Generation of genetically modified mice using SpCas9-NG engineered nuclease.

abstract：:Chronic suppurative otitis media (CSOM) is one of the most common infectious diseases of the middle ear especially affecting children, leading to delay in language development and communication. Although Staphylococcus aureus is the most common pathogen associated with CSOM, its interaction with middle ear epithelial ...

journal_title：Scientific reports

authors： Mittal R,Debs LH,Patel AP,Nguyen D,Blackwelder P,Yan D,Weckwerth PH,Liu XZ

更新日期：2019-07-25 00:00:00

abstract：:Intermediate level radioactive waste (ILW) generally contains a heterogeneous range of organic and inorganic materials, of which some are encapsulated in cement. Of particular concern are cellulosic waste items, which will chemically degrade under the conditions predicted during waste disposal, forming significant qua...

journal_title：Scientific reports

authors： Kuippers G,Boothman C,Bagshaw H,Ward M,Beard R,Bryan N,Lloyd JR

更新日期：2018-06-08 00:00:00

abstract：:Variations in isotopic composition of water vapor in the atmosphere is an important indicator of the processes within the hydrological cycle. Isotopic signature of water vapor and precipitation can be helpful in partitioning evaporation and transpiration fluxes. It is well known that transpiration from forested region...

journal_title：Scientific reports

authors： Pradhan R,Singh N,Singh RP

更新日期：2019-12-09 00:00:00

abstract：:The conventional multifocal optical elements cannot precisely control the focal number, spot size, as well as the energy distribution in between. Here, the binary amplitude-type super-oscillatory lens (SOL) is utilized, and a robust and universal optimization method based on the vectorial angular spectrum (VAS) theory...

journal_title：Scientific reports

authors： Li M,Li W,Li H,Zhu Y,Yu Y

更新日期：2017-05-02 00:00:00

abstract：:Understanding the processes that shaped contemporary pathogen populations in agricultural landscapes is quite important to define appropriate management strategies and to support crop improvement efforts. Here, we took advantage of an historical record to examine the adaptation pathway of the rice pathogen Xanthomonas...

journal_title：Scientific reports

authors： Quibod IL,Perez-Quintero A,Booher NJ,Dossa GS,Grande G,Szurek B,Vera Cruz C,Bogdanove AJ,Oliva R

更新日期：2016-09-26 00:00:00

abstract：:Glycosyltransferases (GTs) are bidirectional biocatalysts catalyzing the glycosylation of diverse molecules. However, the extensive applications of GTs in glycosides formation are limited due to their requirements of expensive nucleotide diphosphate (NDP)-sugars or NDP as the substrates. Here, in an effort to characte...

journal_title：Scientific reports

authors： Yuan S,Yin S,Liu M,Kong JQ

更新日期：2018-04-12 00:00:00

abstract：:Transcatheter arterial embolization (TAE), as an alternative to surgery for iatrogenic renal vascular injury (IRVI), may have unsatisfactory outcomes. Nonetheless, there is inadequate information regarding the predictors of TAE outcomes for IRVI in the literature. The aim of this retrospective study was to investigate...

journal_title：Scientific reports

authors： Lee SY,Wang ML,Wong YC,Wu CH,Wang LJ

更新日期：2019-11-19 00:00:00

abstract：:Radiation weighting factor wR for photons and electrons has been defined as unity independently of the energy of the particles. However, the biological effects depend on the incident energies according to in vitro experimental data. In this study, we have quantified the energy concentration along electron tracks in te...

journal_title：Scientific reports

authors： Yachi Y,Yoshii Y,Matsuya Y,Mori R,Oikawa J,Date H

更新日期：2019-11-27 00:00:00

abstract：:The prognostic factors of patients who undergo radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is not fully elucidated. We aimed to investigate the role of liver stiffness (LS) and spleen stiffness (SS) measured by acoustic radiation force impulse (ARFI) elastography in determining the prognoses of pa...

journal_title：Scientific reports

authors： Lee PC,Chiou YY,Chiu NC,Chen PH,Liu CA,Kao WY,Huo TI,Huang YH,Hou MC,Lin HC,Wu JC,Su CW

更新日期：2020-02-06 00:00:00

abstract：:Air pollution has been classified as a group 1 carcinogen in humans, but the underlying tumourigenic mechanisms remain unclear. In Xuanwei city of Yunnan Province, the lung cancer incidence is among the highest in China, owing to severe air pollution generated by the combustion of smoky coal, providing a unique opport...

journal_title：Scientific reports

authors： Pan HL,Wen ZS,Huang YC,Cheng X,Wang GZ,Zhou YC,Wang ZY,Guo YQ,Cao Y,Zhou GB

更新日期：2015-09-23 00:00:00

abstract：:Conventional concentrators with inhomogeneous coating materials that fully enclose the destined region pose great challenges for fabrication. In this paper, we propose to design an EM concentrator with homogeneous materials. Distinguished from conventional ones, the elaborately designed EM concentrator features a conc...

journal_title：Scientific reports

authors： Madni HA,Hussain K,Jiang WX,Liu S,Aziz A,Iqbal S,Mahboob A,Cui TJ

更新日期：2018-06-25 00:00:00

abstract：:We have prepared and studied a family of cyanobiphenyl dimers with varying linking groups with a view to exploring how molecular structure dictates the stability of the nematic and twist-bend nematic mesophases. Using molecular modelling and 1D 1H NOESY NMR spectroscopy, we determine the angle between the two aromatic...

journal_title：Scientific reports

authors： Mandle RJ,Archbold CT,Sarju JP,Andrews JL,Goodby JW

更新日期：2016-11-07 00:00:00

abstract：:We conducted a prospective cohort study among HIV-negative MSM aged 18 years or older between 2007 and 2012 in Beijing, China to measure the rates of incident HIV and identify risk factors for infection. Among 5,800 participants evaluated at enrollment, we identified 486 prevalent cases of HIV (8.4%). Among the 3,625 ...

journal_title：Scientific reports

authors： Jia Z,Huang X,Wu H,Zhang T,Li N,Ding P,Sun Y,Liu Z,Wei F,Zhang H,Jiao Y,Ji Y,Zhang Y,Guo C,Li W,Mou D,Xia W,Li Z,Chen D,Yan H,Chen X,Zhao J,Meyers K,Cohen T,Mayer K,Salomon JA,Lu Z,Dye C

更新日期：2015-07-02 00:00:00

abstract：:Jagged1 activates Notch signaling and subsequently promotes osteogenic differentiation in human periodontal ligament cells (hPDLs). The present study investigated the participation of the Notch receptor, NOTCH2, in the Jagged1-induced osteogenic differentiation in hPDLs. NOTCH2 and NOTCH4 mRNA expression levels increa...

journal_title：Scientific reports

authors： Manokawinchoke J,Sumrejkanchanakij P,Boonprakong L,Pavasant P,Egusa H,Osathanon T

更新日期：2020-08-07 00:00:00

abstract：:Critical regulation of bile acid (BA) pool size and composition occurs via an intensive molecular crosstalk between the liver and gut, orchestrated by the combined actions of the nuclear Farnesoid X receptor (FXR) and the enterokine fibroblast growth factor 19 (FGF19) with the final aim of reducing hepatic BA synthesi...

journal_title：Scientific reports

authors： Gadaleta RM,Scialpi N,Peres C,Cariello M,Ko B,Luo J,Porru E,Roda A,Sabbà C,Moschetta A

更新日期：2018-11-21 00:00:00

abstract：:Certain bacteria produce iron oxide material assembled with nanoparticles (NPs) that are doped with silicon (Fe:Si ~ 3:1) in ambient environment. Such biogenous iron oxides (BIOX) proved to be an excellent electrode material for lithium-ion batteries, but underlying atomistic mechanisms remain elusive. Here, quantum m...

journal_title：Scientific reports

authors： Misawa M,Hashimoto H,Kalia RK,Matsumoto S,Nakano A,Shimojo F,Takada J,Tiwari S,Tsuruta K,Vashishta P

更新日期：2019-02-12 00:00:00

abstract：:Anoectochilus roxburghii and Anoectochilus formasanus are the major species of genus Anoectochilus used in traditional Chinese medicine for their abundant content of flavonoids and some other medicinal constituents. In recent years, their wild resources are gradually exhausted due to over-collection and ecological det...

journal_title：Scientific reports

authors： Yang L,Zhang JC,Qu JT,He G,Yu HQ,Li WC,Fu FL

更新日期：2019-12-27 00:00:00

abstract：:Salmonids show a high degree of phenotypic plasticity that can differ among genotypes, and this variation is one of the major factors contributing to uncertainty in extrapolating laboratory-based risk assessment data to nature. Many studies have examined the relative growth and survival of transgenic and non-transgeni...

journal_title：Scientific reports

authors： Vandersteen WE,Leggatt R,Sundström LF,Devlin RH

更新日期：2019-01-23 00:00:00

abstract：:The Near-infrared Fluorescence (NIRF) molecular imaging of cancer is known to be superior in sensitivity, deeper penetration, and low phototoxicity compared to other imaging modalities. In view of an increased need for efficient and targeted imaging agents, we synthesized a NAD(P)H quinone oxidoreductase 1 (NQO1)-acti...

journal_title：Scientific reports

authors： Punganuru SR,Madala HR,Arutla V,Zhang R,Srivenugopal KS

更新日期：2019-06-12 00:00:00

abstract：:p53 is a representative transcription factor that activates multiple target genes. To realize stimulus-dependent specificities, p53 has to recognize targets with structural variety, of which molecular mechanisms are largely unknown. Here, we conducted a series of long-time scale (totally more than 100-ms) coarse-grain...

journal_title：Scientific reports

authors： Terakawa T,Takada S

更新日期：2015-11-24 00:00:00

abstract：:The possibility of cluster radioactivity (CR) of the neutron-deficient nuclei in the trans-tin region is explored by using the effective liquid drop model (ELDM), generalized liquid drop model (GLDM), and several sets of analytic formulas. It is found that the minimal half-lives are at Nd = 50 (Nd is the neutron numbe...

journal_title：Scientific reports

authors： Gao Y,Cui J,Wang Y,Gu J

更新日期：2020-06-04 00:00:00

abstract：:The bacterial stringent response is a key regulator of bacterial virulence, biofilm formation and antibiotic tolerance, and is a promising target for the development of new antibacterial compounds. The intracellular nucleotide (p)ppGpp acts as a messenger orchestrating the stringent response. A synthetic peptide 1018 ...

journal_title：Scientific reports

authors： Andresen L,Tenson T,Hauryliuk V

更新日期：2016-11-07 00:00:00

abstract：:Lipids play an important role in energy storage, membrane structure stabilization and signaling. Parasitoids are excellent models to study lipidomics because a majority of them do not accumulate during their free-living life-stage. Studies on parasitoids have mostly focused on the changes in the lipids and gene transc...

journal_title：Scientific reports

authors： Gao X,Luo J,Lü L,Zhang L,Zhang S,Cui J

更新日期：2018-05-17 00:00:00

abstract：:Many chemical reactions in biological cells occur at very low concentrations of constituent molecules. Thus, transcriptional gene-regulation is often controlled by poorly expressed transcription-factors, such as E.coli lac repressor with few tens of copies. Here we study the effects of inherent concentration fluctuati...

journal_title：Scientific reports

authors： Pulkkinen O,Metzler R

更新日期：2015-12-04 00:00:00

abstract：:Magnetic small-angle neutron scattering (SANS) is a powerful technique for investigating magnetic nanoparticle assemblies in nonmagnetic matrices. For such microstructures, the standard theory of magnetic SANS assumes uniformly magnetized nanoparticles (macrospin model). However, there exist many experimental and theo...

journal_title：Scientific reports

authors： Vivas LG,Yanes R,Michels A

更新日期：2017-10-12 00:00:00

abstract：:Elevated ground-level ozone (O3), which is an important aspect of air quality related to public health, has been causing increasing concern. This study investigated the spatiotemporal distribution of ground-level O3 concentrations in China using a dataset from the Chinese national air quality monitoring network during...

journal_title：Scientific reports

authors： Wang WN,Cheng TH,Gu XF,Chen H,Guo H,Wang Y,Bao FW,Shi SY,Xu BR,Zuo X,Meng C,Zhang XC

更新日期：2017-06-16 00:00:00

abstract：:We study semiconductor hyperbolic metamaterials (SHMs) at the quantum limit experimentally using spectroscopic ellipsometry as well as theoretically using a new microscopic theory. The theory is a combination of microscopic density matrix approach for the material response and Green's function approach for the propaga...

journal_title：Scientific reports

authors： Montaño I,Campione S,Klem JF,Beechem TE,Wolf O,Sinclair MB,Luk TS

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency leads to impaired cortisol biosynthesis. Treatment includes glucocorticoid supplementation. We studied the specific metabolomics signatures in CAH patients using two different algorithms. METHODS:In a case-control study of CAH patients ma...

journal_title：Scientific reports

authors： Nguyen LS,Prifti E,Ichou F,Leban M,Funck-Brentano C,Touraine P,Salem JE,Bachelot A

更新日期：2020-06-01 00:00:00

abstract：:The opportunistic pathogen Staphylococcus aureus is responsible for causing infections related to indwelling medical devices, where this pathogen is able to attach and form biofilms. The intrinsic properties given by the self-produced extracellular biofilm matrix confer high resistance to antibiotics, triggering infec...

journal_title：Scientific reports

authors： Matilla-Cuenca L,Gil C,Cuesta S,Rapún-Araiz B,Žiemytė M,Mira A,Lasa I,Valle J

更新日期：2020-11-03 00:00:00

abstract：:Previous results regarding the associations between esophageal squamous-cell carcinoma (ESCC) risk and smoking/alcohol drinking in high-risk areas are inconsistent. We performed a large population-based case-control study from 2010 to 2013 in a high-incidence area of China, and enrolled 1353 ESCC cases and 1961 contro...

journal_title：Scientific reports

authors： Yang X,Chen X,Zhuang M,Yuan Z,Nie S,Lu M,Jin L,Ye W

更新日期：2017-12-08 00:00:00