Mixture toxicity assisting the design of eco-friendlier plant protection products: a case-study using a commercial herbicide combining nicosulfuron and terbuthylazine.

abstract：:Editing in microRNAs, particularly in seed can significantly alter the choice of their target genes. We show that out of 13 different human tissues, different regions of brain showed higher adenosine to inosine (A-to-I) editing in mature miRNAs. These events were enriched in seed sequence (73.33%), which was not obser...

journal_title：Scientific reports

authors： Paul D,Sinha AN,Ray A,Lal M,Nayak S,Sharma A,Mehani B,Mukherjee D,Laddha SV,Suri A,Sarkar C,Mukhopadhyay A

更新日期：2017-05-26 00:00:00

abstract：:Interspecies electron transfer is a common way to couple metabolic energy balances between different species in mixed culture consortia. Direct interspecies electron transfer (DIET) mechanism has been recently characterised with Geobacter species which couple the electron balance with other species through physical co...

journal_title：Scientific reports

authors： Moscoviz R,de Fouchécour F,Santa-Catalina G,Bernet N,Trably E

更新日期：2017-03-13 00:00:00

abstract：:We study the interaction between localized vibrational modes and propagating phonons in graphene nanoribbons with different types of localized internal and edge defects. We analyze discrete eigenmodes of the nanoribbons with defects and also employ direct numerical simulations of the ballistic phonon and heat transpor...

journal_title：Scientific reports

authors： Savin AV,Kivshar YS

更新日期：2017-07-05 00:00:00

abstract：:Bioluminescence resonance energy transfer (BRET) has been a vital tool for understanding G protein-coupled receptor (GPCR) function. It has been used to investigate GPCR-protein and/or -ligand interactions as well as GPCR oligomerisation. However the utility of BRET is limited by the requirement that the fusion protei...

journal_title：Scientific reports

authors： White CW,Vanyai HK,See HB,Johnstone EKM,Pfleger KDG

更新日期：2017-06-09 00:00:00

abstract：:Many molecular system biology approaches recognize various interactions and functional associations of proteins that occur in cellular processing. Further understanding of the characterization technique reveals noteworthy information. These types of known and predicted interactions, gained through multiple resources, ...

journal_title：Scientific reports

authors： Kaushik AC,Mehmood A,Dai X,Wei DQ

更新日期：2020-03-27 00:00:00

abstract：:Flight initiation distance (FID), a measure of an animal's tolerance to human disturbance and a descriptor of its fear of humans, is increasingly employed for conservation purposes and to predict the response of species to urbanization. However, most work devoted to understanding variability in FID has been conducted ...

journal_title：Scientific reports

authors： Carrete M,Martínez-Padilla J,Rodríguez-Martínez S,Rebolo-Ifrán N,Palma A,Tella JL

更新日期：2016-08-08 00:00:00

abstract：:A GalNAc/Gal-specific lectin (CGL) from the edible mussel Crenomytilus grayanus has been demonstrated to exhibit antibacterial properties. However, the mechanism of immune modulation by CGL in mammalian cells remains unclear. Here, we demonstrated that CGL can activate immune responses in macrophages and in mice. In t...

journal_title：Scientific reports

authors： Chernikov OV,Wong WT,Li LH,Chikalovets IV,Molchanova VI,Wu SH,Liao JH,Hua KF

更新日期：2017-07-24 00:00:00

abstract：:Inhibition of immune checkpoint proteins like programmed death 1 (PD-1) is a promising therapeutic approach for several cancers, including non-small cell lung cancer (NSCLC). Although PD-1 ligand (PD-L1) expression is used to predict anti-PD-1 therapy responses in NSCLC, its accuracy is relatively less. Therefore, we ...

journal_title：Scientific reports

authors： Youn JI,Park SM,Park S,Kim G,Lee HJ,Son J,Hong MH,Ghaderpour A,Baik B,Islam J,Choi JW,Lee EY,Kim HR,Seo SU,Paik S,Yoon HI,Jung I,Xin CF,Jin HT,Cho BC,Seong SY,Ha SJ,Kim HR

更新日期：2020-06-03 00:00:00

abstract：:Transverse-tubules (T-tubules) play pivotal roles in Ca2+-induced, Ca2+ release and excitation-contraction coupling in cardiomyocytes. The purpose of this study was to uncover mechanisms where sarco/endoplasmic reticulum Ca2+ ATPase (SERCA2a) improved cardiac function through T-tubule regulation during myocardial isch...

journal_title：Scientific reports

authors： Wang S,Zhou Y,Luo Y,Kan R,Chen J,Xuan H,Wang C,Chen J,Xu T,Li D

更新日期：2021-01-21 00:00:00

abstract：:An existence of ions dissolved in water has significant effects on bulk properties of water. Superconcentrated conditions have been recently proposed to provide a new concept of lithium ion batteries in order to overcome limitations for practical applications. In those conditions, water would undergo significant chang...

journal_title：Scientific reports

authors： Han S

更新日期：2018-06-19 00:00:00

abstract：:Relapse and metastasis of nasopharyngeal carcinoma (NPC) are presumably attributed to cancer stem cells (CSCs). In recent years, chimeric antigen receptor (CAR)-modified immune effector cells have been shown to have impressive antitumour efficacy. In this study, we aimed to identify appropriate tumour-associated antig...

journal_title：Scientific reports

authors： Guo X,Zheng H,Luo W,Zhang Q,Liu J,Yao K

更新日期：2017-07-07 00:00:00

abstract：:Polysialic acid (PSA) is a large negatively charged glycan mainly attached to the neural cell adhesion molecule (NCAM). Several studies have shown that it is important for correct formation of brain circuitries during development and for synaptic plasticity, learning and memory in the adult. PSA also plays a major rol...

journal_title：Scientific reports

authors： Saini V,Lutz D,Kataria H,Kaur G,Schachner M,Loers G

更新日期：2016-06-21 00:00:00

abstract：:The mandibular proximal ramus segments should be moved and rotated during orthognathic surgery-based skeletofacial reconstruction for the correction of challenging patients with facial asymmetry and malocclusion, but quantitative data regarding this rotation were not sufficient to date. This 3D computer-assisted study...

journal_title：Scientific reports

authors： Wu TY,Denadai R,Lin HH,Ho CT,Lo LJ

更新日期：2019-09-16 00:00:00

abstract：:Induction of premature senescence represents a novel functional strategy to curb the uncontrolled proliferation of malignant cancer cells. This study unveils the regiospecific synthesis of novel isoxazoline derivatives condensed to ring A of medicinal plant product Withaferin-A. Intriguingly, the cis fused products wi...

journal_title：Scientific reports

authors： Rasool F,Nayak D,Katoch A,Faheem MM,Yousuf SK,Hussain N,Belawal C,Satti NK,Goswami A,Mukherjee D

更新日期：2017-10-23 00:00:00

abstract：:Crosstalk between phytohormone pathways is essential in plant growth, development and stress responses. Brassinosteroids (BRs) and ethylene are both pivotal plant growth regulators, and the interaction between these two phytohormones in the tomato response to salt stress is still unclear. Here, we explored the mechani...

journal_title：Scientific reports

authors： Zhu T,Deng X,Zhou X,Zhu L,Zou L,Li P,Zhang D,Lin H

更新日期：2016-10-14 00:00:00

abstract：:Routine immunizations and supplementary immunization activities (SIAs) have significantly improved measles control over the past two decades in China. Progress towards eliminating measles currently faces multiple challenges as the infection age increases, and adult-targeted SIA strategies are being considered. This st...

journal_title：Scientific reports

authors： Chong KC,Zhang C,Jia KM,Zee BCY,Luo T,Wang L,Tam GCH,Sun R,Wang MH,Guan X

更新日期：2018-10-31 00:00:00

abstract：:Liposomes or biological vesicles can be created from cholesterol, phospholipid, and water. Their stability is affected by their phospholipid composition which can influence disease treatment and drug delivery efficacy. In this study, the effect of phospholipid type on the formation and stability of liposomes using coa...

journal_title：Scientific reports

authors： Hashemzadeh H,Javadi H,Darvishi MH

更新日期：2020-02-04 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron loss that ultimately leads to fatal paralysis. Reducing levels or function of the tyrosine kinase, ephrin type-A receptor 4 (EphA4), has been suggested as a potential approach for slowing disease progression in ALS. Becaus...

journal_title：Scientific reports

authors： Dominguez SL,Earr T,Dourado M,Ngu H,Meilandt WJ,Hanson JE

更新日期：2020-09-24 00:00:00

abstract：:Disseminated tumor cells (DTCs) in the bone marrow (BM) and circulating tumor cells (CTCs) in blood of breast cancer patients (pts) are known to correlate with worse outcome. Here we demonstrate a different prognostic value of DTCs and CTCs and explain these findings by early clodronate intake. CTCs (n = 376 pts) were...

journal_title：Scientific reports

authors： Kasimir-Bauer S,Reiter K,Aktas B,Bittner AK,Weber S,Keller T,Kimmig R,Hoffmann O

更新日期：2016-05-23 00:00:00

abstract：:The geographic distribution of species depends on their relationships with climate and on the biotic interactions of the species. Ecological Niche Models (ENMs) mainly consider climatic variables only and may tend to overestimate these distributions, especially for species strongly restricted by biotic interactions. W...

journal_title：Scientific reports

authors： Flores-Tolentino M,García-Valdés R,Saénz-Romero C,Ávila-Díaz I,Paz H,Lopez-Toledo L

更新日期：2020-06-12 00:00:00

abstract：ABTRACT:Establishing a cure for HIV is hindered by the persistence of latently infected cells which constitute the viral reservoir. Real-time qPCR, used for quantification of this reservoir by measuring HIV DNA, requires external calibration; a common choice of calibrator is the 8E5 cell line, which is assumed to be st...

journal_title：Scientific reports

authors： Busby E,Whale AS,Ferns RB,Grant PR,Morley G,Campbell J,Foy CA,Nastouli E,Huggett JF,Garson JA

更新日期：2017-04-26 00:00:00

abstract：:We compared the gut microbial populations in 100 women, from rural Ghana and urban US [50% lean (BMI < 25 kg/m2) and 50% obese (BMI ≥ 30 kg/m2)] to examine the ecological co-occurrence network topology of the gut microbiota as well as the relationship of short chain fatty acids (SCFAs) with obesity. Ghanaians consumed...

journal_title：Scientific reports

authors： Dugas LR,Bernabé BP,Priyadarshini M,Fei N,Park SJ,Brown L,Plange-Rhule J,Nelson D,Toh EC,Gao X,Dong Q,Sun J,Kliethermes S,Gottel N,Luke A,Gilbert JA,Layden BT

更新日期：2018-11-20 00:00:00

abstract：:Ammonia physiology is important to numerous disease states including urea cycle disorders and hepatic encephalopathy. However, many unknowns persist regarding the ammonia response to common and potentially significant physiologic influences, such as food. Our aim was to evaluate the dynamic range of ammonia in respons...

journal_title：Scientific reports

authors： Spacek LA,Strzepka A,Saha S,Kotula J,Gelb J,Guilmain S,Risby T,Solga SF

更新日期：2018-02-07 00:00:00

abstract：:Reconstructing diet is critical to understanding hominin adaptations. Isotopic and functional morphological analyses of early hominins are compatible with consumption of hard foods, such as mechanically-protected seeds, but dental microwear analyses are not. The protective shells surrounding seeds are thought to induc...

journal_title：Scientific reports

authors： van Casteren A,Strait DS,Swain MV,Michael S,Thai LA,Philip SM,Saji S,Al-Fadhalah K,Almusallam AS,Shekeban A,McGraw WS,Kane EE,Wright BW,Lucas PW

更新日期：2020-01-17 00:00:00

abstract：:Partial thrombosis of the false lumen in uncomplicated type B aortic dissection (uTBAD) is associated with an increased late mortality risk. Whether the serum cortisol level can affect false lumen thrombosis in patients with uTBAD has not been well characterized. This study was performed on 87 patients with uTBAD. A c...

journal_title：Scientific reports

authors： Wu Y,Sun Y,Wei X,Zhang L,Han T,Zhao Z,Zhou J,Jing Z

更新日期：2018-01-19 00:00:00

abstract：:As part of an ongoing study of new insulin mimetic agents from medicinal plants, the 70% EtOH extract of Symplocos cochinchinensis was found to have a stimulatory effect on glucose uptake in 3T3-L1 adipocyte cells. The intensive targeted isolation of this active extract resulted in ten new hydroxyoleoside-type compoun...

journal_title：Scientific reports

authors： Lee BW,Ha TKQ,Pham HTT,Hoang QH,Tran VO,Oh WK

更新日期：2019-02-19 00:00:00

abstract：:Hybridization between exotic and native species is of great interest to evolutionary biologists and ecologists because it usually shows a quick evolution of species and invasiveness. It has been reported that such hybridization frequently increases the adaptation and aggressiveness of the new hybrids. A hybrid between...

journal_title：Scientific reports

authors： Sun Z,Chen Y,Schaefer V,Liang H,Li W,Huang S,Peng C

更新日期：2015-11-19 00:00:00

abstract：:Plant extracts, or phytonutrients, are used in traditional medicine practices as supplements to enhance the immune system and gain resistance to various infectious diseases and are used in animal production as health promoting feed additives. To date, there are no studies that have assessed their mechanism of action a...

journal_title：Scientific reports

authors： Wlodarska M,Willing BP,Bravo DM,Finlay BB

更新日期：2015-03-19 00:00:00

abstract：:Sacrospinous ligament fixation (SSLF) is one of the most utilized surgeries in the management of pelvic organ prolapse (POP). We conducted a large-series study of SSLF in a tertiary center by an experienced urogynecologic team. The 453 women with POP who underwent SSLF at National Taiwan University Hospital in the per...

journal_title：Scientific reports

authors： Wu CJ,Chang WC,Huang KJ,Hsieh YC,Wei LH,Sheu BC

更新日期：2020-03-19 00:00:00

abstract：:Genes central to drug absorption, distribution, metabolism and elimination (ADME) also regulate numerous endogenous molecules. The Remote Sensing and Signaling Hypothesis argues that an ADME gene-centered network-including SLC and ABC "drug" transporters, "drug" metabolizing enzymes (DMEs), and regulatory genes-is ess...

journal_title：Scientific reports

authors： Rosenthal SB,Bush KT,Nigam SK

更新日期：2019-08-15 00:00:00