当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Methionine residues around phosphorylation sites are preferentially oxidized in vivo under stress conditions.

Methionine residues around phosphorylation sites are preferentially oxidized in vivo under stress conditions.

Abstract：

:Protein phosphorylation is one of the most prevalent and well-understood protein modifications. Oxidation of protein-bound methionine, which has been traditionally perceived as an inevitable damage derived from oxidative stress, is now emerging as another modification capable of regulating protein activity during stress conditions. However, the mechanism coupling oxidative signals to changes in protein function remains unknown. An appealing hypothesis is that methionine oxidation might serve as a rheostat to control phosphorylation. To investigate this potential crosstalk between phosphorylation and methionine oxidation, we have addressed the co-occurrence of these two types of modifications within the human proteome. Here, we show that nearly all (98%) proteins containing oxidized methionine were also phosphoproteins. Furthermore, phosphorylation sites were much closer to oxidized methionines when compared to non-oxidized methionines. This proximity between modification sites cannot be accounted for by their co-localization within unstructured clusters because it was faithfully reproduced in a smaller sample of structured proteins. We also provide evidence that the oxidation of methionine located within phosphorylation motifs is a highly selective process among stress-related proteins, which supports the hypothesis of crosstalk between methionine oxidation and phosphorylation as part of the cellular defence against oxidative stress.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Veredas FJ,Cantón FR,Aledo JC

doi

10.1038/srep40403

subject

Has Abstract

pub_date

2017-01-12 00:00:00

pages

40403

issn

2045-2322

pii

srep40403

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Non-equilibrium scale invariance and shortcuts to adiabaticity in a one-dimensional Bose gas.

    abstract：:We present experimental evidence for scale invariant behaviour of the excitation spectrum in phase-fluctuating quasi-1d Bose gases after a rapid change of the external trapping potential. Probing density correlations in free expansion, we find that the temperature of an initial thermal state scales with the spatial ex...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09820

    authors： Rohringer W,Fischer D,Steiner F,Mazets IE,Schmiedmayer J,Trupke M

    更新日期：2015-04-13 00:00:00

  • Increased estrogen to androgen ratio enhances immunoglobulin levels and impairs B cell function in male mice.

    abstract：:Sex steroids, such as estrogens and androgens, are important regulators of the humoral immune response. Studies in female mice have demonstrated that alteration of circulating estrogen concentration regulates antibody-mediated immunity. As males have normally little endogenous estrogen, we hypothesized that in males h...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75059-9

    authors： Aguilar-Pimentel JA,Cho YL,Gerlini R,Calzada-Wack J,Wimmer M,Mayer-Kuckuk P,Adler T,Schmidt-Weber CB,Busch DH,Fuchs H,Gailus-Durner V,Ollert M,Hrabě de Angelis M,Ohlsson C,Poutanen M,Teperino R,Strauss L

    更新日期：2020-10-27 00:00:00

  • Mangiferin from Pueraria tuberosa reduces inflammation via inactivation of NLRP3 inflammasome.

    abstract：:Recent reports have demonstrated the role of phyto-constituents in modulating inflammatory responses. Mangiferin isolated from Mangifera indica is known to induce potent anti-oxidative, anti-diabetic and anti-inflammatory activity. However, the molecular mechanism of its anti-inflammatory activity is not properly unde...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42683

    authors： Bulugonda RK,Kumar KA,Gangappa D,Beeda H,Philip GH,Muralidhara Rao D,Faisal SM

    更新日期：2017-02-20 00:00:00

  • Interval Optimization Model Considering Terrestrial Ecological Impacts for Water Rights Transfer from Agriculture to Industry in Ningxia, China.

    abstract：:In this study, an interval optimization model is developed to maximize the benefits of a water rights transfer system that comprises industry and agriculture sectors in the Ningxia Hui Autonomous Region in China. The model is subjected to a number of constraints including water saving potential from agriculture and ec...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02734-9

    authors： Sun L,Li C,Cai Y,Wang X

    更新日期：2017-06-14 00:00:00

  • SPARK-MSNA: Efficient algorithm on Apache Spark for aligning multiple similar DNA/RNA sequences with supervised learning.

    abstract：:Multiple sequence alignment (MSA) is an integral part of molecular biology. But handling massive number of large sequences is still a bottleneck for most of the state-of-the-art software tools. Knowledge driven algorithms utilizing features of input sequences, such as high similarity in case of DNA sequences, can help...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42966-5

    authors： Vineetha V,Biji CL,Nair AS

    更新日期：2019-04-29 00:00:00

  • Effects of biotin on promoting anammox bacterial activity.

    abstract：:Anaerobic ammonium oxidation (anammox) bacteria significantly improve the efficiency and reduce cost of nitrogen removal in wastewater treatment plants. However, their slow growth and vulnerable activity limit the application of anammox technology. In this paper, the enhancement of biotin on the nitrogen removal activ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81738-y

    authors： Li Q,Chen J,Liu GH,Xu X,Zhang Q,Wang Y,Yuan J,Li Y,Qi L,Wang H

    更新日期：2021-01-21 00:00:00

  • A versatile microfluidic device for highly inclined thin illumination microscopy in the moss Physcomitrella patens.

    abstract：:High-resolution microscopy is a valuable tool for studying cellular processes, such as signalling, membrane trafficking, or cytoskeleton remodelling. Several techniques of inclined illumination microscopy allow imaging at a near single molecular level; however, the application of these methods to plant cells is limite...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-51624-9

    authors： Kozgunova E,Goshima G

    更新日期：2019-10-23 00:00:00

  • Validation of multiplex immunofluorescence panels using multispectral microscopy for immune-profiling of formalin-fixed and paraffin-embedded human tumor tissues.

    abstract：:Immune-profiling is becoming an important tool to identify predictive markers for the response to immunotherapy. Our goal was to validate multiplex immunofluorescence (mIF) panels to apply to formalin-fixed and paraffin-embedded tissues using a set of immune marker antibodies, with the Opal™ 7 color Kit (PerkinElmer) ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13942-8

    authors： Parra ER,Uraoka N,Jiang M,Cook P,Gibbons D,Forget MA,Bernatchez C,Haymaker C,Wistuba II,Rodriguez-Canales J

    更新日期：2017-10-17 00:00:00

  • Generation of orbital angular momentum modes via holographic leaky-wave metasurfaces.

    abstract：:Recently, electromagnetic (EM) waves carrying orbital angular momentum (OAM) has received considerable attention in increasingly many different realms, such as communication systems, super-resolution imaging, optical communications and quantum state manipulation. In this paper, two different kinds of two dimensional (...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64278-9

    authors： Oraizi H,Emamian H

    更新日期：2020-04-30 00:00:00

  • Establishment of induced pluripotent stem cells from normal B cells and inducing AID expression in their differentiation into hematopoietic progenitor cells.

    abstract：:B cell derived induced pluripotent stem cells (BiPSCs) were recently established from peripheral blood B cells by the simultaneous transfection of Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) and C/EBPα using a Sendai virus vector. Here, using a different method, we established BiPSCs with immunoglobulin heavy chain (...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01627-1

    authors： Kawamura F,Inaki M,Katafuchi A,Abe Y,Tsuyama N,Kurosu Y,Yanagi A,Higuchi M,Muto S,Yamaura T,Suzuki H,Noji H,Suzuki S,Yoshida MA,Sasatani M,Kamiya K,Onodera M,Sakai A

    更新日期：2017-05-10 00:00:00

  • Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells.

    abstract：:Tudor domain containing protein 3 (TDRD3) is a modular protein identified based on its ability to recognize methylated arginine motifs through its Tudor domain. We have previously shown that TDRD3 localizes to cytoplasmic stress granules, a structure shown to promote survival upon treatment with chemotherapeutic drugs...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04955-4

    authors： Morettin A,Paris G,Bouzid Y,Baldwin RM,Falls TJ,Bell JC,Côté J

    更新日期：2017-07-11 00:00:00

  • Pooled samples and eDNA-based detection can facilitate the "clean trade" of aquatic animals.

    abstract：:The regional and international trade of live animals facilitates the movement, spillover, and emergence of zoonotic and epizootic pathogens around the world. Detecting pathogens in trade is critical for preventing their continued movement and introduction, but screening a sufficient fraction to ensure rare infections ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-66280-7

    authors： Brunner JL

    更新日期：2020-06-24 00:00:00

  • Shortcuts to adiabaticity in a time-dependent box.

    abstract：:A method is proposed to drive an ultrafast non-adiabatic dynamics of an ultracold gas trapped in a time-dependent box potential. The resulting state is free from spurious excitations associated with the breakdown of adiabaticity, and preserves the quantum correlations of the initial state up to a scaling factor. The p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00648

    authors： del Campo A,Boshier MG

    更新日期：2012-01-01 00:00:00

  • Physiological responses to daily light exposure.

    abstract：:Long daylength artificial light exposure associates with disorders, and a potential physiological mechanism has been proposed. However, previous studies have examined no more than three artificial light treatments and limited metabolic parameters, which have been insufficient to demonstrate mechanical responses. Here,...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24808

    authors： Yang Y,Yu Y,Yang B,Zhou H,Pan J

    更新日期：2016-04-21 00:00:00

  • A novel molecular index for secondary oil migration distance.

    abstract：:Determining oil migration distances from source rocks to reservoirs can greatly help in the search for new petroleum accumulations. Concentrations and ratios of polar organic compounds are known to change due to preferential sorption of these compounds in migrating oils onto immobile mineral surfaces. However, these c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02487

    authors： Zhang L,Li M,Wang Y,Yin QZ,Zhang W

    更新日期：2013-01-01 00:00:00

  • Effects of daily L-dopa administration on learning and brain structure in older adults undergoing cognitive training: a randomised clinical trial.

    abstract：:Cognitive aging creates major individual and societal burden, motivating search for treatment and preventive care strategies. Behavioural interventions can improve cognitive performance in older age, but effects are small. Basic research has implicated dopaminergic signalling in plasticity. We investigated whether sup...

    journal_title：Scientific reports

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/s41598-020-62172-y

    authors： Lebedev AV,Nilsson J,Lindström J,Fredborg W,Akenine U,Hillilä C,Andersen P,Spulber G,de Lange ECM,van den Berg DJ,Kivipelto M,Lövdén M

    更新日期：2020-03-23 00:00:00

  • An in-silico layer-by-layer adsorption study of the interaction between Rebaudioside A and the T1R2 human sweet taste receptor: modelling and biosensing perspectives.

    abstract：:The human sweet taste receptor (T1R2) monomer-a member of the G-protein coupled receptor family that detects a wide variety of chemically and structurally diverse sweet tasting molecules, is known to pose a significant threat to human health. Protein that lack crystal structure is a challenge in structure-based protei...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75123-4

    authors： Arodola OA,Kanchi S,Hloma P,Bisetty K,Asiri AM,Inamuddin

    更新日期：2020-10-27 00:00:00

  • Using Baidu Search Engine to Monitor AIDS Epidemics Inform for Targeted intervention of HIV/AIDS in China.

    abstract：:China's reported cases of Human Immunodeficiency Virus (HIV) and AIDS increased from over 50000 in 2011 to more than 130000 in 2017, while AIDS related search indices on Baidu from 2.1 million to 3.7 million in the same time periods. In China, people seek AIDS related knowledge from Baidu which one of the world's larg...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35685-w

    authors： Li K,Liu M,Feng Y,Ning C,Ou W,Sun J,Wei W,Liang H,Shao Y

    更新日期：2019-01-23 00:00:00

  • The redox metabolic pathways function to limit Anaplasma phagocytophilum infection and multiplication while preserving fitness in tick vector cells.

    abstract：:Aerobic organisms evolved conserved mechanisms controlling the generation of reactive oxygen species (ROS) to maintain redox homeostasis signaling and modulate signal transduction, gene expression and cellular functional responses under physiological conditions. The production of ROS by mitochondria is essential in th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49766-x

    authors： Alberdi P,Cabezas-Cruz A,Prados PE,Rayo MV,Artigas-Jerónimo S,de la Fuente J

    更新日期：2019-09-13 00:00:00

  • Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites.

    abstract：:Influenza viruses are among the most common pathogens that threaten the health of humans and animals worldwide. Various anti-viral therapeutic agents are currently used for treatment and prophylaxis of influenza virus, but the targets of these drugs are easily mutated and result in resistance. Therefore, medications t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep29684

    authors： Pang B,Cheung NN,Zhang W,Dai J,Kao RY,Zhang H,Hao Q

    更新日期：2016-07-11 00:00:00

  • Dihydromyricetin Induces Apoptosis and Reverses Drug Resistance in Ovarian Cancer Cells by p53-mediated Downregulation of Survivin.

    abstract：:Ovarian cancer is one of the leading causes of death in gynecological malignancies, and the resistance to chemotherapeutic agents remains a major challenge to successful ovarian cancer chemotherapy. Dihydromyricetin (DHM), a natural flavonoid derived from Ampeopsis Grossdentata, has been widely applied in food industr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep46060

    authors： Xu Y,Wang S,Chan HF,Lu H,Lin Z,He C,Chen M

    更新日期：2017-04-24 00:00:00

  • Climatic and environmental aspects of the Mongol withdrawal from Hungary in 1242 CE.

    abstract：:The Mongol invasion of Eastern Europe, and especially its sudden withdrawal from Hungary in 1242 CE, has generated much speculation and an array of controversial theories. None of them, however, considered multifaceted environmental drivers and the coupled analysis of historical reports and natural archives. Here we i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25606

    authors： Büntgen U,Di Cosmo N

    更新日期：2016-05-26 00:00:00

  • The influence of a single hemodialysis procedure on human T lymphocytes.

    abstract：:At the moment it is unknown to what extent the impaired function of T lymphocytes in ESRD patients depends on uremia, and to what extent on hemodialysis (HD) procedure. Therefore, the purpose of the study was to evaluate percentages of T lymphocyte subpopulations ex vivo, plasma concentrations of IL12p70, TNF, IL-10, ...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-019-41619-x

    authors： Lisowska KA,Pindel M,Pietruczuk K,Kuźmiuk-Glembin I,Storoniak H,Dębska-Ślizień A,Witkowski JM

    更新日期：2019-03-25 00:00:00

  • Superfluid flow above the critical velocity.

    abstract：:Superfluidity and superconductivity have been widely studied since the last century in many different contexts ranging from nuclear matter to atomic quantum gases. The rigidity of these systems with respect to external perturbations results in frictionless motion for superfluids and resistance-free electric current fl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08941-8

    authors： Paris-Mandoki A,Shearring J,Mancarella F,Fromhold TM,Trombettoni A,Krüger P

    更新日期：2017-08-22 00:00:00

  • Multiplex congruence network of natural numbers.

    abstract：:Congruence theory has many applications in physical, social, biological and technological systems. Congruence arithmetic has been a fundamental tool for data security and computer algebra. However, much less attention was devoted to the topological features of congruence relations among natural numbers. Here, we explo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23714

    authors： Yan XY,Wang WX,Chen GR,Shi DH

    更新日期：2016-03-31 00:00:00

  • Effort and performance in a cooperative activity are boosted by perception of a partner's effort.

    abstract：:In everyday life, people must often determine how much time and effort to allocate to cooperative activities. In the current study, we tested the hypothesis that the perception of others' effort investment in a cooperative activity may elicit a sense of commitment, leading people to allocate more time and effort to th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34096-1

    authors： Chennells M,Michael J

    更新日期：2018-10-24 00:00:00

  • Genomic Characterization of Diverse Gyroviruses Identified in the Feces of Domestic Cats.

    abstract：:Gyroviruses (GyVs) are small, single-stranded, circular DNA viruses in the genus Gyrovirus, which consists of the chicken anemia virus (CAV) prototype and nine other viral species. These different GyV species have been reported in chickens, humans, mice, and companion animals. To date, CAV has been identified in the f...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49955-8

    authors： Niu JT,Yi SS,Dong GY,Guo YB,Zhao YL,Huang HL,Wang K,Hu GX,Dong H

    更新日期：2019-09-16 00:00:00

  • Pilot in vivo studies on transcutaneous boiling histotripsy in porcine liver and kidney.

    abstract：:Boiling histotripsy (BH) is a High Intensity Focused Ultrasound (HIFU) method for precise mechanical disintegration of target tissue using millisecond-long pulses containing shocks. BH treatments with real-time ultrasound (US) guidance allowed by BH-generated bubbles were previously demonstrated ex vivo and in vivo in...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56658-7

    authors： Khokhlova TD,Schade GR,Wang YN,Buravkov SV,Chernikov VP,Simon JC,Starr F,Maxwell AD,Bailey MR,Kreider W,Khokhlova VA

    更新日期：2019-12-27 00:00:00

  • Receptor-interacting serine/threonine kinase 1- and 3-dependent inflammation induced in lungs of chicken infected with Pasteurella multocida.

    abstract：:Fowl cholera is a serious, highly contagious disease caused by the bacterium Pasteurella multocida (P. multocida) in a range of avian species and is characterized by an acute form of septicaemia. The pathogenic mechanism of chicken lung injury caused by the bacterium is unclear. Therefore, P. multocida Q (a reference ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62042-7

    authors： Li W,Tang Q,Dai N,Feng W,Xie C,Cheng G,Liu X,Zhang W,Hu X,Gu C

    更新日期：2020-04-14 00:00:00

  • Establish axenic cultures of armored and unarmored marine dinoflagellate species using density separation, antibacterial treatments and stepwise dilution selection.

    abstract：:Academic research on dinoflagellate, the primary causative agent of harmful algal blooms (HABs), is often hindered by the coexistence with bacteria in laboratory cultures. The development of axenic dinoflagellate cultures is challenging and no universally accepted method suit for different algal species. In this study...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80638-x

    authors： Lee TC,Chan PL,Tam NF,Xu SJ,Lee FW

    更新日期：2021-01-08 00:00:00