Abstract：
:The molecular mechanisms underlying viral pathogenesis are yet poorly understood owed to the large number of factors involved and the complexity of their interactions. Could we identify a minimal set of host transcription factors (TF) whose misregulation would result in the transcriptional profile characteristic of infected cells in absence of the virus? How many of such sets exist? Are all orthogonal or share critical TFs involved in specific biological functions? We have developed a computational methodology that uses a quantitative model of the transcriptional regulatory network (TRN) of Arabidopsis thaliana to explore the landscape of all possible re-engineered TRNs whose transcriptomic profiles mimic those observed in infected plants. We found core sets containing between six and 34 TFs, depending on the virus, whose in silico knockout or overexpression in the TRN resulted in transcriptional profiles that minimally deviate from those observed in infected plants.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Carrera J,Elena SFdoi
10.1038/srep01006subject
Has Abstractpub_date
2012-01-01 00:00:00pages
1006issn
2045-2322journal_volume
2pub_type
杂志文章abstract：:Chicken anemia virus (CAV) is an important pathogen that causes severe immunosuppression in young chickens. We have characterized 13 CAVs isolated from different commercial farms in southern China between 2011 and 2012. We discovered 92 variable residues compared to 37 other CAV complete genome sequences from other pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03519
更新日期：2013-12-17 00:00:00
abstract：:The incidence of cancer in the United Kingdom has increased significantly over the last four decades. The aim of this study was to examine trends in UK cancer incidence and mortality by cancer site and assess the potential for overdiagnosis. Using Cancer Research UK incidence and mortality data for the period (1971-20...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32844-x
更新日期：2018-10-02 00:00:00
abstract：:The protein encoded by the TERMINAL FLOWER1 (TFL1) gene maintains indeterminacy in inflorescence meristem to repress flowering, and has undergone multiple duplications. However, basal angiosperms have one copy of a TFL1-like gene, which clusters with eudicot TFL1/CEN paralogs. Functional conservation has been reported...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13645-0
更新日期：2017-11-01 00:00:00
abstract：:Development of quantitative analysis software has enabled application of several standardised uptake values (SUV) for bone analysis in single photon emission computed tomography (SPECT). The present retrospective study aimed to develop a reliable method of monitoring bone inflammatory activity in antiresorptive agent-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68428-x
更新日期：2020-07-09 00:00:00
abstract：:Nedd4-2 (NEDD4L in humans) is a ubiquitin protein ligase best known for its role in regulating ion channel internalization and turnover. Nedd4-2 deletion in mice causes perinatal lethality associated with increased epithelial sodium channel (ENaC) expression in lung and kidney. Abundant data suggest that Nedd4-2 plays...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32957
更新日期：2016-09-08 00:00:00
abstract：:Shoulder problems are common in patients with a cervical herniated intervertebral disc (HIVD). This study aimed to explore the incidence and risk of shoulder capsulitis/tendonitis following cervical HIVD surgery. We used data from the Taiwan "Longitudinal Health Insurance Database". We identified all patients who were...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26898
更新日期：2016-05-27 00:00:00
abstract：:Our study focused on radiocaesium (137Cs) partitioning in forests, three vegetation periods after the Fukushima Daiichi nuclear power plant accident. 137Cs distribution in forest components (organic and mineral soil layers as well as tree compartments: stem, bark, needles, branches and roots) was measured for two Japa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37618
更新日期：2016-11-23 00:00:00
abstract：:Camouflage has been a textbook example of natural selection and adaptation since the time of the earliest evolutionists. However, aside from correlational evidence and studies using artificial dummy prey, experiments directly showing that better camouflaged prey to predator vision are at reduced risk of attack are lac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34470-z
更新日期：2018-10-30 00:00:00
abstract：:Genome-wide studies on high-altitude adaptation have received increased attention as a classical case of organismal evolution under extreme environment. However, the current genetic understanding of high-altitude adaptation emanated mainly from autosomal analyses. Only a few earlier genomic studies paid attention to t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35004
更新日期：2016-10-07 00:00:00
abstract：:Autophagy is the major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in the vacuole/lysosome in eukaryotic cells. MoAtg14 in M. oryzae, a hitherto uncharacterized protein, is the highly divergent homolog of the yeast Atg14 and the mammal BARKOR. The MoATG14 deletion muta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40018
更新日期：2017-01-09 00:00:00
abstract：:The heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is considered as a human carcinogenic or mutagenic compound that is produced from the co-condensation of creatinine and amino acids as meats cook at high temperatures. The cooking of meats at high temperatures produces fumes, and these fumes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11502-8
更新日期：2017-09-07 00:00:00
abstract：:Urbanization is associated with dramatic increases in noise and light pollution, which affect animal behaviour, physiology and fitness. However, few studies have examined these stressors simultaneously. Moreover, effects of urbanization during early-life may be detrimental but are largely unknown. In developing great ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02940-5
更新日期：2017-06-05 00:00:00
abstract：:There is increasing interest in applications which use the 30 to 90 GHz frequency range, including automotive radar, 5 G cellular networks and wireless local area links. This study investigated pulsed 30-90 GHz radiation penetration into the human ear canal and tympanic membrane using computational phantoms. Modelling...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58091-7
更新日期：2020-01-30 00:00:00
abstract：:While neurofilament light chain (NfL) measurement in serum is a well-established marker of neuroaxonal damage in multiple sclerosis (MS), data on astroglial markers in serum are missing. In our study, glial fibrillary acid protein (GFAP) and NfL were measured in cerebrospinal fluid (CSF) and serum of MS patients and p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33158-8
更新日期：2018-10-04 00:00:00
abstract：:Studies of past human-landscape interactions rely upon the integration of archaeological, biological and geological information within their geographical context. However, detecting the often ephemeral traces of human activities at a landscape scale remains difficult with conventional archaeological field survey. Geop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01517
更新日期：2013-01-01 00:00:00
abstract：:Hormones are an important component in the regulatory networks guiding plant development. Cytokinins are involved in different physiological and developmental processes in plants. In the model plant Arabidopsis thaliana, cytokinin application during gynoecium development produces conspicuous phenotypes. On the other h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25017-3
更新日期：2018-05-01 00:00:00
abstract：:The cell adhesion molecule Cadherin 2 (Cdh2) plays important roles in somatic cell adhesion, proliferation and migration. Cdh2 is also highly expressed in mouse epiblast stem cells (mEpiSCs), but its function in these cells is unknown. To understand the function of Cdh2 in mEpiSCs, we compared the expression of plurip...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14722
更新日期：2015-09-30 00:00:00
abstract：:High Resolution Melt (HRM) is a versatile and rapid post-PCR DNA analysis technique primarily used to differentiate sequence variants among only a few short amplicons. We recently developed a one-vs-one support vector machine algorithm (OVO SVM) that enables the use of HRM for identifying numerous short amplicon seque...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19218
更新日期：2016-01-18 00:00:00
abstract：:Familial hypercholesterolemia (FH) is an inherited disease of lipoprotein metabolism caused by a defect in the LDL receptor (LDLR) leading to severe hypercholesterolemia, and associated with an increased risk of coronary heart disease and myocardial infarction. We have developed a gene therapy protocol for FH using AA...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43459-1
更新日期：2019-05-06 00:00:00
abstract：:Memristive systems have gained considerable attention in the field of neuromorphic engineering, because they allow the emulation of synaptic functionality in solid state nano-physical systems. In this study, we show that memristive behavior provides a broad working framework for the phenomenological modelling of cellu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27616-6
更新日期：2018-06-19 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep30212. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/srep46831
更新日期：2017-05-26 00:00:00
abstract：:The oral microflora is composed of both health-promoting as well as disease-initiating bacteria. Many of the disease-initiating bacteria are anaerobic and include organisms such as Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, and Tannerella forsythia. Here we investigated a novel therapeut...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09616-0
更新日期：2017-09-05 00:00:00
abstract：:Enzymatic gold nanoparticles (B-GNPs) have been synthesized using a natural anticancer agent bromelain (a cysteine protease) and these nanoparticles were used to bioconjugate Cisplatin (highly effective against osteosarcoma and lung cancer). Cisplatin bioconjugated bromelain encapsulated gold nanoparticles (B-C-GNPs) ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50215-y
更新日期：2019-09-25 00:00:00
abstract：:Plant chloroplasts proliferate through binary fission, and the stromal-side molecules that are involved in chloroplast division are bacterial derivatives. As in bacteria, the prokaryotic tubulin homolog FtsZ assembles into a ring-like structure (Z ring) at mid-chloroplast, and this process is followed by constriction....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03698-6
更新日期：2017-06-14 00:00:00
abstract：:The accurate calculation of decimal fractions is still a challenge for the binary-coded computations that rely on von Neumann paradigm. Here, we report a kind of memristive abacus based on synaptic Ag-Ge-Se device, in which the memristive long-term potentiation and depression are caused by a chemically driven phase tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01230
更新日期：2013-01-01 00:00:00
abstract：:The melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by neurons in the lateral hypothalamus and zona incerta. MCHergic neurons project throughout the central nervous system, indicating the involvements of many physiological functions, but the role in pain has yet to be determined. In thi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19145-z
更新日期：2018-01-15 00:00:00
abstract：:Hydrogen sulfide (H2S) is involved in cancer biological processes. However, there are several controversies concerning the role of H2S in cancer development and progression. In this study, we found that the growth and migration of hepatocellular carcinoma (HCC) cells were enhanced by 10-100 μM NaHS and dose-dependentl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05457-z
更新日期：2017-07-11 00:00:00
abstract：:We present a new collusion attack to a kind of quantum secret sharing schemes with entangled states. Using this attack, an unauthorized set of agents can gain access to the shared secret without the others' cooperation. Furthermore, we establish a general model for this kind of quantum secret sharing schemes and then ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02543-0
更新日期：2017-05-30 00:00:00
abstract：:Delay embedding-a method for reconstructing dynamical systems by delay coordinates-is widely used to forecast nonlinear time series as a model-free approach. When multivariate time series are observed, several existing frameworks can be applied to yield a single forecast combining multiple forecasts derived from vario...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57255-4
更新日期：2020-01-20 00:00:00
abstract：:Liquid extraction surface analysis mass spectrometry imaging (LESA-MSI) has been shown to be an effective tissue profiling and imaging technique, producing robust and reliable qualitative distribution images of an analyte or analytes in tissue sections. Here, we expand the use of LESA-MSI beyond qualitative analysis t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37648
更新日期：2016-11-24 00:00:00
