The Effect of Ganoderma Microsporum immunomodulatory proteins on alleviating PM2.5-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings.

Abstract:

:Fine particulate matter 2.5 (PM2.5) induces free radicals and oxidative stress in animals, leading to a range of illnesses. In this study, Ganoderma Microsporum immunomodulatory (GMI) proteins were administered to alleviate PM2.5-induced inflammatory responses in mother rats, and PM2.5-induced inflammatory responses and neurological damage in their offspring. The results suggested that GMI administration decreased the risk of neurological disorders in mother rats and their offspring by reducing the white blood cell count, lessening inflammatory responses and PM2.5-induced memory impairment, and preventing dendritic branches in the hippocampi from declining and microRNAs from PM2.5-induced modulation.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Tseng CY,Yu JY,Chuang YC,Lin CY,Wu CH,Liao CW,Yang FH,Chao MW

doi

10.1038/s41598-019-38810-5

subject

Has Abstract

pub_date

2019-05-02 00:00:00

pages

6854

issue

1

issn

2045-2322

pii

10.1038/s41598-019-38810-5

journal_volume

9

pub_type

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