to overcome prejudices from excessive use of antibiotics and environmental impacts. Natural supplements are traditionally applied orally. In this study, we demonstrated another pathway: the gills. Humic substances...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80449-0
更新日期:2021-01-08 00:00:00
abstract::E. coli is the main causative agent of mastitis in dairy cows, but the mechanism of molecular regulation underlying the occurrence and development of mastitis has not yet been fully elucidated. In this study, an E. coli-induced mastitis model was created and RNASeq technology was used to measure the miRNA expression p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30518-2
更新日期:2018-08-23 00:00:00
abstract::The microbiota colonized on human body is renowned as "a forgotten organ" due to its big impacts on human health and disease. Recently, microbiome studies have identified a large number of microbes differentially regulated in a variety of conditions, such as disease and diet. However, methods for discovering biologica...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40200
更新日期:2017-01-10 00:00:00
abstract::Bemisia tabaci is a cryptic whitefly-species complex that includes some of the most damaging pests and plant-virus vectors of a diverse range of food and fibre crops worldwide. We combine experimental evidence of: (i) differences in reproductive compatibility, (ii) hybrid verification using a specific nuclear DNA mark...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29305-w
更新日期:2018-07-18 00:00:00
abstract::Influenza virus evolves constantly in an unpredictable fashion, making it necessary to vaccinate people annually for effective prevention and control of influenza. In general, however, during the first wave of an influenza outbreak caused by a newly emerging virus strain, influenza morbidity and mortality have been ob...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28729
更新日期:2016-06-29 00:00:00
abstract::Amplicon based metabarcoding promises rapid and cost-efficient analyses of species composition. However, it is disputed whether abundance estimates can be derived from metabarcoding due to taxon specific PCR amplification biases. PCR-free approaches have been suggested to mitigate this problem, but come with considera...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17333-x
更新日期:2017-12-15 00:00:00
abstract::Conventional effluent trading systems (ETSs) between point sources (PSs) and nonpoint sources (NPSs) are often unreliable because of the uncertain characteristics of NPSs. In this study, a new framework was established for PS-NPS ETSs, and a comprehensive analysis was conducted by quantifying the impacts of the uncert...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29398
更新日期:2016-07-11 00:00:00
abstract::Highly porous tri-metallic AgxAuyPdz networks with a sub-monolayer bimetallic Au-Pd nanoparticle coating were synthesized via a designed galvanic replacement reaction of Ag nanosponges suspended in mixed solutions of HAuCl4 and K2PdCl4. The resulting networks' ligaments have a rough surface with bimetallic nanoparticl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37092
更新日期:2016-11-15 00:00:00
abstract::Exudative age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) share similar abnormal choroidal vasculature, but responses to treatments are different. In this study, we sequenced the whole HTRA1 gene and its promoter by direct sequencing in a Hong Kong Chinese PCV cohort. We identified r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28639
更新日期:2016-06-24 00:00:00
abstract::The Xanthomonadaceae family consists of species of non-pathogenic and pathogenic γ-proteobacteria that infect different hosts, including humans and plants. In this study, we performed a comparative analysis using 69 fully sequenced genomes belonging to this family, with a focus on identifying proteins enriched in phyt...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16325-1
更新日期:2017-11-23 00:00:00
abstract::Formation-free multi-level resistive switching characteristics by using 10 nm-thick polycrystalline GeOx film in a simple W/GeOx/W structure and understanding of switching mechanism through redox reaction in H2O2/sarcosine sensing (or changing Ge°/Ge4+ oxidation states under external bias) have been reported for the f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11657-4
更新日期:2017-09-11 00:00:00
abstract::Iron oxide nanoparticles have attracted a great deal of research interest and have been widely used in bioscience and clinical research including as contrast agents for magnetic resonance imaging, hyperthermia and magnetic field assisted radionuclide therapy. It is therefore important to develop methods, which can pro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25852-4
更新日期:2018-05-10 00:00:00
abstract::The focus of this study is to evaluate the efficacy of Machine Learning (ML) algorithms in the long-lead prediction of El Niño (La Niña) Modoki (ENSO Modoki) index (EMI). We evaluated two widely used non-linear ML algorithms namely Support Vector Regression (SVR) and Random Forest (RF) to forecast the EMI at various l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57183-3
更新日期:2020-01-15 00:00:00
abstract::In typical numerical simulations, the space-charge force is calculated by slicing a beam into many longitudinal segments and by solving the two-dimensional Poisson equation in each segment. This method neglects longitudinal leakage of the space-charge force to nearby segments owing to its longitudinal spread over 1/γ....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30960-2
更新日期:2018-08-24 00:00:00
abstract::The role of soil organic carbon in global carbon cycles is receiving increasing attention both as a potentially large and uncertain source of CO2 emissions in response to predicted global temperature rises, and as a natural sink for carbon able to reduce atmospheric CO2. There is general agreement that the technical p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15794-8
更新日期:2017-11-14 00:00:00
abstract::The impacts of ecosystem engineers may be expected to vary along environmental gradients. Due to some resources being more limited in arid than in mesic environments, disturbances created by burrowing mammals are expected to have a greater ameliorating effect in arid environments, with larger differences in microhabit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55917-x
更新日期:2019-12-18 00:00:00
abstract::A correction to this article has been published and is linked from the HTML version of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-24796-z
更新日期:2018-04-19 00:00:00
abstract::Transient hepatic steatosis upon liver resection supposes functional relationships between lipid metabolism and liver regeneration. Repin1 has been suggested as candidate gene for obesity and dyslipidemia by regulating key genes of lipid metabolism and lipid storage. Herein, we characterized the regenerative potential...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35325-3
更新日期:2018-11-15 00:00:00
abstract::GDP-mannose pyrophosphorylase (GMP) catalyzed the formation of GDP-mannose, which serves as a donor for the biosynthesis of mannose-containing polysaccharides. In this study, three GMP genes from Dendrobium officinale (i.e., DoGMPs) were cloned and analyzed. The putative 1000 bp upstream regulatory region of these DoG...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41010
更新日期:2017-02-08 00:00:00
abstract::We developed a novel, erythropoietin-derived, non-erythropoiesis, cyclic helix B peptide (CHBP) that displays potent renoprotection against acute kidney injury (AKI). To determine the mechanism of CHBP-mediated protection, we investigated the proteomic profile of mice treated with CHBP in a kidney ischemia-reperfusion...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18045
更新日期:2015-12-10 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-50828-3
更新日期:2019-10-08 00:00:00