Abstract：
:This study aimed to determine whether bisphosphonates exert an effect on preventing femoral head collapse after osteonecrosis of the femoral head (ONFH) in an animal model and in clinical trials. A systematic literature search was performed for studies published up to January 2017. Twenty-three articles (16 animal studies, seven clinical trials) were included in the meta-analysis. We found that the bisphosphonate group obtained significant improvement in epiphyseal quotients (MD = 15.32; 95% CI, 9.25-21.39) and provided better performance on bone volume (SMD = 1.57; 95% CI, 0.94-2.20), trabecular number (SMD = 1.30; 95% CI, 0.80-1.79), trabecular thickness (SMD = 0.77; 95% CI, 0.10-1.43) and trabecular separation (SMD = -1.44; 95% CI, -1.70 to -0.58) in the animal model. However, the bisphosphonate group did not achieve better results in pain score, Harris score, the occurrence rate of femoral head collapse, or total hip arthroplasty in the clinical trials. In conclusion, despite bisphosphonates significantly improving bone remodeling outcomes in animal models, no significant efficacy was observed in the treatment of ONFH in the clinical studies. Further studies are required to solve the discordant outcomes between the animal and clinical studies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Li D,Yang Z,Wei Z,Kang Pdoi
10.1038/s41598-018-19884-zsubject
Has Abstractpub_date
2018-01-23 00:00:00pages
1450issue
1issn
2045-2322pii
10.1038/s41598-018-19884-zjournal_volume
8pub_type
杂志文章,meta分析abstract：:Tree leaves are commonly composed of thin mesophyll, carrying out photosynthesis under sunlight, and thick veins. Although the role of leaf veins in water transportation has been known for a long time, their role in providing structural support and guaranteeing large sunlighted area was rarely studied and remains elus...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31763-1
更新日期：2018-09-14 00:00:00
abstract：:Pulmonary fibrosis is a serious lung disorder that can lead to respiratory failure. Here we show that transgenic mice expressing active renin from the liver (RenTgMK) developed progressive pulmonary fibrosis leading to impaired pulmonary function. Histological analyses revealed a marked increase in extracellular matri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15561
更新日期：2015-10-23 00:00:00
abstract：:Baeyer-Villiger monooxygenases (BVMOs) are able to catalyze regiospecific Baeyer-Villiger oxygenation of a variety of cyclic and linear ketones to generate the corresponding lactones and esters, respectively. However, the enzymes are usually difficult to express in a functional form in microbial cells and are rather u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28223
更新日期：2016-06-17 00:00:00
abstract：:In this work, we demonstrate an innovative approach, combing a novel active screen plasma (ASP) technique with green chemical synthesis, for a direct fabrication of uniform Pt nanowire arrays on large-area supports. The ASP treatment enables in-situ N-doping and surface modification to the support surface, significant...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06439
更新日期：2014-09-22 00:00:00
abstract：:Here we report that PTEN contributes to DNA double-strand break (DSB) repair via homologous recombination (HR), as evidenced by (i) inhibition of HR in a reporter plasmid assay, (ii) enhanced sensitivity to mitomycin-C or olaparib and (iii) reduced RAD51 loading at IR-induced DSBs upon PTEN knockdown. No association w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22289-7
更新日期：2018-03-02 00:00:00
abstract：:In this study, we have employed graphene oxide as a matrix to simultaneously and directly quantify serum nonesterified and esterified fatty acids (FAs) using matrix-assisted laser/desorption ionization-Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR MS). Twelve serum nonesterified FAs combined...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34201
更新日期：2016-09-30 00:00:00
abstract：:Propionibacterium freudenreichii, a dairy starter, can reach a population of almost 109 propionibacteria per gram in Swiss-type cheese at the time of consumption. Also consumed as a probiotic, it displays strain-dependent anti-inflammatory properties mediated by surface proteins that induce IL-10 in leukocytes. We sel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46409
更新日期：2017-04-13 00:00:00
abstract：:Malachite green is a common environmental pollutant that poses a great threat to non-target organisms, including humans. This study reports the characterization of a bacterial strain, Pseudomonas veronii JW3-6, which was isolated from a malachite green enrichment culture. This strain degraded malachite green efficient...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61442-z
更新日期：2020-03-11 00:00:00
abstract：:Different subtypes of bone marrow-derived stem cells are characterized by varying functionality and activity after transplantation into the infarcted heart. Improvement of stem cell therapeutics requires deep knowledge about the mechanisms that mediate the benefits of stem cell treatment. Here, we demonstrated that co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10122-6
更新日期：2017-08-29 00:00:00
abstract：:Light-sheet fluorescence microscopy has emerged as a powerful platform for 3-D volumetric imaging in the life sciences. Here, we introduce an important step towards its use deep inside biological tissue. Our new technique, based on digital holography, enables delivery of the light-sheet through a multimode optical fib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18050
更新日期：2015-12-14 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-37133-1
更新日期：2018-12-14 00:00:00
abstract：:Basidiomycetes can bioaccumulate high iron contents, but there are few studies on iron availability from the mycelial biomass in order to support their use as an iron-enriched fungal food. This study aimed to evaluate the in vitro iron bioaccumulation and availability in the mycelial biomass of edible and medicinal ba...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69699-0
更新日期：2020-07-30 00:00:00
abstract：:Population structure and biogeography of marine organisms are formed by different drivers than in terrestrial organisms. Yet, very little information is available even for common marine organisms and even less for their associated parasites. Here we report the first analysis of population structure of both a cephalopo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50555-9
更新日期：2019-10-04 00:00:00
abstract：:This cross-sectional study aimed to investigate the prevalence and risk factors of chronic kidney disease (CKD) among 1,096 primary care type 2 diabetes (T2DM) patients in northern Thailand between October 2016 and September 2017. CKD was defined as estimated glomerular rate filtration values of <60 mL/min/1.73 m2. Pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63443-4
更新日期：2020-04-10 00:00:00
abstract：:Increasing the thermostability of proteins is often crucial for their successful use as analytic, synthetic or therapeutic tools. Most rational thermostabilization strategies were developed on small two-state proteins and, unsurprisingly, they tend to fail when applied to the much more abundant, larger, non-fully coop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09129
更新日期：2015-03-16 00:00:00
abstract：:Currently, diagnostic testing for Lyme disease is done by determination of the serologic responses to Borrelia burgdorferi antigens, with the exception of the early localized phase of disease where diagnosis must be done clinically. Here, we describe the use of microfluidics technology to develop a multiplexed rapid l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35069
更新日期：2016-10-11 00:00:00
abstract：:Accurate species identification is fundamental when recording ecological data. However, the ability to correctly identify organisms visually is rarely questioned. We investigated how experts and non-experts compared in the identification of bumblebees, a group of insects of considerable conservation concern. Experts a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33634
更新日期：2016-09-20 00:00:00
abstract：:Functional interplays of microbial activity, genetic diversity and contaminant transformation are poorly understood in reactors for mineralizing halogenated aromatics anaerobically. Here, we investigated abundance and distribution of potential microbes and functional genes associated with pentachlorophenol (PCP) anaer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19015
更新日期：2016-01-11 00:00:00
abstract：:Bone scan abnormalities, especially rib lesions, are often confusing for physicians due to a high number of false-positive lesions. This study investigated risk factors that are associated with bone metastasis in 613 breast cancer patients with bone scan abnormalities. Significantly increased rates of bone metastasis ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09587
更新日期：2015-05-05 00:00:00
abstract：:We aimed to establish the collective influence of four lifestyle practices (physical activity, diet, smoking and alcohol consumption) on the prevalence and incidence of AMD. At baseline, 2428 participants aged 49+ with complete lifestyle and AMD data were examined, and of these, 1903 participants were re-examined 15 y...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04697-3
更新日期：2017-06-28 00:00:00
abstract：:Previous studies have demonstrated that gestational diabetes mellitus (GDM) and Type 2 diabetes mellitus (T2D) share common genetic polymorphisms. We conducted meta-analysis and subgroup analysis of all available variants and determined the effects of confounding and experimental components on the genetic association ...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
doi：10.1038/srep30539
更新日期：2016-07-29 00:00:00
abstract：:Mechanotransduction is crucial for touch sensation, hearing, proprioception, and pain sensing. In C. elegans, male ray neurons have been implicated to be involved in the mechanosensation required for mating behavior. However, whether ray neurons directly sense mechanical stimulation is not yet known, and the underlyin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25542-1
更新日期：2018-05-08 00:00:00
abstract：:In HIV-1/HCV-coinfected patients, chronic HCV infection leads to an increased T-lymphocyte immune activation compared to HIV-monoinfected patients, thereby likely contributing to increase HIV-1 reservoir that is the major barrier for its eradication. Our objective was to evaluate the influence of HCV coinfection in HI...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41788-9
更新日期：2019-04-03 00:00:00
abstract：:Concurrent spread of Tomato yellow leaf curl virus (TYLCV) with invasion of Bemisia tabaci Q rather than B in China suggests a more mutualistic relationship between TYLCV and Q than B. To assess this hypothesis, we quantified the impacts of TYLCV on the performance and competitiveness of B and Q in the laboratory. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02230
更新日期：2013-01-01 00:00:00
abstract：:The Ah receptor (AhR) is a ligand-dependent transcription factor belonging to the basic helix-loop-helix Per-Arnt-Sim (bHLH-PAS) superfamily. Binding to and activation of the AhR by a variety of chemicals results in the induction of expression of diverse genes and production of a broad spectrum of biological and toxic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47138-z
更新日期：2019-07-23 00:00:00
abstract：:Positron emission tomography (PET) imaging is used to localize recurrent disease in prostate cancer (PCa). The tracer 68Ga-PSMA-11 visualizes lesions overexpressing prostate-specific membrane antigen (PSMA), while 11C-acetate visualizes lesions with increased anabolic metabolism. The aim of this study was to compare t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61910-6
更新日期：2020-03-19 00:00:00
abstract：:Barley (Hordeum vulgare L.) produces five leucine-derived hydroxynitrile glucosides, potentially involved in alleviating pathogen and environmental stresses. These compounds include the cyanogenic glucoside epiheterodendrin. The biosynthetic genes are clustered. Total hydroxynitrile glucoside contents were previously ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41884-w
更新日期：2019-04-05 00:00:00
abstract：:Cystine-knot peptides are attractive templates in drug discovery due to a number of features they possess including their 3D conformation, physicochemical stability and synthetic tractability. Yet, their cellular uptake mechanisms remain largely unexplored. Recently, we demonstrated that the cystine-knot peptide EETI-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43285-5
更新日期：2019-05-06 00:00:00
abstract：:Underutilization due to performance limitations imposed by species and charge transports is one of the key issues that persist with various lithium-ion batteries. To elucidate the relevant mechanisms, two groups of characteristic parameters were proposed. The first group contains three characteristic time parameters, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32639
更新日期：2016-09-07 00:00:00
abstract：:A lack of exercise leads to being overweight or obese affecting regional brain structure and functional connectivity associated with impaired cognitive function and dementia. In recent decades, several studies of healthy individuals suggest that adiposity may also produce negative independent effects on the brain. We ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57345-3
更新日期：2020-01-17 00:00:00
