Abstract：
:The tetanus toxin C-fragment is a non-toxic peptide that can be transported from peripheral axons into spinal motoneurons. In in vitro experiments it has been shown that this peptide activates signaling pathways associated with Trk receptors, leading to cellular survival. Because motoneuron degeneration is the main pathological hallmark in motoneuron diseases, and excitotoxicity is an important mechanism of neuronal death in this type of disorders, in this work we tested whether the tetanus toxin C-fragment is able to protect MN in the spinal cord in vivo. For this purpose, we administered the peptide to rats subjected to excitotoxic motoneuron degeneration induced by the chronic infusion of AMPA in the rat lumbar spinal cord, a well-established model developed in our laboratory. Because the intraspinal infusion of the fragment was only weakly effective, whereas the i.m. administration was remarkably neuroprotective, and because the i.m. injection of an inhibitor of Trk receptors diminished the protection, we conclude that such effects require a retrograde signaling from the neuromuscular junction to the spinal motoneurons. The protection after a simple peripheral route of administration of the fragment suggests a potential therapeutic use of this peptide to target spinal MNs exposed to excitotoxic conditions in vivo.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Netzahualcoyotzi C,Tapia Rdoi
10.1038/s41598-018-35027-wsubject
Has Abstractpub_date
2018-11-08 00:00:00pages
16584issue
1issn
2045-2322pii
10.1038/s41598-018-35027-wjournal_volume
8pub_type
杂志文章abstract：:The novel nuclear protein nBMP2 is synthesized from the BMP2 gene by translational initiation at an alternative start codon. We generated a targeted mutant mouse, nBmp2NLStm, in which the nuclear localization signal (NLS) was inactivated to prevent nuclear translocation of nBMP2 while still allowing the normal synthes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46464
更新日期：2017-04-18 00:00:00
abstract：:Export of messenger ribonucleic acids (mRNAs) into the cytoplasm is a fundamental step in gene regulation processes, which is meticulously quality controlled by highly efficient mechanisms in eukaryotic cells. Yet, it remains unclear how the aberrant mRNAs are recognized and retained inside the nucleus. Using a new mo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35380
更新日期：2016-11-02 00:00:00
abstract：:During germ cell development, epigenetic modifications undergo extensive remodeling. Abnormal epigenetic modifications usually result in germ cell loss and reproductive defect. Prmt5 (Protein arginine methyltransferase 5) encodes a protein arginine methyltransferase which has been demonstrated to play important roles ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11031
更新日期：2015-06-15 00:00:00
abstract：:The voltage-gated sodium channel isoform NaV1.7 is highly expressed in dorsal root ganglion neurons and is obligatory for nociceptive signal transmission. Genetic gain-of-function and loss-of-function NaV1.7 mutations have been identified in select individuals, and are associated with episodic extreme pain disorders a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71135-2
更新日期：2020-09-09 00:00:00
abstract：:High-performance ZnO-Pr6O11 thin-film varistors were fabricated simply by hot-dipping oxygen-deficient zinc oxide thin films in Pr6O11 powder. The films had a composition of ZnO0.81 and a thickness of about 200 nm, which were deposited by radio frequency magnetron sputtering a sintered zinc oxide ceramic target. Speci...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41994
更新日期：2017-02-03 00:00:00
abstract：:Sesamin is a furofuran-type lignan that is found abundantly in seeds of Sesamum indicum (sesame) and has been widely accepted as a dietary supplement with positive effects on human health. The biological activity of sesamin in human cells and organs has been analysed extensively, although comparatively few studies sho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45003-7
更新日期：2019-06-14 00:00:00
abstract：:Pyramidal neurons in the rodent hippocampus exhibit spatial tuning during spatial navigation, and they are reactivated in specific temporal order during sharp-wave ripples observed in quiet wakefulness or slow wave sleep. However, analyzing representations of sleep-associated hippocampal ensemble spike activity remain...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32193
更新日期：2016-08-30 00:00:00
abstract：:This study aimed to investigate whether interleukin-34 (IL-34) mRNA expression is aberrant and modulated by tumor necrosis factor-alpha (TNF-α) in knee osteoarthritis (OA) fibroblast-like synoviocytes (FLS) and determine associations of IL-34 mRNA and protein in the systemic and local joint environments with severity ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64932-2
更新日期：2020-05-14 00:00:00
abstract：:A number of studies have suggested that the irradiation behavior and damage processes occurring during sequential and simultaneous particle irradiations can significantly differ. Currently, there is no definite answer as to why and when such differences are seen. Additionally, the conventional multi-particle irradiati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30191
更新日期：2016-07-28 00:00:00
abstract：:Phase distribution of emerging organic contaminants is highly influential in their presence, fate and transport in surface water. Therefore, it is crucial to determine their state, partitioning behaviour and tendencies in water environments. In this study, Bisphenol A was investigated in both colloidal and soluble pha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77454-8
更新日期：2020-11-23 00:00:00
abstract：:Native collagen is arranged in bundles of aligned fibrils to withstand in vivo mechanical loads. Reproducing such a process under in vitro conditions has not met with major success. Our approach has been to induce nanolinks, during the self-assembly process, leading to delayed rather than inhibited fibrillogenesis. Fo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05968
更新日期：2014-08-06 00:00:00
abstract：:It is rigorously proved that ideal memcapacitors and meminductors are not passive or cyclo-passive devices. Equivalently, this implies that there exist excitation profiles that allow to extract more energy from the device than it is supplied with; so that their energy conversion efficiency exceeds 100%. This means tha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73833-3
更新日期：2020-10-07 00:00:00
abstract：:Biomimetic scales provide a convenient template to tailor the bending stiffness of the underlying slender substrate due to their mutual sliding after engagement. Scale stiffness can therefore directly impact the substrate behavior, opening a potential avenue for substrate stiffness tunability. Here, we have developed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74147-0
更新日期：2020-10-13 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep40037. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep46991
更新日期：2018-05-22 00:00:00
abstract：:Metapristone is the primary metabolite of the abortifacient mifepristone (RU486), and is being developed as a safe and effective cancer metastatic chemopreventive agent for both sexes. Here, we systematically investigated the sex-related pharmacokinetics of metapristone in both rats and dogs, and explored the related ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17225-0
更新日期：2017-12-07 00:00:00
abstract：:The GS Junior sequencer provides simplified procedures for library preparation and data processing. Errors in pyrosequencing generate some biases during library construction and emulsion PCR amplification. False-positive mutations are identified by related characteristics described in the manufacturer's manual, and so...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13116-6
更新日期：2017-10-23 00:00:00
abstract：:Measurements of volcanic tephra fallout deposits provide useful information about the magnitude and intensity of explosive volcanic eruptions and potential for remobilization of deposits as dangerous volcanic flows. However, gathering information in the vicinity of erupting craters is extremely dangerous, and moreover...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71902-1
更新日期：2020-09-09 00:00:00
abstract：:To assess differences between secondary high myopia (SHM) due to congenital glaucoma and primary high myopia (PHM) and non-highly myopic eyes (NHM) in the relationships between axial length and Bruch's membrane (BM) thickness and retinal pigment epithelium (RPE) density. The histomorphometric study included human glob...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62096-7
更新日期：2020-03-20 00:00:00
abstract：:The bacterial flagellar motor is a unique supramolecular complex which converts ion flow into rotational force. Many biological devices mainly use two types of ions, proton and sodium ion. This is probably because of the fact that life originated in seawater, which is rich in protons and sodium ions. The polar flagell...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46038-6
更新日期：2019-08-02 00:00:00
abstract：:H5N1 highly pathogenic avian influenza virus (HPAIV) poses a huge threat to public health and the global economy. These viruses cause systemic infection in poultry and accidental human infection leads to severe pneumonia, associated with high mortality rates. The hemagglutinin (HA) of H5N1 HPAIV possesses multiple bas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74604-w
更新日期：2020-10-22 00:00:00
abstract：:Awe, a complex emotion composed by the appraisal components of vastness and need for accommodation, is a profound and often meaningful experience. Despite its importance, psychologists have only recently begun empirical study of awe. At the experimental level, a main issue concerns how to elicit high intensity awe exp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01242-0
更新日期：2017-04-27 00:00:00
abstract：:Multi-drug resistant Pseudomonas aeruginosa has increased progressively and impedes further regression in mortality in burn patients. Such wound infections serve as bacterial reservoir for nosocomial infections and are associated with significant morbidity and costs. Anti-microbial polycationic dendrimers G3KL and G3R...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22020
更新日期：2016-02-25 00:00:00
abstract：:Adenocarcinoma, large cell carcinoma and squamous cell carcinoma are the most commonly diagnosed subtypes of non-small cell lung cancers (NSCLC). Numerous lung cancer cell types have exhibited electrotaxis under direct current electric fields (dcEF). Physiological electric fields (EF) play key roles in cancer cell mig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44505-8
更新日期：2019-05-30 00:00:00
abstract：:The prevention and control of peri-implantitis is a challenge in dental implant surgery. Dental implants with sustained antimicrobial coating are an ideal way of preventing peri-implantitis. This study reports development of a non- immunotoxicity multilayered coating on a titanium surface that had sustained antimicrob...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16336
更新日期：2015-11-09 00:00:00
abstract：:Changes in climate extremes pose far-reaching consequences to ecological processes and hydrologic cycles in alpine ecosystems of the arid mountain regions. Therefore, regional assessments in various climates and mountain regions are needed for understanding the uncertainties of the change trends for extreme climate ev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02345-4
更新日期：2017-05-22 00:00:00
abstract：:Next generation sequencing is becoming the method of choice for functional genomic studies that use pooled shRNA or CRISPR libraries. A key challenge in sequencing these mixed-oligo libraries is that they are highly susceptible to hairpin and/or heteroduplex formation. This results in polyclonal, low quality, and inco...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01170-z
更新日期：2017-04-21 00:00:00
abstract：:Alveolar type II epithelial cells (ATII) are instrumental in early wound healing in response to lung injury, restoring epithelial integrity through spreading and migration. We previously reported in separate studies that focal adhesion kinase-1 (FAK) and the chemokine receptor CXCR4 promote epithelial repair mechanism...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02204-2
更新日期：2017-05-19 00:00:00
abstract：:RFeO3 orthoferrites, where R is a rare-earth ion of the lanthanide series, are attracting attention mostly because of their promising fast spin dynamics. The magnetic properties of these materials seem to crucially depend on whether the magnetizations of the R and Fe ions' weak ferromagnetic (WFM) components are paral...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37529
更新日期：2016-11-25 00:00:00
abstract：:Silver nanowires (AgNWs) networks are promising candidates for the replacement of indium tin oxide (ITO). However, the surface roughness of the AgNWs network is still too high for its application in optoelectronic devices. In this work, we have reduced the surface roughness of the AgNWs networks to 6.4 nm, compared to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45392
更新日期：2017-03-28 00:00:00
abstract：:Most glioblastoma patients have a dismal prognosis, although some survive several years. However, only few biomarkers are available to predict the disease course. EGR1 and EGR3 have been linked to glioblastoma stemness and tumour progression, and this study aimed to investigate their spatial expression and prognostic ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66236-x
更新日期：2020-06-09 00:00:00
