High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.

abstract：:In this paper, three plastomes of Mankyua chejuense, Helminthostachys zeylanica, and Botrychium ternatum in Ophioglossaceae were completely sequenced in order to investigate the plastome evolution and phylogeny of eusporangiate ferns. They were similar to each other in terms of length and the gene orders; however, six...

journal_title：Scientific reports

authors： Kim HT,Kim KJ

更新日期：2018-11-07 00:00:00

abstract：:Estrogen-related receptor alpha (ESRRa) regulates a number of cellular processes including development of bone and muscles. However, direct evidence regarding its involvement in cartilage development remains elusive. In this report, we establish an in vivo role of Esrra in cartilage development during embryogenesis in...

journal_title：Scientific reports

authors： Kim YI,No Lee J,Bhandari S,Nam IK,Yoo KW,Kim SJ,Oh GS,Kim HJ,So HS,Choe SK,Park R

更新日期：2015-12-10 00:00:00

abstract：:Extracellular vesicles (EVs) such as exosomes and microvesicles serve as messengers of intercellular network, allowing exchange of cellular components between cells. EVs carry lipids, proteins, and RNAs derived from their producing cells, and have potential as biomarkers specific to cell types and even cellular states...

journal_title：Scientific reports

authors： Nakai W,Yoshida T,Diez D,Miyatake Y,Nishibu T,Imawaka N,Naruse K,Sadamura Y,Hanayama R

更新日期：2016-09-23 00:00:00

abstract：:Antibiotic administration, while facilitating clearance of targeted infections, also perturbs commensal microbial communities. Previous studies have all focused on the effects of short term use of antibiotics. Here, we focus on the effects of long term use of antibiotic on gut microbiota and immunity. BALB/c mice rece...

journal_title：Scientific reports

authors： Guo Y,Yang X,Qi Y,Wen S,Liu Y,Tang S,Huang R,Tang L

更新日期：2017-02-21 00:00:00

abstract：:Hereditary Parkinson's disease is commonly caused by mutations in the protein kinase PINK1 or the E3 ubiquitin ligase Parkin, which function together to eliminate damaged mitochondria. PINK1 phosphorylates both Parkin and ubiquitin to stimulate ubiquitination of dozens of proteins on the surface of the outer mitochond...

journal_title：Scientific reports

authors： Klosowiak JL,Park S,Smith KP,French ME,Focia PJ,Freymann DM,Rice SE

更新日期：2016-09-08 00:00:00

abstract：:Metabolic pathways that are corrupted at early stages of insulin resistance (IR) remain elusive. This study investigates changes in body metabolism in clinically healthy and otherwise asymptomatic subjects that may become apparent already under compromised insulin sensitivity (IS) and prior to IR. 47 clinically health...

journal_title：Scientific reports

authors： Halama A,Suleiman NN,Kulinski M,Bettahi I,Hassoun S,Alkasem M,Abdalhakam I,Iskandarani A,Samra TA,Atkin SL,Suhre K,Abou-Samra AB

更新日期：2020-10-13 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer that is consistently associated with Epstein-Barr virus (EBV) infection. In this study, we identify for the first time a role for monoamine oxidase A (MAOA) in NPC. MAOA is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and ...

journal_title：Scientific reports

authors： Lee HM,Sia APE,Li L,Sathasivam HP,Chan MSA,Rajadurai P,Tsang CM,Tsao SW,Murray PG,Tao Q,Paterson IC,Yap LF

更新日期：2020-04-09 00:00:00

abstract：:This study was carried out to use hyperspectral imaging technique for determining color (L*, a* and b*) and eggshell strength and identifying cracked chicken eggs. Partial least squares (PLS) models based on full and selected wavelengths suggested by regression coefficient (RC) method were established to predict the f...

journal_title：Scientific reports

authors： Xie C,He Y

更新日期：2016-02-17 00:00:00

abstract：:Studies suggest that semen quality is declining globally, however, the debate remains open due to the possible effects of ethnic and geographical differences. This study aimed to explore whether semen quality of sperm donor candidates has changed in Henan Province, China from 2009 to 2019. In this retrospective study,...

journal_title：Scientific reports

authors： Liu J,Dai Y,Li Y,Yuan E,Wang Q,Wang X,Guan Y

更新日期：2020-07-01 00:00:00

abstract：:Prognostic biomarkers serve a variety of purposes in cancer treatment and research, such as prediction of cancer progression, and treatment eligibility. Despite growing interest in multi-omic data integration for defining prognostic biomarkers, validated methods have been slow to emerge. Given that breast cancer has b...

journal_title：Scientific reports

authors： Thompson JA,Christensen BC,Marsit CJ

更新日期：2018-03-26 00:00:00

abstract：:Long-term high-fat diet (HFD) consumption leads to not only obese-insulin resistance, but also impaired left ventricular (LV) function. Vagus nerve stimulation (VNS) has been shown to exert cardioprotection. However, its effects on the heart and metabolic parameters under obese-insulin resistant condition is not known...

journal_title：Scientific reports

authors： Samniang B,Shinlapawittayatorn K,Chunchai T,Pongkan W,Kumfu S,Chattipakorn SC,KenKnight BH,Chattipakorn N

更新日期：2016-02-01 00:00:00

abstract：:At the basis of a trophic web, coprophagous animals like dung beetles (Scarabaeoidea) utilize resources that may have advantages (easy gain and handling) as well as drawbacks (formerly processed food). Several studies have characterized the nutrients, e.g. C/N ratios and organic matter content, for specific types of d...

journal_title：Scientific reports

authors： Frank K,Brückner A,Hilpert A,Heethoff M,Blüthgen N

更新日期：2017-09-22 00:00:00

abstract：:The fusion of villous cytotrophoblasts into the multinucleated syncytiotrophoblast is critical for the essential functions of the mammalian placenta. Using RNA-Seq gene expression and quantitative protein expression, we identified genes and their cognate proteins which are coordinately up- or down-regulated in two cel...

journal_title：Scientific reports

authors： Azar C,Valentine M,Trausch-Azar J,Druley T,Nelson DM,Schwartz AL

更新日期：2018-03-23 00:00:00

abstract：:Fermented foods play a major role in the diet of people in Africa, where a wide variety of raw materials are fermented. Understanding the microbial populations of these products would help in the design of specific starter cultures to produce standardized and safer foods. In this study, the bacterial diversity of Afri...

journal_title：Scientific reports

authors： Diaz M,Kellingray L,Akinyemi N,Adefiranye OO,Olaonipekun AB,Bayili GR,Ibezim J,du Plessis AS,Houngbédji M,Kamya D,Mukisa IM,Mulaw G,Manthi Josiah S,Onyango Chienjo W,Atter A,Agbemafle E,Annan T,Bernice Ackah N,Buys EM

更新日期：2019-09-25 00:00:00

abstract：:Dementia is a major cause of disability and dependency among older people. If the lives of people with dementia are to be improved, research and its translation into druggable target are crucial. Ancient systems of healthcare (Ayurveda, Siddha, Unani and Sowa-Rigpa) have been used from centuries for the treatment vasc...

journal_title：Scientific reports

authors： Lagunin AA,Ivanov SM,Gloriozova TA,Pogodin PV,Filimonov DA,Kumar S,Goel RK

更新日期：2020-01-14 00:00:00

abstract：:Tuberculosis is the leading cause of death among people living with HIV (PLH). Preventive tuberculosis therapy reduces mortality in PLH, especially in those with a positive tuberculin skin test (TST). New, more specific technologies for detecting latent tuberculosis infection (LTBI) are now commercially available. We ...

journal_title：Scientific reports

authors： Steffen RE,Pinto M,Kritski A,Trajman A

更新日期：2020-12-11 00:00:00

abstract：:Two supramolecular complexes of trans-1⊂CB[8] and trans-2⊂CB[8] were successfully achieved by the controlled selective complexation process of cucurbit[8]uril (CB[8]) with hetero-guest pair containing azobenzene and bispyridinium moieties in aqueous solution, exhibiting the reversibly light-driven movements of CB[8] u...

journal_title：Scientific reports

authors： Cheng HB,Zhang YM,Xu C,Liu Y

更新日期：2014-02-27 00:00:00

abstract：:Roquins are a family of highly conserved RNA-binding proteins that also contain a RING-type E3 ubiquitin ligase domain. They repress constitutive decay elements containing mRNAs and play a critical role in RNA homeostasis and immunological self-tolerance. Here we present the crystal structures of the RNA-binding regio...

journal_title：Scientific reports

authors： Zhang Q,Fan L,Hou F,Dong A,Wang YX,Tong Y

更新日期：2015-10-22 00:00:00

abstract：:We report the observation of a large linear magnetoresistance in the ohmic regime in commonplace commercial n-type silicon wafer with a P dopant density of (1.4±0.1) ×10(15) cm(-3), and report measurements of it in the temperature range 30-200 K. It arises from the deformation of current paths, which causes a part of ...

journal_title：Scientific reports

authors： Porter NA,Marrows CH

更新日期：2012-01-01 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Hu C,Yu M,Ren Y,Li K,Maggio DM,Mei C,Ye L,Wei J,Jin J,Zhuang Z,Tong H

更新日期：2017-11-07 00:00:00

abstract：:Elevated plasma concentrations of the ketone body β-hydroxybutyrate (BHB), an endogenous agonist of the hydroxycarboxylic acid receptor 2 (HCA2), is associated with an increased incidence of inflammatory diseases during lactation in dairy cows. In the early stages of this pathology, an increase in neutrophil recruitme...

journal_title：Scientific reports

authors： Carretta MD,Barría Y,Borquez K,Urra B,Rivera A,Alarcón P,Hidalgo MA,Burgos RA

更新日期：2020-07-27 00:00:00

abstract：:Carbonic acid (H2CO3) forms in small amounts when CO2 dissolves in H2O, yet decomposes rapidly under ambient conditions of temperature and pressure. Despite its fleeting existence, H2CO3 plays an important role in the global carbon cycle and in biological carbonate-containing systems. The short lifetime in water and p...

journal_title：Scientific reports

authors： Wang H,Zeuschner J,Eremets M,Troyan I,Willams J

更新日期：2016-01-27 00:00:00

abstract：:Physical reservoir computing approaches have gained increased attention in recent years due to their potential for low-energy high-performance computing. Despite recent successes, there are bounds to what one can achieve simply by making physical reservoirs larger. Therefore, we argue that a switch from single-reservo...

journal_title：Scientific reports

authors： Freiberger M,Bienstman P,Dambre J

更新日期：2020-09-02 00:00:00

abstract：:Hydrogels have been developed and applied to various biomedical applications due to their biocompatibility. However, understanding of modulation between cells to hydrogel interface is still unclear, and parameters to explain the interaction are not sophisticated enough. In this report, we studied the effect of polymer...

journal_title：Scientific reports

authors： Lee J,Song B,Subbiah R,Chung JJ,Choi UH,Park K,Kim SH,Oh SJ

更新日期：2019-02-21 00:00:00

abstract：:Optical resolution photoacoustic microscopy (OR-PAM) is a non-invasive, label-free method of in vivo imaging with microscopic resolution and high optical contrast. Based on intrinsic contrasts, OR-PAM has expanded to include in vivo vessel imaging, flow cytometry, physiological parameter analysis, and single-cell char...

journal_title：Scientific reports

authors： Park K,Kim JY,Lee C,Jeon S,Lim G,Kim C

更新日期：2017-10-17 00:00:00

abstract：:A series of novel dioxin-containing pyrazoline derivatives with thiourea skeleton have been designed, synthesized and evaluated for their EGFR/HER-2 inhibitory and anti-proliferation activities. A majority of them displayed selective HER-2 inhibitory activity against EGFR inhibitory activity. Compound C20 displayed th...

journal_title：Scientific reports

authors： Yang B,Yang YS,Yang N,Li G,Zhu HL

更新日期：2016-06-08 00:00:00

abstract：:The core of the Vibrio Harveyi clade contains V. harveyi, V. campbellii, V. owensii, V. jasicida, and V. rotiferianus. They are well recognized aquatic animal pathogens, but misclassification has been common due to similarities in their rDNA sequences and phenotypes. To better understand their evolutionary relationshi...

journal_title：Scientific reports

authors： Ke HM,Prachumwat A,Yu CP,Yang YT,Promsri S,Liu KF,Lo CF,Lu MJ,Lai MC,Tsai IJ,Li WH

更新日期：2017-02-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Chen YP,Yeh CI,Lee TC,Huang JJ,Pei YC

更新日期：2020-06-04 00:00:00

abstract：:Experiments were conducted to improve jenny conception rates through induced ovulation and timed insemination. Jennies in control, hCG and LH groups were injected intramuscularly with saline alone or saline containing hCG or LH, respectively, when the dominant follicle diameter reached 35 mm. Then, follicle developmen...

journal_title：Scientific reports

authors： Chang ZL,Li BX,Liu B,Yao L,Yu J,Jiang GM,Tan JH

更新日期：2019-03-01 00:00:00

abstract：:Stryphnodendron adstringens is a medicinal plant belonging to the Leguminosae family, and it is commonly found in the southeastern savannas, endemic to the Cerrado biome. The goal of this study was to assemble and annotate the chloroplast genome of S. adstringens and to compare it with previously known genomes of the ...

journal_title：Scientific reports

authors： Souza UJB,Nunes R,Targueta CP,Diniz-Filho JAF,Telles MPC

更新日期：2019-10-02 00:00:00