Abstract:
:The secreted Ly-6/uPAR Related Protein-1 (SLURP1) is an immunomodulatory protein that promotes corneal immune- and angiogenic-privilege. Here, we have examined the influence of SLURP1 on neutrophil-vascular endothelial cell interactions using human umbilical vein endothelial cells (HUVEC) and differentiated neutrophil-like HL-60 (dHL-60) cells, or primary human neutrophils. SLURP1 blocked the tumor necrosis factor-alpha (TNF-α)-activated dHL-60 cells (i) binding to TNF-α-activated HUVEC with a concurrent reduction in endothelial cell adhesion molecule E-selectin, (ii) transmigration through TNF-α-activated confluent HUVEC monolayer by stabilizing VE-cadherin and β-catenin on endothelial cell cytoplasmic membranes, (iii) chemotaxis towards chemoattractant formyl Met-Leu-Phe (fMLP) coupled with their decreased polarization, and (iv) TNF-α-stimulated matrix metalloproteinase-9 (MMP9) expression and activity. SLURP1 also suppressed the primary human neutrophil chemotaxis, and interaction with HUVEC. Furthermore, SLURP1 suppressed fMLP-induced phosphorylation of protein kinase-B (AKT) in dHL-60 cells. Collectively, these results provide evidence that SLURP1 suppresses neutrophil (i) docking on HUVEC cells by decreasing endothelial cell adhesion molecule E-Selectin production, (ii) transmigration through HUVEC monolayer by stabilizing endothelial cell membrane localization of VE-cadherin and β-catenin complex and promoting their barrier function, and (iii) chemotaxis by modulating their polarization and TNF-α-stimulated MMP9 production.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Swamynathan S,Tiwari A,Loughner CL,Gnalian J,Alexander N,Jhanji V,Swamynathan SKdoi
10.1038/s41598-019-42437-xsubject
Has Abstractpub_date
2019-04-11 00:00:00pages
5898issue
1issn
2045-2322pii
10.1038/s41598-019-42437-xjournal_volume
9pub_type
杂志文章abstract::Aging is accompanied by a decline in memory and other brain functions. Physical exercise may mitigate this decline through the modulation of factors participating in the crosstalk between skeletal muscle and the brain, such as neurotrophins and oxidative stress parameters. We aimed to determine whether long term exerc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40040-8
更新日期:2019-03-04 00:00:00
abstract::This study was aimed at elucidating the changes of mandible symmetry in a rabbit model with low estrogen levels induced by ovariectomy (OVX) combined with temporomandibular joint (TMJ) anterior disc displacement without reduction (ADDWoR). 32 growing rabbits were randomly allocated into 4 groups; OVX group, ADDWoR gro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34023-4
更新日期:2018-10-23 00:00:00
abstract::Dysregulation of dopaminergic system induced by HIV-1 Tat protein-mediated direct inhibition of the dopamine transporter (DAT) has been implicated as a mediating factor of HIV-1 associated neurocognitive disorders. We have reported that single point mutations on human DAT (hDAT) at tyrosine88 (Y88F), lysine92 (K92M), ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39872-1
更新日期:2019-03-07 00:00:00
abstract::Based on density functional theory and non-equilibrium Green's function formalism, we explore the effect of Fe atom in Au-Fe@C20-Au monomer and dimer systems in comparison with the C20 fullerene molecular junctions. We calculate the spin-dependent transmission coefficient, spin polarization and also their spin thermoe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78111-w
更新日期:2020-12-03 00:00:00
abstract::RNA protein interactions (RPI) play a pivotal role in the regulation of various biological processes. Experimental validation of RPI has been time-consuming, paving the way for computational prediction methods. The major limiting factor of these methods has been the accuracy and confidence of the predictions, and our ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27814-2
更新日期:2018-06-22 00:00:00
abstract::Animals achieve camouflage through a variety of mechanisms, of which background matching and disruptive coloration are likely the most common. Although many studies have investigated camouflage mechanisms using artificial stimuli and in lab experiments, less work has addressed camouflage in the wild. Here we examine e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32059
更新日期:2016-09-12 00:00:00
abstract::Climate can modulate human health at large spatial scales, but the influence of global, regional, and local environments remains poorly understood, especially for neglected diseases, such as mycoses. In this work, we present the correlation between climatic variables and hospitalizations for mycoses in Brazilian state...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43353-w
更新日期:2019-05-06 00:00:00
abstract::The aim of this study was to develop a novel method to detect circulating histones H3 and H2B in plasma based on multiple reaction monitoring targeted mass spectrometry and a multiple reaction monitoring approach (MRM-MS) for its clinical application in critical bacteriaemic septic shock patients. Plasma samples from ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10830-z
更新日期:2017-09-06 00:00:00
abstract::Crop wild relatives are valuable resources for future genetic improvement. Here, we report the de novo genome assembly of Musa itinerans, a disease-resistant wild banana relative in subtropical China. The assembled genome size was 462.1 Mb, covering 75.2% of the genome (615.2Mb) and containing 32, 456 predicted protei...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31586
更新日期:2016-08-17 00:00:00
abstract::Quantum measurement is a fundamental cornerstone of experimental quantum computations. The main issues in current quantum measurement strategies are the high number of measurement rounds to determine a global optimal measurement output and the low success probability of finding a global optimal measurement output. Eac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43250-2
更新日期:2019-05-01 00:00:00
abstract::The manipulation of superparamagnetic microbeads for lab-on-a-chip applications relies on the steering of microbeads across an altering stray field landscape on top of soft magnetic parent structures. Using ab initio principles, we show three-dimensional simulations forecasting the controlled movement of microbeads. S...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65380-8
更新日期:2020-05-29 00:00:00
abstract::In this paper, a new type of porous ceramics was prepared using the raw sepiolite mineral. The porous ceramics was shaped by the dry pressing method and sintered in the range of 700 ~ 1200 °C. The temperature-microstructure evolution and the properties of porous sepiolite ceramics were investigated by thermo gravimetr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43918-9
更新日期:2019-05-14 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-25625-z
更新日期:2018-05-23 00:00:00
abstract::In this paper, a novel explanation on high directive emission of Fabry-Perot resonator antenna with subwavelength metasurface is proposed. Based on image theory and effective constitutive parameter retrieval, the whole Fabry-Perot resonant cavity structure composed of a single-layer metasurface with square ring elemen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11141-z
更新日期:2017-09-13 00:00:00
abstract::The strong electronegativity of O dictates that the ground state of singlet CO has positively charged C and negatively charged O, in agreement with ab initio charge analysis, but in disagreement with the dipole direction. Though this unusual phenomenon has been fairly studied, the study of electrostatic potential (EP)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16307
更新日期:2015-11-06 00:00:00
abstract::A numerical method of solving for the elastic wave eigenmodes in acoustic waveguides of arbitrary cross-section is presented. Operating under the assumptions of linear, isotropic materials, it utilizes a finite-difference method on a staggered grid to solve for the acoustic eigenmodes (field and frequency) of the vect...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17511-x
更新日期:2017-12-13 00:00:00
abstract::The interactions of L-type calcium channels (LTCCs) and NMDA receptors (NMDARs) in memories are poorly understood. Here we investigated the specific roles of anterior piriform cortex (aPC) LTCCs and NMDARs in early odor preference memory in mice. Using calcium imaging in aPC slices, LTCC activation was shown to be dep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35256
更新日期:2016-10-14 00:00:00
abstract::Visceral leishmaniasis (VL) is a fatal form of leishmaniasis which affects 70 countries, worldwide. Increasing drug resistance, HIV co-infection, and poor health system require operative vaccination strategy to control the VL transmission dynamics. Therefore, a holistic approach is needed to generate T and B memory ce...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08842-w
更新日期:2017-08-15 00:00:00
abstract::What's on the label is not what's in the bottle, from food products to herbal medicinal products (HMPs), economically-motivated biomaterials adulteration is a long-term problem affecting the food and drug industry. Accurate identification of the biomaterial ingredients in processed commodities is highly desirable. In ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05083-9
更新日期:2017-07-06 00:00:00
abstract::Vitiligo is characterized by death or functional defects of epidermal melanocytes through still controversial pathogenic process. Previously, we showed that mitochondria-driven pre-senescent phenotype diminishes the capability of vitiligo melanocytes to cope with stressful stimuli. In the current study, we investigate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13961-5
更新日期:2017-10-20 00:00:00
abstract::Solid oxide fuel cells (SOFC) are the cleanest, most efficient, and cost-effective option for direct conversion to electricity of a wide variety of fuels. While significant progress has been made in anode materials with enhanced tolerance to coking and contaminant poisoning, cathodic polarization still contributes con...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02426
更新日期:2013-01-01 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-43786-3
更新日期:2019-10-28 00:00:00
abstract::Spatially-resolved neutron powder diffraction with a gauge volume of 2 × 2 × 20 mm(3) has been applied as an in situ method to probe the lithium concentration in the graphite anode of different Li-ion cells of 18650-type in charged state. Structural studies performed in combination with electrochemical measurements an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18380
更新日期:2015-12-18 00:00:00
abstract::Bacterial lipopolysaccharides (LPS) activate the TRPA1 cation channels in sensory neurons, leading to acute pain and inflammation in mice and to aversive behaviors in fruit flies. However, the precise mechanisms underlying this effect remain elusive. Here we assessed the hypothesis that TRPA1 is activated by mechanica...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30534-2
更新日期:2018-08-13 00:00:00
abstract::Numerous studies have investigated the association between eosinophilia and clinical outcome of patients with chronic obstructive pulmonary disease (COPD) but the evidence is conflicting. We conducted a pooled analysis of outcome measures comparing eosinophilic and non-eosinophilic COPD patients. We searched articles ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-017-13745-x
更新日期:2017-10-18 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-42219-5
更新日期:2019-04-16 00:00:00
abstract::A detailed molecular understanding of botulinum neurotoxin (BoNT)/host-cell-receptor interactions is fundamental both for developing strategies against botulism and for generating improved BoNT variants for medical applications. The X-ray crystal structure of the receptor-binding domain (HC) of BoNT/A1 in complex with...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43588
更新日期:2017-03-02 00:00:00
abstract::This study investigated the effects of 4 aeration levels (varied by injection of air to the soil through subsurface irrigation lines) at two subsurface irrigation line depths (15 and 40 cm) on plant growth, yield and nutritional quality of greenhouse tomato. In all experiments, fruit number, width and length, yield, v...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39307
更新日期:2016-12-20 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is a chronic disease, and dietary modification is a crucial part of disease management. Okara is a sustainable source of fibre-rich food. Most of the valorization research on okara focused more on the physical attributes instead of the possible health attributes. The fermentation of oka...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54021-4
更新日期:2019-11-26 00:00:00
abstract::This study aimed to examine the effect of transcutaneous electrical nerve stimulation (TENS) on stair climbing capacity in individuals with pre-radiographic to mild knee osteoarthritis (OA). This is a secondary analysis of data from a single, participant-blinded, randomized controlled trial with a pre-post design. Par...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-64176-0
更新日期:2020-04-29 00:00:00