Abstract：
:Antibodies of the IgG class to terminal Galα3Gal (IgG anti-αGal) is abundant in human plasma and are reported to bind most sepsis-causing Gram-negative bacteria. However, these seminal findings, made more than two decades ago, have not been reexamined. Our aim was to assess IgG anti-αGal´s pathogen reactivity. We affinity purified IgG anti-αGal from a therapeutic grade normal human IgG pool applying two rounds of positive selection with Galα3Gal-coupled beads and included removal of column matrix reactive antibodies. The purified antibodies were rigorously characterized in terms of specificity and purity in various solid-phase immunoassays. We used flow cytometry to study reactivity against 100 consecutive clinical isolates diagnosed as cause of sepsis in humans. We found that the purified IgG anti-αGal displays high specificity for Galα3Gal. Also, IgG anti-αGal at 5 mg/L bound 56 out of 100 pathogens with predilection for Gram-positive bacteria binding 39 out of 52 strains. We confirm that although IgG anti-αGal comprise a small fraction of the human antibody pool (~0.1%), these antibodies targets an impressively large part of pathogens causing invasive disease.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Bernth Jensen JM,Petersen MS,Ellerman-Eriksen S,Møller BK,Jensenius JC,Sørensen UBS,Thiel Sdoi
10.1038/s41598-020-61632-9subject
Has Abstractpub_date
2020-03-12 00:00:00pages
4611issue
1issn
2045-2322pii
10.1038/s41598-020-61632-9journal_volume
10pub_type
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