Abstract:
:The arrival of infected travelers from endemic regions can trigger sustained autochthonous transmission of mosquito-borne pathogens in Europe. In 2007 a Chikungunya outbreak was observed in central Italy, mostly affecting two villages characterised by a high density of Aedes albopictus. The outbreak was mitigated through intervention strategies reducing the mosquito abundance. Ten years later, in 2017, sustained Chikungunya transmission was documented in both central and southern Italy. The proposed analysis identifies suitable reactive measures for the containment and mitigation of future epidemics by combining epidemiological modeling with a health economic approach, considering different arrival times of imported infections and possible delays in the notification of cases. Obtained estimates suggest that, if the first notification will occur in the middle of the mosquito breeding season, the combination of larvicides, adulticides and breeding sites removal represents the optimal strategy. In particular, we found that interventions implemented in 2007 were cost-effective, with about 3200 prevented cases, 1450 DALYs averted and €13.5 M saved. Moreover, larvicides are proven to be more cost beneficial in early summer and warmer seasons, while adulticides should be preferred in autumn and colder seasons. Our results provide useful indications supporting urgent decision-making of public health authorities in response to emerging mosquito-borne epidemics.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Trentini F,Poletti P,Baldacchino F,Drago A,Montarsi F,Capelli G,Rizzoli A,Rosà R,Rizzo C,Merler S,Melegaro Adoi
10.1038/s41598-018-27443-9subject
Has Abstractpub_date
2018-06-13 00:00:00pages
9034issue
1issn
2045-2322pii
10.1038/s41598-018-27443-9journal_volume
8pub_type
杂志文章abstract::Differences in the pathogenesis of radiation-induced lung injury among murine strains offer a unique opportunity to elucidate the molecular mechanisms driving the divergence in tissue response from repair and recovery to organ failure. Here, we utilized two well-characterized murine models of radiation pneumonitis/fib...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36579
更新日期:2016-11-15 00:00:00
abstract::Biology is adapted to Earth's gravity force, and the long-term effects of varying gravity on the development of animals is unclear. Previously, we reported that high gravity, called hypergravity, increases defects in the development of motor neuron axons in the nematode Caenorhabditis elegans. Here, we show that a mut...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78414-y
更新日期:2020-12-03 00:00:00
abstract::Recruitment is one of the dominant processes regulating fish population productivity. It is, however, notoriously difficult to predict, as it is the result of a complex multi-step process. Various fine-scale drivers might act on the pathway from adult population characteristics to spawning behaviour and egg production...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/s41598-020-73025-z
更新日期:2020-09-30 00:00:00
abstract::The biogeographic history of lichenized fungi remains unrevealed because those organisms rarely fossilize due to their delicate, often tiny and quickly rotting thalli. Also the ecology and factors limiting occurrence of numerous taxa, especially those restricted in their distribution to tropical areas are poorly recog...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38779
更新日期:2016-12-08 00:00:00
abstract::In the presence of a lateral periodic potential modulation, two-dimensional electrons may exhibit interesting phenomena, such as a graphene-like energy-momentum dispersion, Bloch oscillations, or the Hofstadter butterfly band structure. To create a sufficiently strong potential modulation using conventional semiconduc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20967
更新日期:2016-02-11 00:00:00
abstract::Hematopoietic stem/progenitor cells (HSPC) in zebrafish emerge from the aortic hemogenic endothelium (HE) and migrate towards the caudal hematopoietic tissue (CHT), where they expand and differentiate during definitive hematopoiesis. Phospholipase C gamma 1 (Plcγ1) has been implicated for hematopoiesis in vivo and in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36338-8
更新日期:2019-01-21 00:00:00
abstract::Rapid dilation of retinal vessels in response to flickering light (functional hyperemia) is a well-known autoregulatory response driven by increased neural activity in the inner retina. Little is known about flicker-induced changes of activity of retinal neurons themselves. We non-invasively investigated flicker-induc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54930-4
更新日期:2019-12-05 00:00:00
abstract::Insulin gene mutations have been identified to cause monogenic diabetes, and most of which developed permanent neonatal diabetes at young ages before 6 months of age in humans. To establish an animal model of permanent diabetes, we performed genome editing using the CRISPR/Cas9 system. We generated a novel Kuma mutant...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68987-z
更新日期:2020-07-22 00:00:00
abstract::Single molecule localization microscopy (SMLM) techniques allow for sub-diffraction imaging with spatial resolutions better than 10 nm reported. Much has been discussed relating to different variations of SMLM and all-inclusive microscopes can now be purchased, removing the need for in-house software or hardware devel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07924
更新日期:2015-01-21 00:00:00
abstract::Radionuclide concentrations in environmental samples such as surface soils, plants and water were evaluated by high purity germanium detector measurements. The contribution rate of short half-life radionuclides such as (132)I to the exposure dose to residents was discussed from the measured values. The highest values ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02283
更新日期:2013-01-01 00:00:00
abstract::In populations of Drosophila larvae, both, an aggregation and a dispersal behavior can be observed. However, the mechanisms coordinating larval locomotion in respect to other animals, especially in close proximity and during/after physical contacts are currently only little understood. Here we test whether relevant in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31564
更新日期:2016-08-11 00:00:00
abstract::Quantum measurement is a fundamental cornerstone of experimental quantum computations. The main issues in current quantum measurement strategies are the high number of measurement rounds to determine a global optimal measurement output and the low success probability of finding a global optimal measurement output. Eac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43250-2
更新日期:2019-05-01 00:00:00
abstract::We introduce an experimental method based upon a glass micropipette microinjection technique for generating a multitude of interconnected vesicles (IVs) in the interior of a single giant unilamellar phospholipid vesicle (GUV) serving as a cell model system. The GUV membrane, consisting of a mixture of soybean polar li...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70562-5
更新日期:2020-08-20 00:00:00
abstract::The tunneled central venous catheter (CVC) plays an important role for hemodialysis patients, but CVC-related thrombosis in the central veins remain problematic. This study is the first try to numerically find out what hemodynamic parameters are predisposed to the initiation and formation of thrombus after CVC inserti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12456-7
更新日期:2017-11-21 00:00:00
abstract::In this study, Tb3+-doped natural sodium feldspar (NaAlSi3O8) phosphors have been successfully prepared using high-temperature solid-state method with natural sodium feldspar as a substrate. Energy-dispersive X-ray spectrometry analysis (EDX) of NaAlSi3O8 showed that 0.03 wt% of Eu element was present, and elemental d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51171-3
更新日期:2019-10-10 00:00:00
abstract::This study aimed to determine the characteristics of CT changes in patients with severe coronavirus disease 2019 (COVID-19) based on prognosis. Serial CT scans in 47 patients with severe COVID-19 were reviewed. The patterns, distribution and CT score of lung abnormalities were assessed. Scans were classified according...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78965-0
更新日期:2020-12-14 00:00:00
abstract::The rectifying properties of α,ω-dithiol terminated oligo(phenylene ethynylene) molecules sandwiched between heterometallic electrodes, including the molecular length and side group effects, are theoretically investigated using the fully self-consistent nonequilibrium Green's function method combined with density func...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06357
更新日期:2014-09-15 00:00:00
abstract::Corals build their skeletons using extracellular calcifying fluid located in the tissue-skeleton interface. However, the mechanism by which corals control the transport of calcium and other ions from seawater and the mechanism of constant alkalization of calcifying fluid are largely unknown. To address these questions...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40324
更新日期:2017-01-18 00:00:00
abstract::The early diverged Magnoliaceae shows a historical temperate-tropical distribution among lineages indicating divergent evolution, yet which ecophysiological traits are phylogenetically conserved, and whether these traits are involved in correlated evolution remain unclear. Integrating phylogeny and 20 ecophysiological...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12246
更新日期:2015-07-16 00:00:00
abstract::Male infertility due to spermatogenesis defects affects millions of men worldwide. However, the genetic etiology of the vast majority remains unclear. Here we describe three men with primary infertility due to multiple morphological abnormalities of the sperm flagella (MMAF) from two unrelated Han Chinese families. We...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-019-52436-7
更新日期:2019-11-01 00:00:00
abstract::Roots have important roles for plants to withstand adverse environmental conditions, including salt stress. Biostimulant application was shown to enhance plant resilience towards abiotic stresses. Here, we studied the effect of a tannin-based biostimulant on tomato (Solanum lycopersicum L.) grown under salt stress con...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79770-5
更新日期:2021-01-11 00:00:00
abstract::ING2 (inhibitor of growth family member 2) is a component of a chromatin-regulatory complex that represses gene expression and is implicated in cellular processes that promote tumor suppression. However, few direct genomic targets of ING2 have been identified and the mechanism(s) by which ING2 selectively regulates ge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02137
更新日期:2013-01-01 00:00:00
abstract::Primary IgA nephropathy (IgAN) diagnosis is based on IgA-dominant glomerular deposits and histological scoring is done on formalin-fixed paraffin embedded tissue (FFPE) sections using the Oxford classification. Our aim was to use this underexploited resource to extract RNA and identify genes that characterize active (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72026-2
更新日期:2020-09-16 00:00:00
abstract::Azoles are antifungal drugs used to treat fungal infections such as candidiasis in humans. Their extensive use has led to the emergence of drug resistance, complicating antifungal therapy for yeast infections in critically ill patients. Combination therapy has become popular in clinical practice as a potential strateg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17070
更新日期:2015-11-23 00:00:00
abstract::Heart rate variability (HRV) analyses can be performed using group or individual changes. Individual changes could be of potential interest during training camps for national soccer teams. The purpose of this study was to compare whether analysis of individual daily HRV could detect changes in cardiac autonomic respon...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68698-5
更新日期:2020-07-16 00:00:00
abstract::Soil heavy metals exhibit significant spatiotemporal variability and are strongly correlated with other soil heavy metals. Thus, other heavy metals can be used to improve the accuracy of predictions when performing spatiotemporal predictions of soil heavy metals within a given area. In this study, we propose the spati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17018-5
更新日期:2017-12-01 00:00:00
abstract::The Longwangzhuang pluton is a typical example of Paleoproterozoic A-type granite intrusions at the southern margin of the North China Craton. This pluton is composed of arfvedsonite granite and minor aegirine-augite granites. Samples from both granite types display similar zircon U-Pb ages with 207U-206Pb ages of 161...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56820-1
更新日期:2020-01-09 00:00:00
abstract::Accurate estimation of carrier probabilities of cancer susceptibility gene mutations is an important part of pre-test genetic counselling. Many predictive models are available but their applicability in the Asian population is uncertain. We evaluated the performance of five BRCA mutation risk predictive models in a Ch...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46707-6
更新日期:2019-07-15 00:00:00
abstract::Ge-monopnictides (GeAs) plays critical role in high-tech industry, especially in the field of advanced optical devices and infrared. As a secondary material, coal fly ash could be further recycled to retrieve germanium and prepare GeAs material with high added values. Hence, the aim of this paper is to propose a one-p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03398-1
更新日期:2017-06-16 00:00:00
abstract::The present study evaluated the physiological, molecular and hormonal parameters from scion/rootstock interaction of citrus plants during recurrent water deficit. Responses of the Valencia (VO) scion variety grafted on two rootstocks with different soil water extraction capacities, Rangpur Lime (RL) and Sunki Maravilh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14161-x
更新日期:2017-10-20 00:00:00