The secreted Ly6/uPAR-related protein-1 suppresses neutrophil binding, chemotaxis, and transmigration through human umbilical vein endothelial cells.

Abstract:

:The secreted Ly-6/uPAR Related Protein-1 (SLURP1) is an immunomodulatory protein that promotes corneal immune- and angiogenic-privilege. Here, we have examined the influence of SLURP1 on neutrophil-vascular endothelial cell interactions using human umbilical vein endothelial cells (HUVEC) and differentiated neutrophil-like HL-60 (dHL-60) cells, or primary human neutrophils. SLURP1 blocked the tumor necrosis factor-alpha (TNF-α)-activated dHL-60 cells (i) binding to TNF-α-activated HUVEC with a concurrent reduction in endothelial cell adhesion molecule E-selectin, (ii) transmigration through TNF-α-activated confluent HUVEC monolayer by stabilizing VE-cadherin and β-catenin on endothelial cell cytoplasmic membranes, (iii) chemotaxis towards chemoattractant formyl Met-Leu-Phe (fMLP) coupled with their decreased polarization, and (iv) TNF-α-stimulated matrix metalloproteinase-9 (MMP9) expression and activity. SLURP1 also suppressed the primary human neutrophil chemotaxis, and interaction with HUVEC. Furthermore, SLURP1 suppressed fMLP-induced phosphorylation of protein kinase-B (AKT) in dHL-60 cells. Collectively, these results provide evidence that SLURP1 suppresses neutrophil (i) docking on HUVEC cells by decreasing endothelial cell adhesion molecule E-Selectin production, (ii) transmigration through HUVEC monolayer by stabilizing endothelial cell membrane localization of VE-cadherin and β-catenin complex and promoting their barrier function, and (iii) chemotaxis by modulating their polarization and TNF-α-stimulated MMP9 production.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Swamynathan S,Tiwari A,Loughner CL,Gnalian J,Alexander N,Jhanji V,Swamynathan SK

doi

10.1038/s41598-019-42437-x

subject

Has Abstract

pub_date

2019-04-11 00:00:00

pages

5898

issue

1

issn

2045-2322

pii

10.1038/s41598-019-42437-x

journal_volume

9

pub_type

杂志文章
  • Long-term exercise training improves memory in middle-aged men and modulates peripheral levels of BDNF and Cathepsin B.

    abstract::Aging is accompanied by a decline in memory and other brain functions. Physical exercise may mitigate this decline through the modulation of factors participating in the crosstalk between skeletal muscle and the brain, such as neurotrophins and oxidative stress parameters. We aimed to determine whether long term exerc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40040-8

    authors: De la Rosa A,Solana E,Corpas R,Bartrés-Faz D,Pallàs M,Vina J,Sanfeliu C,Gomez-Cabrera MC

    更新日期:2019-03-04 00:00:00

  • Experimental study on mandibular length and facial symmetry of low estrogen level and anterior disc displacement of temporomandibular joint.

    abstract::This study was aimed at elucidating the changes of mandible symmetry in a rabbit model with low estrogen levels induced by ovariectomy (OVX) combined with temporomandibular joint (TMJ) anterior disc displacement without reduction (ADDWoR). 32 growing rabbits were randomly allocated into 4 groups; OVX group, ADDWoR gro...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34023-4

    authors: Jiao Z,Wang X,Zhang X,Yang C

    更新日期:2018-10-23 00:00:00

  • Mutational effects of human dopamine transporter at tyrosine88, lysine92, and histidine547 on basal and HIV-1 Tat-inhibited dopamine transport.

    abstract::Dysregulation of dopaminergic system induced by HIV-1 Tat protein-mediated direct inhibition of the dopamine transporter (DAT) has been implicated as a mediating factor of HIV-1 associated neurocognitive disorders. We have reported that single point mutations on human DAT (hDAT) at tyrosine88 (Y88F), lysine92 (K92M), ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39872-1

    authors: Sun WL,Quizon PM,Yuan Y,Strauss MJ,McCain R Jr,Zhan CG,Zhu J

    更新日期:2019-03-07 00:00:00

  • The impact of Fe atom on the spin-filter and spin thermoelectric properties of Au-Fe@C20-Au monomer and dimer systems.

    abstract::Based on density functional theory and non-equilibrium Green's function formalism, we explore the effect of Fe atom in Au-Fe@C20-Au monomer and dimer systems in comparison with the C20 fullerene molecular junctions. We calculate the spin-dependent transmission coefficient, spin polarization and also their spin thermoe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78111-w

    authors: Khalatbari H,Vishkayi SI,Soleimani HR

    更新日期:2020-12-03 00:00:00

  • A Data Driven Model for Predicting RNA-Protein Interactions based on Gradient Boosting Machine.

    abstract::RNA protein interactions (RPI) play a pivotal role in the regulation of various biological processes. Experimental validation of RPI has been time-consuming, paving the way for computational prediction methods. The major limiting factor of these methods has been the accuracy and confidence of the predictions, and our ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27814-2

    authors: Jain DS,Gupte SR,Aduri R

    更新日期:2018-06-22 00:00:00

  • Camouflage and Clutch Survival in Plovers and Terns.

    abstract::Animals achieve camouflage through a variety of mechanisms, of which background matching and disruptive coloration are likely the most common. Although many studies have investigated camouflage mechanisms using artificial stimuli and in lab experiments, less work has addressed camouflage in the wild. Here we examine e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32059

    authors: Stoddard MC,Kupán K,Eyster HN,Rojas-Abreu W,Cruz-López M,Serrano-Meneses MA,Küpper C

    更新日期:2016-09-12 00:00:00

  • Climate drivers of hospitalizations for mycoses in Brazil.

    abstract::Climate can modulate human health at large spatial scales, but the influence of global, regional, and local environments remains poorly understood, especially for neglected diseases, such as mycoses. In this work, we present the correlation between climatic variables and hospitalizations for mycoses in Brazilian state...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43353-w

    authors: Silva FB,Santos JRN,da Silva LC,Gomes WC,Villis PCM,Gomes EDS,Pinheiro EAD,Azevedo CMPES,Dias RDS,Monteiro CA,Santos JRA

    更新日期:2019-05-06 00:00:00

  • A new mass spectrometry-based method for the quantification of histones in plasma from septic shock patients.

    abstract::The aim of this study was to develop a novel method to detect circulating histones H3 and H2B in plasma based on multiple reaction monitoring targeted mass spectrometry and a multiple reaction monitoring approach (MRM-MS) for its clinical application in critical bacteriaemic septic shock patients. Plasma samples from ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10830-z

    authors: García-Giménez JL,Romá-Mateo C,Carbonell N,Palacios L,Peiró-Chova L,García-López E,García-Simón M,Lahuerta R,Gimenez-Garzó C,Berenguer-Pascual E,Mora MI,Valero ML,Alpízar A,Corrales FJ,Blanquer J,Pallardó FV

    更新日期:2017-09-06 00:00:00

  • Whole genome sequencing of a banana wild relative Musa itinerans provides insights into lineage-specific diversification of the Musa genus.

    abstract::Crop wild relatives are valuable resources for future genetic improvement. Here, we report the de novo genome assembly of Musa itinerans, a disease-resistant wild banana relative in subtropical China. The assembled genome size was 462.1 Mb, covering 75.2% of the genome (615.2Mb) and containing 32, 456 predicted protei...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep31586

    authors: Wu W,Yang YL,He WM,Rouard M,Li WM,Xu M,Roux N,Ge XJ

    更新日期:2016-08-17 00:00:00

  • Dense Quantum Measurement Theory.

    abstract::Quantum measurement is a fundamental cornerstone of experimental quantum computations. The main issues in current quantum measurement strategies are the high number of measurement rounds to determine a global optimal measurement output and the low success probability of finding a global optimal measurement output. Eac...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43250-2

    authors: Gyongyosi L,Imre S

    更新日期:2019-05-01 00:00:00

  • Evaluating and forecasting movement patterns of magnetically driven microbeads in complex geometries.

    abstract::The manipulation of superparamagnetic microbeads for lab-on-a-chip applications relies on the steering of microbeads across an altering stray field landscape on top of soft magnetic parent structures. Using ab initio principles, we show three-dimensional simulations forecasting the controlled movement of microbeads. S...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65380-8

    authors: Klingbeil F,Block F,Sajjad U,Holländer RB,Deshpande S,McCord J

    更新日期:2020-05-29 00:00:00

  • The Preparation and Properties of Porous Sepiolite Ceramics.

    abstract::In this paper, a new type of porous ceramics was prepared using the raw sepiolite mineral. The porous ceramics was shaped by the dry pressing method and sintered in the range of 700 ~ 1200 °C. The temperature-microstructure evolution and the properties of porous sepiolite ceramics were investigated by thermo gravimetr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43918-9

    authors: Tian L,Wang L,Wang K,Zhang Y,Liang J

    更新日期:2019-05-14 00:00:00

  • Publisher Correction: Emergence of Different Recombinant Porcine Reproductive and Respiratory Syndrome Viruses, China.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-018-25625-z

    authors: Liu Y,Li J,Yang J,Zeng H,Guo L,Ren S,Sun W,Chen Z,Cong X,Shi J,Chen L,Du Y,Li J,Wang J,Wu J,Yu J

    更新日期:2018-05-23 00:00:00

  • Enhanced Bandwidth of High Directive Emission Fabry-Perot Resonator Antenna with Tapered Near-Zero Effective Index Using Metasurface.

    abstract::In this paper, a novel explanation on high directive emission of Fabry-Perot resonator antenna with subwavelength metasurface is proposed. Based on image theory and effective constitutive parameter retrieval, the whole Fabry-Perot resonant cavity structure composed of a single-layer metasurface with square ring elemen...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-11141-z

    authors: Liu ZG,Lu WB,Yang W

    更新日期:2017-09-13 00:00:00

  • Intriguing Electrostatic Potential of CO: Negative Bond-ends and Positive Bond-cylindrical-surface.

    abstract::The strong electronegativity of O dictates that the ground state of singlet CO has positively charged C and negatively charged O, in agreement with ab initio charge analysis, but in disagreement with the dipole direction. Though this unusual phenomenon has been fairly studied, the study of electrostatic potential (EP)...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16307

    authors: Kim H,Doan VD,Cho WJ,Valero R,Aliakbar Tehrani Z,Madridejos JM,Kim KS

    更新日期:2015-11-06 00:00:00

  • Acoustic Waveguide Eigenmode Solver Based on a Staggered-Grid Finite-Difference Method.

    abstract::A numerical method of solving for the elastic wave eigenmodes in acoustic waveguides of arbitrary cross-section is presented. Operating under the assumptions of linear, isotropic materials, it utilizes a finite-difference method on a staggered grid to solve for the acoustic eigenmodes (field and frequency) of the vect...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17511-x

    authors: Dostart N,Liu Y,Popović MA

    更新日期:2017-12-13 00:00:00

  • NMDA receptors in mouse anterior piriform cortex initialize early odor preference learning and L-type calcium channels engage for long-term memory.

    abstract::The interactions of L-type calcium channels (LTCCs) and NMDA receptors (NMDARs) in memories are poorly understood. Here we investigated the specific roles of anterior piriform cortex (aPC) LTCCs and NMDARs in early odor preference memory in mice. Using calcium imaging in aPC slices, LTCC activation was shown to be dep...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35256

    authors: Mukherjee B,Yuan Q

    更新日期:2016-10-14 00:00:00

  • Exploring Leishmania secretory proteins to design B and T cell multi-epitope subunit vaccine using immunoinformatics approach.

    abstract::Visceral leishmaniasis (VL) is a fatal form of leishmaniasis which affects 70 countries, worldwide. Increasing drug resistance, HIV co-infection, and poor health system require operative vaccination strategy to control the VL transmission dynamics. Therefore, a holistic approach is needed to generate T and B memory ce...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08842-w

    authors: Khatoon N,Pandey RK,Prajapati VK

    更新日期:2017-08-15 00:00:00

  • Weigh Biomaterials by Quantifying Species-specific DNA with Real-time PCR.

    abstract::What's on the label is not what's in the bottle, from food products to herbal medicinal products (HMPs), economically-motivated biomaterials adulteration is a long-term problem affecting the food and drug industry. Accurate identification of the biomaterial ingredients in processed commodities is highly desirable. In ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-05083-9

    authors: Chen R,Wang J,Yuan Y,Deng Y,Lai X,Du F,Dong J,Huang X,Cui X,Tang Z

    更新日期:2017-07-06 00:00:00

  • Energetic mitochondrial failing in vitiligo and possible rescue by cardiolipin.

    abstract::Vitiligo is characterized by death or functional defects of epidermal melanocytes through still controversial pathogenic process. Previously, we showed that mitochondria-driven pre-senescent phenotype diminishes the capability of vitiligo melanocytes to cope with stressful stimuli. In the current study, we investigate...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13961-5

    authors: Dell'Anna ML,Ottaviani M,Kovacs D,Mirabilii S,Brown DA,Cota C,Migliano E,Bastonini E,Bellei B,Cardinali G,Ricciardi MR,Tafuri A,Picardo M

    更新日期:2017-10-20 00:00:00

  • Highly efficient and robust cathode materials for low-temperature solid oxide fuel cells: PrBa0.5Sr0.5Co(2-x)Fe(x)O(5+δ).

    abstract::Solid oxide fuel cells (SOFC) are the cleanest, most efficient, and cost-effective option for direct conversion to electricity of a wide variety of fuels. While significant progress has been made in anode materials with enhanced tolerance to coking and contaminant poisoning, cathodic polarization still contributes con...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02426

    authors: Choi S,Yoo S,Kim J,Park S,Jun A,Sengodan S,Kim J,Shin J,Jeong HY,Choi Y,Kim G,Liu M

    更新日期:2013-01-01 00:00:00

  • Publisher Correction: Dibutyl phthalate induced testicular dysgenesis originates after seminiferous cord formation in rats.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-019-43786-3

    authors: Lara NLM,van den Driesche S,Macpherson S,França LR,Sharpe RM

    更新日期:2019-10-28 00:00:00

  • Homogeneity of lithium distribution in cylinder-type Li-ion batteries.

    abstract::Spatially-resolved neutron powder diffraction with a gauge volume of 2 × 2 × 20 mm(3) has been applied as an in situ method to probe the lithium concentration in the graphite anode of different Li-ion cells of 18650-type in charged state. Structural studies performed in combination with electrochemical measurements an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18380

    authors: Senyshyn A,Mühlbauer MJ,Dolotko O,Hofmann M,Ehrenberg H

    更新日期:2015-12-18 00:00:00

  • Differential interactions of bacterial lipopolysaccharides with lipid membranes: implications for TRPA1-mediated chemosensation.

    abstract::Bacterial lipopolysaccharides (LPS) activate the TRPA1 cation channels in sensory neurons, leading to acute pain and inflammation in mice and to aversive behaviors in fruit flies. However, the precise mechanisms underlying this effect remain elusive. Here we assessed the hypothesis that TRPA1 is activated by mechanica...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-30534-2

    authors: Startek JB,Talavera K,Voets T,Alpizar YA

    更新日期:2018-08-13 00:00:00

  • Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: a meta-analysis.

    abstract::Numerous studies have investigated the association between eosinophilia and clinical outcome of patients with chronic obstructive pulmonary disease (COPD) but the evidence is conflicting. We conducted a pooled analysis of outcome measures comparing eosinophilic and non-eosinophilic COPD patients. We searched articles ...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/s41598-017-13745-x

    authors: Ho J,He W,Chan MTV,Tse G,Liu T,Wong SH,Leung CCH,Wong WT,Tsang S,Zhang L,Chan RYP,Gin T,Leung J,Lau BWM,Wu WKK,Ngai SPC

    更新日期:2017-10-18 00:00:00

  • Publisher Correction: Increase in Interfacial Adhesion and Electrochemical Charge Storage Capacity of Polypyrrole on Au Electrodes Using Polyethyleneimine.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-019-42219-5

    authors: Kim KG,Kim SY

    更新日期:2019-04-16 00:00:00

  • Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C.

    abstract::A detailed molecular understanding of botulinum neurotoxin (BoNT)/host-cell-receptor interactions is fundamental both for developing strategies against botulism and for generating improved BoNT variants for medical applications. The X-ray crystal structure of the receptor-binding domain (HC) of BoNT/A1 in complex with...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43588

    authors: Benoit RM,Schärer MA,Wieser MM,Li X,Frey D,Kammerer RA

    更新日期:2017-03-02 00:00:00

  • Yields and Nutritional of Greenhouse Tomato in Response to Different Soil Aeration Volume at two depths of Subsurface drip irrigation.

    abstract::This study investigated the effects of 4 aeration levels (varied by injection of air to the soil through subsurface irrigation lines) at two subsurface irrigation line depths (15 and 40 cm) on plant growth, yield and nutritional quality of greenhouse tomato. In all experiments, fruit number, width and length, yield, v...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep39307

    authors: Li Y,Niu W,Dyck M,Wang J,Zou X

    更新日期:2016-12-20 00:00:00

  • Eurotium Cristatum Fermented Okara as a Potential Food Ingredient to Combat Diabetes.

    abstract::Type 2 diabetes mellitus (T2DM) is a chronic disease, and dietary modification is a crucial part of disease management. Okara is a sustainable source of fibre-rich food. Most of the valorization research on okara focused more on the physical attributes instead of the possible health attributes. The fermentation of oka...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-54021-4

    authors: Chan LY,Takahashi M,Lim PJ,Aoyama S,Makino S,Ferdinandus F,Ng SYC,Arai S,Fujita H,Tan HC,Shibata S,Lee CK

    更新日期:2019-11-26 00:00:00

  • Transcutaneous Electrical Nerve Stimulation Improves Stair Climbing Capacity in People with Knee Osteoarthritis.

    abstract::This study aimed to examine the effect of transcutaneous electrical nerve stimulation (TENS) on stair climbing capacity in individuals with pre-radiographic to mild knee osteoarthritis (OA). This is a secondary analysis of data from a single, participant-blinded, randomized controlled trial with a pre-post design. Par...

    journal_title:Scientific reports

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41598-020-64176-0

    authors: Iijima H,Eguchi R,Shimoura K,Yamada K,Aoyama T,Takahashi M

    更新日期:2020-04-29 00:00:00