Plk1 phosphorylation of CAP-H2 triggers chromosome condensation by condensin II at the early phase of mitosis.

abstract：:The prevalence of tobacco use in people with schizophrenia is much higher than in general population, which indicates a close relationship between nicotine addiction and schizophrenia. However, the molecular mechanism underlying the high comorbidity of tobacco smoking and schizophrenia remains largely unclear. In this...

journal_title：Scientific reports

authors： Hu Y,Fang Z,Yang Y,Rohlsen-Neal D,Cheng F,Wang J

更新日期：2018-02-13 00:00:00

abstract：:Despite advances in therapy, glioblastoma remains an incurable disease with a dismal prognosis. Recent studies have implicated cancer stem cells within glioblastoma (glioma stem cells, GSCs) as mediators of therapeutic resistance and tumor progression. In this study, we investigated the role of the transforming growth...

journal_title：Scientific reports

authors： Sachdeva R,Wu M,Johnson K,Kim H,Celebre A,Shahzad U,Graham MS,Kessler JA,Chuang JH,Karamchandani J,Bredel M,Verhaak R,Das S

更新日期：2019-10-10 00:00:00

abstract：:Hepadnaviruses, including human hepatitis B virus (HBV), replicate their tiny DNA genomes by protein-primed reverse transcription of a pregenomic (pg) RNA. Replication initiation as well as pgRNA encapsidation depend on the interaction of the viral polymerase, P protein, with the ε RNA element, featuring a lower and a...

journal_title：Scientific reports

authors： Gajer M,Dörnbrack K,Rösler C,Schmid B,Beck J,Nassal M

更新日期：2017-08-02 00:00:00

abstract：:The purpose of this study was to permit bone marrow mesenchymal stem cells (BMSCs) to reach their full potential in the treatment of chronic wounds. A biocompatible multifunctional crosslinker based temperature sensitive hydrogel was developed to deliver BMSCs, which improve the chronic inflammation microenvironments ...

journal_title：Scientific reports

authors： Chen S,Shi J,Zhang M,Chen Y,Wang X,Zhang L,Tian Z,Yan Y,Li Q,Zhong W,Xing M,Zhang L,Zhang L

更新日期：2015-12-08 00:00:00

abstract：:Hair regenerative medicine has emerged as a promising approach for the treatment of severe hair loss. Recent advances in three-dimensional tissue engineering, such as formation of hair follicle germs (HFGs), have considerably improved hair regeneration after transplantation in animal models. Here, we proposed an appro...

journal_title：Scientific reports

authors： Kageyama T,Chun YS,Fukuda J

更新日期：2021-01-12 00:00:00

abstract：:Many experiments on human cooperation have revealed that individuals differ systematically in their tendency to cooperate with others. It has also been shown that individuals condition their behaviour on the overall cooperation level of their peers. Yet, little is known about how individuals respond to heterogeneity i...

journal_title：Scientific reports

authors： van den Berg P,Molleman L,Junikka J,Puurtinen M,Weissing FJ

更新日期：2015-11-04 00:00:00

abstract：:Dry eye disease (DED) is a highly prevalent, ocular disorder characterized by an abnormal tear film and ocular surface. Recent experimental data has suggested that the underlying pathology of DED involves inflammation of the lacrimal functional unit (LFU), comprising the cornea, conjunctiva, lacrimal gland and interco...

journal_title：Scientific reports

authors： Ratay ML,Balmert SC,Acharya AP,Greene AC,Meyyappan T,Little SR

更新日期：2017-12-13 00:00:00

abstract：:Although pneumococcal infection is a serious problem worldwide and has a high mortality rate, the molecular mechanisms underlying the lethality caused by pneumococcus remain elusive. Here, we show that BLT2, a G protein-coupled receptor for leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid (12-HHT), protects mice...

journal_title：Scientific reports

authors： Shigematsu M,Koga T,Ishimori A,Saeki K,Ishii Y,Taketomi Y,Ohba M,Jo-Watanabe A,Okuno T,Harada N,Harayama T,Shindou H,Li JD,Murakami M,Hoka S,Yokomizo T

更新日期：2016-10-05 00:00:00

abstract：:Neurotransmission and secretion of hormones involve a sequence of protein/lipid interactions with lipid turnover impacting on vesicle trafficking and ultimately fusion of secretory vesicles with the plasma membrane. We previously demonstrated that sphingosine, a sphingolipid metabolite, promotes formation of the SNARE...

journal_title：Scientific reports

authors： Darios FD,Jorgacevski J,Flašker A,Zorec R,García-Martinez V,Villanueva J,Gutiérrez LM,Leese C,Bal M,Nosyreva E,Kavalali ET,Davletov B

更新日期：2017-07-20 00:00:00

abstract：:Oxaliplatin, a chemotherapy medication, causes severe peripheral neuropathy. Although oxaliplatin-induced peripheral neuropathy is a dose-limiting toxicity, a therapeutic strategy against its effects has not been established. We previously reported the involvement of N-methyl-D-aspartate receptors and their intracellu...

journal_title：Scientific reports

authors： Yamamoto S,Ushio S,Egashira N,Kawashiri T,Mitsuyasu S,Higuchi H,Ozawa N,Masuguchi K,Ono Y,Masuda S

更新日期：2017-08-29 00:00:00

abstract：:In HIV-1/HCV-coinfected patients, chronic HCV infection leads to an increased T-lymphocyte immune activation compared to HIV-monoinfected patients, thereby likely contributing to increase HIV-1 reservoir that is the major barrier for its eradication. Our objective was to evaluate the influence of HCV coinfection in HI...

journal_title：Scientific reports

authors： López-Huertas MR,Palladino C,Garrido-Arquero M,Esteban-Cartelle B,Sánchez-Carrillo M,Martínez-Román P,Martín-Carbonero L,Ryan P,Domínguez-Domínguez L,Santos IL,Moral SF,Benito JM,Rallón N,Alcamí J,Resino S,Fernández-Rodrígu

更新日期：2019-04-03 00:00:00

abstract：:Trimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared by the kidney and linked to renal function. We explored the relationship between TMAO and all-cause mortality, and determined whether this association was modified by renal function. A prospective study was performed among PREVEND partici...

journal_title：Scientific reports

authors： Gruppen EG,Garcia E,Connelly MA,Jeyarajah EJ,Otvos JD,Bakker SJL,Dullaart RPF

更新日期：2017-10-23 00:00:00

abstract：:The Malay people are an important ethnic composition in Southeast Asia, but their genetic make-up and population structure remain poorly studied. Here we conducted a genome-wide study of four geographical Malay populations: Peninsular Malaysian Malay (PMM), Singaporean Malay (SGM), Indonesian Malay (IDM) and Sri Lanka...

journal_title：Scientific reports

authors： Deng L,Hoh BP,Lu D,Saw WY,Twee-Hee Ong R,Kasturiratne A,Janaka de Silva H,Zilfalil BA,Kato N,Wickremasinghe AR,Teo YY,Xu S

更新日期：2015-09-23 00:00:00

abstract：:Securin overexpression correlates with poor prognosis in various tumours. We have previously shown that securin depletion promotes radiation-induced senescence and enhances radiosensitivity in human cancer cells. However, the underlying molecular mechanisms and the paracrine effects remain unknown. In this study, we s...

journal_title：Scientific reports

authors： Yu YC,Yang PM,Chuah QY,Huang YH,Peng CW,Lee YJ,Chiu SJ

更新日期：2013-01-01 00:00:00

abstract：:A major challenge in current exome sequencing in autosomal recessive (AR) families is the lack of an effective method to prioritize single-nucleotide variants (SNVs). AR families are generally too small for linkage analysis, and length of homozygous regions is unreliable for identification of causative variants. Vario...

journal_title：Scientific reports

authors： Imai A,Nakaya A,Fahiminiya S,Tétreault M,Majewski J,Sakata Y,Takashima S,Lathrop M,Ott J

更新日期：2015-07-06 00:00:00

abstract：:Highly malignant triple-negative breast cancer (TNBC) cells rely mostly on glycolysis to maintain cellular homeostasis; however, mitochondria are still required for migration and metastasis. Taking advantage of the metabolic flexibility of TNBC MDA-MB-231 cells to generate subpopulations with glycolytic or oxidative p...

journal_title：Scientific reports

authors： Urra FA,Muñoz F,Córdova-Delgado M,Ramírez MP,Peña-Ahumada B,Rios M,Cruz P,Ahumada-Castro U,Bustos G,Silva-Pavez E,Pulgar R,Morales D,Varela D,Millas-Vargas JP,Retamal E,Ramírez-Rodríguez O,Pessoa-Mahana H,Pavani M,Fer

更新日期：2018-09-04 00:00:00

abstract：:Herein, water-oxidation reaction by cobalt(II) phthalocyanine, N,N'-bis (salicylidene) ethylenediamino cobalt(II), nickel(II) Schiff base (N,N'-bis (salicylidene)ethylenediamino nickel(II), nickel(II)) phthalocyanine-tetrasulfonate tetrasodium, manganese(II) phthalocyanine, 5,10,15,20-Tetraphenyl-21H,23H-porphine mang...

journal_title：Scientific reports

authors： Najafpour MM,Feizi H

更新日期：2019-05-16 00:00:00

abstract：:Controlling the nanoscale arrangement in polymer-fullerene organic solar cells is of paramount importance to boost the performance of such promising class of photovoltaic diodes. In this work, we use a pseudo-bilayer system made of poly(2,5-bis(3-hexadecylthiophen-2-yl)thieno[3,2-b]thiophene (PBTTT) and [6,6]-phenyl-C...

journal_title：Scientific reports

authors： Paternò GM,Skoda MW,Dalgliesh R,Cacialli F,Sakai VG

更新日期：2016-10-04 00:00:00

abstract：:Jellyfish locomotion and orientation have been studied in the past both in the laboratory, testing mostly small jellyfish, and in the field, where it was impossible to control the seawater currents. Utilizing an outdoor water flume, we tested the locomotion of jellyfish when swimming against and with currents of up to...

journal_title：Scientific reports

authors： Malul D,Lotan T,Makovsky Y,Holzman R,Shavit U

更新日期：2019-12-30 00:00:00

abstract：:Chronic hepatitis viral infection, alcoholic intoxication, and obesity cause liver fibrosis, which progresses to decompensated liver cirrhosis, a disease for which medical demands cannot be met. Since there are currently no approved anti-fibrotic therapies for established liver fibrosis, the development of novel modal...

journal_title：Scientific reports

authors： Itaba N,Kono Y,Watanabe K,Yokobata T,Oka H,Osaki M,Kakuta H,Morimoto M,Shiota G

更新日期：2019-05-02 00:00:00

abstract：:Analyzing drug-drug interactions may unravel previously unknown drug action patterns, leading to the development of new drug discovery tools. We present a new approach to analyzing drug-drug interaction networks, based on clustering and topological community detection techniques that are specific to complex network sc...

journal_title：Scientific reports

authors： Udrescu L,Sbârcea L,Topîrceanu A,Iovanovici A,Kurunczi L,Bogdan P,Udrescu M

更新日期：2016-09-07 00:00:00

abstract：:Genes central to drug absorption, distribution, metabolism and elimination (ADME) also regulate numerous endogenous molecules. The Remote Sensing and Signaling Hypothesis argues that an ADME gene-centered network-including SLC and ABC "drug" transporters, "drug" metabolizing enzymes (DMEs), and regulatory genes-is ess...

journal_title：Scientific reports

authors： Rosenthal SB,Bush KT,Nigam SK

更新日期：2019-08-15 00:00:00

abstract：:Influence maximization is the problem of finding the set of nodes of a network that maximizes the size of the outbreak of a spreading process occurring on the network. Solutions to this problem are important for strategic decisions in marketing and political campaigns. The typical setting consists in the identificatio...

journal_title：Scientific reports

authors： Erkol Ş,Castellano C,Radicchi F

更新日期：2019-10-22 00:00:00

abstract：:Aneuploidy has been reported to occur at remarkably high levels in normal somatic tissues using Fluorescence In Situ Hybridization (FISH). Recently, these reports were contradicted by single-cell low-coverage whole genome sequencing (scL-WGS) analyses, which showed aneuploidy frequencies at least an order of magnitude...

journal_title：Scientific reports

authors： Andriani GA,Maggi E,Piqué D,Zimmerman SE,Lee M,Quispe-Tintaya W,Maslov A,Campisi J,Vijg J,Mar JC,Montagna C

更新日期：2019-07-19 00:00:00

abstract：:Neutron grating interferometry (nGI) is a unique technique allowing to probe magnetic and nuclear properties of materials not accessible in standard neutron imaging. The signal-to-noise ratio of an nGI setup is strongly dependent on the achievable visibility. Hence, for analysis of weak signals or short measurement ti...

journal_title：Scientific reports

authors： Neuwirth T,Backs A,Gustschin A,Vogt S,Pfeiffer F,Böni P,Schulz M

更新日期：2020-02-04 00:00:00

abstract：:Laparoscopic experience and relevant reports about PD catheter emplacement in Chinese patients are seldom. In this study, we described our experience with advanced laparoscopy for PD catheter implantation in Chinese patients. There were one hundred and thirty Chinese patients accepted advanced laparoscopic approach fo...

journal_title：Scientific reports

authors： Mo M,Ju Y,Hu H,Zhang W,Pan J,Zheng Q,Chen J,Su L,Dou X

更新日期：2017-08-22 00:00:00

abstract：:To determine whether regular cervical dilatation is effective for preventing cervical stenosis, and to identify the associated risk factors, in postmenopausal women after LEEP. This was a prospective randomized clinical trial in postmenopausal women who underwent LEEP at our hospital between August 2018 and May 2019. ...

journal_title：Scientific reports

authors： Lin J,Meng Y,Chen Y,Li Z,Xu Y,Wu D

更新日期：2020-05-22 00:00:00

abstract：:Several microbes, including Staphylococcus epidermidis (S. epidermidis), a Gram-positive bacterium, live inside the human nasal cavity as commensals. The role of these nasal commensals in host innate immunity is largely unknown, although bacterial interference in the nasal microbiome may promote ecological competition...

journal_title：Scientific reports

authors： Chen HW,Liu PF,Liu YT,Kuo S,Zhang XQ,Schooley RT,Rohde H,Gallo RL,Huang CM

更新日期：2016-06-16 00:00:00

abstract：:Antimicrobial resistance seriously threatened human health. Combination therapy is generally an effective strategy to fight resistance, while some data on its effects are conflicting. To explore the reasons, the fractional inhibitory concentration indexes (FICIs) of three designed combinations against methicillin-resi...

journal_title：Scientific reports

authors： Xu X,Xu L,Yuan G,Wang Y,Qu Y,Zhou M

更新日期：2018-05-08 00:00:00

abstract：:High-throughput sequencing was applied to analyze the effects of toxic Microcystis aeruginosa on the silver carp Hypophthalmichthys molitrix. Silver carps were exposed to two cyanobacteria species (toxic and non-toxic) for RNA-seq and miRNA-seq analysis. RNA-seq revealed that the liver tissue contained 105,379 unigene...

journal_title：Scientific reports

authors： Hu M,Qu X,Pan L,Fu C,Jia P,Liu Q,Wang Y

更新日期：2017-09-05 00:00:00