Genetic variants associated with gestational diabetes mellitus: a meta-analysis and subgroup analysis.

abstract：:The Spike protein of the novel coronavirus SARS-CoV2 contains an insertion 680SPRRAR↓SV687 forming a cleavage motif RxxR for furin-like enzymes at the boundary of S1/S2 subunits. Cleavage at S1/S2 is important for efficient viral entry into target cells. The insertion is absent in other CoV-s of the same clade, includ...

journal_title：Scientific reports

authors： Örd M,Faustova I,Loog M

更新日期：2020-10-09 00:00:00

abstract：:Antibodies of the IgG class to terminal Galα3Gal (IgG anti-αGal) is abundant in human plasma and are reported to bind most sepsis-causing Gram-negative bacteria. However, these seminal findings, made more than two decades ago, have not been reexamined. Our aim was to assess IgG anti-αGal´s pathogen reactivity. We affi...

journal_title：Scientific reports

authors： Bernth Jensen JM,Petersen MS,Ellerman-Eriksen S,Møller BK,Jensenius JC,Sørensen UBS,Thiel S

更新日期：2020-03-12 00:00:00

abstract：:Human CD4+FoxP3+T-cells are heterogeneous in function and include not only suppressive cells (Tregs), but also effector cells that transiently express FoxP3 upon activation. Previous studies in Granulomatosis with Polyangiitis (GPA-)patients have demonstrated an increase in FoxP3+T-cells with impaired suppressive capa...

journal_title：Scientific reports

authors： Reijnders TDY,Stegeman CA,Huitema MG,Rutgers A,Heeringa P,Abdulahad WH

更新日期：2019-06-04 00:00:00

abstract：:Animals are capable of using visual cues to find the correct route during navigation. These visual cues, which contain spatial information on the direction towards the goal point, are perceived either allocentrically or egocentrically. In this study, we examined how navigating with these two types of visual cues affec...

journal_title：Scientific reports

authors： Chun J,Kim Y,Choi JW,Kim D,Jo S

更新日期：2019-04-23 00:00:00

abstract：:Curvature components derived from satellite gravity gradients provide new global views of Earth's structure. The satellite gravity gradients are based on the GOCE satellite mission and we illustrate by curvature images how the Earth is seen differently compared to seismic imaging. Tectonic domains with similar seismic...

journal_title：Scientific reports

authors： Ebbing J,Haas P,Ferraccioli F,Pappa F,Szwillus W,Bouman J

更新日期：2018-11-05 00:00:00

abstract：:Insulin resistance is a major risk factor for metabolic diseases such as Type 2 diabetes. Although the underlying mechanisms of insulin resistance remain elusive, oxidative stress is a unifying driver by which numerous extrinsic signals and cellular stresses trigger insulin resistance. Consequently, we sought to under...

journal_title：Scientific reports

authors： Chaudhuri R,Krycer JR,Fazakerley DJ,Fisher-Wellman KH,Su Z,Hoehn KL,Yang JYH,Kuncic Z,Vafaee F,James DE

更新日期：2018-01-29 00:00:00

abstract：:Current knowledge about the overall and site-specific risk of malignancy associated with ankylosing spondylitis (AS) is inconsistent. We conducted a systematic review and meta-analysis to address this knowledge gap. Five databases (PubMed, EMBASE, Web of Science, the Cochrane library and the virtual health library) we...

journal_title：Scientific reports

authors： Deng C,Li W,Fei Y,Li Y,Zhang F

更新日期：2016-08-18 00:00:00

abstract：:We evaluated bioactive glass graft (S53P4) in patients undergoing Le Fort I osteotomy, with non-grafted patients as controls. Computed tomography facial scans of the 25 patients submitted for Le Fort I were divided into two groups: Group 1-S53P4 group and Group 2-without grafting. CT scans were analyzed in the immedia...

journal_title：Scientific reports

authors： de Souza Cruz EL,de Souza FJ Jr,de Menezes LM,Tuji FM,Carneiro JT Jr

更新日期：2020-07-29 00:00:00

abstract：:Although the association between social support and postpartum depression has been previously investigated, its causal relationship remains unclear. Therefore, we examined prospectively whether social support during pregnancy affected postpartum depression. Social support and depressive symptoms were assessed by Japan...

journal_title：Scientific reports

authors： Morikawa M,Okada T,Ando M,Aleksic B,Kunimoto S,Nakamura Y,Kubota C,Uno Y,Tamaji A,Hayakawa N,Furumura K,Shiino T,Morita T,Ishikawa N,Ohoka H,Usui H,Banno N,Murase S,Goto S,Kanai A,Masuda T,Ozaki N

更新日期：2015-05-29 00:00:00

abstract：:Pertuzumab is an antihuman HER2 antibody developed for HER2 positive breast cancer. Glycosylation profiles are always the important issue for antibody based therapy. Previous findings have suggested the impact of glycosylation profiles on the function of antibodies, like pharmacodynamics, antibody-dependent cellular c...

journal_title：Scientific reports

authors： Luo C,Chen S,Xu N,Wang C,Sai WB,Zhao W,Li YC,Hu XJ,Tian H,Gao XD,Yao WB

更新日期：2017-04-11 00:00:00

abstract：:The inter-relationship between subtropical western-central Pacific sea surface temperatures (STWCPSST), sea ice concentrations in the Beaufort Sea (SICBS), and the North Atlantic Oscillation (NAO) in summer are investigated over the period 1980-2016. It is shown that the Arctic response to the remote impact of the Pac...

journal_title：Scientific reports

authors： Lim YK,Cullather RI,Nowicki SMJ,Kim KM

更新日期：2019-03-05 00:00:00

abstract：:The effect on the reproductive system and fertility of living in a space environment remains unclear. Here, we caged 12 male mice under artificial gravity (≈1 gravity) (AG) or microgravity (MG) in the International Space Station (ISS) for 35 days, and characterized the male reproductive organs (testes, epididymides, a...

journal_title：Scientific reports

authors： Matsumura T,Noda T,Muratani M,Okada R,Yamane M,Isotani A,Kudo T,Takahashi S,Ikawa M

更新日期：2019-09-24 00:00:00

abstract：:Referential pointing is a characteristically human behavior, which involves moving a finger through space to direct an addressee towards a desired mental state. Planning this type of action requires an interface between sensorimotor and conceptual abilities. A simple interface could supplement spatially-guided motor r...

journal_title：Scientific reports

authors： Murillo Oosterwijk A,de Boer M,Stolk A,Hartmann F,Toni I,Verhagen L

更新日期：2017-06-27 00:00:00

abstract：:Peste des petits ruminants (PPR) is a highly contagious and devastating viral disease affecting mainly sheep and goats, but also a large number of wild species within the order Artiodactyla. A better understanding of PPR transmission dynamics in multi-host systems is necessary to efficiently control the disease, in pa...

journal_title：Scientific reports

authors： Bataille A,Kwiatek O,Belfkhi S,Mounier L,Parida S,Mahapatra M,Caron A,Chubwa CC,Keyyu J,Kock R,Jones BA,Libeau G

更新日期：2019-03-18 00:00:00

abstract：:The pathophysiological implications of plasminogen activator inhibitor-1 (PAI-1) in HCV infection remain obscure. This prospective study evaluated 669 HCV patients, of whom 536 had completed a course of anti-HCV therapy and had pre-, peri- and post-therapy measurements of various profiles, including PAI-1 levels. Mult...

journal_title：Scientific reports

authors： Chang ML,Lin YS,Pao LH,Huang HC,Chiu CT

更新日期：2017-02-13 00:00:00

abstract：:We recently showed that spinal cord injury (SCI) leads to a decrease in mRNA editing of serotonin receptor 2C (5-HT2CR) contributing to post-SCI spasticity. Here we study post-SCI mRNA editing and global gene expression using massively parallel sequencing. Evidence is presented that the decrease in 5-HT2CR editing is ...

journal_title：Scientific reports

authors： Di Narzo AF,Kozlenkov A,Ge Y,Zhang B,Sanelli L,May Z,Li Y,Fouad K,Cardozo C,Koonin EV,Bennett DJ,Dracheva S

更新日期：2015-07-30 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Sykora-Bodie ST,Bezy V,Johnston DW,Newton E,Lohmann KJ

更新日期：2018-04-19 00:00:00

abstract：:The increasing antibiotic resistance evolved by Helicobacter pylori has alarmingly reduced the eradication rates of first-line therapies. To overcome the current circulating resistome, we selected a novel potential therapeutic target in order to identify new candidate drugs for treating H. pylori infection. We screene...

journal_title：Scientific reports

authors： González A,Salillas S,Velázquez-Campoy A,Espinosa Angarica V,Fillat MF,Sancho J,Lanas Á

更新日期：2019-08-05 00:00:00

abstract：:Previously, we cloned a new gene termed 'tongue cancer resistance-associated protein 1' (TCRP1), which modulates tumorigenesis, enhances cisplatin (cDDP) resistance in cancers, and may be a potential target for reversing drug resistance. However, the mechanisms for regulating TCRP1 expression remain unclear. Herein, w...

journal_title：Scientific reports

authors： Jia X,Zhang Z,Luo K,Zheng G,Lu M,Song Y,Liu H,Qiu H,He Z

更新日期：2017-06-16 00:00:00

abstract：:The coincidence of flood flows in a mainstream and its tributaries may lead to catastrophic floods. In this paper, we investigated the flood coincidence risk under nonstationary conditions arising from climate changes. The coincidence probabilities considering flood occurrence dates and flood magnitudes were calculate...

journal_title：Scientific reports

authors： Feng Y,Shi P,Qu S,Mou S,Chen C,Dong F

更新日期：2020-02-25 00:00:00

abstract：:Algae-bacteria interaction is one of the main factors underlying the formation of harmful algal blooms (HABs). The aim of this study was to develop a genome-wide high-throughput screening method to identify HAB-influenced specific interactive bacterial metabolites using a comprehensive collection of gene-disrupted E. ...

journal_title：Scientific reports

authors： Heo J,Cho K,Kim U,Cho DH,Ko S,Tran QG,Lee YJ,Ryu CM,Kim HS

更新日期：2020-06-30 00:00:00

abstract：:The present study tested whether the LPS/TLR4 signal pathway in endometrial stromal cells is essential for the pathogenesis of adenomyosis. We tested the expression of TLR4, MD2 in the endometrium without adenomyosis (CE), the eutopic endometrium with adenomyosis (EuE) and the ectopic endometrium with adenomyosis (EE)...

journal_title：Scientific reports

authors： Guo J,Chen L,Luo N,Li C,Chen R,Qu X,Liu M,Kang L,Cheng Z

更新日期：2016-02-22 00:00:00

abstract：:Multifactorial lifestyle intervention is known to be more effective for ameliorating cognitive decline than single factor intervention; however, the effects of combining exercise with long-chain polyunsaturated fatty acids (LCPUFA) on the elderlies' cognitive function remain unclear. We conducted a randomised, single-...

journal_title：Scientific reports

authors： Tokuda H,Ito M,Sueyasu T,Sasaki H,Morita S,Kaneda Y,Rogi T,Kondo S,Kouzaki M,Tsukiura T,Shibata H

更新日期：2020-07-31 00:00:00

abstract：:More than 20 years after the first outbreaks, the phylogenetic picture of PRRSV is still incomplete and full of gaps, especially in regards of PRRSV 1. Due to the exceptional diversity observed at the eastern borders of Europe and the low number of available sequences from Central Eastern European countries, the autho...

journal_title：Scientific reports

authors： Balka G,Podgórska K,Brar MS,Bálint Á,Cadar D,Celer V,Dénes L,Dirbakova Z,Jedryczko A,Márton L,Novosel D,Petrović T,Sirakov I,Szalay D,Toplak I,Leung FC,Stadejek T

更新日期：2018-05-17 00:00:00

abstract：:Pompe disease (PD) is a metabolic myopathy due to acid alpha-glucosidase deficiency and characterized by extensive glycogen storage and impaired autophagy. We previously showed that modulation of autophagy and lysosomal exocytosis by overexpression of the transcription factor EB (TFEB) gene was effective in improving ...

journal_title：Scientific reports

authors： Gatto F,Rossi B,Tarallo A,Polishchuk E,Polishchuk R,Carrella A,Nusco E,Alvino FG,Iacobellis F,De Leonibus E,Auricchio A,Diez-Roux G,Ballabio A,Parenti G

更新日期：2017-11-08 00:00:00

abstract：:Saponins from defatted root-extract of Securidaca longipedunculata were systematically entrapped in emulsion monolayer-barrier and finally recovered in pure form through demulsification. First, their molecules were dispersed in water to engineer a monomolecular film architecture, via self-assembly. Emulsifying with et...

journal_title：Scientific reports

authors： Obasi TC,Moldovan R,Toiu A,Braicu C,Bodoki E,Berindan-Neagoe I,Oniga I,Sandulescu R,Oprean R

更新日期：2017-11-06 00:00:00

abstract：:We compared commercial kits for extraction of genomic DNA from the Gram-negative bacterium Klebsiella pneumoniae for subsequent Miseq sequencing. Purification of DNA was based on matrix binding (silica or anion exchange resin) or differential precipitation (salting out), respectively. The choice of extraction kit had ...

journal_title：Scientific reports

authors： Becker L,Steglich M,Fuchs S,Werner G,Nübel U

更新日期：2016-06-17 00:00:00

abstract：:A major limitation for better understanding the role of the human gut virome in health and disease is the lack of validated methods that allow high throughput virome analysis. To overcome this, we evaluated the quantitative effect of homogenisation, centrifugation, filtration, chloroform treatment and random amplifica...

journal_title：Scientific reports

authors： Conceição-Neto N,Zeller M,Lefrère H,De Bruyn P,Beller L,Deboutte W,Yinda CK,Lavigne R,Maes P,Van Ranst M,Heylen E,Matthijnssens J

更新日期：2015-11-12 00:00:00

abstract：:In chickens, the sensory organs for taste are the taste buds in the oral cavity, of which there are ~240-360 in total number as estimated by scanning electron microscopy (SEM). There is not an easy way to visualize all taste buds in chickens. Here, we report a highly efficient method for labeling chicken taste buds in...

journal_title：Scientific reports

authors： Rajapaksha P,Wang Z,Venkatesan N,Tehrani KF,Payne J,Swetenburg RL,Kawabata F,Tabata S,Mortensen LJ,Stice SL,Beckstead R,Liu HX

更新日期：2016-11-17 00:00:00

abstract：:Despite a long history, the clinical efficacy of cupping therapy is still under debate. This is likely due to the lack of direct evidence for the biological actions of cupping, since the short exposure of cells to vacuum condition rarely has affects cellular activity. In this study, the medicinal properties of a recen...

journal_title：Scientific reports

authors： Lee HY,Lee HJ,Kim GC,Choi JH,Hong JW

更新日期：2019-03-07 00:00:00