Genome-wide identification of target genes for miR-204 and miR-211 identifies their proliferation stimulatory role in breast cancer cells.

abstract：:The rise of antibiotic resistance (AMR) is one of the most important public health threats worldwide.Today, increasing attention is being paid to multidrug resistant staphylococci isolated from healthcare and non-healthcare environments as the treatment of these bacteria has become increasingly difficult. In this stud...

journal_title：Scientific reports

authors： Cave R,Misra R,Chen J,Wang S,Mkrtchyan HV

更新日期：2019-08-01 00:00:00

abstract：:Photodynamic therapy is attracting increasing attention, but how to increase its tumor-specificity remains a daunting challenge. Herein we report a theranostic probe (azo-PDT) that integrates pyropheophorbide α as a photosensitizer and a NIR fluorophore for tumor imaging. The two functionalities are linked with a hypo...

journal_title：Scientific reports

authors： Wang C,Wang S,Wang Y,Wu H,Bao K,Sheng R,Li X

更新日期：2020-07-22 00:00:00

abstract：:State of the art clinical hand prostheses are controlled in a simple and limited way that allows the activation of one function at a time. More advanced laboratory approaches, based on machine learning, offer a significant increase in functionality, but their clinical impact is limited, mainly due to lack of reliabili...

journal_title：Scientific reports

authors： Hahne JM,Markovic M,Farina D

更新日期：2017-06-30 00:00:00

abstract：:To improve the understanding of the complex biological processes underlying the development of non-alcoholic steatohepatitis (NASH), a multi-omics approach combining bulk RNA-sequencing based transcriptomics, quantitative proteomics and single-cell RNA-sequencing was used to characterize tissue biopsies from histologi...

journal_title：Scientific reports

authors： Ægidius HM,Veidal SS,Feigh M,Hallenborg P,Puglia M,Pers TH,Vrang N,Jelsing J,Kornum BR,Blagoev B,Rigbolt KTG

更新日期：2020-01-24 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) are expected to be both a revolutionary cell source for regenerative medicine and a powerful tool to investigate the molecular mechanisms underlying human cell development in vitro. In the present study, we tried to elucidate the steroidogenic differentiation processes usi...

journal_title：Scientific reports

authors： Matsuo K,Sone M,Honda-Kohmo K,Toyohara T,Sonoyama T,Taura D,Kojima K,Fukuda Y,Ohno Y,Inoue M,Ohta A,Osafune K,Nakao K,Inagaki N

更新日期：2017-11-09 00:00:00

abstract：:Maternal overnutrition increases the risk of long-term metabolic dysfunction in offspring. Exercise improves metabolism partly by upregulating mitochondrial biogenesis or function, via increased levels of nicotinamide adenine dinucleotide (NAD+). We have shown that the NAD+ precursor, nicotinamide mononucleotide (NMN)...

journal_title：Scientific reports

authors： Uddin GM,Youngson NA,Doyle BM,Sinclair DA,Morris MJ

更新日期：2017-11-08 00:00:00

abstract：:Current saliva testing methods rely on cutting edge yet expensive techniques for the detection and analysis of genetic material, proteins and biomarkers for clinical use. However, these techniques are limited in scope and often cannot be used with complex food materials. We propose an efficient ex-vivo tool for evalua...

journal_title：Scientific reports

authors： Dinu V,Liu C,Ali J,Ayed C,Gershkovich P,Adams GG,Harding SE,Fisk ID

更新日期：2018-09-06 00:00:00

abstract：:Plasmonic nanostructures can significantly advance broadband visible-light absorption, with absorber thicknesses in the sub-wavelength regime, much thinner than conventional broadband coatings. Such absorbers have inherently very small heat capacity, hence a very rapid response time, and high light power-to-temperatur...

journal_title：Scientific reports

authors： Tagliabue G,Eghlidi H,Poulikakos D

更新日期：2014-11-24 00:00:00

abstract：:Parkinson's disease (PD) is an incapacitating neurodegenerative disease. Patients with PD and their caregivers may have interactive effects on each other's psychological well-being. This study aimed to assess the dyadic dynamics of resilience, fatigue, and suicidal ideation on the depression severity of PD patients an...

journal_title：Scientific reports

authors： Lee Y,Chiou YJ,Hung CF,Chang YY,Chen YF,Lin TK,Wang LJ

更新日期：2021-01-13 00:00:00

abstract：:Although affective and semantic word properties are known to independently influence our sensorimotor system, less is known about their interaction. We investigated this issue applying a data-driven mixed-effects regression approach, evaluating the impact of lexical-semantic properties on electrophysiological paramete...

journal_title：Scientific reports

authors： Vergallito A,Petilli MA,Cattaneo L,Marelli M

更新日期：2019-12-27 00:00:00

abstract：:Nanofluids using nanoencapsulated Phase Change Materials (nePCM) allow increments in both the thermal conductivity and heat capacity of the base fluid. Incremented heat capacity is produced by the melting enthalpy of the nanoparticles core. In this work two important advances in this nanofluid type are proposed and ex...

journal_title：Scientific reports

authors： Navarrete N,Gimeno-Furio A,Mondragon R,Hernandez L,Cabedo L,Cordoncillo E,Julia JE

更新日期：2017-12-14 00:00:00

abstract：:It has been reported that in patients with operable stage I non-small cell lung cancer (NSCLC), overall survival (OS) is better in those who undergo hypofractionated stereotactic radiation therapy (HSRT) than in those who undergo surgery. However, the reason that HSRT has a better OS has not been fully explored. Here,...

journal_title：Scientific reports

authors： Zhang T,Yu H,Ni C,Zhang T,Liu L,Lv Q,Zhang Z,Wang Z,Wu D,Wu P,Chen G,Wang L,Wei Q,Huang J,Wang X

更新日期：2017-07-07 00:00:00

abstract：:GLP-1 receptor agonists (GLP-1RA) and SGLT2 inhibitors (SGLT2i) have been associated with improved glycemic control, body weight loss and favorable changes in cardiovascular risk factors and outcomes. We conducted a systematic review and meta-analysis to evaluate the effects of the addition of GLP-1RA to SGLT2i in pat...

journal_title：Scientific reports

authors： Castellana M,Cignarelli A,Brescia F,Perrini S,Natalicchio A,Laviola L,Giorgino F

更新日期：2019-12-18 00:00:00

abstract：:Inosine-5'-monophosphate dehydrogenase (IMPDH) is an essential enzyme for nucleotide metabolism and cell proliferation. Despite IMPDH is the target of drugs with antiviral, immunosuppressive and antitumor activities, its physiological mechanisms of regulation remain largely unknown. Using the enzyme from the industria...

journal_title：Scientific reports

authors： Buey RM,Fernández-Justel D,Marcos-Alcalde Í,Winter G,Gómez-Puertas P,de Pereda JM,Luis Revuelta J

更新日期：2017-06-01 00:00:00

abstract：:A novel process for improving tar yield through catalytic depolymerization of a typical lignite was put forward. The catalytic depolymerization of the lignite over CoCl2 and ZnCl2 catalyst in different concentrations were investigated by a Gray-King apparatus. The optimal catalyst concentrations of CoCl2 and ZnCl2 cat...

journal_title：Scientific reports

authors： Liang L,Huai J,Zhang Q,Liu J,Huang W,Zhang Z,Hao X,Guan G

更新日期：2017-10-31 00:00:00

abstract：:Abiotic emergence of ordered information stored in the form of RNA is an important unresolved problem concerning the origin of life. A polymer longer than 40-100 nucleotides is necessary to expect a self-replicating activity, but the formation of such a long polymer having a correct nucleotide sequence by random react...

journal_title：Scientific reports

authors： Totani T

更新日期：2020-02-03 00:00:00

abstract：:Numerous studies have been conducted to examine the molecular mechanism of Haemophilus parasuis resistance to antibiotic, but rarely to tildipirosin. In the current study, transcriptional profiling was applied to analyse the variation in gene expression of JS0135 and tildipirosin-resistant JS32. The growth curves show...

journal_title：Scientific reports

authors： Lei Z,Fu S,Yang B,Liu Q,Ahmed S,Xu L,Xiong J,Cao J,Qiu Y

更新日期：2017-08-08 00:00:00

abstract：:Thioflavin T (ThT) is standardly used as a fluorescent marker to detect aggregation of amyloid fibrils by conventional fluorescence microscopy, including polarization resolved imaging that brings information on the orientational order of the fibrils. These techniques are however diffraction limited and cannot provide ...

journal_title：Scientific reports

authors： Shaban HA,Valades-Cruz CA,Savatier J,Brasselet S

更新日期：2017-10-02 00:00:00

abstract：:The mobilities of electrons and holes determine the applicability of any semiconductor, but their individual measurement remains a major challenge. Here, we show that time-resolved terahertz spectroscopy (TRTS) can distinguish the mobilities of minority and majority charge carriers independently of the doping-type and...

journal_title：Scientific reports

authors： Hempel H,Hages CJ,Eichberger R,Repins I,Unold T

更新日期：2018-09-27 00:00:00

abstract：:The number of osteoarthritis patients is increasing with the rise in the number of elderly people in developed countries. Osteoarthritis, which causes joint pain and deformity leading to loss of activities of daily living, is often treated surgically. Here we show that mechanical stress promotes accumulation of reacti...

journal_title：Scientific reports

authors： Kaneko Y,Tanigawa N,Sato Y,Kobayashi T,Nakamura S,Ito E,Soma T,Miyamoto K,Kobayashi S,Harato K,Matsumoto M,Nakamura M,Niki Y,Miyamoto T

更新日期：2019-12-10 00:00:00

abstract：:As the magnetic storage density increases in commercial products, e.g. the hard disc drives, a full understanding of dynamic magnetism in nanometer resolution underpins the development of next-generation products. Magnetic force microscopy (MFM) is well suited to exploring ferromagnetic domain structures. However, ato...

journal_title：Scientific reports

authors： Li Z,Li X,Dong D,Liu D,Saito H,Ishio S

更新日期：2014-07-11 00:00:00

abstract：:HUWE1 is a HECT domain containing ubiquitin ligase implicated in neurogenesis, spermatogenesis and cancer development. The purpose of the current study is to investigate the role of HUWE1 in early embryo development. Here we demonstrate that Huwe1 is expressed in both nucleus and cytoplasm of preimplantation mouse emb...

journal_title：Scientific reports

authors： Chen LJ,Xu WM,Yang M,Wang K,Chen Y,Huang XJ,Ma QH

更新日期：2016-11-30 00:00:00

abstract：:Animals are capable of using visual cues to find the correct route during navigation. These visual cues, which contain spatial information on the direction towards the goal point, are perceived either allocentrically or egocentrically. In this study, we examined how navigating with these two types of visual cues affec...

journal_title：Scientific reports

authors： Chun J,Kim Y,Choi JW,Kim D,Jo S

更新日期：2019-04-23 00:00:00

abstract：:Triassic archosaurs and stem-archosaurs show a remarkable disparity in their ankle and pelvis morphologies. However, the implications of these different morphologies for specific functions are still poorly understood. Here, we present the first quantitative analysis into the locomotor abilities of a stem-archosaur app...

journal_title：Scientific reports

authors： Demuth OE,Rayfield EJ,Hutchinson JR

更新日期：2020-09-21 00:00:00

abstract：:In this study we characterise three tandem promoters (PR1-1, PR1-2 and PR1-3) within the PR1 regulatory region of the Escherichia coli kps capsule gene cluster. Transcription from promoter PR1-2 was dependent on the activity of the upstream promoter PR1-1, which activated PR1-2 via transcription coupled DNA supercoili...

journal_title：Scientific reports

authors： Jia J,King JE,Goldrick MC,Aldawood E,Roberts IS

更新日期：2017-12-20 00:00:00

abstract：:Down syndrome (DS), caused by trisomy of chromosome 21, is one of the most common genetic disorders. Patients with DS display growth retardation and inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neurofibrillary tangles and neuritic plaques. The expression of amyloid precursor pro...

journal_title：Scientific reports

authors： Wu Y,Zhang S,Xu Q,Zou H,Zhou W,Cai F,Li T,Song W

更新日期：2016-03-03 00:00:00

abstract：:Leber congenital amaurosis (LCA) is a genetically and clinically heterogeneous disease, and represents the most severe form of inherited retinal dystrophy (IRD). The present study reports the mutation spectra and frequency of known LCA and IRD-associated genes in 34 Japanese families with LCA (including three families...

journal_title：Scientific reports

authors： Hosono K,Nishina S,Yokoi T,Katagiri S,Saitsu H,Kurata K,Miyamichi D,Hikoya A,Mizobuchi K,Nakano T,Minoshima S,Fukami M,Kondo H,Sato M,Hayashi T,Azuma N,Hotta Y

更新日期：2018-05-29 00:00:00

abstract：:Several cobalt-based Heusler alloys have been predicted to exhibit Weyl Semimetal behavior due to time reversal symmetry breaking. Co2TiGe is one of the predicted ferromagnetic Weyl semimetals. In this work, we report weak localization and small anomalous Hall conductivity in half-metallic Co2TiGe thin films grown by ...

journal_title：Scientific reports

authors： Dulal RP,Dahal BR,Forbes A,Bhattarai N,Pegg IL,Philip J

更新日期：2019-03-04 00:00:00

abstract：:Magnetotactic bacteria biomineralize ordered chains of uniform, membrane-bound magnetite or greigite nanocrystals that exhibit nearly perfect crystal structures and species-specific morphologies. Transmission electron microscopy (TEM) is a critical technique for providing information regarding the organization of cell...

journal_title：Scientific reports

authors： Woehl TJ,Kashyap S,Firlar E,Perez-Gonzalez T,Faivre D,Trubitsyn D,Bazylinski DA,Prozorov T

更新日期：2014-10-31 00:00:00

abstract：:Regulatory T-cells (Tregs) play a pivotal role in maintaining peripheral tolerance. Increasing Treg numbers/functions has been shown to ameliorate autoimmune diseases. However, common Treg expansion approaches use T-Cell Receptor (TCR)-mediated stimulation which also causes proliferation of effector T-cells (Teff). To...

journal_title：Scientific reports

authors： Kumar P,Alharshawi K,Bhattacharya P,Marinelarena A,Haddad C,Sun Z,Chiba S,Epstein AL,Prabhakar BS

更新日期：2017-01-03 00:00:00