Abstract：
:Oxidative stress (OS), mitochondrial dysfunction, and dysregulation of alpha-synuclein (aSyn) homeostasis are key pathogenic factors in Parkinson's disease. Nevertheless, the role of aSyn in mitochondrial physiology remains elusive. Thus, we addressed the impact of aSyn specifically on mitochondrial response to OS in neural cells. We characterize a distinct type of mitochondrial fragmentation, following H2O2 or 6-OHDA-induced OS, defined by spherically-shaped and hyperpolarized mitochondria, termed "mitospheres". Mitosphere formation mechanistically depended on the fission factor Drp1, and was paralleled by reduced mitochondrial fusion. Furthermore, mitospheres were linked to a decrease in mitochondrial activity, and preceded Caspase3 activation. Even though fragmentation of dysfunctional mitochondria is considered to be a prerequisite for mitochondrial degradation, mitospheres were not degraded via Parkin-mediated mitophagy. Importantly, we provide compelling evidence that aSyn prevents mitosphere formation and reduces apoptosis under OS. In contrast, aSyn did not protect against Rotenone, which led to a different, previously described donut-shaped mitochondrial morphology. Our findings reveal a dichotomic role of aSyn in mitochondrial biology, which is linked to distinct types of stress-induced mitochondrial fragmentation. Specifically, aSyn may be part of a cellular defense mechanism preserving neural mitochondrial homeostasis in the presence of increased OS levels, while not protecting against stressors directly affecting mitochondrial function.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Menges S,Minakaki G,Schaefer PM,Meixner H,Prots I,Schlötzer-Schrehardt U,Friedland K,Winner B,Outeiro TF,Winklhofer KF,von Arnim CA,Xiang W,Winkler J,Klucken Jdoi
10.1038/srep42942subject
Has Abstractpub_date
2017-02-22 00:00:00pages
42942issn
2045-2322pii
srep42942journal_volume
7pub_type
杂志文章abstract：:Wnt/β-catenin signalling plays a prominent role in maintaining self-renewal and pluripotency of mouse embryonic stem cells (mESCs). microRNAs (miRNAs) have critical roles in maintaining pluripotency and directing reprogramming. To investigate the effect of GSK3 inhibitors on miRNA expression, we analysed the miRNA exp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08666
更新日期：2015-03-02 00:00:00
abstract：:Microorganisms in vertebrate guts have been recognized as important symbionts influencing host life. However, it remains unclear about the gut microbiota in long-distance migratory Anseriformes herbivores, which could be functionally important for these wetland-dependent animals. We collected faeces of the greater whi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32655
更新日期：2016-09-07 00:00:00
abstract：:Processing the meaning of action language correlates with somatotopic activity in premotor cortex (PMC). A previous neurostimulation study supported a causal contribution of PMC activity to action verb understanding, but the direction of the effect was unexpected: inhibiting PMC made participants respond faster to act...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29600-6
更新日期：2018-07-30 00:00:00
abstract：:Potato (Solanum tuberosum L.) is the fourth most important crop worldwide. Potato virus A (PVA) is one of the most harmful viruses infecting potatoes. However, the molecular mechanisms governing the responses to PVA infection in potato at the transcriptional and post-transcriptional levels are not well understood. In ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17059-w
更新日期：2017-12-05 00:00:00
abstract：:Pesticide use is one of the main causes of pollinator declines in agricultural ecosystems. Traditionally, most laboratory studies on bee ecotoxicology test acute exposure to single compounds. However, under field conditions, bees are often chronically exposed to a variety of chemicals, with potential synergistic effec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50255-4
更新日期：2019-09-24 00:00:00
abstract：:1β-hydroxy alantolactone, a sesquiterpene lactone, exhibits potent anti-inflammatory and anticancer activities. Recently, it has been found to target UbcH5s by covalently bonding with Cys85 specifically, but the exact molecular basis remains unclear. Here, we analyzed the structural specificity of the catalytic site o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57104-4
更新日期：2020-01-10 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-71638-y
更新日期：2020-09-09 00:00:00
abstract：:An intermediate band in the band gap of semiconductors is fundamental to the development of the intermediate band solar cells, but it is usually produced artificially, which imposes technical challenges on the experimental realization. Here we found that there are natural intermediate bands in the band gaps of the I2-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19935-5
更新日期：2018-01-25 00:00:00
abstract：:Bone is a dynamic organ continuously undergoing shaping, repairing and remodeling. The homeostasis of bone is maintained by the balance between osteoblastic bone formation and osteoclastic bone resorption. Osteoclasts (OCs) are specialized multinucleated cells derived from hematopoietic stem cells (HSCs) or monocytes/...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21499
更新日期：2016-02-09 00:00:00
abstract：:Sacha inchi (Plukenetia volubilis L.) is a shrub native to Amazon rainforests that's of commercial interest as its seeds contain 35-60% edible oil (dry weight). This oil is one of the healthiest vegetable oils due to its high polyunsaturated fatty acid content and favourable ratio of omega-6 to omega-3 fatty acids. De...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77177-w
更新日期：2020-11-24 00:00:00
abstract：:Zirconium compounds has been widely attention over the last decades due to its excellent physical and chemical properties. Zirconium nitride nanopowders were synthesized via a simple direct carbothermic nitridation process of internal gel derived zirconia in the presence of nano-sized carbon black. The effects of reac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55450-x
更新日期：2019-12-16 00:00:00
abstract：:A previous study identified 3 nonsynonymous and 6 synonymous mutations in the entire mosquito sodium channel of Culex quinquefasciatus, the prevalence of which were strongly correlated with levels of resistance and increased dramatically following insecticide selection. However, it is unclear whether this is unique to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00781
更新日期：2012-01-01 00:00:00
abstract：:Many experimental techniques rely on specific recognition and stringent binding of proteins by antibodies. This can readily be achieved by introducing an epitope tag. We employed an approach that uses a relative lack of evolutionary conservation to inform epitope tag site selection, followed by integration of the tag-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36986
更新日期：2016-11-28 00:00:00
abstract：:To investigate how consensus is reached on a large self-organized peer-to-peer network, we extended the naming game model commonly used in language and communication to Naming Game in Groups (NGG). Differing from other existing naming game models, in NGG everyone in the population (network) can be both speaker and hea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06149
更新日期：2014-08-21 00:00:00
abstract：:An existence of ions dissolved in water has significant effects on bulk properties of water. Superconcentrated conditions have been recently proposed to provide a new concept of lithium ion batteries in order to overcome limitations for practical applications. In those conditions, water would undergo significant chang...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27706-5
更新日期：2018-06-19 00:00:00
abstract：:Psoriasis is a chronic, relapsing inflammatory skin disease. The pathogenesis of psoriasis is complex and has not been fully understood. C10orf99 was a recently identified human antimicrobial peptide whose mRNA expression is elevated in psoriatic human skin samples. In this study, we investigated the functional roles ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26996-z
更新日期：2018-06-05 00:00:00
abstract：:Alumina toughened zirconia (ATZ) and zirconia toughened alumina (ZTA) are currently the materials of choice to meet the need for tough, strong, and bioinert ceramics for medical devices. However, the mechanical properties of ZrO2/Al2O3 dispersion ceramics could be considerably increased by reducing the corresponding g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20589
更新日期：2016-02-05 00:00:00
abstract：:We have studied the formation of Pd42.5Cu30Ni7.5P20 metallic glass droplets and wires in the gas atomization process. We demonstrate that the sizes of droplets and wires can be distinguished by the Ohnesorge number (Oh), which is the proportion of the spinnability to the capillary instability, and the diameter distrib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10711
更新日期：2015-06-01 00:00:00
abstract：:Several studies found that 50-100% serum eye drops provided greater benefits without inducing detrimental effects on the corneal epithelial healing. This study assessed the efficacy of undiluted serum eye drops for the treatment of persistent corneal epithelial defects (PED). A total of 109 eyes received 100% serum ey...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38143
更新日期：2016-12-02 00:00:00
abstract：:This study uses retrospective forecasts made using an APEC Climate Center seasonal forecast model to investigate the cause of errors in predicting the amplitude of El Niño Southern Oscillation (ENSO)-driven sea surface temperature variability. When utilizing Bjerknes coupled stability (BJ) index analysis, enhanced err...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05221-3
更新日期：2017-07-20 00:00:00
abstract：:Pesticides are the main tactics for pest control because they reduce the pest population very fast and their efficiency does not depend on abiotic factors. However, the indiscriminate use of these substances can speed up the development of resistant populations and causing environmental contamination. Therefore, alter...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26043-x
更新日期：2018-05-16 00:00:00
abstract：:This study aimed to explore the development of mental rotation ability throughout life by comparing different kinds of stimuli. Thirty-six children (6-9 years-old), 30 young (20-28 years-old) and 30 elderly people (60-82 years-old) performed mental rotation tasks with abstract (i.e. two-dimensional lines) and concrete...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37729-7
更新日期：2019-02-04 00:00:00
abstract：:Micronutrient deficiency is common in patients with HIV/AIDS, usually caused by mal-absorption and/or drug interactions. 25-hydroxyvitamin D is of fundamental importance for the homeostasis of musculoskeletal health. The current study aimed to evaluate the nutritional status of HIV-infected subjects in order to make t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12990
更新日期：2015-08-10 00:00:00
abstract：:Parkinson's disease (PD) is a neurodegenerative disorder characterised by motor abnormalities. Many non-demented patients with PD have cognitive impairment especially in executive functions. Using magnetoencephalographic (MEG) recording combined with event-related desynchronisation/synchronisation (ERD/ERS) analysis, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43762-x
更新日期：2019-05-10 00:00:00
abstract：:The key to arthritis management is early diagnosis and treatment to prevent further joint destruction and maximize functional ability. Osteoarthritis (OA) and rheumatoid arthritis (RA) are two common types of arthritis that the primary care provider must differentiate, in terms of diagnosis and treatment. Effective an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35473-6
更新日期：2018-11-20 00:00:00
abstract：:The methylotrophic yeast Komagataella phaffii (Pichia pastoris) has been developed into a highly successful system for heterologous protein expression in both academia and industry. However, overexpression of recombinant protein often leads to severe burden on the physiology of K. phaffii and triggers cellular stress....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16577-x
更新日期：2017-11-24 00:00:00
abstract：:Hierarchical classification (HC) stratifies and classifies data from broad classes into more specific classes. Unlike commonly used data classification strategies, this enables the probabilistic prediction of unknown classes at different levels, minimizing the burden of incomplete databases. Despite these advantages, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14092-7
更新日期：2017-11-03 00:00:00
abstract：:A physically active lifestyle is associated with better health in body and mind, and it is urgent that supporting agents for such lifestyles be developed. In rodents, voluntary locomotor activity as an active physical behavior may be mediated by dopaminergic neurons (DNs). Thiamine phosphate esters can stimulate DNs, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28462-2
更新日期：2018-07-11 00:00:00
abstract：:The interaction between matter and electromagnetic radiation provides a rich understanding of what the matter is composed of and how it can be quantified using spectrometers. In many cases, however, the calibration of the spectrometer changes as a function of time (such as in electron spectrometers), or the absolute c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38482-1
更新日期：2019-02-14 00:00:00
abstract：:Turner syndrome (TS) is associated with decreased bone mineral density and increased fracture rate. However, the developmental trajectory of bone density or body composition in patients with TS is still unclear. The present study tested the hypothesis that different karyotypes and/or age contributes to abnormal body c...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep38026
更新日期：2016-11-30 00:00:00
