Abstract：
:Influenza's propensity for antigenic drift and shift, and to elicit predominantly strain specific antibodies (Abs) leaves humanity susceptible to waves of new strains with pandemic potential for which limited or no immunity may exist. Subsequently new clinical interventions are needed. To identify hemagglutinin (HA) epitopes that if targeted may confer universally protective humoral immunity, we examined plasmablasts from a subject that was immunized with the seasonal influenza inactivated vaccine, and isolated a human monoclonal Ab (mAb), KPF1. KPF1 has broad and potent neutralizing activity against H1 influenza viruses, and recognized 83% of all H1 isolates tested, including the pandemic 1918 H1. Prophylactically, KPF1 treatment resulted in 100% survival of mice from lethal challenge with multiple H1 influenza strains and when given as late as 72 h after challenge with A/California/04/2009 H1N1, resulted in 80% survival. KPF1 recognizes a novel epitope in the HA globular head, which includes a highly conserved amino acid, between the Ca and Cb antigenic sites. Although recent HA stalk-specific mAbs have broader reactivity, their potency is substantially limited, suggesting that cocktails of broadly reactive and highly potent HA globular head-specific mAbs, like KPF1, may have greater clinical feasibility for the treatment of influenza infections.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Nogales A,Piepenbrink MS,Wang J,Ortega S,Basu M,Fucile CF,Treanor JJ,Rosenberg AF,Zand MS,Keefer MC,Martinez-Sobrido L,Kobie JJdoi
10.1038/s41598-018-22307-8subject
Has Abstractpub_date
2018-03-12 00:00:00pages
4374issue
1issn
2045-2322pii
10.1038/s41598-018-22307-8journal_volume
8pub_type
杂志文章abstract：:Although plants are essentially sessile in nature, these organisms are very much in tune with their environment and are capable of a variety of movements. This may come as a surprise to many non-botanists, but not to Charles Darwin, who reported that plants do produce movements. Following Darwin's specific interest on...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53118-0
更新日期：2019-11-12 00:00:00
abstract：:The variation in mortality-to-incidence ratios (MIRs) among countries reflects the clinical outcomes and the available interventions for colorectal cancer treatments. The association between MIR of prostate cancer and cancer care disparities among countries is an interesting issue that is rarely investigated. For the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40003
更新日期：2017-01-04 00:00:00
abstract：:Ebola virus (EBOV), isolate Makona, was the causative agent of the West African epidemic devastating predominantly Guinea, Liberia and Sierra Leone from 2013-2016. While several experimental vaccine and treatment approaches have been accelerated through human clinical trials, there is still no approved countermeasure ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-19041-y
更新日期：2018-01-16 00:00:00
abstract：:The largest tsunamis are generated by seafloor uplift resulting from rupture of offshore subduction-zone megathrusts. The rupture of the shallowest part of a megathrust often produces unexpected outsize tsunami relative to their seismic magnitude. These are so called 'tsunami earthquakes', which are difficult to ident...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68097-w
更新日期：2020-07-06 00:00:00
abstract：:Microglia are the resident phagocytic cells with various functions in the central nervous system, and the morphologies of microglia imply the different stages and functions. In optical nerve transection (ONT) model in the retina, the retrograde degeneration of retinal ganglion cells (RGCs) induces microglial activatio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10788
更新日期：2015-06-02 00:00:00
abstract：:Spontaneous clearance of hepatitis C virus (HCV) occurs in 10-40% of the infections. Specific human leukocyte antigen (HLA) alleles have been identified in associating with HCV clearance. However, data on the association of HLA with the spontaneous clearance of HCV are scarce in the Chinese population. In the current ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31485
更新日期：2016-08-11 00:00:00
abstract：:The late Ediacaran witnessed an increase in metazoan diversity and ecological complexity, marking the inception of the Cambrian Explosion. To constrain the drivers of this diversification, we combine redox and nutrient data for two shelf transects, with an inventory of biotic diversity and distribution from the Nama G...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59335-2
更新日期：2020-02-10 00:00:00
abstract：:We demonstrate a novel route to achieving highly efficient and strongly confined spoof surface plasmon polaritons (SPPs) waveguides at subwavelength scale enabled by planar staggered plasmonic waveguides (PSPWs). The structure of these new waveguides consists of an ultrathin metallic strip with periodic subwavelength ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38528
更新日期：2016-12-05 00:00:00
abstract：:The actinopterygians comprise nearly one-half of all extant vertebrate species and are very important for human well-being. However, the phylogenetic relationships among certain groups within the actinopterygians are still uncertain, and debates about these relationships have continued for a long time. Along with the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00665
更新日期：2012-01-01 00:00:00
abstract：:Nonunions of the tibia, particularly those located in the distal third of the bone, are relatively common in clinical practice. There is no gold standard for the treatment of nonunions of the tibia. The purpose of our study was to assess the results of treatment with the Ilizarov method in patients with aseptic nonuni...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77569-y
更新日期：2020-11-25 00:00:00
abstract：:Environmental impacts from ecotourism and outdoor recreation activities on terrestrial and aquatic ecosystems are well-reported in the literature, but less is known regarding the impacts of outdoor environmental education activities. Student activity during stream classes may cause substrate disruption and localized i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38210-1
更新日期：2019-02-05 00:00:00
abstract：:Trimethylation on H3K27 mediated by Polycomb Repressive Complex 2 (PRC2) is required to control gene repression programs involved in development, regulation of tissue homeostasis or maintenance and lineage specification of stem cells. In Drosophila, the PRC2 catalytic subunit is the single protein E(z), while in mamma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40738-9
更新日期：2019-03-13 00:00:00
abstract：:Currently, light pollution has become a nonnegligible issue in our daily life. Artificial light sources with high color temperature were deem to be the major pollution source, which could induce several adverse effects on human's health. In our previous research, we have firstly developed an artificial indoor light wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43864-6
更新日期：2019-05-17 00:00:00
abstract：:We investigated the effect of vacancy formation on brittle (D022) to ductile (L12-like) transition in Al3Ti using DFT calculations. The well-known pseudogap on the density of states of Al3Ti migrates towards its Fermi level from far above, via a W - M co-doping strategy, where M is Si, Ge, Sn or Pb respectively. In pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14398-6
更新日期：2017-10-25 00:00:00
abstract：:Overuse of nitrogen (N) fertilizer has led to low N use efficiency (NUE) and high N loss in single rice cropping systems in southeast China. Application of controlled-release urea (CRU) is considered as an effective N fertilizer practice for improving crop yields and NUE. Here, field experiments were conducted during ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67110-6
更新日期：2020-06-26 00:00:00
abstract：:Mycoplasma pneumoniae (MP) is considered a common cause of pneumonia, causing about 15-20% of adult community-acquired pneumonia (CAP) and up to 40% of cases in children. It has often been observed that MP epidemics last approximately 1-2 years and occur every 3-7 years, with the dominant strains alternating between e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36325-z
更新日期：2019-01-24 00:00:00
abstract：:Short-term exposures to outdoor air pollutants have been associated with lower lung function, but the results are inconsistence. The effects of different pollutant levels on lung function changes are still unclear. We quantified the effects of outdoor air pollution exposure (NO2, PM10, O3, and PM2.5) on lung function ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34947
更新日期：2016-10-13 00:00:00
abstract：:Seeing with two eyes usually helps one respond faster. Here we show that with ambiguous stimuli, binocular viewing can paradoxically slow down reaction time. This is explained by the observers basing their decision on a noisy neuronal representation within the visual system, with the added noise breaking the symmetry ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16799
更新日期：2015-11-18 00:00:00
abstract：:During action observation, several visual features of observed actions can modulate the level of sensorimotor reactivity in the onlooker. Among possibly relevant parameters, one of the less investigated in humans is the visual perspective from which actions are observed. In the present EEG study, we assessed the react...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30912-w
更新日期：2018-08-20 00:00:00
abstract：:Intracerebroventricular (ICV) administration of ouabain, an inhibitor of the Na, K-ATPase, is an approach used to study the physiological functions of the Na, K-ATPase and cardiotonic steroids in the central nervous system, known to cause mania-like hyperactivity in rats. We describe a mouse model of ouabain-induced m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52058-z
更新日期：2019-10-30 00:00:00
abstract：:The mechanistic target of rapamycin (mTOR) is a central mediator of protein synthesis in skeletal muscle. We utilized immunofluorescence approaches to study mTOR cellular distribution and protein-protein co-localisation in human skeletal muscle in the basal state as well as immediately, 1 and 3 h after an acute bout o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05483-x
更新日期：2017-07-10 00:00:00
abstract：:During the infection process, the influenza fusion peptide (FP) inserts into the host membrane, playing a crucial role in the fusion process between the viral and host membranes. In this work we used a combination of simulation and experimental techniques to analyse the molecular details of this process, which are lar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28099
更新日期：2016-06-15 00:00:00
abstract：:Nature provides remarkable examples of mass-produced microscale particles with structures and chemistries optimized by evolution for particular functions. Synthetic chemical tailoring of such sustainable biogenic particles may be used to generate new multifunctional materials. Herein, we report a facile method for the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73615-x
更新日期：2020-10-06 00:00:00
abstract：:Extracellular vesicles (EVs) are an important class of membrane-bound structures that have been widely investigated for their roles in intercellular communication in the contexts of tumor progression, vascular function, immunity and regenerative medicine. Much of the current knowledge on the functions of EVs pertains ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44021-9
更新日期：2019-05-17 00:00:00
abstract：:Cake layer formation in membrane processes is an inevitable phenomenon. For hard particles, especially cake porosity and thickness determine the membrane flux, but when the particles forming the cake are soft, the variables one has to take into account in the prediction of cake behavior increase considerably. In this ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39820-z
更新日期：2019-02-28 00:00:00
abstract：:Long non-coding RNAs (lncRNAs) have been found to play important roles in various biological processes; however, many of their functions remain unclear. In this study, we present a novel approach to identify the lncRNA-associated protein-protein interaction (PPI) modules and ascertain their functions in human lung squ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35939
更新日期：2016-10-27 00:00:00
abstract：:The myxozoan parasite, Tetracapsuloides bryosalmonae has a two-host life cycle alternating between freshwater bryozoans and salmonid fish. Infected fish can develop Proliferative Kidney Disease, characterised by a gross lymphoid-driven kidney pathology in wild and farmed salmonids. To facilitate an in-depth understand...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77881-7
更新日期：2021-01-25 00:00:00
abstract：:A light reflection device combined with visible light spectrophotometer was used to measure the reflectance-wavelength curves of colored stainless steel after coloring, hardening and sealing. After these processes, the coordinate in CIE 1931 color coordinate system and brightness of samples were confirmed by chromatom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70359-6
更新日期：2020-08-11 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-25179-0
更新日期：2018-05-10 00:00:00
abstract：:Statistical learning is a key mechanism for detecting regularities from a variety of sensory inputs. Precocial newborn domestic chicks provide an excellent model for (1) exploring unsupervised forms of statistical learning in a comparative perspective, and (2) elucidating the ecological function of statistical learnin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72090-8
更新日期：2020-09-15 00:00:00
