Abstract：
:Crypt neurons are a third type of olfactory receptor neurons with a highly unusual "one cell type--one receptor" mode of expression, the same receptor being expressed by the entire population of crypt neurons. Attempts to identify the target region(s) of crypt neurons have been inconclusive so far. We report that TrkA-like immunoreactivity specifically labeled somata, axons, and terminals of zebrafish crypt neurons and reveal a single glomerulus, mdg2 of the dorsomedial group, as target glomerulus of crypt neurons. Injection of a fluorescent tracing dye into the mdg2 glomerulus retrogradely labeled mostly crypt neurons, as assessed by quantitative morphometry, whereas no crypt neurons were found after injections in neighboring glomeruli. Our data provide strong evidence that crypt neurons converge onto a single glomerulus, and thus form a labeled line consisting of a single sensory cell type, a single olfactory receptor and a single target glomerulus.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ahuja G,Ivandic I,Saltürk M,Oka Y,Nadler W,Korsching SIdoi
10.1038/srep02063subject
Has Abstractpub_date
2013-01-01 00:00:00pages
2063issn
2045-2322pii
srep02063journal_volume
3pub_type
杂志文章abstract：:Protocadherin 19 (Pcdh19) is an X-linked gene belonging to the protocadherin superfamily, whose members are predominantly expressed in the central nervous system and have been implicated in cell-cell adhesion, axon guidance and dendrite self-avoidance. Heterozygous loss-of-function mutations in humans result in the ch...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26765
更新日期：2016-05-31 00:00:00
abstract：:Accumulating evidence supports the polygenic nature of most complex diseases, suggesting the involvement of many susceptibility genes with small effect sizes. Although hundreds of genes may underlie the genetic architecture of complex diseases, those involved in a given disease are probably not randomly distributed, b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33460
更新日期：2016-09-14 00:00:00
abstract：:The molecular mechanisms underlying viral pathogenesis are yet poorly understood owed to the large number of factors involved and the complexity of their interactions. Could we identify a minimal set of host transcription factors (TF) whose misregulation would result in the transcriptional profile characteristic of in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01006
更新日期：2012-01-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-58429-1
更新日期：2020-01-27 00:00:00
abstract：:Hollow microporous organic nanorods (HMORs) with hypercrosslinked polymer (HCPs) shells were synthesized through emulsion polymerization followed by hypercrosslinking. The HMORs have tunable aspect ratios, high BET surface areas and monodispersed morphologies, showing good performance in gas adsorpion. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31359
更新日期：2016-08-10 00:00:00
abstract：:MiR-204 and miR-211 (miR-204/211) share the same seed site sequence, targeting many of the same genes. Their role in cancer development remains controversial, as both cell proliferative and suppressive effects have been identified. This study aimed to address the relationship between the two structurally similar micro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25287
更新日期：2016-04-28 00:00:00
abstract：:Oxidative stress due to hypobaric hypoxia at extreme altitudes causes severe neuronal damage and irreversible cognitive loss. Owing to contraindications of current drug therapies, the aim of the study was to investigate memory enhancing potential of aqueous extract of Ganoderma lucidum (GLAQ) and underlying neuroprote...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65812-5
更新日期：2020-06-02 00:00:00
abstract：:The development of the peripheral nervous system relies on long-distance signaling from target organs back to the soma. In sympathetic neurons, this long-distance signaling is mediated by target derived Nerve Growth Factor (NGF) interacting with its axonal receptor, TrkA. This ligand receptor complex internalizes into...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23036-8
更新日期：2018-03-16 00:00:00
abstract：:The role of non-bilayer lipids and non-lamellar lipid phases in biological membranes is an enigmatic problem of membrane biology. Non-bilayer lipids are present in large amounts in all membranes; in energy-converting membranes they constitute about half of their total lipid content-yet their functional state is a bila...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68854-x
更新日期：2020-07-20 00:00:00
abstract：:FMS-like Tyrosine Kinase 3 (FLT3) is a clinically validated target for acute myeloid leukemia (AML). Inhibitors targeting FLT3 have been evaluated in clinical studies and have exhibited potential to treat FLT3-driven AML. A frequent, clinical limitation is FLT3 selectivity, as concomitant inhibition of FLT3 and c-KIT ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21839-3
更新日期：2018-02-27 00:00:00
abstract：:High-resolution spectroscopy in the 1-10 μm region has never been fully tackled for the lack of widely-tunable and practical light sources. Indeed, all solutions proposed thus far suffer from at least one of three issues: they are feasible only in a narrow spectral range; the power available for spectroscopy is limite...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12891-6
更新日期：2017-10-06 00:00:00
abstract：:Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne bunyavirus, can cause a life-threatening hemorrhagic syndrome in humans but not in its animal host. The virus is widely distributed throughout southeastern Europe, the Middle East, Africa, and Asia. Disease management has proven difficult and there are no bro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44210-6
更新日期：2019-05-23 00:00:00
abstract：:Finding strategies to preserve quantum resources in open systems is nowadays a main requirement for reliable quantum-enhanced technologies. We address this issue by considering structured cavities embedding qubits driven by a control technique known as frequency modulation. We first study a single qubit in a lossy cav...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32661-2
更新日期：2018-09-24 00:00:00
abstract：:The aim of this prospective study was to evaluate the changes in stereopsis in patients who underwent vitrectomy for macular hole (MH) and assess the relationship between stereopsis and retinal microstructures. Fifty-two patients who underwent successful vitrectomy for unilateral MH and 20 control participants were re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76648-4
更新日期：2020-11-11 00:00:00
abstract：:Modern microbial mats can provide key insights into early Earth ecosystems, and Shark Bay, Australia, holds one of the best examples of these systems. Identifying the spatial distribution of microorganisms with mat depth facilitates a greater understanding of specific niches and potentially novel microbial interaction...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15607
更新日期：2015-10-26 00:00:00
abstract：:Cu removal by a novel multi-amines decorated resin (PAMD) from wastewater in the absence or presence of citric acid (CA) was examined. Adsorption capacity of Cu onto PAMD markedly increased by 186% to 5.07 mmol/g in the presence of CA, up to 7 times of that onto four commercial resins under the same conditions. Preloa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09944
更新日期：2015-05-12 00:00:00
abstract：:The nuclear receptor, farnesoid X receptor (FXR), has been recently considered as a tumor suppressor in HCC. IL-6/Janus kinase 2 (Jak-2)/signal transducer and activator of transcription 3 (STAT3) pathway has been implicated as a key player in many cancer types. This study aimed at investigating the potential effect of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12629-4
更新日期：2017-10-02 00:00:00
abstract：:Nanodidamonds containing colour centres open up many applications in quantum information processing, metrology, and quantum sensing. However, controlling the synthesis of nanodiamonds containing silicon vacancy (SiV) centres is still not well understood. Here we study nanodiamonds produced by a high-pressure high-temp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21953-2
更新日期：2018-02-28 00:00:00
abstract：:Both chronic calorie restriction (CCR) and intermittent calorie restriction (ICR) have shown anticancer effects. However, the direct evidence comparing ICR to CCR with respect to cancer prevention is controversial and inconclusive. PubMed and Web of Science were searched on November 25, 2015. The relative risk (RR) [9...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33739
更新日期：2016-09-22 00:00:00
abstract：:Emerging evidence demonstrates the importance of sufficient vitamin D (1α, 25-dihydroxyvitamin D3) levels during early life stage development with deficiencies associated with long-term effects into adulthood. While vitamin D has traditionally been associated with mineral ion homeostasis, accumulating evidence suggest...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72622-2
更新日期：2020-09-29 00:00:00
abstract：:In many ways, the complement of cell subtypes determines the information processing that a local brain circuit can perform. For example, the balance of excitatory and inhibitory (E/I) signaling within a brain region contributes to response magnitude and specificity in ways that influence the effectiveness of informati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56293-2
更新日期：2019-12-27 00:00:00
abstract：:Tobacco smoking is the major cause of many chronic diseases, especially lung cancer. Knowledge about population-wide tobacco use and exposure is essential to characterise its burden on public health and evaluate policy efficacy. Obtaining such knowledge remains challenging with current methods (e.g., surveys, biomonit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31324-6
更新日期：2018-09-05 00:00:00
abstract：:Referential pointing is a characteristically human behavior, which involves moving a finger through space to direct an addressee towards a desired mental state. Planning this type of action requires an interface between sensorimotor and conceptual abilities. A simple interface could supplement spatially-guided motor r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04442-w
更新日期：2017-06-27 00:00:00
abstract：:Tellurite (TeO32-) is a hazardous and toxic oxyanion for living organisms. However, several microorganisms can bioconvert TeO32- into the less toxic form of elemental tellurium (Te0). Here, Rhodococcus aetherivorans BCP1 resting (non-growing) cells showed the proficiency to produce tellurium-based nanoparticles (NPs) ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22320-x
更新日期：2018-03-02 00:00:00
abstract：:We present and demonstrate an approach for femtosecond laser processing by using patterned vector optical fields (PVOFs) composed of multiple individual vector optical fields. The PVOFs can be flexibly engineered due to the diversity of individual vector optical fields in spatial arrangement and distribution of states...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02281
更新日期：2013-01-01 00:00:00
abstract：:The 170 National Forests and Grasslands (NFs) in the conterminous United States are public lands that provide important ecosystem services such as clean water and timber supply to the American people. This study investigates the potential impacts of climate change on two key ecosystem functions (i.e., water yield and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24441
更新日期：2016-04-21 00:00:00
abstract：:Epithelial ovarian cancer (EOC) is the most deadly of the gynecological cancers. New approaches and better tools for monitoring treatment efficacy and disease progression of EOC are required. In this study, metabolomics using rapid resolution liquid chromatography mass spectrometry was applied to a systematic investig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23334
更新日期：2016-03-21 00:00:00
abstract：:Preclinical studies show that the dopamine D3 receptor (D3R) is involved in the reinstatement of drug seeking and motivation for drugs of abuse. A D3R gene variant, Ser9Gly (rs6280) has been linked to nicotine dependence, yet the mechanisms underlying its involvement in nicotine dependence is unclear. This study inves...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60940-4
更新日期：2020-03-05 00:00:00
abstract：:The aim of this systematic review was taken to investigate the efficacy and safety of docetaxel plus thalidomide vs. docetaxel alone for treating androgen-independent prostate cancer (AIPC). Data were collected from different databases independently by three researchers according to the pre-defined inclusion and exclu...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
doi：10.1038/srep04818
更新日期：2014-04-28 00:00:00
abstract：:Various sea foods including fish, shellfish and shrimp were collected from different coastal areas of Fujian in China, and their Pb species characteristics were investigated in detail. The results indicated that there are two different species characteristics of Pb existing in sea food samples. About half of samples w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33294
更新日期：2016-09-14 00:00:00
