当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Hydrogen sulfide acts as a double-edged sword in human hepatocellular carcinoma cells through EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways.

Hydrogen sulfide acts as a double-edged sword in human hepatocellular carcinoma cells through EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways.

Abstract：

:Hydrogen sulfide (H2S) is involved in cancer biological processes. However, there are several controversies concerning the role of H2S in cancer development and progression. In this study, we found that the growth and migration of hepatocellular carcinoma (HCC) cells were enhanced by 10-100 μM NaHS and dose-dependently inhibited by 600-1000 μM NaHS. The apoptotic levels were reduced by 25-100 μM NaHS but increased by 400-1000 μM NaHS in HCC cells. After treatment with 25-50 μM NaHS, the protein levels of p-EGFR, p-ERK, MMP-2, and p-AKT were increased, whereas the levels of PTEN and the ratio of BAX/BCL-2 were down-regulated. Administration of 800-1000 μM NaHS showed opposite effects on these protein levels in HCC cells. However, H2S showed no effects on the growth, migration, apoptosis, and the protein levels of the EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways in L02 cells. Furthermore, 25-100 μM NaHS promoted HCC tumor growth and blood vessel formation, while 800-1000 μM NaHS inhibited angiogenesis and tumor growth with no obvious systemic toxicity. These results indicate that H2S acts as a double-edged sword in HCC cells through EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways. Novel H2S donors could be designed and applied for further antitumor research.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wu D,Li M,Tian W,Wang S,Cui L,Li H,Wang H,Ji A,Li Y

doi

10.1038/s41598-017-05457-z

subject

Has Abstract

pub_date

2017-07-11 00:00:00

pages

5134

issue

1

issn

2045-2322

pii

10.1038/s41598-017-05457-z

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Assessing fatty acid oxidation flux in rodent cardiomyocyte models.

    abstract：:The healthy adult heart primarily relies on fatty acid oxidation (FAO) for energy production but instantaneously adapts its substrate preference in response to physiological or pathological challenges. Accurate FAO measurements are crucial to investigate early metabolic (mal)adaptations. While measurements in intact c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19478-9

    authors： Rech M,Luiken JJFP,Glatz JFC,van Bilsen M,Schroen B,Nabben M

    更新日期：2018-01-24 00:00:00

  • Measurement of collateral perfusion in acute stroke: a vessel-encoded arterial spin labeling study.

    abstract：:Collateral perfusion is important for sustaining tissue viability in acute ischemic stroke. Conventional techniques for its visualization are invasive, require contrast agents and demonstrate collateral vessels, rather than measuring perfusion directly. In this study we utilize a non-invasive, non-contrast magnetic re...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44417-7

    authors： Okell TW,Harston GWJ,Chappell MA,Sheerin F,Kennedy J,Jezzard P

    更新日期：2019-06-03 00:00:00

  • Controllable design of super-oscillatory lenses with multiple sub-diffraction-limit foci.

    abstract：:The conventional multifocal optical elements cannot precisely control the focal number, spot size, as well as the energy distribution in between. Here, the binary amplitude-type super-oscillatory lens (SOL) is utilized, and a robust and universal optimization method based on the vectorial angular spectrum (VAS) theory...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01492-y

    authors： Li M,Li W,Li H,Zhu Y,Yu Y

    更新日期：2017-05-02 00:00:00

  • An orientation measurement method based on Hall-effect sensors for permanent magnet spherical actuators with 3D magnet array.

    abstract：:An orientation measurement method based on Hall-effect sensors is proposed for permanent magnet (PM) spherical actuators with three-dimensional (3D) magnet array. As there is no contact between the measurement system and the rotor, this method could effectively avoid friction torque and additional inertial moment exis...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06756

    authors： Yan L,Zhu B,Jiao Z,Chen CY,Chen IM

    更新日期：2014-10-24 00:00:00

  • The First 250 ms of Auditory Processing: No Evidence of Early Processing Negativity in the Go/NoGo Task.

    abstract：:Past evidence of an early Processing Negativity in auditory Go/NoGo event-related potential (ERP) data suggests that young adults proactively process sensory information in two-choice tasks. This study aimed to clarify the occurrence of Go/NoGo Processing Negativity and investigate the ERP component series related to ...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-020-61060-9

    authors： Fogarty JS,Barry RJ,Steiner GZ

    更新日期：2020-03-04 00:00:00

  • Transfer of a bla CTX-M-1-carrying plasmid between different Escherichia coli strains within the human gut explored by whole genome sequencing analyses.

    abstract：:Horizontal transfer of antibiotic resistance determinants contributes to dissemination of antibiotic resistance. Such transfer of resistance genes within the human gut has been documented in some in vivo studies. The present study investigated seven bla CTX-M-1-carrying Escherichia coli isolates from three consecutive...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18659-2

    authors： Knudsen PK,Gammelsrud KW,Alfsnes K,Steinbakk M,Abrahamsen TG,Müller F,Bohlin J

    更新日期：2018-01-10 00:00:00

  • A meta-analysis of the efficacy of HAART on HIV transmission and its impact on sexual risk behaviours among men who have sex with men.

    abstract：:Evidence showed preventive impacts of the highly active antiretroviral therapy (HAART) on the Human Immunodeficiency Virus (HIV) transmission amomg heterosexual population, however, that is of deficit among men who have sex with men (MSM). The aim was to systematically examine the efficacy of HAART on HIV transmission...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41598-019-56530-8

    authors： Jiang Y,Su S,Borné Y

    更新日期：2020-01-23 00:00:00

  • Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox.

    abstract：:Interleukin (IL)-27, a member of the IL-12 cytokine family, plays an important and diverse role in the function of the immune system. We have previously demonstrated that IL-27 is an anti-viral cytokine which inhibits HIV-1, HIV-2, Influenza virus and herpes simplex virus infection, and enhances the potential of react...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43441

    authors： Sowrirajan B,Saito Y,Poudyal D,Chen Q,Sui H,DeRavin SS,Imamichi H,Sato T,Kuhns DB,Noguchi N,Malech HL,Lane HC,Imamichi T

    更新日期：2017-02-27 00:00:00

  • GreedyPlus: An Algorithm for the Alignment of Interface Interaction Networks.

    abstract：:The increasing ease and accuracy of protein-protein interaction detection has resulted in the ability to map the interactomes of multiple species. We now have an opportunity to compare species to better understand how interactomes evolve. As DNA and protein sequence alignment algorithms were required for comparative g...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12074

    authors： Law B,Bader GD

    更新日期：2015-07-13 00:00:00

  • Lithospheric folding by flexural slip in subduction zones as source for reverse fault intraslab earthquakes.

    abstract：:Subduction requires the permanent generation of a bend fold in the subducting slab which mechanics is not well understood. Lithospheric bending of subducting slabs was traditionally considered to be accommodated by orthogonal flexure, generating extensional outer rise earthquakes responsible of the external arc elonga...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19682-7

    authors： Romeo I,Álvarez-Gómez JA

    更新日期：2018-01-22 00:00:00

  • Individual differences in the attentional modulation of the human auditory brainstem response to speech inform on speech-in-noise deficits.

    abstract：:People with normal hearing thresholds can nonetheless have difficulty with understanding speech in noisy backgrounds. The origins of such supra-threshold hearing deficits remain largely unclear. Previously we showed that the auditory brainstem response to running speech is modulated by selective attention, evidencing ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-50773-1

    authors： Saiz-Alía M,Forte AE,Reichenbach T

    更新日期：2019-10-01 00:00:00

  • The first two cell-fate decisions of preimplantation mouse embryo development are not functionally independent.

    abstract：:During mouse preimplantation embryo development, three distinct cell lineages are formed, represented by the differentiating trophectoderm (TE), primitive endoderm (PrE) and the pluripotent epiblast (EPI). Classically, lineage derivation has been presented as a two-step process whereby outer TE cells are first segrega...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep15034

    authors： Mihajlović AI,Thamodaran V,Bruce AW

    更新日期：2015-10-13 00:00:00

  • A Fast and Sensitive Luciferase-based Assay for Antibody Engineering and Design of Chimeric Antigen Receptors.

    abstract：:Success of immunotherapeutic approaches using genetically engineered antibodies and T cells modified with chimeric antigen receptors (CARs) depends, among other things, on the selection of antigen binding domains with desirable expression and binding characteristics. We developed a luciferase-based assay, termed Malib...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59099-9

    authors： Natarajan V,Gopalakrishnan R,Matta H,Choi S,Gong S,Jeronimo A,Keerthipati PS,Morales A,Venkatesh H,Chaudhary PM

    更新日期：2020-02-11 00:00:00

  • Ultra-stable clock laser system development towards space applications.

    abstract：:The increasing performance of optical lattice clocks has made them attractive for scientific applications in space and thus has pushed the development of their components including the interrogation lasers of the clock transitions towards being suitable for space, which amongst others requires making them more power e...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep33973

    authors： Świerad D,Häfner S,Vogt S,Venon B,Holleville D,Bize S,Kulosa A,Bode S,Singh Y,Bongs K,Rasel EM,Lodewyck J,Le Targat R,Lisdat C,Sterr U

    更新日期：2016-09-26 00:00:00

  • Self-propelled droplet transport on shaped-liquid surfaces.

    abstract：:The transport of small amounts of liquids on solid surfaces is fundamental for microfluidics applications. Technologies allowing control of droplets of liquid on flat surfaces generally involve the generation of a wettability contrast. This approach is however limited by the resistance to motion caused by the direct c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70988-x

    authors： Launay G,Sadullah MS,McHale G,Ledesma-Aguilar R,Kusumaatmaja H,Wells GG

    更新日期：2020-09-11 00:00:00

  • Adolescent dental arch development among Southern Chinese in Hong Kong: a geometric morphometric approach.

    abstract：:This study aimed to investigate changes in types of dental arch form during adolescence and explore adolescent changes in size and form of dental arch. Hong Kong Chinese were recruited and digital dental arch models were obtained at ages 12, 15, and 18 years. Geometric morphometrics was used to investigate adolescent ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55073-2

    authors： Wen YF,Wong HM,Pei T,McGrath C

    更新日期：2019-12-06 00:00:00

  • Histologic tissue components provide major cues for machine learning-based prostate cancer detection and grading on prostatectomy specimens.

    abstract：:Automatically detecting and grading cancerous regions on radical prostatectomy (RP) sections facilitates graphical and quantitative pathology reporting, potentially benefitting post-surgery prognosis, recurrence prediction, and treatment planning after RP. Promising results for detecting and grading prostate cancer on...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-66849-2

    authors： Han W,Johnson C,Gaed M,Gómez JA,Moussa M,Chin JL,Pautler S,Bauman GS,Ward AD

    更新日期：2020-06-18 00:00:00

  • Ecosystem functions including soil organic carbon, total nitrogen and available potassium are crucial for vegetation recovery.

    abstract：:The effects of biodiversity on ecosystem functions have been extensively studied, but little is known about the effects of ecosystem functions on biodiversity. This knowledge is important for understanding biodiversity-ecosystem functioning relationships. Desertification reversal is a significant global challenge, but...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-25875-x

    authors： Qiu K,Xie Y,Xu D,Pott R

    更新日期：2018-05-15 00:00:00

  • Design of (Nb, Mo)40Ti30Ni30 alloy membranes for combined enhancement of hydrogen permeability and embrittlement resistance.

    abstract：:The effect of substitution of Nb by Mo in Nb40Ti30Ni30 was investigated with respect to microstructural features and hydrogen dissolution, diffusion and permeation. As-cast Nb40-xMoxTi30Ni30 (x = 0, 5, 10) alloys consist of primary bcc-Nb phase and binary eutectic (bcc-Nb + B2-TiNi). The substitution of Nb by Mo reduc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00335-0

    authors： Li X,Liang X,Liu D,Chen R,Huang F,Wang R,Rettenmayr M,Su Y,Guo J,Fu H

    更新日期：2017-03-16 00:00:00

  • Light guiding and switching using eccentric core-shell geometries.

    abstract：:High Refractive Index (HRI) dielectric nanoparticles have been proposed as an alternative to metallic ones due to their low absorption and magnetodielectric response in the VIS and NIR ranges. For the latter, important scattering directionality effects can be obtained. Also, systems constituted by dimers of HRI dielec...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11401-y

    authors： Barreda ÁI,Gutiérrez Y,Sanz JM,González F,Moreno F

    更新日期：2017-09-11 00:00:00

  • Restricted regions of enhanced growth of Antarctic krill in the circumpolar Southern Ocean.

    abstract：:Food webs in high-latitude oceans are dominated by relatively few species. Future ocean and sea-ice changes affecting the distribution of such species will impact the structure and functioning of whole ecosystems. Antarctic krill (Euphausia superba) is a key species in Southern Ocean food webs, but there is little und...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07205-9

    authors： Murphy EJ,Thorpe SE,Tarling GA,Watkins JL,Fielding S,Underwood P

    更新日期：2017-07-31 00:00:00

  • Electrochemical affinity biosensors for fast detection of gene-specific methylations with no need for bisulfite and amplification treatments.

    abstract：:This paper describes two different electrochemical affinity biosensing approaches for the simple, fast and bisulfite and PCR-free quantification of 5-methylated cytosines (5-mC) in DNA using the anti-5-mC antibody as biorecognition element. One of the biosensing approaches used the anti-5-mC as capture bioreceptor and...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-24902-1

    authors： Povedano E,Vargas E,Montiel VR,Torrente-Rodríguez RM,Pedrero M,Barderas R,Segundo-Acosta PS,Peláez-García A,Mendiola M,Hardisson D,Campuzano S,Pingarrón JM

    更新日期：2018-04-23 00:00:00

  • Genetic structure in the paternal lineages of South East Spain revealed by the analysis of 17 Y-STRs.

    abstract：:The genetic data of 17 Y chromosome short tandem repeats in 146 unrelated donor residents in the provinces of Granada, Málaga, and Almería (GMA) were analyzed to determine the genetic legacy of the male inhabitants of the former Kingdom of Granada. A total of 139 unique haplotypes were identified. Observed allele freq...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41580-9

    authors： Saiz M,Alvarez-Cubero MJ,Lorente JA,Alvarez JC,Martinez-Gonzalez LJ

    更新日期：2019-03-26 00:00:00

  • Modeling of amorphous SiCxO6/5 by classical molecular dynamics and first principles calculations.

    abstract：:Polymer-derived silicon oxycarbide (SiCO) presents excellent performance for high temperature and lithium-ion battery applications. Current experiments have provided some information on nano-structure of SiCO, while it is very challenging for experiments to take further insight into the molecular structure and its rel...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42705

    authors： Liao N,Zhang M,Zhou H,Xue W

    更新日期：2017-02-14 00:00:00

  • Optical pumping and readout of bismuth hyperfine states in silicon for atomic clock applications.

    abstract：:The push for a semiconductor-based quantum information technology has renewed interest in the spin states and optical transitions of shallow donors in silicon, including the donor bound exciton transitions in the near-infrared and the Rydberg, or hydrogenic, transitions in the mid-infrared. The deepest group V donor i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10493

    authors： Saeedi K,Szech M,Dluhy P,Salvail JZ,Morse KJ,Riemann H,Abrosimov NV,Nötzel N,Litvinenko KL,Murdin BN,Thewalt ML

    更新日期：2015-05-20 00:00:00

  • Analysis of uncoated LPGs written in B-Ge doped fiber under proton irradiation for sensing applications at CERN.

    abstract：:In this contribution, a complete dissertation concerning the behavior of a Long Period Grating (LPG) inscribed in a B-Ge co-doped optical fiber by means of an excimer laser and exposed to proton irradiation during a recent extensive campaign performed at the European Organization for Nuclear Research (CERN) with a flu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-58049-9

    authors： Berruti GM,Vaiano P,Quero G,Pimentel Das Neves TF,Boniello A,Consales M,Petagna P,Cusano A

    更新日期：2020-01-28 00:00:00

  • Cholecystectomy is associated with higher risk of early recurrence and poorer survival after curative resection for early stage hepatocellular carcinoma.

    abstract：:Although cholecystectomy has been reported to be associated with increased risk of developing hepatocellular carcinoma (HCC), the association between cholecystectomy and prognosis of HCC patients underwent curative resection has never been examined. Through retrospective analysis of the data of 3933 patients underwent...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep28229

    authors： Li T,Wang SK,Zhi XT,Zhou J,Dong ZR,Zhang ZL,Sun HC,Ye QH,Fan J

    更新日期：2016-06-20 00:00:00

  • Characteristics of Cadmium Sorption by Heat-Activated Red Mud in Aqueous Solution.

    abstract：:Red mud as a waste material is produced in large quantities by the aluminum industry. Heat activation has been used to enhance sorption capacity of red mud for its beneficial reuse as an effective sorbent. In this study, heat-activated red mud (HARM) was investigated for its Cd(II) sorption capacity under various proc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-31967-5

    authors： Yang T,Sheng L,Wang Y,Wyckoff KN,He C,He Q

    更新日期：2018-09-10 00:00:00

  • Importance of Experimental Environmental Conditions in Estimating Risks and Associated Uncertainty of Transgenic Fish Prior to Entry into Nature.

    abstract：:Salmonids show a high degree of phenotypic plasticity that can differ among genotypes, and this variation is one of the major factors contributing to uncertainty in extrapolating laboratory-based risk assessment data to nature. Many studies have examined the relative growth and survival of transgenic and non-transgeni...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35826-1

    authors： Vandersteen WE,Leggatt R,Sundström LF,Devlin RH

    更新日期：2019-01-23 00:00:00

  • Abundant human anti-Galα3Gal antibodies display broad pathogen reactivity.

    abstract：:Antibodies of the IgG class to terminal Galα3Gal (IgG anti-αGal) is abundant in human plasma and are reported to bind most sepsis-causing Gram-negative bacteria. However, these seminal findings, made more than two decades ago, have not been reexamined. Our aim was to assess IgG anti-αGal´s pathogen reactivity. We affi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-61632-9

    authors： Bernth Jensen JM,Petersen MS,Ellerman-Eriksen S,Møller BK,Jensenius JC,Sørensen UBS,Thiel S

    更新日期：2020-03-12 00:00:00