Reduction of fatigue and anger-hostility by the oral administration of 5-aminolevulinic acid phosphate: a randomized, double-blind, placebo-controlled, parallel study.

abstract：:In this paper, the composition, structure, morphology and kinetics of evolution during isothermal oxidation of Fe48Cr15Mo14Y2C15B6 metallic glass powder in the supercooled region are investigated by an integrated ex-situ and in-situ characterization and modelling approach. Raman and X-ray diffraction spectra establish...

journal_title：Scientific reports

authors： Paul T,Zhang L,Biswas S,Loganathan A,Frith MG,Ilavsky J,Kuzmenko I,Puckette J,Kalkan AK,Agarwal A,Harimkar SP

更新日期：2019-05-02 00:00:00

abstract：:Inspired by the well-documented tumor protecting ability of paullones, recently, we synthesized novel paullone-like scaffolds, indole-fused benzo-oxazepines (IFBOs), and screened them against hepatocellular carcinoma (HCC) specific Hep-G2 cells. Three of the synthesized compounds significantly attenuated the progressi...

journal_title：Scientific reports

authors： Singh AK,Bhadauria AS,Kumar U,Raj V,Rai A,Kumar P,Keshari AK,Kumar D,Maity B,Nath S,Prakash A,Saha S

更新日期：2018-04-12 00:00:00

abstract：:Water, methane, and ammonia are commonly considered to be the key components of the interiors of Uranus and Neptune. Modelling the planets' internal structure, evolution, and dynamo heavily relies on the properties of the complex mixtures with uncertain exact composition in their deep interiors. Therefore, characteris...

journal_title：Scientific reports

authors： Guarguaglini M,Hernandez JA,Okuchi T,Barroso P,Benuzzi-Mounaix A,Bethkenhagen M,Bolis R,Brambrink E,French M,Fujimoto Y,Kodama R,Koenig M,Lefevre F,Miyanishi K,Ozaki N,Redmer R,Sano T,Umeda Y,Vinci T,Ravasio A

更新日期：2019-07-12 00:00:00

abstract：:The complexity of the frictional dynamics at the microscopic scale makes difficult to identify all of its controlling parameters. Indeed, experiments on sheared elastic bodies have shown that the static friction coefficient depends on loading conditions, the real area of contact along the interfaces and the confining ...

journal_title：Scientific reports

authors： Giacco F,Ciamarra MP,Saggese L,de Arcangelis L,Lippiello E

更新日期：2014-10-27 00:00:00

abstract：:Kyoto probe 1 (KP-1) rapidly distinguishes between human ES/iPS (hES/iPS) cells and their differentiated cells. Recently, we generated induced tissue-specific stem cells from pancreas (iTS-P cells) using reprogramming factors and tissue-specific selection. The iTS-P cells have self-renewal potential, and subcutaneousl...

journal_title：Scientific reports

authors： Miyagi-Shiohira C,Saitoh I,Watanabe M,Noguchi H

更新日期：2020-10-22 00:00:00

abstract：:Nucleic acid polymers (NAPs) block the release of subviral particles from hepatocytes, a mechanism consistent with their antiviral activity against hepatitis B virus (HBV) in patients. Analysis of immunostimulatory properties of NAPs were conducted with several NAP species: REP 2006, the prototypic degenerate NAP [dN]...

journal_title：Scientific reports

authors： Real CI,Werner M,Paul A,Gerken G,Schlaak JF,Vaillant A,Broering R

更新日期：2017-03-08 00:00:00

abstract：:Nano-flowers reported so far were mostly constituted of inorganic or hybrid materials. We have synthesized and crystallized a new organic compound, 1, 2-bis(tritylthio)ethane forming an organic nano-flower consisting of single crystalline petals. Crystal structure at nano and micro level indicates that π-π stacking in...

journal_title：Scientific reports

authors： Sasidharan S,P C S,Chaudhary N,Ramakrishnan V

更新日期：2017-12-11 00:00:00

abstract：:SNPs, abundant in human genome with lower mutation rate, are attractive to genetic application like forensic, anthropological and evolutionary studies. Universal SNPs showing little allelic frequency variation among populations while remaining highly informative for human identification were obtained from previous stu...

journal_title：Scientific reports

authors： Zhang S,Bian Y,Zhang Z,Zheng H,Wang Z,Zha L,Cai J,Gao Y,Ji C,Hou Y,Li C

更新日期：2015-12-22 00:00:00

abstract：:Continuous gas-phase synthesis of nanoparticles is associated with rapid agglomeration, which can be a limiting factor for numerous applications. In this report, we challenge this paradigm by providing experimental evidence to support that gas-phase methods can be used to produce ultrapure non-agglomerated "singlet" n...

journal_title：Scientific reports

authors： Feng J,Biskos G,Schmidt-Ott A

更新日期：2015-10-29 00:00:00

abstract：:Three-dimensional models of kidney tissue that recapitulate human responses are needed for drug screening, disease modeling, and, ultimately, kidney organ engineering. Here, we report a bioprinting method for creating 3D human renal proximal tubules in vitro that are fully embedded within an extracellular matrix and h...

journal_title：Scientific reports

authors： Homan KA,Kolesky DB,Skylar-Scott MA,Herrmann J,Obuobi H,Moisan A,Lewis JA

更新日期：2016-10-11 00:00:00

abstract：:Our study is major to establish and validate a simple type||diabetes mellitus (T2DM) screening model for identifying high-risk individuals among Chinese adults. A total of 643,439 subjects who participated in the national health examination had been enrolled in this cross-sectional study. After excluding subjects with...

journal_title：Scientific reports

authors： Xue M,Su Y,Feng Z,Wang S,Zhang M,Wang K,Yao H

更新日期：2020-07-14 00:00:00

abstract：:Several dietary factors have been suspected to play a role in the development of advanced islet autoimmunity (IA) and/or type 1 diabetes (T1D), but the evidence is fragmentary. A prospective population-based cohort of 6081 Finnish newborn infants with HLA-DQB1-conferred susceptibility to T1D was followed up to 15 year...

journal_title：Scientific reports

authors： Syrjälä E,Nevalainen J,Peltonen J,Takkinen HM,Hakola L,Åkerlund M,Veijola R,Ilonen J,Toppari J,Knip M,Virtanen SM

更新日期：2019-05-23 00:00:00

abstract：:MicroRNAs are potent regulators of gene expression that have been widely implicated in reproduction and embryo development. Recent studies have demonstrated that miR-21, a microRNA extensively studied in the context of disease, is important in multiple facets of reproductive biology including folliculogenesis, ovulati...

journal_title：Scientific reports

authors： Tscherner A,Brown AC,Stalker L,Kao J,Dufort I,Sirard MA,LaMarre J

更新日期：2018-08-01 00:00:00

abstract：:The recent development of a CRISPR-Cas9-based homing system for the suppression of Anopheles gambiae is encouraging; however, with current designs, the slow emergence of homing-resistant alleles is expected to result in suppressed populations rapidly rebounding, as homing-resistant alleles have a significant fitness a...

journal_title：Scientific reports

authors： Marshall JM,Buchman A,Sánchez C HM,Akbari OS

更新日期：2017-06-19 00:00:00

abstract：:The MITF transcription factor is a master regulator of melanocyte development and a critical factor in melanomagenesis. The related transcription factors TFEB and TFE3 regulate lysosomal activity and autophagy processes known to be important in melanoma. Here we show that MITF binds the CLEAR-box element in the promot...

journal_title：Scientific reports

authors： Möller K,Sigurbjornsdottir S,Arnthorsson AO,Pogenberg V,Dilshat R,Fock V,Brynjolfsdottir SH,Bindesboll C,Bessadottir M,Ogmundsdottir HM,Simonsen A,Larue L,Wilmanns M,Thorsson V,Steingrimsson E,Ogmundsdottir MH

更新日期：2019-01-31 00:00:00

abstract：:Scattering of H2 on CO is of great importance in astrophysics and also is a benchmark system for comparing theory to experiment. We present here a new 6-dimensional potential energy surface for the ground electronic state of H2-CO with an estimated uncertainty of about 0.6 cm(-1) in the global minimum region, several ...

journal_title：Scientific reports

authors： Faure A,Jankowski P,Stoecklin T,Szalewicz K

更新日期：2016-06-23 00:00:00

abstract：:Early fruit development is crucial for crop production in tomato. After fertilization, the ovary undergoes cell division and cell expansion before maturation. Although the roles of regulatory signals such as hormone and carbohydrate during early fruit development have been studied, the spatial distribution and the seq...

journal_title：Scientific reports

authors： Zhang S,Xu M,Qiu Z,Wang K,Du Y,Gu L,Cui X

更新日期：2016-03-18 00:00:00

abstract：:Thrombosis has proven to be extremely difficult to predict. Measuring the generation of thrombin is a very sensitive method to detect changes in the hemostatic system. We developed a method based on the generation of thrombin to further fingerprint hemostasis, which we have named thrombin dynamics. Via this method we ...

journal_title：Scientific reports

authors： de Laat-Kremers RMW,Yan Q,Ninivaggi M,de Maat M,de Laat B

更新日期：2020-07-27 00:00:00

abstract：:Studies of past human-landscape interactions rely upon the integration of archaeological, biological and geological information within their geographical context. However, detecting the often ephemeral traces of human activities at a landscape scale remains difficult with conventional archaeological field survey. Geop...

journal_title：Scientific reports

authors： De Smedt P,Van Meirvenne M,Herremans D,De Reu J,Saey T,Meerschman E,Crombé P,De Clercq W

更新日期：2013-01-01 00:00:00

abstract：:Coherent Anti-Stokes Raman Spectroscopy (CARS) is performed on single spores (conidia) of the fungus Aspergillus nidulans in order to establish a baseline measurement for fungal spores. Chemical maps of single spores are generated and spectral differentiation between the cell wall and the cytoplasm is achieved. Princi...

journal_title：Scientific reports

authors： D Strycker B,Han Z,Commer B,D Shaw B,V Sokolov A,O Scully M

更新日期：2019-02-11 00:00:00

abstract：:Realization of phosphor-free white-light emitters is becoming an important milestone on the road to achieve high quality and reliability in high-power white-light-emitting diodes (LEDs). However, most of reported methods have not been applied to practical use because of their difficulties and complexity. In this study...

journal_title：Scientific reports

authors： Min D,Park D,Jang J,Lee K,Nam O

更新日期：2015-12-02 00:00:00

abstract：:Autophagy is a major regulator of pancreatic beta cell homeostasis. Altered autophagic activity has been implicated in the beta cells of patients with type 2 diabetes, and in the beta cells of obese diabetic rodents. Here, we show that autophagy was induced in beta cells by either a high-fat diet or a combined high-fa...

journal_title：Scientific reports

authors： Sheng Q,Xiao X,Prasadan K,Chen C,Ming Y,Fusco J,Gangopadhyay NN,Ricks D,Gittes GK

更新日期：2017-11-27 00:00:00

abstract：:Protein colocalisation is often studied using pixel intensity-based coefficients such as Pearson, Manders, Li or Costes. However, these methods cannot be used to study object-based colocalisations in biological systems. Therefore, a novel method is required to automatically identify regions of fluorescent signal in tw...

journal_title：Scientific reports

authors： Khushi M,Napier CE,Smyth CM,Reddel RR,Arthur JW

更新日期：2017-08-21 00:00:00

abstract：:As any cognitive task, visual search involves a number of underlying processes that cannot be directly observed and measured. In this way, the movement of the eyes certainly represents the most explicit and closest connection we can get to the inner mechanisms governing this cognitive activity. Here we show that the p...

journal_title：Scientific reports

authors： Amor TA,Reis SD,Campos D,Herrmann HJ,Andrade JS Jr

更新日期：2016-02-11 00:00:00

abstract：:Production of lactic acid from glycerol is a cascade catalytic procedure using multifunctional catalysts combined with oxidative and acidic catalytic sites. Therefore, a series of silver-exchanged phosphomolybdic acid catalysts (AgxH3-xPMo12O40, x = 1 ~ 3, abbreviated as AgxPMo) was designed and applied in glycerol ox...

journal_title：Scientific reports

authors： Tao M,Dan Zhang,Guan H,Huang G,Wang X

更新日期：2016-07-19 00:00:00

abstract：:High frequency oscillations (HFOs) are bursts of neural activity in the range of 80 Hz or higher, recorded from intracranial electrodes during epileptiform discharges. HFOs are a proposed biomarker of epileptic brain tissue and may also be useful for seizure forecasting. Despite such clinical utility of HFOs, the spat...

journal_title：Scientific reports

authors： Smith EH,Merricks EM,Liou JY,Casadei C,Melloni L,Thesen T,Friedman DJ,Doyle WK,Emerson RG,Goodman RR,McKhann GM 2nd,Sheth SA,Rolston JD,Schevon CA

更新日期：2020-11-05 00:00:00

abstract：:We study universal uncertainty relations and present a method called joint probability distribution diagram to improve the majorization bounds constructed independently in [Phys. Rev. Lett. 111, 230401 (2013)] and [J. Phys. A. 46, 272002 (2013)]. The results give rise to state independent uncertainty relations satisfi...

journal_title：Scientific reports

authors： Li T,Xiao Y,Ma T,Fei SM,Jing N,Li-Jost X,Wang ZX

更新日期：2016-10-24 00:00:00

abstract：:The estrogen receptor (ER) regulates the survival and growth of breast cancer cells, but it is less clear how components of the tissue microenvironment affect ER-mediated responses. We set out to test how human mammary fibroblasts (HMFs) modulate ER signaling and downstream cellular responses. We exposed an organotypi...

journal_title：Scientific reports

authors： Morgan MM,Livingston MK,Warrick JW,Stanek EM,Alarid ET,Beebe DJ,Johnson BP

更新日期：2018-05-08 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are highly plastic cells that are able to transdifferentiate or dedifferentiate under appropriate conditions. In the present study, we reported here that after in vitro induction of osteogenic differentiation, MSCs could be reverted to a primitive stem cell population (dedifferentiated os...

journal_title：Scientific reports

authors： Rui Y,Xu L,Chen R,Zhang T,Lin S,Hou Y,Liu Y,Meng F,Liu Z,Ni M,Tsang KS,Yang F,Wang C,Chan HC,Jiang X,Li G

更新日期：2015-06-08 00:00:00

abstract：:The bacterial flagellar motor is a unique supramolecular complex which converts ion flow into rotational force. Many biological devices mainly use two types of ions, proton and sodium ion. This is probably because of the fact that life originated in seawater, which is rich in protons and sodium ions. The polar flagell...

journal_title：Scientific reports

authors： Onoue Y,Iwaki M,Shinobu A,Nishihara Y,Iwatsuki H,Terashima H,Kitao A,Kandori H,Homma M

更新日期：2019-08-02 00:00:00