Exploring and challenging the network of angiogenesis.

abstract：:Xenotransplantation of human cancers into immunodeficient mice is a very useful approach for studying human tumor biology. However, the occasional occurrence of lymphomagenesis in some mice can spoil the model and must be investigated in detail. We found that a high percentage (32.5%, 26/80) of cancer patient-derived ...

journal_title：Scientific reports

authors： Zhang L,Liu Y,Wang X,Tang Z,Li S,Hu Y,Zong X,Wu X,Bu Z,Wu A,Li Z,Li Z,Huang X,Jia L,Kang Q,Liu Y,Sutton D,Wang L,Luo L,Ji J

更新日期：2015-03-30 00:00:00

abstract：:Advances in lab-on-a-chip (LOC) devices have led to significant improvements in the on-chip manipulation, separation, sorting, and isolation of particles and cells. Among various LOC-based approaches such as inertia-based methods, acoustophoresis, and magnetophoresis, the planar-slanted-electrode dielectrophoresis (DE...

journal_title：Scientific reports

authors： Dalili A,Taatizadeh E,Tahmooressi H,Tasnim N,Rellstab-Sánchez PI,Shaunessy M,Najjaran H,Hoorfar M

更新日期：2020-07-16 00:00:00

abstract：:Silicon nanocrystals offer huge advantages compared to other semi-conductor quantum dots as they are made from an abundant, non-toxic material and are compatible with silicon devices. Besides, among a wealth of extraordinary properties ranging from catalysis to nanomedicine, metal nanoparticles are known to increase t...

journal_title：Scientific reports

authors： Goffard J,Gérard D,Miska P,Baudrion AL,Deturche R,Plain J

更新日期：2013-01-01 00:00:00

abstract：:Klf5, a member of the Krüppel-like transcription factor family, has essential roles during embryonic development, cell proliferation, differentiation, migration and apoptosis. This study was to define molecular mechanism of Klf5 during the odontoblastic differentiation. The expression of Klf5, odontoblast-differentiat...

journal_title：Scientific reports

authors： Chen Z,Zhang Q,Wang H,Li W,Wang F,Wan C,Deng S,Chen H,Yin Y,Li X,Xie Z,Chen S

更新日期：2017-04-25 00:00:00

abstract：:The secreted Ly-6/uPAR Related Protein-1 (SLURP1) is an immunomodulatory protein that promotes corneal immune- and angiogenic-privilege. Here, we have examined the influence of SLURP1 on neutrophil-vascular endothelial cell interactions using human umbilical vein endothelial cells (HUVEC) and differentiated neutrophil...

journal_title：Scientific reports

authors： Swamynathan S,Tiwari A,Loughner CL,Gnalian J,Alexander N,Jhanji V,Swamynathan SK

更新日期：2019-04-11 00:00:00

abstract：:Recently, magnetic nanoparticles (MNPs), which can be manipulated in the magnetic field, have received much attention in tumor therapy. Extremely low frequency magnetic field (ELMF) system can initiate MNPs vibrating and the movement of MNPs inside of cells can be controlled by adjusting the frequency and intensity of...

journal_title：Scientific reports

authors： Li W,Liu Y,Qian Z,Yang Y

更新日期：2017-04-11 00:00:00

abstract：:β-lactam antibiotics act as suicide substrates of transpeptidases responsible for the last cross-linking step of peptidoglycan synthesis in the bacterial cell wall. Nucleophilic attack of the β-lactam carbonyl by the catalytic residue (Ser or Cys) of transpeptidases results in the opening of the β-lactam ring and in t...

journal_title：Scientific reports

authors： Edoo Z,Arthur M,Hugonnet JE

更新日期：2017-08-22 00:00:00

abstract：:Next generation sequencing is becoming the method of choice for functional genomic studies that use pooled shRNA or CRISPR libraries. A key challenge in sequencing these mixed-oligo libraries is that they are highly susceptible to hairpin and/or heteroduplex formation. This results in polyclonal, low quality, and inco...

journal_title：Scientific reports

authors： Islam MF,Watanabe A,Wong L,Lazarou C,Vizeacoumar FS,Abuhussein O,Hill W,Uppalapati M,Geyer CR,Vizeacoumar FJ

更新日期：2017-04-21 00:00:00

abstract：:The human β-defensin-1 (HBD1) is an antimicrobial peptide constitutively expressed by epithelial cells at mucosal surfaces. In addition to its microbicidal properties, the loss of HBD1 expression in several cancers suggests that it may also have an anti-tumor activity. Here, we investigated the link between HBD1 expre...

journal_title：Scientific reports

authors： Bonamy C,Sechet E,Amiot A,Alam A,Mourez M,Fraisse L,Sansonetti PJ,Sperandio B

更新日期：2018-12-21 00:00:00

abstract：:The systematics of Oriental freshwater mussels (Bivalvia: Unionidae) is poorly known. Here, we present an integrative revision of the genus Trapezoideus Simpson, 1900 to further understanding of freshwater mussel diversity in the region. We demonstrate that Trapezoideus as currently circumscribed is non-monophyletic, ...

journal_title：Scientific reports

authors： Konopleva ES,Pfeiffer JM,Vikhrev IV,Kondakov AV,Gofarov MY,Aksenova OV,Lunn Z,Chan N,Bolotov IN

更新日期：2019-03-11 00:00:00

abstract：:Antimonite [Sb(III)]-oxidizing bacteria can transform the toxic Sb(III) into the less toxic antimonate [Sb(V)]. Recently, the cytoplasmic Sb(III)-oxidase AnoA and the periplasmic arsenite [As(III)] oxidase AioAB were shown to responsible for bacterial Sb(III) oxidation, however, disruption of each gene only partially ...

journal_title：Scientific reports

authors： Li J,Yang B,Shi M,Yuan K,Guo W,Wang Q,Wang G

更新日期：2017-03-02 00:00:00

abstract：:Connectivity is fundamentally important for shaping the resilience of complex human and natural networks when systems are disturbed. Ecosystem resilience is, in part, shaped by the spatial arrangement of habitats, the permeability and fluxes between them, the stabilising functions performed by organisms, their dispers...

journal_title：Scientific reports

authors： Pearson RM,Schlacher TA,Jinks KI,Olds AD,Brown CJ,Connolly RM

更新日期：2021-01-13 00:00:00

abstract：:The conformation of the German shepherd dog (GSD) varies considerably within the breed. These differences may result in large variation in the movement and limb loading and undesirable consequences to their musculoskeletal health. This study aimed to investigate the relationship between conformation and biomechanical ...

journal_title：Scientific reports

authors： Humphries A,Shaheen AF,Gómez Álvarez CB

更新日期：2020-10-15 00:00:00

abstract：:In this study, membrane filtration tests showed that the membrane rejection degree of difloxacin hydrochloride (DFHC) increased significantly in the presence of Suwannee River DOM or Aldrich humic acid (2-10 mg-C/L). Titration experiments showed that the excitation and emission of Peak R belonging to DFHC exhibited bl...

journal_title：Scientific reports

authors： Liang S,Lu L,Meng F

更新日期：2017-07-14 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Passari AK,Mishra VK,Singh G,Singh P,Kumar B,Gupta VK,Sarma RK,Saikia R,Donovan AO,Singh BP

更新日期：2018-03-12 00:00:00

abstract：:Epilepsy is a chronic neurological disease with a variable therapeutic response. To design effective treatment strategies for epilepsy, it is important to understand treatment responses and predictive factors. However, limited data are available in Africa, including Ethiopia. The aim of this study was therefore to ass...

journal_title：Scientific reports

authors： Gidey K,Chelkeba L,Gemechu TD,Daba FB

更新日期：2019-11-07 00:00:00

abstract：:Over 80% of perinatal mortality in Japan is due to stillbirths after 22 weeks of gestation, with one in 300 families experiencing fetal loss every year. This study aimed to assess causes and risk factors for singleton stillbirth in Japan. A retrospective cross-sectional study was conducted using the Japan Society of O...

journal_title：Scientific reports

authors： Haruyama R,Gilmour S,Ota E,Abe SK,Rahman MM,Nomura S,Miyasaka N,Shibuya K

更新日期：2018-03-07 00:00:00

abstract：:In the study, 15 K. pneumoniae strains were isolated from the mink experiencing respiratory distress in mideastern Shandong province, China, and the prevalence of K. pneumoniae in the sampled mink was 11.9% (15/126). Fourteen (93.33%) of the 15 K. pneumoniae isolates were identified as serotype K2 and hypermucoviscosi...

journal_title：Scientific reports

authors： Jian-Li W,Yuan-Yuan S,Shou-Yu G,Fei-Fei D,Jia-Yu Y,Xue-Hua W,Yong-Feng Z,Shi-Jin J,Zhi-Jing X

更新日期：2017-12-11 00:00:00

abstract：:Spinocerebellar ataxia type-3 (SCA3) is a neurodegenerative disorder caused by a polyglutamine repeat expansion in the ataxin-3 protein. Cleavage of mutant ataxin-3 by proteolytic enzymes yields ataxin-3 fragments containing the polyglutamine stretch. These shorter ataxin-3 fragments are thought to be involved in SCA3...

journal_title：Scientific reports

authors： Toonen LJ,Schmidt I,Luijsterburg MS,van Attikum H,van Roon-Mom WM

更新日期：2016-10-12 00:00:00

abstract：:The hip fracture is one major clinical challenge associated with osteoporosis, resulting in heavy socioeconomic burdens and high mortality. Systemic therapies of anti-osteoporosis drugs are expensive, time-consuming and also evoke substantial side effects, which fails to provide early protection from fractures. Accumu...

journal_title：Scientific reports

authors： Jing D,Hao X,Xu F,Liu J,Xu F,Luo E,Meng G

更新日期：2016-06-22 00:00:00

abstract：:It was previously demonstrated that microRNA-199a (miR-199a) was down-regulated in testicular germ cell tumor (TGCT) partially caused by hypermethylation of its promoter. miR-199a is encoded by two loci in the human genome, miR-199a-1 on chromosome (Chr) 19 and miR-199a-2 on Chr 1. Both loci encode the same miR-199a. ...

journal_title：Scientific reports

authors： Chen BF,Suen YK,Gu S,Li L,Chan WY

更新日期：2014-09-18 00:00:00

abstract：:Deriving cell populations from human embryonic stem cells (hESCs) for cell-based therapy is considered a promising strategy to achieve functional cells, yet its translation to clinical practice depends on achieving fully defined differentiated cells. In this work, we generated a miRNA-responsive lethal mRNA construct ...

journal_title：Scientific reports

authors： Elovic E,Etzion S,Cohen S

更新日期：2019-10-10 00:00:00

abstract：:The demand for high efficiency intermediate band (IB) solar cells is driving efforts in producing high quality IB photovoltaic materials. Here, we demonstrate ZnTe:O highly mismatched alloys synthesized by high dose ion implantation and pulsed laser melting exhibiting optically active IB states and efficient sub-gap p...

journal_title：Scientific reports

authors： Li J,Ye J,Ren F,Tang D,Yang Y,Tang K,Gu S,Zhang R,Zheng Y

更新日期：2017-03-10 00:00:00

abstract：:Long-branch attraction (LBA) is a major obstacle in phylogenetic reconstruction. The phylogenetic relationships among Juniperus (J), Cupressus (C) and the Hesperocyparis-Callitropsis-Xanthocyparis (HCX) subclades of Cupressoideae are controversial. Our initial analyses of plastid protein-coding gene matrix revealed bo...

journal_title：Scientific reports

authors： Qu XJ,Jin JJ,Chaw SM,Li DZ,Yi TS

更新日期：2017-01-25 00:00:00

abstract：:The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilize...

journal_title：Scientific reports

authors： Stasyuk E,Sкuridin V,Rogov A,Zelchan R,Sadkin V,Varlamova N,Nestеrov E

更新日期：2020-03-20 00:00:00

abstract：:Methanol (MOH) and monomethylamine (MMA) are two typical one-carbon (C1) compounds found in natural environments. They play an important role in marine and atmospheric chemistry, cloud formation, and global climate. The main biological sink of MOH and MMA is rapid consumption by marine microbes. Here, field-based time...

journal_title：Scientific reports

authors： Deng W,Peng L,Jiao N,Zhang Y

更新日期：2018-10-18 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) are expected to be both a revolutionary cell source for regenerative medicine and a powerful tool to investigate the molecular mechanisms underlying human cell development in vitro. In the present study, we tried to elucidate the steroidogenic differentiation processes usi...

journal_title：Scientific reports

authors： Matsuo K,Sone M,Honda-Kohmo K,Toyohara T,Sonoyama T,Taura D,Kojima K,Fukuda Y,Ohno Y,Inoue M,Ohta A,Osafune K,Nakao K,Inagaki N

更新日期：2017-11-09 00:00:00

abstract：:Drug repositioning strategies have improved substantially in recent years. At present, two advances are poised to facilitate new strategies. First, the LINCS project can provide rich transcriptome data that reflect the responses of cells upon exposure to various drugs. Second, machine learning algorithms have been app...

journal_title：Scientific reports

authors： Xie L,He S,Wen Y,Bo X,Zhang Z

更新日期：2017-08-02 00:00:00

abstract：:The successful determination of reliable protein interaction networks (PINs) in several species in the post-genomic era has hitherto facilitated the quest to understanding systems and structural properties of such networks. It is envisaged that a clearer understanding of their intrinsic topological properties would el...

journal_title：Scientific reports

authors： Fadhal E,Gamieldien J,Mwambene EC

更新日期：2015-02-27 00:00:00

abstract：:The present study applied the PacBio single molecule, real-time sequencing technology (SMRT) in evaluating the quality of silage production. Specifically, we produced four types of Medicago sativa silages by using four different lactic acid bacteria-based additives (AD-I, AD-II, AD-III and AD-IV). We monitored the cha...

journal_title：Scientific reports

authors： Bao W,Mi Z,Xu H,Zheng Y,Kwok LY,Zhang H,Zhang W

更新日期：2016-06-24 00:00:00