Site of asteroid impact changed the history of life on Earth: the low probability of mass extinction.

abstract：:Here we report the study of two bioengineered variants of human trace amine-associated receptor 5 (hTAAR5) that were expressed in stable tetracycline-inducible HEK293S cell lines. A systematic detergent screen showed that fos-choline-14 was the optimal detergent to solubilize and subsequently purify the receptors. Mil...

journal_title：Scientific reports

authors： Wang X,Corin K,Rich C,Zhang S

更新日期：2011-01-01 00:00:00

abstract：:Nucleic acid-based diagnostic techniques such as polymerase chain reaction (PCR) are used extensively in medical diagnostics due to their high sensitivity, specificity and quantification capability. In settings with limited infrastructure and unreliable electricity, however, access to such devices is often limited due...

journal_title：Scientific reports

authors： Jiang L,Mancuso M,Lu Z,Akar G,Cesarman E,Erickson D

更新日期：2014-02-20 00:00:00

abstract：:Elevated emissions of sulfur dioxide, nitrogen oxides and ammonia in China have resulted in high levels of sulfur and nitrogen deposition, being contributors to soil acidification, especially in and near large cities. However, knowledge gaps still exist in the way that large cities shape spatial patterns of acid depos...

journal_title：Scientific reports

authors： Du E,de Vries W,Liu X,Fang J,Galloway JN,Jiang Y

更新日期：2015-07-27 00:00:00

abstract：:That the human brain contains magnetite is well established; however, its spatial distribution in the brain has remained unknown. We present room temperature, remanent magnetization measurements on 822 specimens from seven dissected whole human brains in order to systematically map concentrations of magnetic remanence...

journal_title：Scientific reports

authors： Gilder SA,Wack M,Kaub L,Roud SC,Petersen N,Heinsen H,Hillenbrand P,Milz S,Schmitz C

更新日期：2018-07-27 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Tan FN,Gan WL,Ang CCI,Wong GDH,Liu HX,Poh F,Lew WS

更新日期：2019-11-21 00:00:00

abstract：:Diabetes mellitus (DM) is associated with higher risk of tendinopathy, which reduces tolerance to exercise and functional activities and affects lifestyle and glycemic control. Expression of tendon-related genes and matrix metabolism in tenocytes are essential for maintaining physiological functions of tendon. However...

journal_title：Scientific reports

authors： Wu YF,Wang HK,Chang HW,Sun J,Sun JS,Chao YH

更新日期：2017-03-07 00:00:00

abstract：:Invasive non-native species have pervasive impacts on native biodiversity, including population extirpations and species extinctions. Identifying reasons why a population of a native species is extirpated following an invasion often relies on literature-based results of anecdotal observations. The well-established sch...

journal_title：Scientific reports

authors： Haubrock PJ,Balzani P,Britton JR,Haase P

更新日期：2020-12-10 00:00:00

abstract：:Osteoarthritis (OA) is characterized by a slowly progressing, irreversible loss of articular cartilage. Tissue engineering approaches for cartilage regeneration include stem cell-based strategies but not much is known about their repair capacity in an OA microenvironment. The aim of the present study was to identify f...

journal_title：Scientific reports

authors： Mayer U,Benditz A,Grässel S

更新日期：2017-10-16 00:00:00

abstract：:We have proposed and successfully demonstrated a novel approach to direct conversion of mechanical energy into electrical energy using microfluidics. The method combines previously demonstrated reverse electrowetting on dielectric (REWOD) phenomenon with the fast self-oscillating process of bubble growth and collapse....

journal_title：Scientific reports

authors： Hsu TH,Manakasettharn S,Taylor JA,Krupenkin T

更新日期：2015-11-16 00:00:00

abstract：:The aberrant accumulation of ubiquitinated protein aggregates in cells plays a critical role in the pathogenesis of several degenerative diseases, including Parkinson disease (PD) and cystic fibrosis (CF). In this study, we found that Ras GTPase-activating protein-binding protein 1 (G3BP1) inhibits ubiquitinated prote...

journal_title：Scientific reports

authors： Anisimov S,Takahashi M,Kakihana T,Katsuragi Y,Kitaura H,Zhang L,Kakita A,Fujii M

更新日期：2019-09-09 00:00:00

abstract：:Ultrasound-enhanced drug delivery has shown great promise in providing targeted burst release of drug at the site of the disease. Yet current solid ultrasound-responsive particles are non-degradable with limited potential for drug-loading. Here, we report on an ultrasound-responsive multi-cavity poly(lactic-co-glycoli...

journal_title：Scientific reports

authors： Su X,Thomas RG,Bharatula LD,Kwan JJ

更新日期：2019-07-03 00:00:00

abstract：:The endogenous peptide C-type natriuretic peptide (CNP) binds its receptor, guanylyl cyclase B (GCB), and is expressed by endothelial cells in diverse tissues. Because the endothelial cells of visceral adipose tissue have recently been reported to play a role in lipid metabolism and inflammation, we investigated the e...

journal_title：Scientific reports

authors： Bae CR,Hino J,Hosoda H,Arai Y,Son C,Makino H,Tokudome T,Tomita T,Kimura T,Nojiri T,Hosoda K,Miyazato M,Kangawa K

更新日期：2017-08-29 00:00:00

abstract：:The causes of the severest crisis in the history of life around the Permian-Triassic boundary (PTB) remain controversial. Here we report that the latest Permian alluvial plains in Shanxi, North China, went through a rapid transition from meandering rivers to braided rivers and aeolian systems. Soil carbonate carbon is...

journal_title：Scientific reports

authors： Zhu Z,Liu Y,Kuang H,Benton MJ,Newell AJ,Xu H,An W,Ji S,Xu S,Peng N,Zhai Q

更新日期：2019-11-14 00:00:00

abstract：:Despite the quintessential role that music plays in human societies by enabling us to release and share emotions with others, traces of its evolutionary origins in other species remain scarce. Drumming like humans whilst producing music is practically unheard of in our most closely related species, the great apes. Alt...

journal_title：Scientific reports

authors： Dufour V,Poulin N,Charlotte Curé,Sterck EH

更新日期：2015-06-17 00:00:00

abstract：:Several studies found that 50-100% serum eye drops provided greater benefits without inducing detrimental effects on the corneal epithelial healing. This study assessed the efficacy of undiluted serum eye drops for the treatment of persistent corneal epithelial defects (PED). A total of 109 eyes received 100% serum ey...

journal_title：Scientific reports

authors： Lekhanont K,Jongkhajornpong P,Anothaisintawee T,Chuckpaiwong V

更新日期：2016-12-02 00:00:00

abstract：:Hyperphosphorylation of tau and imbalanced expression of 3R-tau and 4R-tau as a result of dysregulation of tau exon 10 splicing are believed to be pivotal to the pathogenesis of tau pathology, but the molecular mechanism leading to the pathologic tau formation in Alzheimer's disease (AD) brain is not fully understood....

journal_title：Scientific reports

authors： Chen C,Gu J,Basurto-Islas G,Jin N,Wu F,Gong CX,Iqbal K,Liu F

更新日期：2017-10-18 00:00:00

abstract：:Mitochondrial activity is central to tissue homeostasis. Mitochondria dysfunction constitutes a hallmark of many genetic diseases and plays a key role in tumor progression. The essential role of mitochondria, added to their recently documented capacity to transfer from cell to cell, obviously contributes to their curr...

journal_title：Scientific reports

authors： Caicedo A,Fritz V,Brondello JM,Ayala M,Dennemont I,Abdellaoui N,de Fraipont F,Moisan A,Prouteau CA,Boukhaddaoui H,Jorgensen C,Vignais ML

更新日期：2015-03-13 00:00:00

abstract：:Molecular chaperones assist proteins in achieving a functional structure and prevent them from misfolding into aggregates, including disease-associated deposits. The BRICHOS domain from familial dementia associated protein Bri2 (or ITM2B) probably chaperones its specific proprotein region with high β-sheet propensity ...

journal_title：Scientific reports

authors： Poska H,Leppert A,Tigro H,Zhong X,Kaldmäe M,Nilsson HE,Hebert H,Chen G,Johansson J

更新日期：2020-06-17 00:00:00

abstract：:Hypertension is the most common and lethal risk factor for cardiovascular disease (CVD). Numerous variants have been associated with hypertension, however, most of which failed to get replication due to ethnic differences. In this study, we analyzed associations of 10 newly reported single nucleotide polymorphisms (SN...

journal_title：Scientific reports

authors： Yu Q,Sun HP,Chen WQ,Chen XQ,Xu Y,He YH,Kong QP

更新日期：2015-10-21 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder resulting from mutations in the dystrophin gene. The mdx/utrn -/- mouse, lacking in both dystrophin and its autosomal homologue utrophin, is commonly used to model the clinical symptoms of DMD. Interestingly, these mice are infertile but the mechanisms ...

journal_title：Scientific reports

authors： Chen HC,Chin YF,Lundy DJ,Liang CT,Chi YH,Kuo P,Hsieh PCH

更新日期：2017-08-07 00:00:00

abstract：:Depression is a severe and chronic mental disorder, affecting about 322 million individuals worldwide. A recent study showed that diterpene ginkgolides (DG) have antidepressant-like effects on baseline behaviours in mice. Here, we examined the effects of DG and venlafaxine (VLX) in a chronic social defeat stress model...

journal_title：Scientific reports

authors： Bai S,Zhang X,Chen Z,Wang W,Hu Q,Liang Z,Shen P,Gui S,Zeng L,Liu Z,Chen J,Xie X,Huang H,Han Y,Wang H,Xie P

更新日期：2017-08-29 00:00:00

abstract：:Most gliomas are invasive tumors formed from glial cells and associated with high mortality rates. In this study, we characterized four glioma cell lines of varying degree of aggressiveness (H4, SW1088, A172 and U87-MG) in terms of morphology, cytoskeleton organization and stiffness, and evaluated their invasive poten...

journal_title：Scientific reports

authors： Louca M,Stylianou A,Minia A,Pliaka V,Alexopoulos LG,Gkretsi V,Stylianopoulos T

更新日期：2019-05-23 00:00:00

abstract：:Pluripotency can be induced in vitro from adult somatic mammalian cells by enforced expression of defined transcription factors regulating and initiating the pluripotency network. Despite the substantial advances over the last decade to improve the efficiency of direct reprogramming, exact mechanisms underlying the co...

journal_title：Scientific reports

authors： Raab S,Klingenstein M,Möller A,Illing A,Tosic J,Breunig M,Kuales G,Linta L,Seufferlein T,Arnold SJ,Kleger A,Liebau S

更新日期：2017-11-29 00:00:00

abstract：:Despite the detailed characterization of the inflammatory and endothelial changes observed in Sickle Cell Disease (SCD), the hierarchical relationship between elements involved in the pathogenesis of this complex disease is yet to be described. Meta-analyses of gene expression studies from public repositories represen...

journal_title：Scientific reports

authors： Hounkpe BW,Fiusa MM,Colella MP,da Costa LN,Benatti Rde O,Saad ST,Costa FF,dos Santos MN,De Paula EV

更新日期：2015-12-09 00:00:00

abstract：:The changes of balance control mechanism caused by lumbar disc herniation (LDH) has not been well understood. This study aimed to investigate the effects of LDH on the balance control during standing on sloped surfaces. Ten patients with LDH and 10 gender- and age-matched healthy subjects were instructed to stand quie...

journal_title：Scientific reports

authors： Li J,Zhang Y,Song S,Hou Y,Hong Y,Yue S,Li K

更新日期：2020-02-03 00:00:00

abstract：:What is intuitive: pro-social or anti-social behaviour? To answer this fundamental question, recent studies analyse decision times in game theory experiments under the assumption that intuitive decisions are fast and that deliberation is slow. These analyses keep track of the average time taken to make decisions under...

journal_title：Scientific reports

authors： Gallotti R,Grujić J

更新日期：2019-11-19 00:00:00

abstract：:In many cancers, the establishment of a patient's future treatment regime often relies on histopathological assessment of tumor tissue specimens in order to determine the extent of the 'pathological response' to a given therapy. However, histopathological assessment of pathological response remains subjective. Here we...

journal_title：Scientific reports

authors： Patterson NH,Alabdulkarim B,Lazaris A,Thomas A,Marcinkiewicz MM,Gao ZH,Vermeulen PB,Chaurand P,Metrakos P

更新日期：2016-11-14 00:00:00

abstract：:Cartilage tissue is avascular and hypoxic which regulates chondrocyte phenotype via stabilization of HIFs. Here, we investigated the role of hypoxia and HIFs in regulation of Rho and canonical Wnt signaling in chondrocytes. Our data demonstrates that hypoxia controls the expression of RhoA in chondrocytes in a context...

journal_title：Scientific reports

authors： Öztürk E,Hobiger S,Despot-Slade E,Pichler M,Zenobi-Wong M

更新日期：2017-08-22 00:00:00

abstract：:Prestin in the lateral membrane of outer hair cells, is responsible for electromotility (EM) and a corresponding nonlinear capacitance (NLC). Prestin's voltage sensitivity is influenced by intracellular chloride. A regulator of intracellular chloride is a stretch-sensitive, non-selective conductance within the lateral...

journal_title：Scientific reports

authors： Bai JP,Moeini-Naghani I,Zhong S,Li FY,Bian S,Sigworth FJ,Santos-Sacchi J,Navaratnam D

更新日期：2017-04-19 00:00:00

abstract：:The food supply is being increasingly challenged by climate change and water scarcity. However, incremental changes in traditional cropping systems have achieved only limited success in meeting these multiple challenges. In this study, we applied a systematic approach, using model simulation and data from two groups o...

journal_title：Scientific reports

authors： Meng Q,Wang H,Yan P,Pan J,Lu D,Cui Z,Zhang F,Chen X

更新日期：2017-02-03 00:00:00