Augmentation of CD134 (OX40)-dependent NK anti-tumour activity is dependent on antibody cross-linking.

Abstract:

:CD134 (OX40) is a member of the tumour necrosis factor receptor superfamily (TNFRSF). It acts as a costimulatory receptor on T cells, but its role on NK cells is poorly understood. CD137, another TNFRSF member has been shown to enhance the anti-tumour activity of NK cells in various malignancies. Here, we examine the expression and function of CD134 on human and mouse NK cells in B-cell lymphoma. CD134 was transiently upregulated upon activation of NK cells in both species. In contrast to CD137, induction of CD134 on human NK cells was dependent on close proximity to, or cell-to-cell contact with, monocytes or T cells. Stimulation with an agonistic anti-CD134 mAb but not CD134 ligand, increased IFNγ production and cytotoxicity of human NK cells, but this was dependent on simultaneous antibody:Fcγ receptor binding. In complementary murine studies, intravenous inoculation with BCL1 lymphoma into immunocompetent syngeneic mice resulted in transient upregulation of CD134 on NK cells. Combination treatment with anti-CD20 and anti-CD134 mAb produced a synergistic effect with durable remissions. This therapeutic benefit was abrogated by NK cell depletion and in Fcγ chain -/- mice. Hence, anti-CD134 agonists may enhance NK-mediated anti-tumour activity in an Fcγ receptor dependent fashion.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Turaj AH,Cox KL,Penfold CA,French RR,Mockridge CI,Willoughby JE,Tutt AL,Griffiths J,Johnson PWM,Glennie MJ,Levy R,Cragg MS,Lim SH

doi

10.1038/s41598-018-20656-y

subject

Has Abstract

pub_date

2018-02-02 00:00:00

pages

2278

issue

1

issn

2045-2322

pii

10.1038/s41598-018-20656-y

journal_volume

8

pub_type

杂志文章
  • Printable, wide band-gap chalcopyrite thin films for power generating window applications.

    abstract::Printable, wide band-gap chalcopyrite compound films (CuInGaS2, CIGS) were synthesized on transparent conducting oxide substrates. The wide band-gap and defective nature of the films reveal semi-transparent and bifacial properties that are beneficial for power generating window applications. Importantly, solar cell de...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04408

    authors: Moon SH,Park SJ,Hwang YJ,Lee DK,Cho Y,Kim DW,Min BK

    更新日期:2014-03-18 00:00:00

  • Task-dependent functional organizations of the visual ventral stream.

    abstract::The visual hierarchy of the ventral stream has been widely studied. However, it remains unclear how the hierarchical system organizes its functional coupling during top-down cognitive process. The present fMRI study investigated task-dependent functional connectivity along the ventral stream, while twenty-eight partic...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45707-w

    authors: Jo HG,Ito J,Schulte Holthausen B,Baumann C,Grün S,Habel U,Kellermann T

    更新日期:2019-06-27 00:00:00

  • In situ Scanning Electron Microscopy of Silicon Anode Reactions in Lithium-Ion Batteries during Charge/Discharge Processes.

    abstract::A comprehensive understanding of the charge/discharge behaviour of high-capacity anode active materials, e.g., Si and Li, is essential for the design and development of next-generation high-performance Li-based batteries. Here, we demonstrate the in situ scanning electron microscopy (in situ SEM) of Si anodes in a con...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep36153

    authors: Chen CY,Sano T,Tsuda T,Ui K,Oshima Y,Yamagata M,Ishikawa M,Haruta M,Doi T,Inaba M,Kuwabata S

    更新日期:2016-10-26 00:00:00

  • Acute and chronic gregarisation are associated with distinct DNA methylation fingerprints in desert locusts.

    abstract::Desert locusts (Schistocerca gregaria) show a dramatic form of socially induced phenotypic plasticity known as phase polyphenism. In the absence of conspecifics, locusts occur in a shy and cryptic solitarious phase. Crowding with conspecifics drives a behavioural transformation towards gregariousness that occurs withi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35608

    authors: Mallon EB,Amarasinghe HE,Ott SR

    更新日期:2016-10-18 00:00:00

  • Revealing higher than expected diversity of Harpacticoida (Crustacea:Copepoda) in the North Sea using MALDI-TOF MS and molecular barcoding.

    abstract::The North Sea is one of the most extensively studied marine regions of the world. Hence, large amounts of molecular data for species identification are available in public repositories, and expectations to find numerous new species in this well-known region are rather low. However, molecular reference data for harpact...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45718-7

    authors: Rossel S,Martínez Arbizu P

    更新日期:2019-06-24 00:00:00

  • Analysis of Co-Associated Transcription Factors via Ordered Adjacency Differences on Motif Distribution.

    abstract::Transcription factors (TFs) binding to specific DNA sequences or motifs, are elementary to the regulation of transcription. The gene is regulated by a combination of TFs in close proximity. Analysis of co-TFs is an important problem in understanding the mechanism of transcriptional regulation. Recently, ChIP-seq in ma...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43597

    authors: Pan G,Tang J,Guo F

    更新日期:2017-02-27 00:00:00

  • Proximity of breeding and foraging areas affects foraging effort of a crepuscular, insectivorous bird.

    abstract::When complementary resources are required for an optimal life cycle, most animals need to move between different habitats. However, the level of connectivity between resources can vary and, hence, influence individuals' behaviour. We show that landscape composition and configuration affect the connectivity between bre...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21321-0

    authors: Evens R,Beenaerts N,Neyens T,Witters N,Smeets K,Artois T

    更新日期:2018-02-14 00:00:00

  • Predicting Microstructural Void Nucleation in Discontinuous Fiber Composites through Coupled in-situ X-ray Tomography Experiments and Simulations.

    abstract::Composite materials have become widely used in engineering applications, in order to reduce the overall weight of structures while retaining their required strength. In this work, a composite material consisting of discontinuous glass fibers in a polypropylene matrix is studied at the microstructural level through cou...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-60368-w

    authors: Hanhan I,Agyei RF,Xiao X,Sangid MD

    更新日期:2020-02-27 00:00:00

  • Gender differences in the influence of obstructive sleep apnea on optic nerve head circulation.

    abstract::We investigated gender differences in the optic nerve head (ONH) microcirculation status in association with obstructive sleep apnea (OSA) by using laser speckle flowgraphy (LSFG). We evaluated 150 men (60.5 ± 11.0 yrs) and 45 women (63.0 ± 10.6 yrs) who underwent overnight polysomnography. The mean blur rate (MBR), m...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55470-7

    authors: Shiba T,Takahashi M,Matsumoto T,Hori Y

    更新日期:2019-12-11 00:00:00

  • Widespread distribution of prophage-encoded virulence factors in marine Vibrio communities.

    abstract::Prophages are known to encode important virulence factors in the human pathogen Vibrio cholerae. However, little is known about the occurrence and composition of prophage-encoded traits in environmental vibrios. A database of 5,674 prophage-like elements constructed from 1,874 Vibrio genome sequences, covering sixty-f...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-28326-9

    authors: Castillo D,Kauffman K,Hussain F,Kalatzis P,Rørbo N,Polz MF,Middelboe M

    更新日期:2018-07-02 00:00:00

  • Sample-Index Misassignment Impacts Tumour Exome Sequencing.

    abstract::Sample pooling enabled by dedicated indexes is a common strategy for cost-effective and robust high-throughput sequencing. Index misassignment leading to mutual contamination between pooled samples has however been described as a general problem of the latest Illumina sequencing instruments utilizing exclusion amplifi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23563-4

    authors: Vodák D,Lorenz S,Nakken S,Aasheim LB,Holte H,Bai B,Myklebost O,Meza-Zepeda LA,Hovig E

    更新日期:2018-03-28 00:00:00

  • Characterizing scientific production and consumption in physics.

    abstract::We analyze the entire publication database of the American Physical Society generating longitudinal (50 years) citation networks geolocalized at the level of single urban areas. We define the knowledge diffusion proxy, and scientific production ranking algorithms to capture the spatio-temporal dynamics of Physics know...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01640

    authors: Zhang Q,Perra N,Gonçalves B,Ciulla F,Vespignani A

    更新日期:2013-01-01 00:00:00

  • Screening of Parkinsonian subtle fine-motor impairment from touchscreen typing via deep learning.

    abstract::Fine-motor impairment (FMI) is progressively expressed in early Parkinson's Disease (PD) patients and is now known to be evident in the immediate prodromal stage of the condition. The clinical techniques for detecting FMI may not be robust enough and here, we show that the subtle FMI of early PD patients can be effect...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69369-1

    authors: Iakovakis D,Chaudhuri KR,Klingelhoefer L,Bostantjopoulou S,Katsarou Z,Trivedi D,Reichmann H,Hadjidimitriou S,Charisis V,Hadjileontiadis LJ

    更新日期:2020-07-28 00:00:00

  • Ultra-monochromatic far-infrared Cherenkov diffraction radiation in a super-radiant regime.

    abstract::Nowadays, intense electromagnetic (EM) radiation in the far-infrared (FIR) spectral range is an advanced tool for scientific research in biology, chemistry, and material science because many materials leave signatures in the radiation spectrum. Narrow-band spectral lines enable researchers to investigate the matter re...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76996-1

    authors: Karataev P,Fedorov K,Naumenko G,Popov K,Potylitsyn A,Vukolov A

    更新日期:2020-12-01 00:00:00

  • The time course of auditory recognition measured with rapid sequences of short natural sounds.

    abstract::Human listeners are able to recognize accurately an impressive range of complex sounds, such as musical instruments or voices. The underlying mechanisms are still poorly understood. Here, we aimed to characterize the processing time needed to recognize a natural sound. To do so, by analogy with the "rapid visual seque...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43126-5

    authors: Isnard V,Chastres V,Viaud-Delmon I,Suied C

    更新日期:2019-05-29 00:00:00

  • Four translation initiation pathways employed by the leaderless mRNA in eukaryotes.

    abstract::mRNAs lacking 5' untranslated regions (leaderless mRNAs) are molecular relics of an ancient translation initiation pathway. Nevertheless, they still represent a significant portion of transcriptome in some taxons, including a number of eukaryotic species. In bacteria and archaea, the leaderless mRNAs can bind non-diss...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37905

    authors: Akulich KA,Andreev DE,Terenin IM,Smirnova VV,Anisimova AS,Makeeva DS,Arkhipova VI,Stolboushkina EA,Garber MB,Prokofjeva MM,Spirin PV,Prassolov VS,Shatsky IN,Dmitriev SE

    更新日期:2016-11-28 00:00:00

  • Modality-specific improvements in sensory processing among baseball players.

    abstract::Long-term skills training is known to induce neuroplastic alterations, but it is still debated whether these changes are always modality-specific or can be supramodal components. To address this issue, we compared finger-targeted somatosensory-evoked and auditory-evoked potentials under both Go (response) and Nogo (re...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81852-x

    authors: Yamashiro K,Yamazaki Y,Siiya K,Ikarashi K,Baba Y,Otsuru N,Onishi H,Sato D

    更新日期:2021-01-26 00:00:00

  • Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients.

    abstract::Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. Individuals with RA have a higher risk of periodontitis and periodontitis has been linked to RA through the production of enzymes by periodontal pathogens that citrullinate proteins. This linkage is supported by findings that perio...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44674-6

    authors: Corrêa JD,Fernandes GR,Calderaro DC,Mendonça SMS,Silva JM,Albiero ML,Cunha FQ,Xiao E,Ferreira GA,Teixeira AL,Mukherjee C,Leys EJ,Silva TA,Graves DT

    更新日期:2019-06-10 00:00:00

  • A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth.

    abstract::Breast cancer is a heterogeneous disease consisting of several subtypes. Among these subtypes, triple negative breast cancer is particularly difficult to treat. This is due to a lack of understanding of the mechanisms behind the disease, and consequently a lack of druggable targets. PAK4 plays critical roles in cell s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep42555

    authors: Rane C,Senapedis W,Baloglu E,Landesman Y,Crochiere M,Das-Gupta S,Minden A

    更新日期:2017-02-15 00:00:00

  • Author Correction: Anthropometric measures and HbA1c to detect dysglycemia in young Asian women planning conception: The S-PRESTO cohort.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-69653-0

    authors: Chu AHY,Aris IM,Ng S,Loy SL,Bernard JY,Tint MT,Yuan WL,Godfrey KM,Chan JKY,Shek LP,Chong YS,Tan KH,Ang SB,Tan HH,Chern BSM,Yap F,Lee YS,Lek N,Leow MK,Khoo CM,Chan SY

    更新日期:2020-07-24 00:00:00

  • 3-bromopyruvate ameliorate autoimmune arthritis by modulating Th17/Treg cell differentiation and suppressing dendritic cell activation.

    abstract::Recent studies have shown that cellular metabolism plays an important role in regulating immune cell functions. In immune cell differentiation, both interleukin-17-producing T (Th17) cells and dendritic cells (DCs) exhibit increased glycolysis through the upregulation of glycolytic enzymes, such as hexokinase-2 (HK2)....

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep42412

    authors: Okano T,Saegusa J,Nishimura K,Takahashi S,Sendo S,Ueda Y,Morinobu A

    更新日期:2017-02-10 00:00:00

  • Sustained kidney biochemical derangement in treated experimental diabetes: a clue to metabolic memory.

    abstract::The occurrence of biochemical alterations that last for a long period of time in diabetic individuals even after adequate handling of glycemia is an intriguing phenomenon named metabolic memory. In this study, we show that a kidney pathway is gradually altered during the course of diabetes and remains persistently cha...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40544

    authors: de Oliveira AA,de Oliveira TF,Bobadilla LL,Garcia CC,Berra CM,de Souza-Pinto NC,Medeiros MH,Di Mascio P,Zatz R,de M Loureiro AP

    更新日期:2017-01-12 00:00:00

  • Prognostic significance of Rab27 expression in solid cancer: a systematic review and meta-analysis.

    abstract::Rab27 is an essential molecule of vesicle fusion and trafficking in exosome secretion process, which plays important roles in cancer progression and metastasis. Recent studies reported that Rab27 expression is also associated with cancer prognosis. Therefore, we performed a meta-analysis to reveal the prognostic signi...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/s41598-020-71104-9

    authors: Koh HM,Jang BG,Kim DC

    更新日期:2020-08-24 00:00:00

  • Author Correction: A rapid quality control test to foster the development of genetic control in mosquitoes.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-019-44071-z

    authors: Culbert NJ,Balestrino F,Dor A,Herranz GS,Yamada H,Wallner T,Bouyer J

    更新日期:2019-06-05 00:00:00

  • Noiseonomics: the relationship between ambient noise levels in the sea and global economic trends.

    abstract::In recent years, the topic of noise in the sea and its effects on marine mammals has attracted considerable attention from both the scientific community and the general public. Since marine mammals rely heavily on acoustics as a primary means of communicating, navigating, and foraging in the ocean, any change in their...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00437

    authors: Frisk GV

    更新日期:2012-01-01 00:00:00

  • Characterization of aspartyl aminopeptidase from Toxoplasma gondii.

    abstract::Aminopeptidases have emerged as new promising drug targets for the development of novel anti-parasitic drugs. An aspartyl aminopeptidase-like gene has been identified in the Toxoplasma gondii genome (TgAAP), although its function remains unknown. In this study, we characterized TgAAP and performed functional analysis ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34448

    authors: Zheng J,Cheng Z,Jia H,Zheng Y

    更新日期:2016-09-28 00:00:00

  • Association of pre-pregnancy body mass index, gestational weight gain with cesarean section in term deliveries of China.

    abstract::China has one of the highest rates of cesarean sections in the world. However, limited epidemiological studies have evaluated the risk factors for cesarean section among Chinese women. Thus, the aim of this cohort study was to investigate the associations between pre-pregnancy BMI, gestational weight gain (GWG) and th...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37168

    authors: Xiong C,Zhou A,Cao Z,Zhang Y,Qiu L,Yao C,Wang Y,Zhang B

    更新日期:2016-11-22 00:00:00

  • Controlling Light Transmission Through Highly Scattering Media Using Semi-Definite Programming as a Phase Retrieval Computation Method.

    abstract::Complex Semi-Definite Programming (SDP) is introduced as a novel approach to phase retrieval enabled control of monochromatic light transmission through highly scattering media. In a simple optical setup, a spatial light modulator is used to generate a random sequence of phase-modulated wavefronts, and the resulting i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02716-x

    authors: N'Gom M,Lien MB,Estakhri NM,Norris TB,Michielssen E,Nadakuditi RR

    更新日期:2017-05-31 00:00:00

  • Microstructure analysis and mechanical properties of phosphorus-reinforced ZCuPb20Sn5 alloy.

    abstract::An investigation was carried out to assess the effect of the P content on the microstructure and mechanical properties of ZCuPb20Sn5 alloy. Alloys of various compositions, (0.05, 0.1, 0.2, 0.3, 0.5% wt.% P) were melted in a melting furnace under 1200 °C and cast into metal mould, the hardness, strength and elongation ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49441-1

    authors: Ren XY,Zhang X,Hong X,Ren J

    更新日期:2019-09-16 00:00:00

  • Resolving the Architecture and Early Evolution of a Forearc Basin (Georgia Basin, Canada) Using Detrital Zircon.

    abstract::Convergent-margin basins (CMBs) are commonly associated with active arcs, and hence are rich in detrital zircon (DZ) whose ages closely reflect the timing of deposition. Consequently, maximum depositional ages (MDA) from DZ geochronology can be employed to resolve the stratigraphy and evolution of CMBs. Herein, we use...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51795-5

    authors: Huang C,Dashtgard SE,Kent BAP,Gibson HD,Matthews WA

    更新日期:2019-10-25 00:00:00