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Glaulactams A-C, daphniphyllum alkaloids from Daphniphyllum glaucescens.

Abstract：

:Glaulactams A-C (1-3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by spectroscopic analyses and time-dependent density-functional-theory-calculated electronic circular dichroism spectra; the data were subsequently analyzed to gain insight into the respective biogenetic relationships between the isolates, which exhibited anti-H1N1 and immunosuppressive activities.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Chao CH,Cheng JC,Gonçalves TP,Huang KW,Lin CC,Huang HC,Hwang SY,Wu YC

doi

10.1038/s41598-018-33748-6

subject

Has Abstract

pub_date

2018-10-18 00:00:00

pages

15417

issue

1

issn

2045-2322

pii

10.1038/s41598-018-33748-6

journal_volume

8

pub_type

杂志文章

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