Abstract：
:Accumulating evidence supports the polygenic nature of most complex diseases, suggesting the involvement of many susceptibility genes with small effect sizes. Although hundreds of genes may underlie the genetic architecture of complex diseases, those involved in a given disease are probably not randomly distributed, but likely to be functionally related. Protein-protein interaction networks have been used to evaluate the functional relatedness of susceptibility genes. However, these networks do not account for tissue specificity, are limited to protein-coding genes, and are typically biased by incomplete biological knowledge. Here, we present Gene Link Inspector Through Tissue-specific coExpRession (GLITTER), a web-based application for assessing the functional relatedness of susceptibility genes, either coding or noncoding, according to tissue-specific gene expression profiles. GLITTER can also shed light on the specific tissues in which susceptibility genes might exert their functions. We further demonstrate examples of how GLITTER can evaluate the functional relatedness of susceptibility genes underlying schizophrenia and breast cancer, and provide clues about etiology.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu X,Yu P,Cheng C,Potash JB,Han Sdoi
10.1038/srep33460subject
Has Abstractpub_date
2016-09-14 00:00:00pages
33460issn
2045-2322pii
srep33460journal_volume
6pub_type
杂志文章abstract：:Deregulated IGF-1R-AKT signaling influences multiple nodes of cancer cell physiology and assists in migration, metastasis and acquirement of radio/chemoresistance. Enrichment of cancer stem cells (CSC) positively correlates with radio/chemoresistance development in various malignancies. It is unclear though, how IGF-1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36612
更新日期：2016-11-07 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40871-5
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-10-06 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03592-1
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1038/srep36140
更新日期：2016-10-27 00:00:00
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pub_type： 杂志文章
doi：10.1038/s41598-020-73349-w
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09331-w
更新日期：2017-08-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23226
更新日期：2016-03-16 00:00:00
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journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-60498-1
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journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-74970-5
更新日期：2020-10-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51334-2
更新日期：2019-10-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37049
更新日期：2017-01-10 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39407-8
更新日期：2019-02-28 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14817
更新日期：2015-10-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05754-7
更新日期：2017-07-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05694
更新日期：2014-07-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15489-0
更新日期：2017-12-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12227-4
更新日期：2017-09-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00543-8
更新日期：2017-03-28 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66712-4
更新日期：2020-06-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39534
更新日期：2016-12-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-06-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06868-8
更新日期：2017-08-08 00:00:00
