Abstract：
:Epithelial ovarian cancer (EOC) is the most deadly of the gynecological cancers. New approaches and better tools for monitoring treatment efficacy and disease progression of EOC are required. In this study, metabolomics using rapid resolution liquid chromatography mass spectrometry was applied to a systematic investigation of metabolic changes in response to advanced EOC, surgery and recurrence. The results revealed considerable metabolic differences between groups. Moreover, 37, 30, and 26 metabolites were identified as potential biomarkers for primary, surgical and recurrent EOC, respectively. Primary EOC was characterized by abnormal lipid metabolism and energy disorders. Oxidative stress and surgical efficacy were clear in the post-operative EOC patients. Recurrent EOC patients showed increased amino acid and lipid metabolism compared with primary EOC patients. After cytoreductive surgery, eight metabolites (e.g. l-kynurenine, retinol, hydroxyphenyllactic acid, 2-octenoic acid) corrected towards levels of the control group, and four (e.g. hydroxyphenyllactic acid, 2-octenoic acid) went back again to primary EOC levels after disease relapse. In conclusion, this study delineated metabolic changes in response to advanced EOC, surgery and recurrence, and identified biomarkers that could facilitate both understanding and monitoring of EOC development and progression.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ke C,Li A,Hou Y,Sun M,Yang K,Cheng J,Wang J,Ge T,Zhang F,Li Q,Li J,Wu Y,Lou G,Li Kdoi
10.1038/srep23334subject
Has Abstractpub_date
2016-03-21 00:00:00pages
23334issn
2045-2322pii
srep23334journal_volume
6pub_type
杂志文章abstract：:We generated self-induced retinal ganglion cells (RGCs) with functional axons from human induced pluripotent stem cells. After development of the optic vesicle from the induced stem cell embryoid body in three-dimensional culture, conversion to two-dimensional culture, achieved by supplementation with BDNF, resulted i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08344
更新日期：2015-02-10 00:00:00
abstract：:Sufficient tissue oxygenation is required for regular brain function; thus oxygen supply must be tightly regulated to avoid hypoxia and irreversible cell damage. If hypoxia occurs the transcription factor complex hypoxia-inducible factor (HIF) will accumulate and coordinate adaptation of cells to hypoxia. However, eve...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75838-4
更新日期：2020-11-05 00:00:00
abstract：:The study was aimed to investigate the pathogens distribution and risk factors for PICC-related bloodstream infection in intensive care unit (ICU) patients. 402 patients placed with PICC in ICU were recruited in the study. The microbiological characteristics of PICC-related infection were investigated by Vitek 2 Compa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10037-2
更新日期：2017-11-08 00:00:00
abstract：:Magnetic skyrmions are hailed as a potential technology for data storage and other data processing devices. However, their stability against thermal fluctuations is an open question that must be answered before skyrmion-based devices can be designed. In this work, we study paths in the energy landscape via which the t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03391-8
更新日期：2017-06-22 00:00:00
abstract：:Optical elastography is undergoing extensive development as an imaging tool to map mechanical contrast in tissue. Here, we present a new platform for optical elastography by generating sub-millimetre-scale mechanical contrast from a simple digital camera. This cost-effective, compact and easy-to-implement approach ope...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72603-5
更新日期：2020-09-29 00:00:00
abstract：:Liposomes or biological vesicles can be created from cholesterol, phospholipid, and water. Their stability is affected by their phospholipid composition which can influence disease treatment and drug delivery efficacy. In this study, the effect of phospholipid type on the formation and stability of liposomes using coa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58730-z
更新日期：2020-02-04 00:00:00
abstract：:Low pH in the tumor micromilieu is a recognized pathological feature of cancer. This attribute of cancerous cells has been targeted herein for the controlled release of chemotherapeutics at the tumour site, while sparing healthy tissues. To this end, pH-sensitive, hollow ZnO-nanocarriers loaded with paclitaxel were sy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11760
更新日期：2015-07-06 00:00:00
abstract：:HOX proteins interact with PBX and MEIS cofactors, which belong to the TALE-class of homeodomain (HD)-containing transcription factors. Although the formation of HOX-PBX complexes depends on a unique conserved HOX motif called hexapeptide (HX), the additional presence of MEIS induces a remodeling of the interaction, l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42096-y
更新日期：2019-04-05 00:00:00
abstract：:We analyze the symmetry and topological features of a family of materials closely related to penta-graphene, derived from it by adsorption or substitution of different atoms. Our description is based on a novel approach, called topological quantum chemistry, that allows to characterize the topology of the electronic b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49187-w
更新日期：2019-09-04 00:00:00
abstract：:This article shows that nanodiamonds can transmigrate through the insect cuticle easily, and the doses used were not hemocytotoxic and did not cause inhibition of cellular and humoral immune responses in larvae, pupae and adults of Tenebrio molitor. The examination of the nanodiamond biodistribution in insect cells de...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46720-9
更新日期：2019-07-17 00:00:00
abstract：:Epidemiological investigation have suggested that there is a significantly inverse association between circulating 25-hydroxyvitamin D (25(OH)D) and the risk for developing colorectal cancer (CRC) in humans. However, little is known about the role of vitamin D binding protein (VDBP) in colorectal carcinogenesis. Blood...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07956
更新日期：2015-01-22 00:00:00
abstract：:We present an efficient concept based on time varying and non reciprocal metamaterials to achieve an active control of the spoof plasmon (SP) propagation at sub-wavelength scale. An experimental demonstration of non-reciprocal guiding device based on split ring resonator is proposed as an application of this concept i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36948-2
更新日期：2019-02-20 00:00:00
abstract：:The local flexibility of an enzyme's active center plays pivotal roles in catalysis, however, little is known about how the flexibility of these flexible residues affects stability. In this study, we proposed an active center stabilization (ACS) strategy to improve the kinetic thermostability of Candida rugosa lipase1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33797
更新日期：2016-09-26 00:00:00
abstract：:The carrier transport characteristics of Sb2Se2Te topological insulators were investigated, after exposure to different levels of nitrogen gas. The magnetoresistance (MR) slope for the Sb2Se2Te crystal increased by approximately 100% at 10 K after 2-days of exposure. The Shubnikov-de Haas (SdH) oscillation amplitude i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05369-y
更新日期：2017-07-11 00:00:00
abstract：:The intermolt crustacean Y-organ (YO) maintains a basal state mediated by pulsatile release of molt inhibiting hormone (MIH), a neuropeptide produced in the eyestalk ganglia, inhibiting YO ecdysteroidogenesis. Reduction of MIH results in YO activation and the animal enters premolt. In the crab, Gecarcinus lateralis, m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25368-x
更新日期：2018-05-09 00:00:00
abstract：:A link between periodontitis and atherothrombosis has been highlighted. The aim of this study was to determine the influence of Porphyromonas gingivalis on endothelial microvesicles (EMVPg) shedding and their contribution to endothelial inflammation. Endothelial cells (EC) were infected with P. gingivalis (MOI = 100) ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58374-z
更新日期：2020-02-04 00:00:00
abstract：:Nuclear proteins are primarily regulatory factors governing gene expression. Multiple factors determine the localization of a protein in the nucleus. An upright identification of nuclear proteins is way far from accuracy. We have attempted to combine information from subcellular prediction tools, experimental evidence...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70713-8
更新日期：2020-09-15 00:00:00
abstract：:Zebrafish embryos are translucent and develop rapidly in individual eggs ex utero; they are widely used as models for embryogenesis and organ development for human diseases and drug discovery. Lysine crotonylation (Kcr) is a type of histone post-translational modifications discovered in 2011. Kcr dynamics are involved...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22069-3
更新日期：2018-02-26 00:00:00
abstract：:SUMO belongs to the ubiquitin-like family (UbL) of protein modifiers. SUMO is conserved among eukaryotes and is essential for the regulation of processes such as DNA damage repair, transcription, DNA replication and mitosis. UbL modification of proteins occurs via a specific enzymatic cascade formed by the crosstalk b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41998
更新日期：2017-02-06 00:00:00
abstract：:A culture system that can recapitulate myelination in vitro will not only help us better understand the mechanism of myelination and demyelination, but also find out possible therapeutic interventions for treating demyelinating diseases. Here, we introduce a simple and reproducible myelination culture system using mou...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15122
更新日期：2015-10-12 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-017-15019-y
更新日期：2017-11-10 00:00:00
abstract：:Insects are a promising alternative protein source. One of the bottlenecks in applying insects in food is the fast darkening initiated during grinding. Besides enzymatic browning, non-enzymatic factors can cause off-colour formation, which differs between species. This study investigates the impact of iron, phenoloxid...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38923-x
更新日期：2019-02-27 00:00:00
abstract：:Liraglutide, a glucagon-like peptide-1 receptor (GLP-1R) agonist, is widely used to treat diabetes. However, its effect on pulmonary arterial hypertension (PAH) is unknown. In this study, we investigated its effects on rats with monocrotaline (MCT)-induced PAH and mechanisms on rat pulmonary artery smooth muscle cells...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31788
更新日期：2016-09-01 00:00:00
abstract：:The linkage between oxidative stress and idiopathic chronic fatigue (ICF) has not been explored in detail. This study thoroughly compared the serum levels of biomarkers for oxidative stress and antioxidants from 103 subjects with ICF (20 men and 83 women) to those of 82 healthy volunteers (27 men and 55 women). Oxidat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31270-3
更新日期：2018-08-27 00:00:00
abstract：:This is the first study to investigate the impact of a second fibula flap or a soft tissue flap combined with bridging plate for a repeated segmental mandibulectomy reconstruction on flap outcomes in head and neck cancer patients. A retrospective comparative analysis (2007-2016) of 61 patients who underwent a second s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44467-x
更新日期：2019-05-28 00:00:00
abstract：:Patients with type 1 diabetes have lower bone mineral density and higher risk of fractures. The role of osteoblasts in diabetes-related osteoporosis is well acknowledged whereas the role of osteoclasts (OCLs) is still unclear. We hypothesize that OCLs participate in pathological bone remodeling. We conducted studies i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30639
更新日期：2016-07-29 00:00:00
abstract：:A reliable method for the diagnosis of minimal cardiac ischemia would meet a strong demand for the sensitive diagnosis of coronary artery disease in cardiac stress testing and risk stratification in patients with chest pain but unremarkable ECGs and biomarkers. We hypothesized that platelets accumulate early on in isc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38161
更新日期：2016-12-02 00:00:00
abstract：:There is a well-established relationship between joint hypermobility and anxiety in humans, that has not previously been investigated in other species. A population of 5575 assistance dogs were scored for both hip hypermobility and 13 behaviour characteristics using previously validated methods. Our results suggest a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45096-0
更新日期：2019-06-13 00:00:00
abstract：:Estradiol derived from neural aromatization of testosterone plays a key role in the organization and activation of neural structures underlying male behaviors. This study evaluated the contribution of the estrogen receptor (ER) β in estradiol-induced modulation of social and mood-related behaviors by using mice lackin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63427-4
更新日期：2020-04-10 00:00:00
abstract：:NbP is a recently realized Weyl semimetal (WSM), hosting Weyl points through which conduction and valence bands cross linearly in the bulk and exotic Fermi arcs appear. The most intriguing transport phenomenon of a WSM is the chiral anomaly-induced negative magnetoresistance (NMR) in parallel electric and magnetic fie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43394
更新日期：2017-03-06 00:00:00
