Abstract:
:We here develop a three-dimensional DMF (3D DMF) platform with patterned electrodes submerged in an oil medium to provide fundamental solutions to the technical limitations of 2D DMF platforms and water-air systems. 3D droplet manipulation on patterned electrodes is demonstrated by programmably controlling electrical signals. We also demonstrate the formation of precipitates on the 3D DMF platform through the reaction of different chemical samples. A droplet containing precipitates, hanging on the top electrode, can be manipulated without adhesion of precipitates to the solid surface. This method could be a good alternative strategy to alleviate the existing problems of 2D DMF systems such as cross-contamination and solute adsorption. In addition, we ascertain the feasibility of temperature-controlled chemical reaction on the 3D DMF platform by introducing a simple heating process. To demonstrate applicability of the 3D DMF system to 3D biological process, we examine the 3D manipulation of droplets containing mouse fibroblasts in the 3D DMF platform. Finally, we show detachment of droplets wrapped by a flexible thin film by adopting the electro-elasto-capillarity (EEC). The employment of the EEC may offer a strong potential in the development of 3D DMF platforms for drug encapsulation and actuation of microelectromechanical devices.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hong J,Kim YK,Won DJ,Kim J,Lee SJdoi
10.1038/srep10685subject
Has Abstractpub_date
2015-06-02 00:00:00pages
10685issn
2045-2322pii
srep10685journal_volume
5pub_type
杂志文章abstract::In this paper, the annually average Defense Meteorological Satellite Program-Operational Linescan System (DMSP/OLS) night-time light data is first proposed as a surrogate indicator to mine and forecast the average housing prices in the inland capital cities of China. First, based on the time-series analysis of individ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64506-2
更新日期:2020-05-07 00:00:00
abstract::Wind speed and variability are the most critical climatic factors affecting sand/dust storms, which have not been sufficiently studied in the middle reaches of the Yarlung Tsangpo River (MYR). In this study, wind speed variability was investigated using the moving average over shifting horizon method (MASH), combined ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69392-2
更新日期:2020-07-29 00:00:00
abstract::Gastric cancer (GC) is a common aggressive malignant tumor with high incidence and mortality worldwide. GC is classified into intestinal and diffuse types according to the histo-morphological features. Because of distinctly different clinico-pathological features, new cancer therapy strategies and in vitro preclinical...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41541
更新日期:2017-01-27 00:00:00
abstract::This study aimed to identify and distinguish various factors that may influence the occurrence of mandibular coronoid fractures. From January 2000 to December 2009, a total of 1131 patients with maxillofacial fractures were enrolled in this statistical study to evaluate the association between mandibular coronoid frac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02335-6
更新日期:2017-05-19 00:00:00
abstract::Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive tumors with low survival rates and the leading cause of death in neurofibromatosis type 1 (NF1) patients under 40 years old. Surgical resection is the standard of care for MPNSTs, but is often incomplete and can generate loss of function, necessitating t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37035
更新日期:2016-11-11 00:00:00
abstract::Recent studies showed that somatic cancer mutations target genes that are in specific signaling and cellular pathways. However, in each patient only a few of the pathway genes are mutated. Current approaches consider only existing pathways and ignore the topology of the pathways. For this reason, new efforts have been...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80204-5
更新日期:2021-01-12 00:00:00
abstract::The recent reported trapped "rainbow" storage of light using metamaterials and plasmonic graded surface gratings has generated considerable interest for on-chip slow light. The potential for controlling the velocity of broadband light in guided photonic structures opens up tremendous opportunities to manipulate light ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01249
更新日期:2013-01-01 00:00:00
abstract::Urinary tract infections (UTIs) are the third most common types of infection in human medicine worldwide. There is increasing appreciation for the pathogenic role of Gram-positive cocci (GPC) in UTIs, as they have a plethora of virulence factors, maintaining their pathogenicity and high affinity for the epithelial cel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74834-y
更新日期:2020-10-19 00:00:00
abstract::Although hepatitis B virus (HBV) infection is the leading cause of liver fibrosis (LF), the mechanisms underlying liver fibrotic progression remain unclear. Here, we investigated the gene expression profiles of HBV-related LF patients. Whole genome expression arrays were used to detect gene expression in liver biopsy ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43446
更新日期:2017-03-06 00:00:00
abstract::Cellular interactions can be modeled as complex dynamical systems represented by weighted graphs. The functionality of such networks, including measures of robustness, reliability, performance, and efficiency, are intrinsically tied to the topology and geometry of the underlying graph. Utilizing recently proposed geom...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12323
更新日期:2015-07-14 00:00:00
abstract::Stem cell therapy that can restore function to damaged tissue, avoid host rejection and reduce inflammation throughout body without use of immunosuppressive drugs. The established methods were used to identify and to isolate specific stem cell markers by FACS or by immunomagnetic cell separation. The procedures for di...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09543-0
更新日期:2017-08-29 00:00:00
abstract::Staphylococcus aureus colonizes the skin of atopic dermatitis (AD) individuals, but the impact of its enterotoxins on the chronic activation of CD4+ T cells demands further analysis. We aimed to analyze the CD4+ T cell anergy profile and their phenotypic and functional features through differential expression of cellu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49421-5
更新日期:2019-09-11 00:00:00
abstract::To enhance the carbon dioxide (CO2) uptake of metal-organic frameworks (MOFs), amine functionalization of their pore surfaces has been studied extensively. In general, amine-functionalized MOFs have been synthesized via post-synthetic modifications. Herein, we introduce a one-step construction of a MOF ([(NiLethylamin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19337
更新日期:2016-01-13 00:00:00
abstract::The precision prediction of peptide retention time (RT) plays an increasingly important role in liquid chromatography-tandem mass spectrometry (LC-MS/MS) based proteomics. Owing to the high reproducibility of liquid chromatography, RT prediction provides promising information for both identification and quantification...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43959
更新日期:2017-03-17 00:00:00
abstract::Fibrolamellar carcinoma (FLC) is a unique liver cancer primarily affecting young adults and characterized by a fusion event between DNAJB1 and PRKACA. By analyzing RNA-sequencing data from The Cancer Genome Atlas (TCGA) for >9,100 tumors across ~30 cancer types, we show that the DNAJB1-PRKACA fusion is specific to FLC...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44653
更新日期:2017-03-17 00:00:00
abstract::We adopted a vision-based tracking system for augmented reality (AR), and evaluated whether it helped surgeons to localize the recurrent laryngeal nerve (RLN) during robotic thyroid surgery. We constructed an AR image of the trachea, common carotid artery, and RLN using CT images. During surgery, an AR image of the tr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65439-6
更新日期:2020-05-21 00:00:00
abstract::Phelan McDermid Syndrome (PMDS) is a genetic disorder characterized by features of Autism spectrum disorders. Similar to reports of Zn deficiency in autistic children, we have previously reported high incidence of Zn deficiency in PMDS. However, the underlying mechanisms are currently not well understood. Here, using ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45190
更新日期:2017-03-27 00:00:00
abstract::Uropathogenic strains of Escherichia coli establish urinary tract infections by attaching to host epithelial cells using adhesive organelles called fimbriae. Fimbriae are helix-like structures with a remarkable adaptability, offering safeguarding for bacteria exposed to changing fluid forces in the urinary tract. We c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03393
更新日期:2013-12-02 00:00:00
abstract::This study provides a pore-scale investigation of two-phase flow dynamics during primary drainage in a realistic heterogeneous rock sample. Using the lattice Boltzmann (LB) method, a series of three-dimensional (3D) immiscible displacement simulations are conducted and three typical flow patterns are identified and ma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39741-x
更新日期:2019-03-04 00:00:00
abstract::In this study, we report a metallogel developed based on metal-phenolic coordination of natural low-cost polyphenolic molecule and metal ions. Gelation occurs by mixing tannic acid (TA) and group (IV) titanium ions (TiIV) to form TA-TiIV gel. The TA-TiIV gel exhibits good capability to incorporate diverse metal ions b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47978-9
更新日期:2019-08-09 00:00:00
abstract::The early diverged Magnoliaceae shows a historical temperate-tropical distribution among lineages indicating divergent evolution, yet which ecophysiological traits are phylogenetically conserved, and whether these traits are involved in correlated evolution remain unclear. Integrating phylogeny and 20 ecophysiological...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12246
更新日期:2015-07-16 00:00:00
abstract::Health-risk assessments of temperature are central to determine total non-accidental human mortality; however, few studies have investigated the effect of temperature on accidental human mortality. We performed a time-series study combined with a distributed lag non-linear model (DLNM) to quantify the non-linear and d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65344-y
更新日期:2020-05-21 00:00:00
abstract::We have studied the transformation of carbides in AISI M42 high-speed steels in the temperature window used for forging. The annealing was found to result in the partial transformation of the large, metastable M2C carbides into small, more stable grains of M6C, with an associated change in the crystal orientation. In ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16202
更新日期:2015-11-05 00:00:00
abstract::Glutamate dehydrogenase (GDH) is a key enzyme interlinking carbon and nitrogen metabolism. Recent discoveries of the GDH specific role in breast cancer, hyperinsulinism/hyperammonemia (HI/HA) syndrome, and neurodegenerative diseases have reinvigorated interest on GDH regulation, which remains poorly understood despite...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73743-4
更新日期:2020-10-05 00:00:00
abstract::Oscillatory media can exhibit the coexistence of synchronized and desynchronized regions, so-called chimera states, for uniform parameters and symmetrical coupling. In a phase-balanced chimera state, where the totals of synchronized and desynchronized regions, respectively, are of the same size, the symmetry of the sy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09883
更新日期:2015-04-30 00:00:00
abstract::Superfluidity and superconductivity have been widely studied since the last century in many different contexts ranging from nuclear matter to atomic quantum gases. The rigidity of these systems with respect to external perturbations results in frictionless motion for superfluids and resistance-free electric current fl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08941-8
更新日期:2017-08-22 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-69653-0
更新日期:2020-07-24 00:00:00
abstract::The Pyrrolysyl-tRNA synthetase (PylRS) and its cognate tRNAPyl are extensively used to add non-canonical amino acids (ncAAs) to the genetic code of bacterial and eukaryotic cells. However, new ncAAs often require a cumbersome de novo engineering process to generate an appropriate PylRS/tRNAPyl pair. We here report a s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48357-0
更新日期:2019-08-19 00:00:00
abstract::Virtual planning of open cranial vault reconstruction is used to simulate and define an pre-operative plan for craniosynostosis surgery. However, virtual planning techniques are subjective and dependent on the experience and preferences of the surgical team. To develop an objective automated 3D pre-operative planning ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21662-w
更新日期:2018-02-20 00:00:00
abstract::We demonstrate the capability of a novel Electron Backscatter Diffraction (EBSD) dictionary indexing (DI) approach by means of orientation mapping of a highly deformed graded microstructure in a shot peened Aluminium 7075-T651 alloy. A low microscope accelerating voltage was used to extract, for the first time from a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29315-8
更新日期:2018-07-20 00:00:00