EGFP-EGF1-conjugated poly (lactic-co-glycolic acid) nanoparticles as a carrier for the delivery of CCR2- shRNA to atherosclerotic macrophage in vitro.

abstract：:Spatially targeted, genetically-specific strategies for sustained inhibition of nociceptors may help transform pain science and clinical management. Previous optogenetic strategies to inhibit pain have required constant illumination, and chemogenetic approaches in the periphery have not been shown to inhibit pain. Her...

journal_title：Scientific reports

authors： Iyer SM,Vesuna S,Ramakrishnan C,Huynh K,Young S,Berndt A,Lee SY,Gorini CJ,Deisseroth K,Delp SL

更新日期：2016-08-03 00:00:00

abstract：:The dispensing of tiny droplets is a basic and crucial process in a myriad of applications, such as DNA/protein microarray, cell cultures, chemical synthesis of microparticles, and digital microfluidics. This work systematically demonstrates droplet dispensing into immiscible fluids through electric charge concentrati...

journal_title：Scientific reports

authors： Um T,Hong J,Im do J,Lee SJ,Kang IS

更新日期：2016-08-18 00:00:00

abstract：:Little is known about the composition and clinical implications of lung microbiome in patients with chronic obstructive pulmonary disease (COPD) and community-acquired pneumonia requiring invasive mechanical ventilation and intensive care unit admission. Therefore, this study aimed to explore the longitudinal changes ...

journal_title：Scientific reports

authors： Huang WC,Wu MF,Huang CC,Liu SY,Chen HC,Chen YY,Hsu JY,Huang CC

更新日期：2020-07-06 00:00:00

abstract：:Pristine and functionalized multi-walled carbon nanotubes (MWCNTs) were investigated as adsorbent materials inside solid-phase extraction (SPE) cartridges for extraction and preconcentration of 8 EU-relevant organic micropollutants (with different pKa and polarity) before chromatographic analysis of surface water. The...

journal_title：Scientific reports

authors： Barbosa MO,Ribeiro RS,Ribeiro ARL,Pereira MFR,Silva AMT

更新日期：2020-12-18 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Dahan A,Reiner M

更新日期：2018-04-24 00:00:00

abstract：:Given that the biological processes governing the oncogenesis of pancreatic cancers could present useful therapeutic targets, there is a pressing need to molecularly distinguish between different clinically relevant pancreatic cancer subtypes. To address this challenge, we used targeted proteomics and other molecular ...

journal_title：Scientific reports

authors： Sinkala M,Mulder N,Martin D

更新日期：2020-01-27 00:00:00

abstract：:Magnesium has been shown to effectively prevent vascular calcification associated with chronic kidney disease. Magnesium has been hypothesized to prevent the upregulation of osteoblastic genes that potentially drives calcification. However, extracellular effects of magnesium on hydroxyapatite formation are largely neg...

journal_title：Scientific reports

authors： Ter Braake AD,Tinnemans PT,Shanahan CM,Hoenderop JGJ,de Baaij JHF

更新日期：2018-02-01 00:00:00

abstract：:We present active manipulation of the structural vibrations of an elastic body to generate an acoustic illusion. The resultant illusion misrepresents the nature, size and number of objects in the exterior acoustic domain. We demonstrate our technique, herein termed active structural acoustic illusion, using an elastic...

journal_title：Scientific reports

authors： Eggler D,Kessissoglou N

更新日期：2020-06-17 00:00:00

abstract：:Haemodynamic disorders are common clinical findings in hypertension and lead to adverse cardiovascular events. However, the haemodynamic conditions in hypertension models are poorly understood. This study aimed to observe the characteristics of haemodynamics in spontaneously hypertensive rats (SHRs) and antihypertensi...

journal_title：Scientific reports

authors： Chen Z,Yu H,Shi Y,Zhu M,Wang Y,Hu X,Zhang Y,Chang Y,Xu M,Gao W

更新日期：2017-05-17 00:00:00

abstract：:Rapid in situ detection of pathogens coupled with high resolution imaging in the distal human lung has the potential to provide new insights and diagnostic utility in patients in whom pneumonia is suspected. We have previously described an antimicrobial peptide (AMP) Ubiquicidin (fragment UBI29-41) labelled with an en...

journal_title：Scientific reports

authors： Akram AR,Avlonitis N,Scholefield E,Vendrell M,McDonald N,Aslam T,Craven TH,Gray C,Collie DS,Fisher AJ,Corris PA,Walsh T,Haslett C,Bradley M,Dhaliwal K

更新日期：2019-06-10 00:00:00

abstract：:Predictive coding theories propose that the brain creates internal models of the environment to predict upcoming sensory input. Hierarchical predictive coding models of vision postulate that higher visual areas generate predictions of sensory inputs and feed them back to early visual cortex. In V1, sensory inputs that...

journal_title：Scientific reports

authors： Edwards G,Vetter P,McGruer F,Petro LS,Muckli L

更新日期：2017-11-28 00:00:00

abstract：:Minimum toe clearance (MTC) occurs during a highly dynamic phase of the gait cycle and is associated with the highest risk of unintentional contact with obstacles or the ground. Age, cognitive function, attention and visual feedback affect foot clearance but how these factors interact to influence MTC control is not f...

journal_title：Scientific reports

authors： Killeen T,Easthope CS,Demkó L,Filli L,Lőrincz L,Linnebank M,Curt A,Zörner B,Bolliger M

更新日期：2017-05-15 00:00:00

abstract：:The adipogenic process is characterized by the expression of adipocyte differentiation markers that lead to changes in cell metabolism and to the accumulation of lipid droplets. Moreover, during early adipogenesis, cells undergo a strong downregulation of translational activity with a decrease in cell size, proliferat...

journal_title：Scientific reports

authors： Marcon BH,Shigunov P,Spangenberg L,Pereira IT,de Aguiar AM,Amorín R,Rebelatto CK,Correa A,Dallagiovanna B

更新日期：2019-04-04 00:00:00

abstract：:Most women with ovarian cancer are diagnosed at an advanced stage and there are few therapeutic options. Recently, monoclonal antibody therapies have had limited success, thus more effective antibodies are needed to improve long-term survival. In this report, we prepared polyclonal rabbit anti-ovarian cancer antibody ...

journal_title：Scientific reports

authors： Zhang S,Yu M,Deng H,Shen G,Wei Y

更新日期：2014-05-15 00:00:00

abstract：:Microorganisms in vertebrate guts have been recognized as important symbionts influencing host life. However, it remains unclear about the gut microbiota in long-distance migratory Anseriformes herbivores, which could be functionally important for these wetland-dependent animals. We collected faeces of the greater whi...

journal_title：Scientific reports

authors： Yang Y,Deng Y,Cao L

更新日期：2016-09-07 00:00:00

abstract：:Some studies have demonstrated interactions of AD-risk single nucleotide polymorphisms (SNPs) in non-APOE regions with APOE genotype. Nevertheless, no study reported interactions of expression quantitative trait locus (eQTL) for APOE with APOE genotype. In present study, we included 9286 unrelated AD patients and 8479...

journal_title：Scientific reports

authors： Zhang A,Zhao Q,Xu D,Jiang S

更新日期：2018-05-23 00:00:00

abstract：:Proteasomes are a critical component of quality control that regulate turnover of short-lived, unfolded, and misfolded proteins. Proteasome activity has been therapeutically targeted and considered as a treatment option for several chronic lung disorders including pulmonary fibrosis. Although pharmacologic inhibition ...

journal_title：Scientific reports

authors： Sitaraman S,Na CL,Yang L,Filuta A,Bridges JP,Weaver TE

更新日期：2019-08-29 00:00:00

abstract：:Mild cognitive impairment (MCI) is a precursor phase of Alzheimer's disease (AD). As current treatments may be effective only at the early stages of AD, it is important to track MCI patients who will convert to AD. The aim of this study is to develop a high performance semi-mechanism based approach to predict the conv...

journal_title：Scientific reports

authors： Liu H,Zhou X,Jiang H,He H,Liu X,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2016-06-07 00:00:00

abstract：:Humans are host to a multitude of microorganisms that rapidly populate the body at birth, subject to a complex interplay that is dependent on host genetics, lifestyle, and environment. The host-associated microbiome, including the oral microbiome, presents itself in a complex ecosystem important to health and disease....

journal_title：Scientific reports

authors： Freire M,Moustafa A,Harkins DM,Torralba MG,Zhang Y,Leong P,Saffery R,Bockmann M,Kuelbs C,Hughes T,Craig JM,Nelson KE

更新日期：2020-05-14 00:00:00

abstract：:Neural responses to incentives are altered in chronic pain and by opioid use. To understand how opioid use modulates the neural response to reward/value in chronic pain, we compared brain functional magnetic resonance imaging (fMRI) responses to a monetary incentive delay (MID) task in patients with fibromyalgia takin...

journal_title：Scientific reports

authors： Martucci KT,MacNiven KH,Borg N,Knutson B,Mackey SC

更新日期：2019-07-03 00:00:00

abstract：:Aluminium adjuvants remain the most widely used and effective adjuvants in vaccination and immunotherapy. Herein, the particle size distribution (PSD) of aluminium oxyhydroxide and aluminium hydroxyphosphate adjuvants was elucidated in attempt to correlate these properties with the biological responses observed post v...

journal_title：Scientific reports

authors： Mold M,Shardlow E,Exley C

更新日期：2016-08-12 00:00:00

abstract：:The interaction of (quasi)particles with a periodic potential arises in various domains of science and engineering, such as solid-state physics, chemical physics, and communication theory. An attractive test ground to investigate this interaction is represented by superconductors with artificial pinning sites, where m...

journal_title：Scientific reports

authors： Dobrovolskiy OV,Huth M,Shklovskij VA,Vovk RV

更新日期：2017-10-23 00:00:00

abstract：:It is rigorously proved that ideal memcapacitors and meminductors are not passive or cyclo-passive devices. Equivalently, this implies that there exist excitation profiles that allow to extract more energy from the device than it is supplied with; so that their energy conversion efficiency exceeds 100%. This means tha...

journal_title：Scientific reports

authors： Jeltsema D,van der Schaft A

更新日期：2020-10-07 00:00:00

abstract：:Spotted seal (Phoca largha) is a critically endangered pinniped in China and South Korea. The conventional method to protect and maintain the P. largha population is to keep them captive in artificially controlled environments. However, little is known about the physiological differences between wild and captive P. la...

journal_title：Scientific reports

authors： Tian J,Du J,Han J,Bao X,Song X,Lu Z

更新日期：2020-10-30 00:00:00

abstract：:We show that widely used approaches in statistical physics incorrectly indicate the existence of power-law cross-correlations between financial stock market fluctuations measured over several years and the neuronal activity of the human brain lasting for only a few minutes. While such cross-correlations are nonsensica...

journal_title：Scientific reports

authors： Blythe DA,Nikulin VV,Müller KR

更新日期：2016-06-02 00:00:00

abstract：:Upon illumination, a dielectric microsphere (μS) can generate a photonic nanojet (PNJ), which plays a role in the super-resolution imaging of a sample placed in the μS's immediate proximity. Recent microscopy implementations pioneered this concept but, despite the experimental characterization and theoretical modeling...

journal_title：Scientific reports

authors： Migliozzi D,Gijs MAM,Huszka G

更新日期：2018-10-12 00:00:00

abstract：:For the first time, soil core samples from the Jiuquan region have been analyzed for Pu isotopes for radioactive source identification and radiological assessment. The Jiuquan region is in downwind from the Lop Nor Chinese nuclear test (CNT) site. The high Pu inventories (13 to 546 Bq/m(2)) in most of the sampling loc...

journal_title：Scientific reports

authors： Bu W,Ni Y,Guo Q,Zheng J,Uchida S

更新日期：2015-07-17 00:00:00

abstract：:High-risk human papillomavirus (HPV) type 16, which is responsible for greater than 50% of cervical cancer cases, is the most prevalent and lethal HPV type. However, the molecular mechanisms of cervical carcinogenesis remain elusive, particularly the early steps of HPV infection that may transform normal cervical epit...

journal_title：Scientific reports

authors： Liu C,Lin J,Li L,Zhang Y,Chen W,Cao Z,Zuo H,Chen C,Kee K

更新日期：2015-01-07 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a rising cause of hepatocellular carcinoma (HCC). We examined whether inherited pathogenic variants in candidate genes (n = 181) were enriched in patients with NAFLD-HCC. To this end, we resequenced peripheral blood DNA of 142 NAFLD-HCC, 59 NAFLD with advanced fibrosis, and ...

journal_title：Scientific reports

authors： Pelusi S,Baselli G,Pietrelli A,Dongiovanni P,Donati B,McCain MV,Meroni M,Fracanzani AL,Romagnoli R,Petta S,Grieco A,Miele L,Soardo G,Bugianesi E,Fargion S,Aghemo A,D'Ambrosio R,Xing C,Romeo S,De Francesco R,Reeves

更新日期：2019-03-06 00:00:00

abstract：:Proton therapy as a promising candidate in cancer treatment has attracted much attentions and many studies have been performed to investigate the new methods to enhance its radiation effectiveness. In this regard, two research groups have suggested that using boron isotopes will lead to a radiation effectiveness enhan...

journal_title：Scientific reports

authors： Tabbakh F,Hosmane NS

更新日期：2020-03-25 00:00:00