Abstract：
:Protein synthesis is traditionally associated with specific cytoplasmic compartments. We now show that OFD1, a centrosomal/basal body protein, interacts with components of the Preinitiation complex of translation (PIC) and of the eukaryotic Initiation Factor (eIF)4F complex and modulates the translation of specific mRNA targets in the kidney. We demonstrate that OFD1 cooperates with the mRNA binding protein Bicc1 to functionally control the protein synthesis machinery at the centrosome where also the PIC and eIF4F components were shown to localize in mammalian cells. Interestingly, Ofd1 and Bicc1 are both involved in renal cystogenesis and selected targets were shown to accumulate in two models of inherited renal cystic disease. Our results suggest a possible role for the centrosome as a specialized station to modulate translation for specific functions of the nearby ciliary structures and may provide functional clues for the understanding of renal cystic disease.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Iaconis D,Monti M,Renda M,van Koppen A,Tammaro R,Chiaravalli M,Cozzolino F,Pignata P,Crina C,Pucci P,Boletta A,Belcastro V,Giles RH,Surace EM,Gallo S,Pende M,Franco Bdoi
10.1038/s41598-017-01156-xsubject
Has Abstractpub_date
2017-04-27 00:00:00pages
1224issue
1issn
2045-2322pii
10.1038/s41598-017-01156-xjournal_volume
7pub_type
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