Src activation in the hypothalamic arcuate nucleus may play an important role in pain hypersensitivity.

abstract：:Stromal capillary sheath cells in human spleens strongly express CD271, the low affinity nerve growth factor receptor p75. Serial sections of a representative adult human spleen were double-stained for CD271 versus smooth muscle alpha actin (SMA) plus CD34 to visualise capillary sheaths, the arterial tree and endothel...

journal_title：Scientific reports

authors： Steiniger BS,Wilhelmi V,Berthold M,Guthe M,Lobachev O

更新日期：2018-10-24 00:00:00

abstract：:Phylogenetic incongruence has frequently been encountered among different molecular markers. Recent progress in molecular phylogenomics has provided detailed and important information for evolutionary biology and taxonomy. Here we focused on the freshwater viviparid snails (Cipangopaludina chinensis chinensis and C. c...

journal_title：Scientific reports

authors： Hirano T,Saito T,Tsunamoto Y,Koseki J,Ye B,Do VT,Miura O,Suyama Y,Chiba S

更新日期：2019-04-17 00:00:00

abstract：:Carcinomas constitute over 80% of all human cancer types with no effective therapy for metastatic disease. Here, we demonstrate, for the first time, the efficacy of therapeutic-ultrasound (TUS) to deliver a human tumor suppressor gene, hSef-b, to prostate tumors in vivo. Sef is downregulated in various human carcinoma...

journal_title：Scientific reports

authors： Mishel S,Shneyer B,Korsensky L,Goldshmidt-Tran O,Haber T,Machluf M,Ron D

更新日期：2017-11-08 00:00:00

abstract：:Various folk remedies employ certain odorous compounds with analgesic effects. In fact, linalool, a monoterpene alcohol found in lavender extracts, has been found to attenuate pain responses via subcutaneous, intraperitoneal, intrathecal, and oral administration. However, the analgesic effects of odorous compounds med...

journal_title：Scientific reports

authors： Tashiro S,Yamaguchi R,Ishikawa S,Sakurai T,Kajiya K,Kanmura Y,Kuwaki T,Kashiwadani H

更新日期：2016-11-15 00:00:00

abstract：:The importance of metallurgy for social and economic development is indisputable. Although copper (Cu) was essential for the wealth of pre- and post-colonial societies in the Andes, the onset of extensive Cu metallurgy in South America is still debated. Comprehensive archaeological findings point to first sophisticate...

journal_title：Scientific reports

authors： Eichler A,Gramlich G,Kellerhals T,Tobler L,Rehren T,Schwikowski M

更新日期：2017-01-31 00:00:00

abstract：:Exploiting pattern formation - such as that observed in nature - in the context of micro/nanotechnology could have great benefits if coupled with the traditional top-down lithographic approach. Here, we demonstrate an original and simple method to produce unique, localized and controllable self-organised patterns on e...

journal_title：Scientific reports

authors： Seghir R,Arscott S

更新日期：2015-10-06 00:00:00

abstract：:The biliary tree is an essential component of transplantable human liver tissue. Despite recent advances in liver tissue engineering, attempts at re-creating the intrahepatic biliary tree have not progressed significantly. The finer branches of the biliary tree are structurally and functionally complex and heterogeneo...

journal_title：Scientific reports

authors： Lewis PL,Su J,Yan M,Meng F,Glaser SS,Alpini GD,Green RM,Sosa-Pineda B,Shah RN

更新日期：2018-08-15 00:00:00

abstract：:Climate-driven environmental change and land-use change often interact in their impact on biodiversity, but these interactions have received little scientific attention. Here we study the effects of climate-driven environmental variation (i.e. vegetation greenness) and land-use (protected versus unprotected areas) on ...

journal_title：Scientific reports

authors： Santangeli A,Spiegel O,Bridgeford P,Girardello M

更新日期：2018-08-29 00:00:00

abstract：:Connecting genome-wide association study (GWAS) to biological mechanisms underlying complex traits is a major challenge. Mastitis resistance and milk production are complex traits of economic importance in the dairy sector and are associated with intra-mammary infection (IMI). Here, we integrated IMI-relevant RNA-Seq ...

journal_title：Scientific reports

authors： Fang L,Sahana G,Su G,Yu Y,Zhang S,Lund MS,Sørensen P

更新日期：2017-03-30 00:00:00

abstract：:In HIV-1/HCV-coinfected patients, chronic HCV infection leads to an increased T-lymphocyte immune activation compared to HIV-monoinfected patients, thereby likely contributing to increase HIV-1 reservoir that is the major barrier for its eradication. Our objective was to evaluate the influence of HCV coinfection in HI...

journal_title：Scientific reports

authors： López-Huertas MR,Palladino C,Garrido-Arquero M,Esteban-Cartelle B,Sánchez-Carrillo M,Martínez-Román P,Martín-Carbonero L,Ryan P,Domínguez-Domínguez L,Santos IL,Moral SF,Benito JM,Rallón N,Alcamí J,Resino S,Fernández-Rodrígu

更新日期：2019-04-03 00:00:00

abstract：:Continuous solidification experiments were carried out with Cu-Bi-Sn alloys under the effects of Electric Current Pulses (ECPs). A model describing the microstructure evolution was developed. The formation of the microstructure in the continuously solidified alloys was calculated. The calculations demonstrated that EC...

journal_title：Scientific reports

authors： Hongxiang J,Jie H,Jiuzhou Z

更新日期：2015-07-31 00:00:00

abstract：:The genome of influenza A virus (IAV) comprises eight RNA segments (vRNA) which are transcribed and replicated by the heterotrimeric IAV RNA-dependent RNA-polymerase (RdRp). RdRp consists of three subunits (PA, PB1 and PB2) and binds both the highly conserved 3'- and 5'-ends of the vRNA segment. The IAV RdRp is an imp...

journal_title：Scientific reports

authors： Swale C,Monod A,Tengo L,Labaronne A,Garzoni F,Bourhis JM,Cusack S,Schoehn G,Berger I,Ruigrok RW,Crépin T

更新日期：2016-04-20 00:00:00

abstract：:Ecological adaptations to seasonal changes are often observed in the phenotypic traits of plants and animals, and these adaptations are usually expressed through the production of different biochemical end products. In this study, ecological adaptations are observed in a biochemical pathway without alteration of the e...

journal_title：Scientific reports

authors： Hirata H,Ohnishi T,Tomida K,Ishida H,Kanda M,Sakai M,Yoshimura J,Suzuki H,Ishikawa T,Dohra H,Watanabe N

更新日期：2016-02-01 00:00:00

abstract：:Contest behaviour, and in particular the propensity to attack an unfamiliar conspecific, is influenced by an individual's aggressiveness, as well as by experience of winning and losing (so called 'winner-loser effects'). Individuals vary in aggressiveness and susceptibility to winner-loser effects but the relationship...

journal_title：Scientific reports

authors： Oldham L,Camerlink I,Arnott G,Doeschl-Wilson A,Farish M,Turner SP

更新日期：2020-08-07 00:00:00

abstract：:A coherent anti-Stokes Raman scattering (CARS) rigid endoscope was developed to visualize peripheral nerves without labeling for nerve-sparing endoscopic surgery. The developed CARS endoscope had a problem with low imaging speed, i.e. low imaging rate. In this study, we demonstrate that noise reduction with deep learn...

journal_title：Scientific reports

authors： Yamato N,Niioka H,Miyake J,Hashimoto M

更新日期：2020-09-16 00:00:00

abstract：:Electrically pumped GaAsBi/GaAs quantum well lasers are a promising new class of near-infrared devices where, by use of the unusual band structure properties of GaAsBi alloys, it is possible to suppress the dominant energy-consuming Auger recombination and inter-valence band absorption loss mechanisms, which greatly i...

journal_title：Scientific reports

authors： Marko IP,Broderick CA,Jin S,Ludewig P,Stolz W,Volz K,Rorison JM,O'Reilly EP,Sweeney SJ

更新日期：2016-07-01 00:00:00

abstract：:Because Africa's climate hampers DNA preservation, knowledge of its genetic variability is mainly restricted to modern samples, even though population genetics dynamics and back-migrations from Eurasia may have modified haplotype frequencies, masking ancient genetic scenarios. Thanks to improved methodologies, ancient...

journal_title：Scientific reports

authors： Vai S,Sarno S,Lari M,Luiselli D,Manzi G,Gallinaro M,Mataich S,Hübner A,Modi A,Pilli E,Tafuri MA,Caramelli D,di Lernia S

更新日期：2019-03-05 00:00:00

abstract：:The fabrication of Ru nanostructures by focused electron beam induced deposition (FEBID) requires suitable precursor molecules and processes to obtain the pure metal. So far this is problematic because established organometallic Ru precursors contain large organic ligands, such as cyclopentadienyl anions, that tend to...

journal_title：Scientific reports

authors： Rohdenburg M,Boeckers H,Brewer CR,McElwee-White L,Swiderek P

更新日期：2020-07-02 00:00:00

abstract：:White light generation by mixing red, green, and blue laser diodes (RGB LDs) was demonstrated with Commission International de l'Eclairage coordinates of (0.2928, 0.2981), a correlated color temperature of 8382 K, and a color rendering index of 54.4 to provide a maximal illuminance of 7540 lux. All the white lights ge...

journal_title：Scientific reports

authors： Wu TC,Chi YC,Wang HY,Tsai CT,Huang YF,Lin GR

更新日期：2017-01-31 00:00:00

abstract：:The archetypal TRPM2-like channel of the sea anemone Nematostella vectensis is gated by ADPR like its human orthologue but additionally exhibits properties of other vertebrate TRPM channels. Thus it can help towards an understanding of gating and regulation of the whole subfamily. To elucidate further the role of Ca2+...

journal_title：Scientific reports

authors： Kühn FJP,Mathis W,Cornelia K,Hoffmann DC,Lückhoff A

更新日期：2017-08-03 00:00:00

abstract：:BST-2/tetherin is an interferon-inducible antiviral protein that blocks the release of various enveloped viruses, including HIV-1. Hepatitis B virus (HBV), a major cause of liver disease, belongs to the Hepadnaviridae family of enveloped DNA viruses. Whether BST-2 regulates HBV production is largely unknown. In this r...

journal_title：Scientific reports

authors： Lv M,Zhang B,Shi Y,Han Z,Zhang Y,Zhou Y,Zhang W,Niu J,Yu XF

更新日期：2015-06-29 00:00:00

abstract：:Inference of the biological roles of lncRNAs in breast cancer development remains a challenge. Here, we analyzed RNA-seq data in tumor and normal breast tissue samples from 18 breast cancer patients and 18 healthy controls and constructed a functional lncRNA-mRNA co-expression network. We revealed two distinctive co-e...

journal_title：Scientific reports

authors： Wu W,Wagner EK,Hao Y,Rao X,Dai H,Han J,Chen J,Storniolo AMV,Liu Y,He C

更新日期：2016-09-06 00:00:00

abstract：:The enzyme alanine racemase (Alr) has been a new target for the development of antibacterial drugs based on the involvement of D-Ala in bacterial cell wall biosynthesis. Our previous study noted that Alr is essential for the growth and interspecies competitiveness of S. mutans, the major causative organism of dental c...

journal_title：Scientific reports

authors： Liu S,Wei Y,Zhou X,Zhang K,Peng X,Ren B,Chen V,Cheng L,Li M

更新日期：2018-04-13 00:00:00

abstract：:Proper regulation of endothelial cell-cell contacts is essential for physiological functioning of the endothelium. Interendothelial junctions are actively involved in the control of vascular leakage, leukocyte diapedesis, and the initiation and progression of angiogenesis. We found that the RNA-binding protein quaking...

journal_title：Scientific reports

authors： de Bruin RG,van der Veer EP,Prins J,Lee DH,Dane MJ,Zhang H,Roeten MK,Bijkerk R,de Boer HC,Rabelink TJ,van Zonneveld AJ,van Gils JM

更新日期：2016-02-24 00:00:00

abstract：:Algicidal microbes could effectively remove the harmful algae from the waters. In this study, we were concerned with the ecological influence of an algicide extracted from Streptomyces alboflavus RPS, which could completely lyse the Phaeocystis globosa cells within two days. In microcosms, 4 μg/mL of the microbial alg...

journal_title：Scientific reports

authors： Cai G,Yang X,Lai Q,Yu X,Zhang H,Li Y,Chen Z,Lei X,Zheng W,Xu H,Zheng T

更新日期：2016-02-05 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Sagers JE,Brown AS,Vasilijic S,Lewis RM,Sahin MI,Landegger LD,Perlis RH,Kohane IS,Welling DB,Patel CJ,Stankovic KM

更新日期：2018-11-23 00:00:00

abstract：:Large amounts of anthropogenic CO2 in the atmosphere are taken up by the ocean, which leads to 'ocean acidification' (OA). In addition, the increasing application of nanoparticles inevitably leads to their increased release into the aquatic environment. However, the impact of OA on the bioaccumulation of nanoparticles...

journal_title：Scientific reports

authors： Shi W,Han Y,Guo C,Su W,Zhao X,Zha S,Wang Y,Liu G

更新日期：2019-03-05 00:00:00

abstract：:Werner syndrome (WS) is the canonical adult human progeroid ('premature aging') syndrome. Patients with this autosomal recessive Mendelian disorder display constitutional genomic instability and an elevated risk of important age-associated diseases including cancer. Remarkably few analyses of WS patient tissue and tum...

journal_title：Scientific reports

authors： Tokita M,Kennedy SR,Risques RA,Chun SG,Pritchard C,Oshima J,Liu Y,Bryant-Greenwood PK,Welcsh P,Monnat RJ

更新日期：2016-08-25 00:00:00

abstract：:It is challenging to create artificial catalysts that approach enzymes with regard to catalytic efficiency and selectivity. The enantioselective catalysis ranks the privileged characteristic of enzymatic transformations. Here, we report two pyridine-linked bis(β-cyclodextrin) (bisCD) copper(II) complexes that enantios...

journal_title：Scientific reports

authors： Xue SS,Zhao M,Ke ZF,Cheng BC,Su H,Cao Q,Cao ZK,Wang J,Ji LN,Mao ZW

更新日期：2016-02-26 00:00:00

abstract：:IgG is an indispensable biological experimental tool as well as a widely-used therapeutic protein. However, cell culture-based expression of monoclonal IgG is costly and time-consuming, making this process difficult to use for high-throughput screening in early-stage evaluation of biologics. With the goal of establish...

journal_title：Scientific reports

authors： Murakami S,Matsumoto R,Kanamori T

更新日期：2019-01-24 00:00:00