当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets.

The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets.

Abstract：

:Protein synthesis is traditionally associated with specific cytoplasmic compartments. We now show that OFD1, a centrosomal/basal body protein, interacts with components of the Preinitiation complex of translation (PIC) and of the eukaryotic Initiation Factor (eIF)4F complex and modulates the translation of specific mRNA targets in the kidney. We demonstrate that OFD1 cooperates with the mRNA binding protein Bicc1 to functionally control the protein synthesis machinery at the centrosome where also the PIC and eIF4F components were shown to localize in mammalian cells. Interestingly, Ofd1 and Bicc1 are both involved in renal cystogenesis and selected targets were shown to accumulate in two models of inherited renal cystic disease. Our results suggest a possible role for the centrosome as a specialized station to modulate translation for specific functions of the nearby ciliary structures and may provide functional clues for the understanding of renal cystic disease.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Iaconis D,Monti M,Renda M,van Koppen A,Tammaro R,Chiaravalli M,Cozzolino F,Pignata P,Crina C,Pucci P,Boletta A,Belcastro V,Giles RH,Surace EM,Gallo S,Pende M,Franco B

doi

10.1038/s41598-017-01156-x

subject

Has Abstract

pub_date

2017-04-27 00:00:00

pages

1224

issue

1

issn

2045-2322

pii

10.1038/s41598-017-01156-x

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Assessing fatty acid oxidation flux in rodent cardiomyocyte models.

    abstract：:The healthy adult heart primarily relies on fatty acid oxidation (FAO) for energy production but instantaneously adapts its substrate preference in response to physiological or pathological challenges. Accurate FAO measurements are crucial to investigate early metabolic (mal)adaptations. While measurements in intact c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19478-9

    authors： Rech M,Luiken JJFP,Glatz JFC,van Bilsen M,Schroen B,Nabben M

    更新日期：2018-01-24 00:00:00

  • An atypical phosphodiesterase capable of degrading haloalkyl phosphate diesters from Sphingobium sp. strain TCM1.

    abstract：:Sphingobium sp. strain TCM1 can degrade tris(2-chloroethyl) phosphate (TCEP) to inorganic phosphate and 2-chloroethanol. A phosphotriesterase (PTE), phosphodiesterase (PDE) and phosphomonoesterase (PME) are believed to be involved in the degradation of TCEP. The PTE and PME that respectively catalyze the first and thi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03142-9

    authors： Abe K,Mukai N,Morooka Y,Makino T,Oshima K,Takahashi S,Kera Y

    更新日期：2017-06-06 00:00:00

  • Insulin2Q104del (Kuma) mutant mice develop diabetes with dominant inheritance.

    abstract：:Insulin gene mutations have been identified to cause monogenic diabetes, and most of which developed permanent neonatal diabetes at young ages before 6 months of age in humans. To establish an animal model of permanent diabetes, we performed genome editing using the CRISPR/Cas9 system. We generated a novel Kuma mutant...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68987-z

    authors： Sakano D,Inoue A,Enomoto T,Imasaka M,Okada S,Yokota M,Koike M,Araki K,Kume S

    更新日期：2020-07-22 00:00:00

  • Galectin-3 is related to right ventricular dysfunction in heart failure patients with reduced ejection fraction and may affect exercise capacity.

    abstract：:Galectin-3 is a biomarker of fibrosis, inflammation and oxidative stress, and its role in heart remodelling and exercise intolerance has not been conclusively proven in heart failure (HF) patients with reduced ejection fraction (rEF). We prospectively assessed 67 consecutive patients with symptomatic HF and left ventr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73634-8

    authors： Zaborska B,Sygitowicz G,Smarż K,Pilichowska-Paszkiet E,Budaj A

    更新日期：2020-10-07 00:00:00

  • Chronic treatment with cisplatin induces chemoresistance through the TIP60-mediated Fanconi anemia and homologous recombination repair pathways.

    abstract：:The Fanconi anemia pathway in coordination with homologous recombination is essential to repair interstrand crosslinks (ICLs) caused by cisplatin. TIP60 belongs to the MYST family of acetyltransferases and is involved in DNA repair and regulation of gene transcription. Although the physical interaction between the TIP...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04223-5

    authors： Su WP,Ho YC,Wu CK,Hsu SH,Shiu JL,Huang JC,Chang SB,Chiu WT,Hung JJ,Liu TL,Wu WS,Wu PY,Su WC,Chang JY,Liaw H

    更新日期：2017-06-20 00:00:00

  • High-effective approach from amino acid esters to chiral amino alcohols over Cu/ZnO/Al2O3 catalyst and its catalytic reaction mechanism.

    abstract：:Developing the high-efficient and green synthetic method for chiral amino alcohols is an intriguing target. We have developed the Mg(2+)-doped Cu/ZnO/Al2O3 catalyst for hydrogenation of L-phenylalanine methyl ester to chiral L-phenylalaninol without racemization. The effect of different L-phenylalanine esters on this ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep33196

    authors： Zhang S,Yu J,Li H,Mao D,Lu G

    更新日期：2016-09-13 00:00:00

  • Declaration of local chemical eradication of the Argentine ant: Bayesian estimation with a multinomial-mixture model.

    abstract：:Determining the success of eradication of an invasive species requires a way to decide when its risk of reoccurrence has become acceptably low. In Japan, the area populated by the Argentine ant, Linepithema humile (Mayr), is expanding, and eradication via chemical treatment is ongoing at various locations. One such pr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03516-z

    authors： Sakamoto Y,Kumagai NH,Goka K

    更新日期：2017-06-13 00:00:00

  • Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling.

    abstract：:Tumor growth and metastasis are responsible for most cancer patients' deaths. Here, we report that eupolyphaga sinensis walker has an essential role in resisting hepatocellular carcinoma growth and metastasis. Compared with proliferation, colony formation, transwell assay and transplantable tumor in nude mouse in vitr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05518

    authors： Zhang Y,Zhan Y,Zhang D,Dai B,Ma W,Qi J,Liu R,He L

    更新日期：2014-07-01 00:00:00

  • Mycobacterium tuberculosis exploits the formation of new blood vessels for its dissemination.

    abstract：:The mechanisms by which the airborne pathogen Mycobacterium tuberculosis spreads within the lung and leaves its primary niche to colonize other organs, thus inducing extrapulmonary forms of tuberculosis (TB) in humans, remains poorly understood. Herein, we used a transcriptomic approach to investigate the host cell ge...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep33162

    authors： Polena H,Boudou F,Tilleul S,Dubois-Colas N,Lecointe C,Rakotosamimanana N,Pelizzola M,Andriamandimby SF,Raharimanga V,Charles P,Herrmann JL,Ricciardi-Castagnoli P,Rasolofo V,Gicquel B,Tailleux L

    更新日期：2016-09-12 00:00:00

  • Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.

    abstract：:Adult neurogenesis occurs in the dentate gyrus of the hippocampus during adulthood and contributes to sustaining the hippocampal formation. To investigate whether neurogenesis-related pathways are associated with hippocampal volume, we performed gene-set enrichment analysis using summary statistics from a large-scale ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-50507-3

    authors： Horgusluoglu-Moloch E,Risacher SL,Crane PK,Hibar D,Thompson PM,Saykin AJ,Nho K,Alzheimer’s Disease Neuroimaging Initiative (ADNI).

    更新日期：2019-10-10 00:00:00

  • HPV16 early gene E5 specifically reduces miRNA-196a in cervical cancer cells.

    abstract：:High-risk human papillomavirus (HPV) type 16, which is responsible for greater than 50% of cervical cancer cases, is the most prevalent and lethal HPV type. However, the molecular mechanisms of cervical carcinogenesis remain elusive, particularly the early steps of HPV infection that may transform normal cervical epit...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep07653

    authors： Liu C,Lin J,Li L,Zhang Y,Chen W,Cao Z,Zuo H,Chen C,Kee K

    更新日期：2015-01-07 00:00:00

  • Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1.

    abstract：:SIRT1 is one of seven mammalian homologs of Sir2 that catalyzes NAD(+)-dependent protein deacetylation. The aim of the present study is to explore the effect of SIRT1 small molecule activator on the anticancer activity and the underlying mechanism. We examined the anticancer activity of a novel oral agent, curcumin, w...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13429

    authors： Hu A,Huang JJ,Li RL,Lu ZY,Duan JL,Xu WH,Chen XP,Fan JP

    更新日期：2015-08-24 00:00:00

  • Growth of high quality and uniformity AlGaN/GaN heterostructures on Si substrates using a single AlGaN layer with low Al composition.

    abstract：:By employing a single AlGaN layer with low Al composition, high quality and uniformity AlGaN/GaN heterostructures have been successfully grown on Si substrates by metal-organic chemical vapor deposition (MOCVD). The heterostructures exhibit a high electron mobility of 2150 cm(2)/Vs with an electron density of 9.3 × 10...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23020

    authors： Cheng J,Yang X,Sang L,Guo L,Zhang J,Wang J,He C,Zhang L,Wang M,Xu F,Tang N,Qin Z,Wang X,Shen B

    更新日期：2016-03-10 00:00:00

  • Cost-effective fibrinolytic enzyme production by Bacillus subtilis WR350 using medium supplemented with corn steep powder and sucrose.

    abstract：:The goal of this study was to develop a cheap and simple medium and to optimize fermentation parameters for fibrinolytic enzyme production by Bacillus subtilis WR350. A low-cost medium containing 35 g/L sucrose, 20 g/L corn steep powder and 2 g/L MgSO4·7H2O was developed via single-factor and orthogonal experiments. A...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43371-8

    authors： Wu R,Chen G,Pan S,Zeng J,Liang Z

    更新日期：2019-05-02 00:00:00

  • Topological and system-level protein interaction network (PIN) analyses to deduce molecular mechanism of curcumin.

    abstract：:Curcumin is an important bioactive component of turmeric and also one of the important natural products, which has been investigated extensively. The precise mode of action of curcumin and its impact on system level protein networks are still not well studied. To identify the curcumin governed regulatory action on pro...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69011-0

    authors： Dhasmana A,Uniyal S,Anukriti,Kashyap VK,Somvanshi P,Gupta M,Bhardwaj U,Jaggi M,Yallapu MM,Haque S,Chauhan SC

    更新日期：2020-07-21 00:00:00

  • Significant Role of Collagen XVII And Integrin β4 in Migration and Invasion of The Less Aggressive Squamous Cell Carcinoma Cells.

    abstract：:Collagen XVII and integrin α6β4 have well-established roles as epithelial adhesion molecules. Their binding partner laminin 332 as well as integrin α6β4 are largely recognized to promote invasion and metastasis in various cancers, and collagen XVII is essential for the survival of colon and lung cancer stem cells. We ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45057

    authors： Moilanen JM,Löffek S,Kokkonen N,Salo S,Väyrynen JP,Hurskainen T,Manninen A,Riihilä P,Heljasvaara R,Franzke CW,Kähäri VM,Salo T,Mäkinen MJ,Tasanen K

    更新日期：2017-03-22 00:00:00

  • Arctic sea ice melt leads to atmospheric new particle formation.

    abstract：:Atmospheric new particle formation (NPF) and growth significantly influences climate by supplying new seeds for cloud condensation and brightness. Currently, there is a lack of understanding of whether and how marine biota emissions affect aerosol-cloud-climate interactions in the Arctic. Here, the aerosol population ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03328-1

    authors： Dall Osto M,Beddows DCS,Tunved P,Krejci R,Ström J,Hansson HC,Yoon YJ,Park KT,Becagli S,Udisti R,Onasch T,O Dowd CD,Simó R,Harrison RM

    更新日期：2017-06-12 00:00:00

  • Whales use distinct strategies to counteract solar ultraviolet radiation.

    abstract：:A current threat to the marine ecosystem is the high level of solar ultraviolet radiation (UV). Large whales have recently been shown to suffer sun-induced skin damage from continuous UV exposure. Genotoxic consequences of such exposure remain unknown for these long-lived marine species, as does their capacity to coun...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02386

    authors： Martinez-Levasseur LM,Birch-Machin MA,Bowman A,Gendron D,Weatherhead E,Knell RJ,Acevedo-Whitehouse K

    更新日期：2013-01-01 00:00:00

  • Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase IIIα to induce mitochondrial fragmentation.

    abstract：:Hepatitis C virus (HCV) has long been observed to take advantage of the host mitochondria to support viral replication and assembly. The HCV core protein has been implicated to fragment host mitochondria. In this report, we have discovered that the non-structural protein 5A (NS5A) plays an instructive role in attachin...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23464

    authors： Siu GK,Zhou F,Yu MK,Zhang L,Wang T,Liang Y,Chen Y,Chan HC,Yu S

    更新日期：2016-03-24 00:00:00

  • Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model.

    abstract：:Combination anti-retroviral therapy (cART) has drastically improved the clinical outcome of HIV-1 infection. Nonetheless, despite effective cART, HIV-1 persists indefinitely in infected individuals. Clonal expansion of HIV-1-infected cells in peripheral blood has been reported recently. cART is effective in stopping t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07307-4

    authors： Satou Y,Katsuya H,Fukuda A,Misawa N,Ito J,Uchiyama Y,Miyazato P,Islam S,Fassati A,Melamed A,Bangham CRM,Koyanagi Y,Sato K

    更新日期：2017-07-31 00:00:00

  • Developmental toxicity of diclofenac and elucidation of gene regulation in zebrafish (Danio rerio).

    abstract：:Environmental pollution by emerging contaminants, e.g. pharmaceuticals, has become a matter of widespread concern in recent years. We investigated the membrane transport of diclofenac and its toxic effects on gene expression and the development of zebrafish embryos. The association of diclofenac with the embryos confo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04841

    authors： Chen JB,Gao HW,Zhang YL,Zhang Y,Zhou XF,Li CQ,Gao HP

    更新日期：2014-05-02 00:00:00

  • Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier.

    abstract：:A weakening of the gut mucous barrier permits an increase in the access of intestinal luminal contents to the epithelial cells, which will trigger the inflammatory response. In inflammatory bowel diseases, there is an inappropriate and ongoing activation of the immune system, possibly because the intestinal mucus is l...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09577

    authors： Gouyer V,Dubuquoy L,Robbe-Masselot C,Neut C,Singer E,Plet S,Geboes K,Desreumaux P,Gottrand F,Desseyn JL

    更新日期：2015-05-14 00:00:00

  • Small molecule ice recrystallization inhibitors enable freezing of human red blood cells with reduced glycerol concentrations.

    abstract：:In North America, red blood cells (RBCs) are cryopreserved in a clinical setting using high glycerol concentrations (40% w/v) with slow cooling rates (~1°C/min) prior to storage at -80°C, while European protocols use reduced glycerol concentrations with rapid freezing rates. After thawing and prior to transfusion, gly...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09692

    authors： Capicciotti CJ,Kurach JD,Turner TR,Mancini RS,Acker JP,Ben RN

    更新日期：2015-04-08 00:00:00

  • Frequency-specific activation of the peripheral auditory system using optoacoustic laser stimulation.

    abstract：:Hearing impairment is one of the most common sensory deficits in humans. Hearing aids are helpful to patients but can have poor sound quality or transmission due to insufficient output or acoustic feedback, such as for high frequencies. Implantable devices partially overcome these issues but require surgery with limit...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40860-8

    authors： Stahn P,Lim HH,Hinsberger MP,Sorg K,Pillong L,Kannengießer M,Schreiter C,Foth HJ,Langenbucher A,Schick B,Wenzel GI

    更新日期：2019-03-12 00:00:00

  • Dual-channel near-field control by polarizations using isotropic and inhomogeneous metasurface.

    abstract：:We propose a method for dual-channel near-field manipulations by designing isotropic but inhomogeneous metasurfaces. As example, we present a dual-channel near-field focusing metasurface device. When the device is driven by surface waves from different channels on the metasurface, the near fields will be focused at th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep15853

    authors： Wan X,Cai BG,Li YB,Cui TJ

    更新日期：2015-11-03 00:00:00

  • Development of a novel UHPLC-MS/MS-based platform to quantify amines, amino acids and methylarginines for applications in human disease phenotyping.

    abstract：:Amine quantification is an important strategy in patient stratification and personalised medicine. This is because amines, including amino acids and methylarginines impact on many homeostatic processes. One important pathway regulated by amine levels is nitric oxide synthase (NOS). NOS is regulated by levels of (i) th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-31055-8

    authors： Ahmetaj-Shala B,Olanipekun M,Tesfai A,MacCallum N,Kirkby NS,Quinlan GJ,Shih CC,Kawai R,Mumby S,Paul-Clark M,Want EJ,Mitchell JA

    更新日期：2018-09-18 00:00:00

  • Proteome Profiling of Urinary Exosomes Identifies Alpha 1-Antitrypsin and H2B1K as Diagnostic and Prognostic Biomarkers for Urothelial Carcinoma.

    abstract：:MALDI-TOF spectrometry has not been used for urinary exosome analysis. We used it for determining UC biomarkers. From 2012 to 2015, we enrolled 129 consecutive patients with UC and 62 participants without UC. Exosomes from their urine were isolated, and analyzed through MALDI-TOF spectrometry. Immunohistochemical (IHC...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34446

    authors： Lin SY,Chang CH,Wu HC,Lin CC,Chang KP,Yang CR,Huang CP,Hsu WH,Chang CT,Chen CJ

    更新日期：2016-09-30 00:00:00

  • Degree of functionalisation dependence of individual Raman intensities in covalent graphene derivatives.

    abstract：:Covalent functionalisation of graphene is a continuously progressing field of research. The optical properties of such derivatives attract particular attention. In virtually all optical responses, however, an enhancement in peak intensity with increase of sp3 carbon content, and a vanishing of the peak position shift ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45165

    authors： Vecera P,Eigler S,Koleśnik-Gray M,Krstić V,Vierck A,Maultzsch J,Schäfer RA,Hauke F,Hirsch A

    更新日期：2017-03-27 00:00:00

  • A Joint Modeling Approach for Childhood Meat, Fish and Egg Consumption and the Risk of Advanced Islet Autoimmunity.

    abstract：:Several dietary factors have been suspected to play a role in the development of advanced islet autoimmunity (IA) and/or type 1 diabetes (T1D), but the evidence is fragmentary. A prospective population-based cohort of 6081 Finnish newborn infants with HLA-DQB1-conferred susceptibility to T1D was followed up to 15 year...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44196-1

    authors： Syrjälä E,Nevalainen J,Peltonen J,Takkinen HM,Hakola L,Åkerlund M,Veijola R,Ilonen J,Toppari J,Knip M,Virtanen SM

    更新日期：2019-05-23 00:00:00

  • Crosstalk between Hedgehog pathway and energy pathways in human adipose-derived stem cells: A deep sequencing analysis of polysome-associated RNA.

    abstract：:Adult stem cells are considered promising candidates for cellular therapies due to their capacity to differentiate and self-renew. Differentiation leads to changes in the metabolism, structure, and gene expression patterns of cells. Hedgehog is one of the pathways that is involved in the enhancement of osteogenesis an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26533-y

    authors： Shigunov P,Balvedi LT,Santos MDM,Herai RH,de Aguiar AM,Dallagiovanna B

    更新日期：2018-05-30 00:00:00