Abstract：
:Polysialic acid (PSA) is a large negatively charged glycan mainly attached to the neural cell adhesion molecule (NCAM). Several studies have shown that it is important for correct formation of brain circuitries during development and for synaptic plasticity, learning and memory in the adult. PSA also plays a major role in nervous system regeneration following injury. As a next step for clinical translation of PSA based therapeutics, we have previously identified the small organic compounds 5-nonyloxytryptamine and vinorelbine as PSA mimetics. Activity of 5-nonyloxytryptamine and vinorelbine had been confirmed in assays with neural cells from the central and peripheral nervous system in vitro and shown to be independent of their function as serotonin receptor 5-HT1B/1D agonist or cytostatic drug, respectively. As we show here in an in vivo paradigm for spinal cord injury in mice, 5-nonyloxytryptamine and vinorelbine enhance regain of motor functions, axonal regrowth, motor neuron survival and remyelination. These data indicate that 5-nonyloxytryptamine and vinorelbine may be re-tasked from their current usage as a 5-HT1B/1D agonist or cytostatic drug to act as mimetics for PSA to stimulate regeneration after injury in the mammalian nervous system.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Saini V,Lutz D,Kataria H,Kaur G,Schachner M,Loers Gdoi
10.1038/srep26927subject
Has Abstractpub_date
2016-06-21 00:00:00pages
26927issn
2045-2322pii
srep26927journal_volume
6pub_type
杂志文章abstract：:EhV-ATPase is an ATP-driven Na+ pump in the eubacteria Enterococcus hirae (Eh). Here, we present the first entire structure of detergent-solubilized EhV-ATPase by single-particle cryo-electron microscopy (cryo-EM) using Zernike phase plate. The cryo-EM map dominantly showed one of three catalytic conformations in this...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33977-9
更新日期：2018-10-23 00:00:00
abstract：:In this paper, we explore the concept of structural Luneburg lens (SLL) as a design framework for performing dynamic structural tailoring to obtain a structural wave cloak and a structural waveguide. The SLL is a graded refractive index lens, which is realized by using a variable thickness structure defined in a thin ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71124-5
更新日期：2020-09-03 00:00:00
abstract：:It was previously demonstrated that microRNA-199a (miR-199a) was down-regulated in testicular germ cell tumor (TGCT) partially caused by hypermethylation of its promoter. miR-199a is encoded by two loci in the human genome, miR-199a-1 on chromosome (Chr) 19 and miR-199a-2 on Chr 1. Both loci encode the same miR-199a. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06413
更新日期：2014-09-18 00:00:00
abstract：:In South American societies, domesticated camelids were of great cultural importance and subject to trade and translocation. South American camelids were even found on remote and hard to reach islands, emphasizing their importance to historic and pre-historic South American populations. Isla Mocha, a volcanic island 3...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38708
更新日期：2016-12-08 00:00:00
abstract：:Dysregulation of iron metabolism, and resultant cytotoxicity, has been implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative processes. Iron accumulation promotes cytotoxicity through various mechanisms including oxidative stress and glutamate toxicity, and occurs in both MS patients an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48087-3
更新日期：2019-08-12 00:00:00
abstract：:This study aimed to determine whether formyl peptide receptors (FPRs) regulated the differentiation of neural stem cells (NSCs). FPRs promote the migration of NSCs both in vitro and in vivo. However, the role of FPRs during differentiation of NSCs is unknown. Analysis by Western blot showed significantly increased exp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00314-5
更新日期：2017-03-16 00:00:00
abstract：:Individuals infected with hepatitis C virus (HCV) are at high risk of developing progressive liver disease, including cirrhosis and hepatocellular carcinoma (HCC). How HCV infection causes liver destruction has been of significant interest for many years, and apoptosis has been proposed as one operative mechanism. In ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37433
更新日期：2016-12-15 00:00:00
abstract：:Although the initial formulation of modern concepts of adaptive radiation arose from consideration of the fossil data, rigorous attempts to identify this phenomenon in the fossil record are largely uncommon. Here I focus on direct evidence of the diet (through tooth-wear patterns) and ecologically-relevant traits of o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29803
更新日期：2016-07-13 00:00:00
abstract：:We evaluated changes in incidence, relative survival (RS), and conditional survival (CS) of head and neck squamous cell carcinoma (HNSCC), focusing on oral tongue squamous cell carcinoma (OTSCC). Data of 74 680 HNSCC patients from 1976 to 2015 were obtained from the Surveillance, Epidemiology, and End Results database...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64748-0
更新日期：2020-05-12 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-42527-w
更新日期：2019-04-12 00:00:00
abstract：:A method is proposed to drive an ultrafast non-adiabatic dynamics of an ultracold gas trapped in a time-dependent box potential. The resulting state is free from spurious excitations associated with the breakdown of adiabaticity, and preserves the quantum correlations of the initial state up to a scaling factor. The p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00648
更新日期：2012-01-01 00:00:00
abstract：:Autism is a common and often severe neurodevelopmental disorder for which diverse pathophysiological processes have been proposed. Recent gene expression data comparing autistic and control brains suggest that the normal differential gene expression between frontal and temporal cortex is attenuated in autistic brains....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01831
更新日期：2013-01-01 00:00:00
abstract：:Mast Cells (MCs) are one of the first immune cells encountered by invading pathogens. Their presence in large numbers in the superficial dermis, where Leishmania is encountered, suggests that they may play a critical role in immune responses to Leishmania. In this study the interactions of Leishmania donovani, the cau...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12753-1
更新日期：2017-10-16 00:00:00
abstract：:Quantum measurement is a fundamental cornerstone of experimental quantum computations. The main issues in current quantum measurement strategies are the high number of measurement rounds to determine a global optimal measurement output and the low success probability of finding a global optimal measurement output. Eac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43250-2
更新日期：2019-05-01 00:00:00
abstract：:We report highly efficient continuous-wave terahertz (THz) photoconductive antenna based photomixer employing nano-gap electrodes in the active region. The tip-to-tip nano-gap electrode structure provides strong THz field enhancement and acts as a nano-antenna to radiate the THz wave generated in the active region of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02824
更新日期：2013-10-08 00:00:00
abstract：:Carbon-based stationary phases for chromatographic separation have been commercially available since the 1980s. Porous graphitic carbon liquid chromatography columns are known to be highly resistant to aggressive mobile phases and extreme pH values of solvents and eluents, an important advantage compared to convention...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33075-w
更新日期：2018-10-03 00:00:00
abstract：:Aerobic organisms evolved conserved mechanisms controlling the generation of reactive oxygen species (ROS) to maintain redox homeostasis signaling and modulate signal transduction, gene expression and cellular functional responses under physiological conditions. The production of ROS by mitochondria is essential in th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49766-x
更新日期：2019-09-13 00:00:00
abstract：:Pathological links between neurodegenerative disease and cancer are emerging. LRRK2 overactivity contributes to Parkinson's disease, whereas our previous analyses of public cancer patient data revealed that decreased LRRK2 expression is associated with lung adenocarcinoma (LUAD). The clinical and functional relevance ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81639-0
更新日期：2021-01-22 00:00:00
abstract：:Since their first appearance, organic-inorganic perovskite absorbers have been capturing the attention of the scientific community. While high efficiency devices highlight the importance of band level alignment, very little is known on the origin of the strong n-doping character observed in the perovskite. Here, by me...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50108-0
更新日期：2019-10-22 00:00:00
abstract：:The purpose of this study was to investigate a preclinical spectral photon-counting CT (SPCCT) prototype compared to conventional CT for pulmonary imaging. A custom-made lung phantom, including nodules of different sizes and shapes, was scanned with a preclinical SPCCT and a conventional CT in standard and high-resolu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35888-1
更新日期：2018-11-26 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41598-017-18751-7
更新日期：2018-01-08 00:00:00
abstract：:Siwei Jianghuang Decoction Powder (SWJH) documented originally in the Four Medical Tantras-Blue Glaze exhibited beneficial effects on diabetic nephropathy (DN) via combined synergistically action of multiple formula components including Curcumae longae Rhizoma, Berberidis dictyophyllae Cortex, Phyllanthi Fructus and T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35148-2
更新日期：2018-11-12 00:00:00
abstract：:Glioblastoma (GBM) is the most aggressive brain primary malignancy. Toll-like receptor 4 (TLR4) has a dual role in cell fate, promoting cell survival or death depending on the context. Here, we analyzed TLR4 expression in different grades of astrocytoma, and observed increased expression in tumors, mainly in GBM, comp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79356-1
更新日期：2021-01-14 00:00:00
abstract：:Emergence of DS-1-like-G1P[8] rotavirus in Asia have been recently reported. We report for the first time the detection and the whole genome phylogenetic analysis of DS-1-like-G1P[8] strains in America. From 2013 to 2017, a total of 4226 fecal samples were screened for rotavirus by ELISA, PAGE, RT-PCR and sequencing. ...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/s41598-019-38703-7
更新日期：2019-02-18 00:00:00
abstract：:Sugarcane (Saccharum spp. hybrids) is a potential lignocellulosic feedstock for biofuel production due to its exceptional biomass accumulation ability, high convertible carbohydrate content and a favorable energy input/output ratio. Genetic modification of biofuel traits to improve biomass conversion requires an under...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30033-4
更新日期：2018-08-02 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-58429-1
更新日期：2020-01-27 00:00:00
abstract：:The Zika virus (ZIKV) outbreak in the Americas and South Pacific poses a significant burden on human health because of ZIKV's neurotropic effects in the course of fetal development. Vaccine candidates against ZIKV are coming online, but immunological tools to study anti-ZIKV responses in preclinical models, particular...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00193-w
更新日期：2017-03-21 00:00:00
abstract：:The effect of n-type interlayer in hybrid white organic light-emitting diodes (WOLEDs) has been systematically investigated by using various n-type materials. A new finding, that the triplet energy rather than electron mobility or hole-blocking ability of interlayer plays a more positive role in the performance of hyb...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07198
更新日期：2014-11-26 00:00:00
abstract：:A delicate balance between proliferating and differentiating signals is necessary to ensure proper growth and neuronal specification. By studying the developing zebrafish brain, we observed a specific and dynamic expression of a microtubule destabilizer gene, stathmin-like 4 (stmn4), in the dorsal midbrain region. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36188
更新日期：2016-11-07 00:00:00
abstract：:All grain boundaries are not equal in their predisposition for fracture due to the complex coupling between lattice geometry, interfacial structure, and mechanical properties. The ability to understand these relationships is crucial to engineer materials resilient to grain boundary fracture. Here, a methodology is pre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08637-z
更新日期：2017-08-21 00:00:00
