Novel Chemically-modified DNAzyme targeting Integrin alpha-4 RNA transcript as a potential molecule to reduce inflammation in multiple sclerosis.

abstract：:A simple, economically viable and fast method has been utilized for the preparation of highly active metal nanoparticles (MNPs) in coating layer of chitosan (CH) over cellulose microfibers of cotton cloth (CC). 2 wt% of CH solution was used for the coating of CC strips (CC-CH), and were kept in aqueous solutions of me...

journal_title：Scientific reports

authors： Ali F,Khan SB,Kamal T,Alamry KA,Asiri AM,Sobahi TRA

更新日期：2017-12-05 00:00:00

abstract：:The mitochondrial genome almost exclusively encodes a handful of transmembrane constituents of the oxidative phosphorylation (OXPHOS) system. Coordinated expression of these genes ensures the correct stoichiometry of the system's components. Translation initiation in mitochondria is assisted by two general initiation ...

journal_title：Scientific reports

authors： Kuzmenko A,Derbikova K,Salvatori R,Tankov S,Atkinson GC,Tenson T,Ott M,Kamenski P,Hauryliuk V

更新日期：2016-01-05 00:00:00

abstract：:There is lack of consensus regarding the prognostic significance of primary tumor location of upper tract urothelial carcinoma(UTUC). We performed a meta-analysis to evaluate the impact of primary tumor location on prognosis in patients with UTUC who had undergone radical nephroureterectomy(RNU). We included eligible ...

journal_title：Scientific reports

authors： Wu Y,Dong Q,Liu L,Han P,Wei Q

更新日期：2014-09-15 00:00:00

abstract：:Anti-cytokine therapeutic antibodies have been demonstrated to be effective in the treatment of several auto-immune disorders. However, The problems in antibody manufacture and the immunogenicity caused by multiple doses of antibodies inspire people to use auto-cytokine as immunogen to induce anti-cytokine antibodies....

journal_title：Scientific reports

authors： Liu C,Zhao Y,He W,Wang W,Chen Y,Zhang S,Ma Y,Gohda J,Ishida T,Walter TS,Owens RJ,Stuart DI,Ren J,Gao B

更新日期：2015-09-28 00:00:00

abstract：:Transcriptional enhancers are non-coding segments of DNA that play a central role in the spatiotemporal regulation of gene expression programs. However, systematically and precisely predicting enhancers remain a major challenge. Although existing methods have achieved some success in enhancer prediction, they still su...

journal_title：Scientific reports

authors： Liu F,Li H,Ren C,Bo X,Shu W

更新日期：2016-06-22 00:00:00

abstract：:Optical antennas can be used to manipulate the direction and polarization of radiation from an emitter. Usually, these metallic nanostructures utilize localized plasmon resonances to generate highly directional and strongly polarized emission, which is determined predominantly by the antenna geometry alone, and is thu...

journal_title：Scientific reports

authors： Ghimire A,Shafran E,Gerton JM

更新日期：2014-09-24 00:00:00

abstract：:Spreading rumors on the Internet has become increasingly pervasive due to the proliferation of online social media. This paper investigates how rumors are amplified by a group of users who share similar interests or views, dubbed as an echo chamber. To this end, we identify and analyze 'rumor' echo chambers, each of w...

journal_title：Scientific reports

authors： Choi D,Chun S,Oh H,Han J,Kwon TT

更新日期：2020-01-15 00:00:00

abstract：:Three H10 subtype avian influenza viruses were isolated from domestic ducks in China, designated as SH602/H10N8, FJ1761/H10N3 and SX3180/H10N7, with an intravenous pathogenicity index (IVPI) of 0.39, 1.60, and 1.27, respectively. These H10 viruses showed a complex pathology pattern in different species, although full ...

journal_title：Scientific reports

authors： Zhang M,Zhang X,Xu K,Teng Q,Liu Q,Li X,Yang J,Xu J,Chen H,Zhang X,Li Z

更新日期：2016-09-28 00:00:00

abstract：:Clinical studies have suggested association of some hepatitis C virus (HCV) subtypes or isolates with progression toward hepatocellular carcinoma (HCC). HCV core protein has been reported to interfere with host Wnt/β-catenin pathway, a cell fate-determining pathway, which plays a major role in HCC. Here, we investigat...

journal_title：Scientific reports

authors： Aicher S,Kakkanas A,Cohen L,Blumen B,Oprisan G,Njouom R,Meurs EF,Mavromara P,Martin A

更新日期：2018-07-25 00:00:00

abstract：:ING2 (inhibitor of growth family member 2) is a component of a chromatin-regulatory complex that represses gene expression and is implicated in cellular processes that promote tumor suppression. However, few direct genomic targets of ING2 have been identified and the mechanism(s) by which ING2 selectively regulates ge...

journal_title：Scientific reports

authors： Bua DJ,Martin GM,Binda O,Gozani O

更新日期：2013-01-01 00:00:00

abstract：:Detection of visible blind UV radiation is not only interesting but also of technologically important. Herein, we demonstrate the efficient detection of UV radiation by using cluster like ZnS quantum dot solid nanostructures prepared by simple reflux condensation technique. The short-chain ligand 3-mercaptopropionic a...

journal_title：Scientific reports

authors： Premkumar S,Nataraj D,Bharathi G,Ramya S,Thangadurai TD

更新日期：2019-12-10 00:00:00

abstract：:Treatment of azo dye effluents has received increasing concerns over the years due to their potential harms to natural environment and human health. The present study described the degrading ability of the as-synthesized crystalline Al-Cu alloys for removal of high-concentration Acid Scarlet 3R in alkaline aqueous sol...

journal_title：Scientific reports

authors： Zhang L,Gao X,Zhang Z,Zhang M,Cheng Y,Su J

更新日期：2016-08-18 00:00:00

abstract：:In vivo, bone morphogenetic protein 2 (BMP-2) exists both in solution and bound to the extracellular matrix (ECM). While these two modes of presentation are known to influence cell behavior distinctly, their role in the niche microenvironment and their functional relevance in the genesis of a biological response has s...

journal_title：Scientific reports

authors： Fitzpatrick V,Fourel L,Destaing O,Gilde F,Albigès-Rizo C,Picart C,Boudou T

更新日期：2017-01-30 00:00:00

abstract：:The pace of two-dimensional materials (2DM) research has been greatly accelerated by the ability to identify exfoliated thicknesses down to a monolayer from their optical contrast. Since this process requires time-consuming and error-prone manual assignment to avoid false-positives from image features with similar con...

journal_title：Scientific reports

authors： Jessen BS,Whelan PR,Mackenzie DMA,Luo B,Thomsen JD,Gammelgaard L,Booth TJ,Bøggild P

更新日期：2018-04-23 00:00:00

abstract：:A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Garcia E,Hayden A,Birts C,Britton E,Rogerson C,Bleaney CW,Cowie A,Pickard K,Mellone M,Choh C,Derouet M,Duriez P,Noble F,White MJ,Primrose JN,Strefford JC,Rose-Zerilli M,Thomas GJ,Ang Y,Sharrocks AD,Fitzgerald RC,

更新日期：2019-01-22 00:00:00

abstract：:The CoCrMo matrix composites with nano-TiO2 particle (2 wt.%, 4 wt.% and 6 wt.%) were fabricated by using a powder metallurgy technique (P/M), and the nano-TiO2 content was optimized in matrix. The microstructures, mechanical and high-temperature tribological properties of the synthesized composites were systematicall...

journal_title：Scientific reports

authors： Cui G,Liu Y,Li S,Liu H,Gao G,Kou Z

更新日期：2020-04-22 00:00:00

abstract：:Sauropodomorpha were herbivorous saurischian dinosaurs that incorporate Sauropoda and early-diverging sauropodomorphs. The oldest sauropodomorph remains are known from Late Triassic deposits, most of them Gondwanan. The Laurasian record comprises some Triassic forms, but the bulk is Jurassic in age. Among the 14 Juras...

journal_title：Scientific reports

authors： Peyre de Fabrègues C,Bi S,Li H,Li G,Yang L,Xu X

更新日期：2020-07-03 00:00:00

abstract：:Recombinant human erythropoietin (rHuEPO) is a biopharmaceutical drug given to patients who have a low hemoglobin related to chronic kidney disease, cancer or anemia. However, some patients repeatedly receiving rHuEPO develop anti-rHuEPO neutralizing antibodies leading to the development of pure red cell aplasia (PRCA...

journal_title：Scientific reports

authors： Susantad T,Fuangthong M,Tharakaraman K,Tit-Oon P,Ruchirawat M,Sasisekharan R

更新日期：2021-01-15 00:00:00

abstract：:Genome-wide experiments to map the DNA-binding locations of transcription-associated factors (TFs) have shown that the number of genes bound by a TF far exceeds the number of possible direct target genes. Distinguishing functional from non-functional binding is therefore a major challenge in the study of transcription...

journal_title：Scientific reports

authors： Banks CJ,Joshi A,Michoel T

更新日期：2016-02-09 00:00:00

abstract：:Aberrant methylated genes (DMGs) play an important role in the etiology and pathogenesis of esophageal squamous cell carcinoma (ESCC). In this study, we aimed to integrate three cohorts profile datasets to ascertain aberrant methylated-differentially expressed genes and pathways associated with ESCC by comprehensive b...

journal_title：Scientific reports

authors： Han BA,Yang XP,Hosseini DK,Zhang P,Zhang Y,Yu JT,Chen S,Zhang F,Zhou T,Sun HY

更新日期：2020-06-16 00:00:00

abstract：:Biomodels made of poly(vinyl alcohol) (PVA) are demanded because they can represent the geometries and mechanical properties of human tissues realistically. Injecting and molding, commonly used in three-dimensional (3D) modeling, help to represent the blood vessels accurately. However, these techniques sometimes requi...

journal_title：Scientific reports

authors： Shimizu Y,Tanabe T,Yoshida H,Kasuya M,Matsunaga T,Haga Y,Kurihara K,Ohta M

更新日期：2018-11-08 00:00:00

abstract：:Although cholecystectomy has been reported to be associated with increased risk of developing hepatocellular carcinoma (HCC), the association between cholecystectomy and prognosis of HCC patients underwent curative resection has never been examined. Through retrospective analysis of the data of 3933 patients underwent...

journal_title：Scientific reports

authors： Li T,Wang SK,Zhi XT,Zhou J,Dong ZR,Zhang ZL,Sun HC,Ye QH,Fan J

更新日期：2016-06-20 00:00:00

abstract：:Substance P (SP) has been implicated in major depressive disorder (MDD), with SP antagonists being studied as potential antidepressants. Although impaired neural plasticity is considered a key mechanism in MDD pathophysiology, the association between SP and brain structural changes in depression has not been investiga...

journal_title：Scientific reports

authors： Won E,Kang J,Choi S,Kim A,Han KM,Yoon HK,Cho SH,Tae WS,Lee MS,Joe SH,Kim YK,Ham BJ

更新日期：2017-08-29 00:00:00

abstract：:Rapid facial mimicry (RFM) is an automatic response, in which individuals mimic others' expressions. RFM, only demonstrated in humans and apes, is grounded in the automatic perception-action coupling of sensorimotor information occurring in the mirror neuron system. In humans, RFM seems to reflect the capacity of indi...

journal_title：Scientific reports

authors： Mancini G,Ferrari PF,Palagi E

更新日期：2013-01-01 00:00:00

abstract：:The phosphatidylinositol (PI) cycle is central to eukaryotic cell signaling. Its complexity, due to the number of reactions and lipid and inositol phosphate intermediates involved makes it difficult to analyze experimentally. Computational modelling approaches are seen as a way forward to elucidate complex biological ...

journal_title：Scientific reports

authors： Mazet F,Tindall MJ,Gibbins JM,Fry MJ

更新日期：2020-08-06 00:00:00

abstract：:Transcriptome expression reflects genetic response in diverse conditions. In this study, RNA sequencing was utilized to profile multiple tissues such as liver, breast, caecum, and gizzard of Korean commercial chicken raised in Korea and Kyrgyzstan. We analyzed ten samples per tissue from each location to identify cand...

journal_title：Scientific reports

authors： Kumar H,Choo H,Iskender AU,Srikanth K,Kim H,Zhunushov AT,Jang GW,Lim Y,Song KD,Park JE

更新日期：2020-11-06 00:00:00

abstract：:Recently, a large number of long noncoding RNAs (lncRNAs) have emerged as important regulators of many biological processes in animals and plants. However, how lncRNAs function during plant DNA virus infection is largely unknown. We performed strand-specific paired-end RNA sequencing of tomato samples infected with To...

journal_title：Scientific reports

authors： Wang J,Yu W,Yang Y,Li X,Chen T,Liu T,Ma N,Yang X,Liu R,Zhang B

更新日期：2015-12-18 00:00:00

abstract：:On-surface synthesis provides a route for the production of 1D and 2D covalently bonded polymeric structures. Such reactions are confined to the surface of a substrate and the catalytic properties of the substrate are often utilised to initiate the reaction. Recent studies have focused on the properties of various cry...

journal_title：Scientific reports

authors： Judd CJ,Kondratuk DV,Anderson HL,Saywell A

更新日期：2019-06-27 00:00:00

abstract：:Several epidemiological studies have found a positive association between diabetic retinopathy (DR) and subclinical hypothyroidism (SCH), but the findings are varied or even contradictory. In the work, we performed a meta-analysis to ascertain the relationship between DR and SCH. We searched relevant studies on the re...

journal_title：Scientific reports

authors： Wu J,Yue S,Geng J,Liu L,Teng W,Liu L,Chen L

更新日期：2015-07-20 00:00:00

abstract：:Heavy metal contamination in water causes severe adverse effects on human health. Millions of tons of kernel shell are produced as waste from oil palm plantation every year. In this study, palm oil kernel shell (PKS), an agricultural waste is utilized as effective adsorbent for the removal of heavy metals, namely; Cr6...

journal_title：Scientific reports

authors： Baby R,Saifullah B,Hussein MZ

更新日期：2019-12-12 00:00:00