Trehalose ameliorates peritoneal fibrosis by promoting Snail degradation and inhibiting mesothelial-to-mesenchymal transition in mesothelial cells.

Abstract:

:Peritoneal fibrosis (PF) is a severe complication of peritoneal dialysis, but there are few effective therapies for it. Recent studies have revealed a new biological function of trehalose as an autophagy inducer. Thus far, there are few reports regarding the therapeutic effects of trehalose on fibrotic diseases. Therefore, we examined whether trehalose has anti-fibrotic effects on PF. PF was induced by intraperitoneal injection of chlorhexidine gluconate (CG). CG challenges induced the increase of peritoneal thickness, ColIα1 mRNA expression and hydroxyproline content, all of which were significantly attenuated by trehalose. In addition, CG challenges induced a marked peritoneal accumulation of α-SMA+ myofibroblasts that was reduced by trehalose. The number of Wt1+ α-SMA+ cells in the peritoneum increased following CG challenges, suggesting that a part of α-SMA+ myofibroblasts were derived from peritoneal mesothelial cells (PMCs). The number of Wt1+ α-SMA+ cells was also suppressed by trehalose. Additionally, trehalose attenuated the increase of α-SMA and ColIα1 mRNA expression induced by TGF-β1 through Snail protein degradation, which was dependent on autophagy in PMCs. These results suggest that trehalose might be a novel therapeutic agent for PF through the induction of autophagy and the suppression of mesothelial-to-mesenchymal transition in PMCs.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Miyake T,Sakai N,Tamai A,Sato K,Kamikawa Y,Miyagawa T,Ogura H,Yamamura Y,Oshima M,Nakagawa S,Sagara A,Shinozaki Y,Toyama T,Kitajima S,Hara A,Iwata Y,Shimizu M,Furuichi K,Kaneko S,Wada T

doi

10.1038/s41598-020-71230-4

subject

Has Abstract

pub_date

2020-08-31 00:00:00

pages

14292

issue

1

issn

2045-2322

pii

10.1038/s41598-020-71230-4

journal_volume

10

pub_type

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