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Random peptide mixtures entrapped within a copper-cuprite matrix: new antimicrobial agent against methicillin-resistant Staphylococcus aureus.

Abstract：

:The emergence of global antibiotic resistance necessitates the urgent need to develop new and effective antimicrobial agents. Combination of two antimicrobial agents can potentially improve antimicrobial potency and mitigate the development of resistance. Therefore, we have utilized metal molecular doping methodology whereby antimicrobial random peptides mixture (RPMs) are entrapped in a bactericidal copper metal matrix. The copper/RPM composite exhibits greater antimicrobial activity toward methicillin-resistant Staphylococcus aureus (MRSA) than either copper or RPMs alone. Our findings indicate that this bactericidal antimicrobial biomaterial could be utilized to efficiently eradicate antibiotic-resistant pathogenic bacteria for health, agricultural and environmental applications.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Bauer TS,Menagen B,Avnir D,Hayouka Z

doi

10.1038/s41598-019-47315-0

subject

Has Abstract

pub_date

2019-08-02 00:00:00

pages

11215

issue

1

issn

2045-2322

pii

10.1038/s41598-019-47315-0

journal_volume

9

pub_type

杂志文章

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