Abstract:
:3-D modeling of coupled thermo-hydro-mechanical (THM) processes in enhanced geothermal systems using the control volume finite element code was done. In a first, a comparative analysis on the effects of coupled processes, operational parameters and reservoir parameters on heat extraction was conducted. We found that significant temperature drop and fluid overpressure occurred inside the reservoirs/fracture that affected the transport behavior of the fracture. The spatio-temporal variations of fracture aperture greatly impacted the thermal drawdown and consequently the net energy output. The results showed that maximum aperture evolution occurred near the injection zone instead of the production zone. Opening of the fracture reduced the injection pressure required to circulate a fixed mass of water. The thermal breakthrough and heat extraction strongly depend on the injection mass flow rate, well distances, reservoir permeability and geothermal gradients. High permeability caused higher water loss, leading to reduced heat extraction. From the results of TH vs THM process simulations, we conclude that appropriate coupling is vital and can impact the estimates of net heat extraction. This study can help in identifying the critical operational parameters, and process optimization for enhanced energy extraction from a geothermal system.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Pandey SN,Vishal Vdoi
10.1038/s41598-017-14273-4subject
Has Abstractpub_date
2017-12-06 00:00:00pages
17057issue
1issn
2045-2322pii
10.1038/s41598-017-14273-4journal_volume
7pub_type
杂志文章abstract::The outbreak of multidrug-resistant pathogenic bacteria made the discovery of novel control strategies necessary. Phages have regained attention for their specific lytic activity against pathogenic bacterium. A newly isolated phage infecting the clinical Escherichia coli isolates, including several multidrug-resistant...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26004-4
更新日期:2018-05-24 00:00:00
abstract::Antimicrobial peptides (AMPs) exhibit broad-spectrum antimicrobial activity, and have promise as new therapeutic agents. While the adult North American bullfrog (Rana [Lithobates] catesbeiana) is a prolific source of high-potency AMPs, the aquatic tadpole represents a relatively untapped source for new AMP discovery. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38442-1
更新日期:2019-02-06 00:00:00
abstract::Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04946-5
更新日期:2017-07-05 00:00:00
abstract::The direct fabrication of microstructures, having a non-symmetrical morphology with controllable inclination, presents nowadays a challenging task. Natural examples of surfaces with inclined topographies have shown to provide anisotropic functionalities, which have attracted the interest of several researchers in the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41902-x
更新日期:2019-04-01 00:00:00
abstract::In this paper, we propose a feasible tool that uses a terahertz (THz) imaging system for identifying wheat grains at different stages of germination. The THz spectra of the main changed components of wheat grains, maltose and starch, which were obtained by THz time spectroscopy, were distinctly different. Used for ori...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21299
更新日期:2016-02-19 00:00:00
abstract::Bispecific killer cells engagers (BiKEs) which can bind to natural killer (NK) cells through the activating receptor CD16A and guide them to cells expressing the HIV-1 envelope glycoprotein (Env) are a promising new weapon for elimination of infected cells and eradication of the virus. Here we report the design, gener...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07966-3
更新日期:2017-08-22 00:00:00
abstract::The centromeric nucleosome is a key epigenetic determinant of centromere identity and function. Consequently, deciphering how CENP-A containing nucleosomes contribute structurally to centromere function is a fundamental question in chromosome biology. Here, we performed microsecond timescale all-atom molecular dynamic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17038
更新日期:2015-11-25 00:00:00
abstract::Surface incident solar radiation (Rs) of reanalysis products is widely used in ecological conservation, agricultural production, civil engineering and various solar energy applications. It is of great importance to have a good knowledge of the uncertainty of reanalysis Rs products. In this study, we evaluated the Rs e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60460-1
更新日期:2020-02-26 00:00:00
abstract::The tetanus toxin C-fragment is a non-toxic peptide that can be transported from peripheral axons into spinal motoneurons. In in vitro experiments it has been shown that this peptide activates signaling pathways associated with Trk receptors, leading to cellular survival. Because motoneuron degeneration is the main pa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35027-w
更新日期:2018-11-08 00:00:00
abstract::During locomotion, the human ankle-foot system dynamically alters its gearing, or leverage of the ankle joint on the ground. Shifting ankle-foot gearing regulates speed of plantarflexor (i.e., calf muscle) contraction, which influences economy of force production. Here, we tested the hypothesis that manipulating ankle...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65626-5
更新日期:2020-05-29 00:00:00
abstract::Desmoid tumors (aggressive fibromatosis) are locally invasive soft tissue tumors that lack the ability to metastasize. There are no directed therapies or standard treatment plan, and chemotherapeutics, radiation, and surgery often have temporary effects. The majority of desmoid tumors are related to T41A and S45F muta...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18921-7
更新日期:2018-01-12 00:00:00
abstract::Membrane type 1 metalloproteinase (MT1-MMP) is an important regulator of cancer invasion, growth and angiogenesis, thus making it an attractive target for cancer imaging and therapy. A non-substrate peptide (MT1-AF7p) that bonded to the "MT-Loop" region of MT1-MMP was identified by using a phage-displayed peptide libr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28493-9
更新日期:2018-07-09 00:00:00
abstract::Junction-less nanowire transistors are being investigated to solve short channel effects in future CMOS technology. Here we demonstrate 8 nm diameter silicon nanowire junction-less transistors with metallic doping densities which demonstrate clear 1D electronic transport characteristics. The 1D regime allows excellent...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03138-5
更新日期:2017-06-07 00:00:00
abstract::Starting from the dataset of the publication corpus of the APS during the period 1955-2009, we reconstruct the individual researchers trajectories, namely the list of the consecutive affiliations for each scholar. Crossing this information with different geographic datasets we embed these trajectories in a spatial fra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04860
更新日期:2014-05-07 00:00:00
abstract::It is well established that boys are born heavier and longer than girls, but it remains unclear whether birth size in twins is affected by the sex of their co-twin. We conducted an individual-based pooled analysis of 21 twin cohorts in 15 countries derived from the COllaborative project of Development of Anthropometri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24634-2
更新日期:2018-04-19 00:00:00
abstract::Chloroquine (CQ) is widely used as an anti-inflammatory therapeutic for rheumatic diseases. Although its modes of action on the innate immune system are well described, there is still insufficient knowledge about its direct effects on the adaptive immune system. Thus, we evaluated the influence of CQ on activation par...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42191
更新日期:2017-02-07 00:00:00
abstract::In this paper, α-Fe2O3 nanoparticles (NPs)-reduced graphene oxide (RGO), α-FeOOH nanorods (NRs)-RGO and porous α-Fe2O3 NRs-RGO could be selectively synthesized by hydrothermal method. The investigations indicated that the obtained α-Fe2O3 NPs, α-FeOOH NRs and porous α-Fe2O3 NRs were either attached on the surface of R...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11131-1
更新日期:2017-09-11 00:00:00
abstract::A high throughput method for species identification and classification through chemometric processing of direct analysis in real time (DART) mass spectrometry-derived fingerprint signatures has been developed. The method entails introduction of samples to the open air space between the DART ion source and the mass spe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11520
更新日期:2015-07-09 00:00:00
abstract::To begin studies on reproduction in common bed bug, Cimex lectularius, we identified three genes coding for vitellogenin (Vg, a protein required for the reproductive success of insects) and studied their hormonal regulation. RNA interference studied showed that expression of Vg3 gene in the adult females is a prerequi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35546
更新日期:2016-10-20 00:00:00
abstract::Meromictic lakes are useful biogeochemical models because of their stratified chemical gradients and separation of redox reactions down the water column. Perennially ice-covered meromictic lakes are particularly stable, with long term constancy in their density profiles. Here we sampled Lake A, a deep meromictic lake ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00604
更新日期:2012-01-01 00:00:00
abstract::We report the experimental observation of extreme instabilities in a self-pulsing fiber laser under the influence of stimulated Brillouin scattering (SBS). Specifically, we observe temporally localized structures with high intensities that can be referred to as rogue events through their statistical behaviour with hig...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45868
更新日期:2017-04-04 00:00:00
abstract::Water, methane, and ammonia are commonly considered to be the key components of the interiors of Uranus and Neptune. Modelling the planets' internal structure, evolution, and dynamo heavily relies on the properties of the complex mixtures with uncertain exact composition in their deep interiors. Therefore, characteris...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46561-6
更新日期:2019-07-12 00:00:00
abstract::Fluid strategy is the key to the successful management of patients with sepsis. However, previous studies failed to consider individualized treatment strategy, and clinical trials typically included patients with sepsis as a homogeneous study population. We aimed to develop sequential decision rules for managing fluid...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74906-z
更新日期:2020-10-21 00:00:00
abstract::Oxidative stress due to hypobaric hypoxia at extreme altitudes causes severe neuronal damage and irreversible cognitive loss. Owing to contraindications of current drug therapies, the aim of the study was to investigate memory enhancing potential of aqueous extract of Ganoderma lucidum (GLAQ) and underlying neuroprote...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65812-5
更新日期:2020-06-02 00:00:00
abstract::In some fibroblasts, casein kinase 1α (CK1α) is localized to nuclear speckles, which are sub-nuclear compartments supplying splicing factors, whereas it is recruited on keratin filaments in colorectal cancer cells such as DLD1 cells. In order to obtain a deeper understanding of why CK1α is localized to these different...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34472
更新日期:2016-09-29 00:00:00
abstract::Understanding the transcriptional regulatory elements that influence the progression of liver disease in the presence of hepatitis C virus (HCV) infection is critical for the development of diagnostic and therapeutic approaches. Systems biology provides a roadmap by which these elements may be integrated. In this stud...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32464-5
更新日期:2018-09-24 00:00:00
abstract::Familial hypercholesterolemia (FH) is an inherited disease of lipoprotein metabolism caused by a defect in the LDL receptor (LDLR) leading to severe hypercholesterolemia, and associated with an increased risk of coronary heart disease and myocardial infarction. We have developed a gene therapy protocol for FH using AA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43459-1
更新日期:2019-05-06 00:00:00
abstract::In contrast to mild infections of Group A Streptococcus (GAS) invasive infections of GAS still pose a serious health hazard: GAS disseminates from sterile sites into the blood stream or deep tissues and causes sepsis or necrotizing fasciitis. In this case antibiotics do not provide an effective cure as the bacteria ar...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11276-z
更新日期:2017-09-18 00:00:00
abstract::Receptor-mediated endocytosis is an essential process in signalling pathways for activation of intracellular signalling cascades. One example is the Wnt signalling pathway that seems to depend on endocytosis of the ligand-receptor complex for initiation of Wnt signal transduction. To date, the roles of different endoc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49082-4
更新日期:2019-09-10 00:00:00
abstract::Nitrification directly contributes to the ammonia removal in sponges, and it plays an indispensable role in sponge-mediated nitrogen cycle. Previous studies have demonstrated genomic evidences of nitrifying lineages in the sponge Theonella swinhoei. However, little is known about the transcriptional activity of nitrif...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24966
更新日期:2016-04-26 00:00:00