Levels of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in raw wastewater as an innovative perspective for investigating population-wide exposure to third-hand smoke.

abstract：:Genome-wide studies on high-altitude adaptation have received increased attention as a classical case of organismal evolution under extreme environment. However, the current genetic understanding of high-altitude adaptation emanated mainly from autosomal analyses. Only a few earlier genomic studies paid attention to t...

journal_title：Scientific reports

authors： Wu H,Liu YH,Wang GD,Yang CT,Otecko NO,Liu F,Wu SF,Wang L,Yu L,Zhang YP

更新日期：2016-10-07 00:00:00

abstract：:Upper urinary tract urothelial carcinomas are usually managed by radical nephroureterectomy (RNU), often followed by intravesical chemotherapy to minimize recurrence. Open surgery is the gold standard procedure for RNU, but it associates with high morbidity, and it has been increasingly replaced by minimally invasive ...

journal_title：Scientific reports

authors： Oliveira C,Barros AA,Reis RL,Correia-Pinto J,Lima E

更新日期：2019-12-10 00:00:00

abstract：:The Klein tunneling of optical waves near the Dirac points in the metal-dielectric multilayer metamaterials is theoretically investigated and demonstrated through the coupled-mode theory under the tight-binding approximation and the rigorous band structure analysis based on the transfer-matrix method. The optical anal...

journal_title：Scientific reports

authors： Sun L,Gao J,Yang X

更新日期：2017-08-29 00:00:00

abstract：:The motion of a laser-heated Janus particle is experimentally measured under a rotating electric field. Directionally circular motions of the Janus particle following or countering the direction of the rotating electric field are observed in the low-frequency region (from 1 to 6 kHz) depending on the direction of elec...

journal_title：Scientific reports

authors： Chen YL,Yang CX,Jiang HR

更新日期：2018-04-13 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) exists in a complex desmoplastic microenvironment. As part of it, pancreatic stellate cells (PSCs) provide a fibrotic niche, stimulated by a dynamic communication between activated PSCs and tumour cells. Investigating how PSCs contribute to tumour development and for identifying...

journal_title：Scientific reports

authors： Marzoq AJ,Mustafa SA,Heidrich L,Hoheisel JD,Alhamdani MSS

更新日期：2019-03-28 00:00:00

abstract：:Kidney transplantations using expanded criteria donors (ECD) are being increasingly adopted, but no consensus tools are available to evaluate donor kidney status. Beta-2 microglobulin (B2MG) is a marker of kidney function, and herein, we evaluate the usefulness of assessing B2MG to evaluate donor kidney status. Fifty-...

journal_title：Scientific reports

authors： Cha SW,Shin IS,Kim DG,Kim SH,Lee JY,Kim JS,Yang JW,Han BG,Choi SO

更新日期：2020-05-15 00:00:00

abstract：:Urothelial carcinoma (UC) is a common disease causing significant morbidity and mortality as well as considerable costs for health systems. Extensive aberrant methylation of DNA is broadly documented in early UC, contributing to genetic instability, altered gene expression and tumor progression. However the triggers i...

journal_title：Scientific reports

authors： Erichsen L,Seifert HH,Schulz WA,Hoffmann MJ,Niegisch G,Araúzo-Bravo MJ,Bendhack ML,Poyet C,Hermanns T,Beermann A,Hassan M,Theis L,Mahmood W,Santourlidis S

更新日期：2020-03-02 00:00:00

abstract：:Echovirus 11 (E-11) is one of the most frequently isolated enteroviruses causing meningitis and other diseases such as hand, foot, and mouth disease (HFMD) and acute flaccid paralysis (AFP). Fifty-nine newly determined E-11 VP1 sequences from the China AFP and HFMD surveillance network and 500 E-11 VP1 sequences obtai...

journal_title：Scientific reports

authors： Li J,Yan D,Chen L,Zhang Y,Song Y,Zhu S,Ji T,Zhou W,Gan F,Wang X,Hong M,Guan L,Shi Y,Wu G,Xu W

更新日期：2019-07-22 00:00:00

abstract：:Oceanic archipelagos are the ideal setting for investigating processes that shape species assemblages. Focusing on keyhole limpets, genera Fissurella and Diodora from Cape Verde Islands, we used an integrative approach combining molecular phylogenetics with ocean transport simulations to infer species distribution pat...

journal_title：Scientific reports

authors： Cunha RL,Assis JM,Madeira C,Seabra R,Lima FP,Lopes EP,Williams ST,Castilho R

更新日期：2017-02-02 00:00:00

abstract：:The formation of proper sensory afferent connections during development is essential for brain function. Activity-based competition is believed to drive ocular dominance columns (ODC) in mammals and in experimentally-generated three-eyed frogs. ODC formation is thus a compromise of activity differences between two eye...

journal_title：Scientific reports

authors： Elliott KL,Houston DW,Fritzsch B

更新日期：2015-02-09 00:00:00

abstract：:Traumatic brain injury (TBI) increases the risk of Alzheimer's disease (AD). Calpain activation and tau hyperphosphorylation have been implicated in both TBI and AD. However, the link between calpain and tau phosphorylation has not been fully identified. We recently discovered that the two major calpain isoforms in th...

journal_title：Scientific reports

authors： Wang Y,Hall RA,Lee M,Kamgar-Parsi A,Bi X,Baudry M

更新日期：2017-09-18 00:00:00

abstract：:Integrin alpha-4 (ITGA4) is a validated therapeutic target for multiple sclerosis (MS) and Natalizumab, an antibody targeting ITGA4 is currently approved for treating MS. However, there are severe side effects related to this therapy. In this study, we report the development of a novel DNAzyme that can efficiently cle...

journal_title：Scientific reports

authors： Chakravarthy M,Aung-Htut MT,Le BT,Veedu RN

更新日期：2017-05-09 00:00:00

abstract：:The CRISPR/Cas9 system is a powerful method of editing genes by randomly introducing errors into the target sites. Here, we describe a CRISPR-based test for gene essentiality (CRISPR-E test) that allows the identification of essential genes. Specifically, we use sgRNA-mediated CRISPR/Cas9 to target the open reading fr...

journal_title：Scientific reports

authors： You Y,Ramachandra SG,Jin T

更新日期：2020-09-08 00:00:00

abstract：:We show that widely used approaches in statistical physics incorrectly indicate the existence of power-law cross-correlations between financial stock market fluctuations measured over several years and the neuronal activity of the human brain lasting for only a few minutes. While such cross-correlations are nonsensica...

journal_title：Scientific reports

authors： Blythe DA,Nikulin VV,Müller KR

更新日期：2016-06-02 00:00:00

abstract：:HUWE1 is a HECT domain containing ubiquitin ligase implicated in neurogenesis, spermatogenesis and cancer development. The purpose of the current study is to investigate the role of HUWE1 in early embryo development. Here we demonstrate that Huwe1 is expressed in both nucleus and cytoplasm of preimplantation mouse emb...

journal_title：Scientific reports

authors： Chen LJ,Xu WM,Yang M,Wang K,Chen Y,Huang XJ,Ma QH

更新日期：2016-11-30 00:00:00

abstract：:Diffusion tensor imaging (DTI) studies have detected white matter microstructural changes in essential tremor (ET). However, it is still unclear whether these changes are related to cognitive deficits, which have been described in ET patients. DTI-derived fractional anisotropy, mean diffusivity (MD), axial diffusivity...

journal_title：Scientific reports

authors： Benito-León J,Mato-Abad V,Louis ED,Hernández-Tamames JA,Álvarez-Linera J,Bermejo-Pareja F,Domingo-Santos Á,Collado L,Romero JP

更新日期：2017-06-07 00:00:00

abstract：:We aimed to investigate whether the newborns of mothers with maternal depression (MD) had lower vitamin D levels than newborns of non-MD (NMD) mothers and identify the potential mechanism underlying this association. Maternal depressive symptoms in late pregnancy and concentrations of cord blood 25 hydroxyvitamin D (2...

journal_title：Scientific reports

authors： Zhou QF,Zhang MX,Tong SL,Tao RX,Hao JH,Huang K,Tao FB,Zhu P

更新日期：2017-05-08 00:00:00

abstract：:Recently there has not been a systematic, objective assessment of the metabolic capabilities of the human platelet. A manually curated, functionally tested, and validated biochemical reaction network of platelet metabolism, iAT-PLT-636, was reconstructed using 33 proteomic datasets and 354 literature references. The n...

journal_title：Scientific reports

authors： Thomas A,Rahmanian S,Bordbar A,Palsson BØ,Jamshidi N

更新日期：2014-01-29 00:00:00

abstract：:In this paper, we prepared a novel structure to enhance the electroluminescence intensity from Si quantum dots/SiO2multilayers. An amorphous Si/SiO2 multilayer film was fabricated by plasma-enhanced chemical vapor deposition on a Pt nanoparticle (NP)-coated Si nanopillar array substrate. By thermal annealing, an embed...

journal_title：Scientific reports

authors： Li W,Wang S,Hu M,He S,Ge P,Wang J,Guo YY,Zhaowei L

更新日期：2015-07-03 00:00:00

abstract：:Thermodynamics is a branch of science blessed by an unparalleled combination of generality of scope and formal simplicity. Based on few natural assumptions together with the four laws, it sets the boundaries between possible and impossible in macroscopic aggregates of matter. This triggered groundbreaking achievements...

journal_title：Scientific reports

authors： Correa LA,Palao JP,Alonso D,Adesso G

更新日期：2014-02-04 00:00:00

abstract：:Microbial induced calcite precipitation (MICP) based on ureolysis has a high potential for many applications, e.g. restoration of construction materials. The gram-positive bacterium Sporosarcina pasteurii is the most commonly used microorganism for MICP due to its high ureolytic activity. However, Sporosarcina pasteur...

journal_title：Scientific reports

authors： Lapierre FM,Schmid J,Ederer B,Ihling N,Büchs J,Huber R

更新日期：2020-12-31 00:00:00

abstract：:The triboelectric nanogenerator (TENG) is a promising device in energy harvesting and self-powered sensing. In this work, we demonstrate a magnetic-assisted TENG, utilizing the magnetic force for electric generation. Maximum power density of 541.1 mW/m(2) is obtained at 16.67 MΩ for the triboelectric part, while the e...

journal_title：Scientific reports

authors： Han M,Zhang XS,Sun X,Meng B,Liu W,Zhang H

更新日期：2014-04-28 00:00:00

abstract：:While is widely acknowledged that nonmuscle myosin II (NMMII) enables stress fibers (SFs) to generate traction forces against the extracellular matrix, little is known about how specific NMMII isoforms and functional domains contribute to SF mechanics. Here we combine biophotonic and genetic approaches to address thes...

journal_title：Scientific reports

authors： Chang CW,Kumar S

更新日期：2015-09-04 00:00:00

abstract：:Bovine lactoferrin is a biglobular multifunctional iron binding glycoprotein that plays an important role in innate immunity against infections. We have previously demonstrated that selected peptides from bovine lactoferrin C-lobe are able to prevent both Influenza virus hemagglutination and cell infection. To deeper ...

journal_title：Scientific reports

authors： Scala MC,Sala M,Pietrantoni A,Spensiero A,Di Micco S,Agamennone M,Bertamino A,Novellino E,Bifulco G,Gomez-Monterrey IM,Superti F,Campiglia P

更新日期：2017-09-06 00:00:00

abstract：:Pathologic diagnoses mainly depend on visual scoring by pathologists, a process that can be time-consuming, laborious, and susceptible to inter- and/or intra-observer variations. This study proposes a novel method to enhance pathologic scoring of renal allograft rejection. A fully automated system using a convolutiona...

journal_title：Scientific reports

authors： Kim YG,Choi G,Go H,Cho Y,Lee H,Lee AR,Park B,Kim N

更新日期：2019-03-26 00:00:00

abstract：:T helper 17 (Th17) cells not only play critical roles in protecting against bacterial and fungal infections but are also involved in the pathogenesis of autoimmune diseases. The retinoic acid-related orphan receptor (RORγt) is a key transcription factor involved in Th17 cell differentiation through direct transcriptio...

journal_title：Scientific reports

authors： Wu Q,Nie J,Gao Y,Xu P,Sun Q,Yang J,Han L,Chen Z,Wang X,Lv L,Tsun A,Shen J,Li B

更新日期：2015-11-09 00:00:00

abstract：:The Mongol invasion of Eastern Europe, and especially its sudden withdrawal from Hungary in 1242 CE, has generated much speculation and an array of controversial theories. None of them, however, considered multifaceted environmental drivers and the coupled analysis of historical reports and natural archives. Here we i...

journal_title：Scientific reports

authors： Büntgen U,Di Cosmo N

更新日期：2016-05-26 00:00:00

abstract：:We investigated high-efficiency two-terminal tandem photovoltaic (PV) devices consisting of a p/i/n thin film silicon top sub-cell (p/i/n-TFS) and a heterojunction with an intrinsic thin-layer (HIT) bottom sub-cell. We used computer simulations and experimentation. The short-circuit current density (Jsc) of the top su...

journal_title：Scientific reports

authors： Park J,Dao VA,Kim S,Pham DP,Kim S,Le AHT,Kang J,Yi J

更新日期：2018-10-18 00:00:00

abstract：:Rapid diagnostic tests (RDTs) have been widely deployed in low-resource settings. These tests are typically read by visual inspection, and accurate record keeping and data aggregation remains a substantial challenge. A successful malaria elimination campaign will require new strategies that maximize the sensitivity of...

journal_title：Scientific reports

authors： Scherr TF,Gupta S,Wright DW,Haselton FR

更新日期：2016-06-27 00:00:00

abstract：:Secondary visual loss occurs in millions of patients due to a wound-healing response, known as posterior capsule opacification (PCO), following cataract surgery. An intraocular lens (IOL) is implanted into residual lens tissue, known as the capsular bag, following cataract removal. Standard IOLs allow the anterior and...

journal_title：Scientific reports

authors： Eldred JA,McDonald M,Wilkes HS,Spalton DJ,Wormstone IM

更新日期：2016-04-14 00:00:00