Abstract:
:The aim of this study was to identify novel genetic markers related to coronary artery disease (CAD) using a whole-exome sequencing (WES) approach and determine any associations between the selected gene polymorphisms and CAD prevalence. CUBN, HNF1A and LIPC gene polymorphisms related to CAD susceptibility were identified using WES screening. Possible associations between the five gene polymorphisms and CAD susceptibility were examined in 452 CAD patients and 421 control subjects. Multivariate logistic regression analyses indicated that the CUBN rs2291521GA and HNF1A rs55783344CT genotypes were associated with CAD (GG vs. GA; adjusted odds ratio [AOR] = 1.530; 95% confidence interval [CI] 1.113-2.103; P = 0.002 and CC vs. CT; AOR = 1.512; 95% CI 1.119-2.045; P = 0.007, respectively). The CUBN rs2291521GA and HNF1A rs55783344CT genotype combinations exhibited a stronger association with CAD risk (AOR = 2.622; 95% CI 1.518-4.526; P = 0.001). Gene-environment combinatorial analyses indicated that the CUBN rs2291521GA, HNF1A rs55783344CT, and LIPC rs17269397AA genotype combination and several clinical factors (fasting blood sugar (FBS), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels) were associated with increased CAD risk. The CUBN rs2291521GA, HNF1A rs55783344CT, and LIPC rs17269397AA genotypes in conjunction with abnormally elevated cholesterol levels increase the risk of developing CAD. This exploratory study suggests that polymorphisms in the CUBN, HNF1A, and LIPC genes can be useful biomarkers for CAD diagnosis and treatment.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Park HS,Kim IJ,Kim EG,Ryu CS,Lee JY,Ko EJ,Park HW,Sung JH,Kim NKdoi
10.1038/s41598-020-73048-6subject
Has Abstractpub_date
2020-10-01 00:00:00pages
16294issue
1issn
2045-2322pii
10.1038/s41598-020-73048-6journal_volume
10pub_type
杂志文章abstract::In the present work, a catalyst-free physical vapour deposition method is used to synthesize high yield of Bi2Se3 nanoribbons. By replacing standard glass or quartz substrates with aluminium covered with ultrathin porous anodized aluminium oxide (AAO), the number of synthesized nanoribbons per unit area can be increas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47547-0
更新日期:2019-08-05 00:00:00
abstract::Prostate cancer (PCa) is the second most common cancer among men worldwide. Its etiology remains largely unknown compared to other common cancers. We have developed a risk stratification model combining environmental factors with family history and genetic susceptibility. 818 PCa cases and 1,006 healthy controls were ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09386-9
更新日期:2017-08-21 00:00:00
abstract::The present work assessed the effects of dietary ratios of essential fatty acids, arachidonic (ARA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), on liver and intestine oxidative status, intestinal histomorphology and gut microbiota of gilthead sea bream. Four isoproteic and isolipidic plant-based diets were...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70716-5
更新日期:2020-08-14 00:00:00
abstract::We study the rotational dynamics of solid chiral and birefringent microparticles induced by elliptically polarized laser light in optical tweezers. We find that both reflection of left circularly polarized light and residual linear retardance affect the particle dynamics. The degree of ellipticity of laser light neede...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31977
更新日期:2016-09-07 00:00:00
abstract::Streptococcus pneumoniae (S. pneumoniae) is a leading human pathogen, which takes large responsibility for severe otitis media, acute meningitis and septicaemia. It encodes up to three distinct sialidases: NanA, NanB and NanC, which are promising drug targets. Recent experimental studies have shown that these three si...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38131-z
更新日期:2019-02-15 00:00:00
abstract::Early detection of cancer is essential for effective intervention. Urine has been used to reflect early changes in various tumor-bearing models. However, urine has not been used to predict whether tumors will form in animal models. In this study, a cancer model was established by tail vein injection of 2 million NuTu-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68674-z
更新日期:2020-07-16 00:00:00
abstract::Tract tracing with neuronal tracers not only represents a straightforward approach to identify axonal projection connection between regions of the nervous system at distance but also provides compelling evidence for axonal regeneration. An ideal neuronal tracer meets certain criteria including high labeling efficacy, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46285-7
更新日期:2019-07-09 00:00:00
abstract::A large retreat of sea-ice in the 'stormy' Atlantic Sector of the Arctic Ocean has become evident through a series of record minima for the winter maximum sea-ice extent since 2015. Results from the Norwegian young sea ICE (N-ICE2015) expedition, a five-month-long (Jan-Jun) drifting ice station in first and second yea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45574-5
更新日期:2019-06-25 00:00:00
abstract::Zika virus is a teratogenic mosquito-transmitted flavivirus that is associated with birth defects in newborns and Guillain-Barré syndrome in adults. The virus can also be sexually transmitted, but currently, very little is known about the cell types supporting virus replication and persistence in human testes. Using p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23899-x
更新日期:2018-04-03 00:00:00
abstract::Sensitivity of the anatase and rutile phases of titanium dioxide to Swift Heavy Ion (SHI) irradiation was experimentally probed and compared with the predictions of the Coulomb explosion, analytical and inelastic thermal spike models of ion-matter interaction. Conforming to the predictions of all these models, our stu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30281-4
更新日期:2018-08-06 00:00:00
abstract::Prior to this study, complete mitochondrial genomes from Order Thysanoptera were restricted to a single family, the Thripidae, resulting in a biased view of their evolution. Here we present the sequences for the mitochondrial genomes of four additional thrips species, adding three extra families and an additional subf...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57705-4
更新日期:2020-01-20 00:00:00
abstract::We study a minimal model of the stress-driven p53 regulatory network that includes competition between active and mutant forms of the tumor-suppressor gene p53. Depending on the nature and level of the external stress signal, four distinct dynamical states of p53 are observed. These states can be distinguished by diff...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-82054-1
更新日期:2021-01-27 00:00:00
abstract::Oxidative stress (OS), mitochondrial dysfunction, and dysregulation of alpha-synuclein (aSyn) homeostasis are key pathogenic factors in Parkinson's disease. Nevertheless, the role of aSyn in mitochondrial physiology remains elusive. Thus, we addressed the impact of aSyn specifically on mitochondrial response to OS in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42942
更新日期:2017-02-22 00:00:00
abstract::The RIβ subunit of cAMP-dependent protein kinase (PKA), encoded by Prkar1b, is a neuronal isoform of the type I regulatory subunit of PKA. Mice lacking the RIβ subunit exhibit normal long-term potentiation (LTP) in the Schaffer collateral pathway of the hippocampus and normal behavior in the open-field and fear condit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81515-x
更新日期:2021-01-21 00:00:00
abstract::Soil microorganisms play a crucial role in the biogeochemical cycling of nutrient elements and maintaining soil health. We aimed to investigate the response of bacteria communities to organic farming over different crops (rice, tea and vegetable) along the middle and lower reaches of the Yangtze River of China. Compar...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35046
更新日期:2016-10-11 00:00:00
abstract::Attraction to infants is a common feature of non-human primates. Frequent affiliative male-infant interactions have been observed in many multimale, multifemale groups of macaques, including a behaviour termed 'bridging' in which two male macaques simultaneously lift an infant. This behaviour has been suggested to ser...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34406-7
更新日期:2018-11-02 00:00:00
abstract::The mammalian cochlea has historically resisted attempts at high-resolution, non-invasive imaging due to its small size, complex three-dimensional structure, and embedded location within the temporal bone. As a result, little is known about the relationship between an individual's cochlear pathology and hearing functi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33288
更新日期:2016-09-16 00:00:00
abstract::Women who have previously had an induced abortion (IA) before their first birth have been associated with preterm birth (PTB). However, previous studies on the PTB are inconsistent. Therefore, the aim of this study was to clarify the association between IA and PTB and low birth weight (LBW) for first-time mothers. A t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23695-7
更新日期:2018-03-29 00:00:00
abstract::Here, we combine elicitors and transcriptomics to investigate the inducible biosynthesis of the ginsenoside from the Panax quinquefolium. Treatment of P. quinquefolium adventitious root with methyl jasmonate (MJ) results in an increase in ginsenoside content (43.66 mg/g compared to 8.32 mg/g in control group). Therefo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37263
更新日期:2016-11-23 00:00:00
abstract::An understanding of all aspects of fluoride metabolism is critical to identify its biological effects and avoid fluoride toxicity in humans. Fluoride metabolism and subsequently its body retention may be affected by physiological responses to acute exercise. This pilot study investigated the effect of exercise on plas...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/srep16905
更新日期:2015-11-19 00:00:00
abstract::Advances in microfluidics technology has enabled many discoveries on microbial mechanisms and phenotypes owing to its exquisite controls over biological and chemical environments. However, emulating accurate ecologically relevant flow environments (e.g. microbes around a rising oil droplet) in microfluidics remains ch...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50153-9
更新日期:2019-09-24 00:00:00
abstract::The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration. To enable systematic insights into this phenomenon, we generated and integrated a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26822
更新日期:2016-05-31 00:00:00
abstract::Mast cells act as sensors in innate immunity and as effector cells in adaptive immune reactions. Here we demonstrate that SLC10A4, also referred to as the vesicular aminergic-associated transporter, VAAT, modifies mast cell degranulation. Strikingly, Slc10a4 -/- bone marrow-derived mast cells (BMMCs) had a significant...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01121-8
更新日期:2017-04-24 00:00:00
abstract::We demonstrate the optical orbital angular momentum conservation during the transfer process from subwavelength plasmonic vortex lens (PVLs) to light and the generating process of surface plasmon polaritons (SPPs). Illuminating plasmonic vortex lenses with beams carrying optical orbital angular momentum, the SP vortic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03191
更新日期:2013-11-12 00:00:00
abstract::Fossils of the sponge Angulosuspongia sinensis from calcareous mudstones of the middle and upper part of the Kaili Formation (Cambrian Stage 5) in the Jianhe area of Guizhou province, South China, exhibit an apparently reticulate pattern, characteristic of the Vauxiidae. Energy Dispersive X-Ray Spectrometry (EDS) and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42945
更新日期:2017-02-21 00:00:00
abstract::In the present work, linoleic acid and oleic acid were isolated from Indonesian corn oil and palm oil and they were used to prepare monoacylglycerol derivatives as the antibacterial agent. Indonesian corn oil contains 57.74% linoleic acid, 19.88% palmitic acid, 11.84% oleic acid and 3.02% stearic acid. While Indonesia...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47373-4
更新日期:2019-07-29 00:00:00
abstract::Composite materials have become widely used in engineering applications, in order to reduce the overall weight of structures while retaining their required strength. In this work, a composite material consisting of discontinuous glass fibers in a polypropylene matrix is studied at the microstructural level through cou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60368-w
更新日期:2020-02-27 00:00:00
abstract::In chickens, the sensory organs for taste are the taste buds in the oral cavity, of which there are ~240-360 in total number as estimated by scanning electron microscopy (SEM). There is not an easy way to visualize all taste buds in chickens. Here, we report a highly efficient method for labeling chicken taste buds in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37247
更新日期:2016-11-17 00:00:00
abstract::Several lines of evidence indicate that Fibronectin Extra Domain A (EDA) promotes metastatic capacity of tumor cells by engaging cell surface α9β1 integrins. This interaction mediated by the C-C loop of EDA activates pro-oncogenic signaling pathways leading to epithelial to mesenchymal transition (EMT) of tumor cells,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37151
更新日期:2016-11-16 00:00:00
abstract::Mastery over the structure of nanoparticles might be an effective way to enhance their performance for a given application. Herein we demonstrate the design of cage-bell nanostructures to enhance the methanol tolerance of platinum (Pt) nanoparticles while remaining their catalytic activity for oxygen reduction reactio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16219
更新日期:2015-11-18 00:00:00